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1680 articles for “BCS Class II/IV drugs”
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Estimation of Alogliptin and Dapagliflozin in Synthetic Mixture by RP-HPLC Method
Abstract: The primary objective of the proposed research was to develop and validate analytical methods for the simultaneous quantification of Alogliptin and Dapagliflozin in a synthetic mixture. Alogliptin and Dapagliflozin are medications used for managing diabetes, with Alogliptin inhibiting the enzyme Dipeptidyl peptidase-4 and Dapagliflozin belonging to the class of sodium-glucose cotransporter 2 inhibitors. High-performance liquid chromatography method development was conducted using a C18 column (250 mmX4.6 mm, 5 μm particle …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 37–46 Read article
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Crop Yield Prediction Using Machine Learning Algorithm Based on Climate Variables
Abstract: India's economy is based primarily on agriculture, as over 50% of the country's population depends on it for their livelihood. The long-term viability of agriculture is seriously threatened by variations in the weather, climate, and other environmental factors. Because machine learning provides tools for decision assistance in agricultural yield prediction, including guidance on which crops to plant and when to plant them during the growing season, it is essential to …
Published in International Journal of Cheminformatics · Vol. 1, Issue 2, 2023 · pp. 49–52 Read article
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Study of Parenting Style and Its Effect on Emotional Regulation and Impulsiveness in Adolescents
Abstract: Parenting styles vary throughout parents, and these styles can have a big impact on the growth and welfare of their kids. The study's goals include the following: (i) To determine how parenting practices affect teenagers' ability to control their emotions and impulsivity. (ii) To find out the impact of parenting style on emotional regulation and impulsiveness in adolescents. (iii) To determine the differences in impulsivity and emotional regulation between teenage …
Published in International Journal of Children · Vol. 1, Issue 2, 2024 · pp. 1–14 Read article
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A Study to Assess the Knowledge and Attitude Regarding Post Dialysis Dietary Regulations Among Care Givers of Chronic Kidney Disease Patient Undergoing Hemodialysis in Selected Hemodialysis Unit at Agartala, West Tripura
Abstract: Introduction and objectives of the study: - Chronic renal failure is a gradual, irreversible decline in kidney function, leading to uremia. This condition necessitates hemodialysis to manage the body's internal environment. Dialysis becomes essential at the final stage of chronic kidney disease, known as end-stage renal disease. Objectives of the study are as: i) The objectives of this study are: i) To evaluate caregivers' understanding of dietary regulations following dialysis …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 2, 2024 · pp. 89–103 Read article
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Comprehensive Approaches to Understanding and Managing Alzheimer’s Disease
Abstract: Alzheimer’s disease is an advanced neurodegenerative disorder described by intense memory loss. It strictly affects the patient’s quality life. The popularity of AD has been increasing in recent years. It is the most common form of mental disorder affecting more than 20 million people in the world. The Alzheimer’s disease is treated with cholinesterase inhibitors or NMDA-receptor (N-methyl D-aspartate) antagonists but here the question is about the therapeutic effect of …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 1–9 Read article
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Anticancer Activity of Calotropis procera by Molecular Docking Analysis
Abstract: Cyclin-dependent kinase 2 (CDK2) is a protein synthesized by Calotropis procera. It is known to be responsible for causing cancer in the human body. Studies have presented the significance of the phytochemicals to inhibit the CDK2 protein. Adsorption, distribution, metabolism, and excretion (Swiss ADME) and PubChem were the pharmacological tools which were used to check molecular weight, which should be less than 500D, acceptors less than 10, and donors less …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 01–07 Read article
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Formulation and Evaluation of Topical Anti-Acne Gel from Coriander and Garlic Extract
Abstract: Objective: To develop and evaluate a topical anti-acne gel formulated using aqueous extracts of coriander (Coriandrum sativum) and garlic (Allium sativum). The study aims to assess the antibacterial efficacy of the gel against acne-causing bacteria, specifically Propionibacterium acnes. Methods: 1.Extraction: Coriander Extract: Aqueous extraction was performed by soaking coriander seeds in distilled water, followed by filtration. Garlic Extract: Non-chemical extraction involved mixing crushed garlic with honey in a 1:1 ratio …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 3, 2024 · pp. 10–15 Read article
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Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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Crystallographic Studies on The Stability of Pharmaceutical Compound
Abstract: Crystallographic studies provide detailed insights into the molecular structure and intermolecular interactions within a crystal lattice, which are key determinants of a compound's stability. By analyzing crystal structures, researchers can identify potential polymorphs, solvates, and hydrates that may impact the physical and chemical stability of the drug. This knowledge helps in optimizing formulation strategies, predicting shelf life, and ensuring consistent drug performance. Advanced techniques like X-ray diffraction and neutron diffraction …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 1, 2024 · pp. 38–42 Read article
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Pedagogical Innovations and Student Voices: A Longitudinal Examination of Engagement in Elementary Schools
Abstract: From 2023 to 2024, this mixed-approaches longitudinal study follows students of varying ages to see how characteristics related to emotional and social development, curriculum flexibility, and innovative teaching methods affect their engagement and performance in the classroom. Educators and students are followed for one year in this study to see how educational approaches change and impact students' learning. For this study, researchers conducted a one-time survey of a sizable group …
Published in International Journal of Education Sciences · Vol. 1, Issue 2, 2024 · pp. 44–55 Read article
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RP-HPLC method for simultaneous determination of Drospirenone and Ethinylestradiol in Bulk and their Pharmaceutical dosage form
Abstract: Oral contraceptive is used to prevent the pregnancy which is contain hormones to block the release of eggs from the ovaries. Most of them contain estrogen and progesterone. Nowadays, usage of hormonal contraceptive is sharply enhancing; around 100 million of women worldwide are taking these drugs. With this drug fertility rate can be supressed as long as they want or plan their activity along with these drugs provide efficacy, reliability, …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 46–67 Read article
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In Silico Molecular Docking Studies of Phytocompounds from Melissa officinalis Against MPXV Poxin Target
Abstract: Objectives: This study aimed to evaluate the inhibitory potential of phytocompounds of Melissa officinalis against the MPXV poxin protein target, a key virulence factor in monkeypox infection. Methods: Molecular docking performed using PyRx, a virtual screening software, was conducted to predict the binding affinities of the compounds to MPXV poxin. Prior to docking, the compounds were subjected to comprehensive analysis, including Lipinski's rule of five, evaluation of physicochemical properties, pharmacological …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 25–38 Read article
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The Analysis of Deep Learning-Based Methods for Identifying Diabetic Retinopathy
Abstract: Diabetic retinopathy (DR) is a degenerative eye condition resulting from diabetes mellitus, where high blood glucose levels lead to lesions on the retina. This condition is considered the leading cause of blindness among working-age diabetic patients, particularly in developing countries. As the disease is irreversible, the treatment aims to preserve the patient’s current vision. Early detection is crucial for effective management of DR to maintain vision. One of the main …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 15–31 Read article
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Antibiotics in the Modern Era: Challenges, Misuse, and the Fight Against Resistance
Abstract: Overuse and inappropriate use of antibiotics in human medicine, agriculture, and environmental pollution. It is one of the biggest public health risks of the 21st century. The discovery of new antibiotics slowdown and the emergence of multidrug-resistant (MDR) microorganisms has highlighted the urgent need to Creative approaches to fighting opposition. This review explores the current challenges in antibiotic use, the factors driving resistance, and the strategies being implemented to address …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 57–70 Read article
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Deep Learning Approach to Produce Artificial Speech (Text-To-Audio)
Abstract: This program utilizes key features of the .NET framework to facilitate smooth text-to-speech conversion and audio playback. Upon execution, users are prompted to input text via a graphical user interface (GUI), which the program converts into speech using the ‘SpeechSynthesizer’ class from the ‘System. Speech.Synthesis’ namespace. The audio that has been synthesized is handled and stored as a WAV file called ‘output.wav’ by utilizing the ‘FileStream’ class, allowing for future …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 12, Issue 1, 2025 · pp. 28–33 Read article
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Fabrics and medical devices (catheters) coated with Zn doped CuO nanoparticles kills micro-oganisms and provide healthy environment
Abstract: These days, drug resistance by microorganisms is a major challenge in the field of medicinal chemistry. Most of the familiar antibiotics turnout to be of no impact in curbing the proliferation of microorganism (bacteria, virus and fungus). To address the issue of multi-drug resistance (MDR) and extremely drug resistance (EDR) in microorganisms that cause various health complications, like the dental decay, biofilm formation, foul smell, delayed wound healing, aggravation of …
Published in Journal of Catalyst & Catalysis · Vol. 12, Issue 1, 2025 · pp. 1–9 Read article
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The Contribution of A. I. in Pharmaceutical Software
Abstract: The integration of Artificial Intelligence (AI) in pharmaceutical software has significantly transformed drug development, regulatory processes, and clinical management. AI-powered tools are revolutionizing data analysis, predictive modeling, and decision-making, enhancing the efficiency and accuracy of drug discovery and development. This article explores the multifaceted contributions of AI to pharmaceutical software, including its applications in drug screening, personalized medicine, clinical trial optimization, and regulatory compliance. Additionally, we examine how AI is …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 1, 2025 · pp. 1–10 Read article
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Expanding Hicks Contraction Theory, Multi-Valued Mappings in Generalized b-Menger Spaces
Abstract: This paper extends the Hicks contraction theory to multi-valued mappings within generalized b-Manger spaces, a class of metric-like structures that accommodate more flexible distance functions. By introducing new definitions, such as generalized admissibility conditions and weak compatibility in the multivalued sense, we provide a comprehensive analysis of how these contractions behave in broader topological and metric contexts. Our approach systematically generalizes classical contraction principles by relaxing conventional constraints, thereby broadening …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 12, Issue 1, 2025 · pp. 1–05 Read article
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Solid Lipid Nanoparticles in Medicine: Formulation, Characterization and Future prospects
Abstract: An alternative to conventional colloidal carriers such liposomes, polymeric nanoparticles, and emulsions, solid lipid nanoparticles (SLNs) were created in the early 1990s. Benefits include targeted medicine distribution, controlled drug release, and improved stability. An extensive review of the excipients utilized, the production techniques, including the membrane contractor approach, and the possible advantages and disadvantages of SLNs is given in this work. It investigates secondary stabilization techniques like freeze-drying and spray-drying, …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 1–15 Read article
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Future Prospects of AI in Pharmaceutical Industry and its Limitation
Abstract: The pharmaceutical industry is facing significant challenges, including prolonged drug development timelines, high costs, and low success rates in clinical trials. Traditional methods often result in inefficiencies, with new drug development taking over a decade and billions of dollars, yet most candidates fail in clinical trials due to issues like inefficacy or safety concerns. Artificial Intelligence (AI) has become a groundbreaking technology with the potential to tackle these issues effectively. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 6–13 Read article