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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Targeting TNFSF4 in the Management of Systemic Lupus Erythematosus
Abstract: Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder that remains a significant challenge for both healthcare providers and researchers. Despite advances in understanding its mechanisms, finding effective therapies is still difficult. This review highlights a potential therapeutic target in SLE research: tumor necrosis factor superfamily member 4 (TNFSF4), also referred to as OX40L. We explore how TNFSF4 contributes to SLE development, looking at its role in immune system regulation …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 3, 2024 · pp. 6–14 Read article
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Preserving Papaya Pulp with Potassium Metabisulfite: A Study on Prolonging Shelf Life
Abstract: Papaya is a highly perishable fruit with a shelf life of only 3 to 6 days under tropical conditions, leading to significant postharvest losses. This study aimed to preserve papaya pulp for subsequent use in product development .Pulp was extracted from “Indian Red Lady Variety” of papaya and treated with potassium metabisulphite (KMS) at concentrations of 500, 1000 and 1500 ppm. The treated pulp was stored at room and refrigerated …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 13, Issue 2, 2024 · pp. 06–14 Read article
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Utilizing circulation-derived cancer cells to evaluate patients with surgically treated stages I–IIIA NSCLC throughout the preoperative phase
Abstract: Context: When a tumor is considered resectable, surgery is viewed as the primary treatment approach for both early-stage and locally advanced non-small cell lung cancer (NSCLC). One of the most exciting areas of cancer research in the past ten years is liquid biopsy, which offers a practical non-invasive method for cancer detection and tracking. Circulating tumor cells (CTCs) have been linked to a worse prognosis and increased chance of relapse …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 3, 2024 · pp. 17–28 Read article
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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Molecular Docking of Saraca asoca (Ashoka) Phytocompounds for Ovarian Cancer Therapy
Abstract: Objective: One of the top five cancers that causes death in women is ovarian cancer, with increases awareness till date the rate of survival is unpredictable. Even though there are advance treatments introduced, chemotherapy is most suggested to the ovarian cancer patients but the rate of relapses increased and the tumors get resistant towards the drugs. This present study is to evaluate the interaction of phytocompounds from Saraca asoca an …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 27–35 Read article
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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Scientists Reinvent Low Energy Nuclear Reaction (LENR)/Cold Fusion
Abstract: Two of the researchers of The University of Utah, USA in 1989 named Dr. Martin Fleishmann and Stanley Pons declared that they had discovered a sustained nuclear fusion reaction at room temperature during electrolysis experiment that could solve the problem of energy requirement on this planet. The cold fusion reaction, also called low energy nuclear reaction (LENR) takes place at room temperature, unlike conventional fusion reaction where temperature required is …
Published in Trends in Mechanical Engineering & Technology · Vol. 14, Issue 3, 2024 Read article
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Design of a Water-Cooling System for the Inside Roof of 20t Electric Arc Furnace for Oxygen Blow Decarburization Using CFD Analysis
Abstract: An electric arc furnace (EAF) roof usually works at high temperature for a long time, undergoes not only heat radiations from electric arc, molten metal, and lining of high temperature, but also is washed and affected by chemical erosion due to high temperature and gas flow. In addition, it might be eroded by slag with high temperature. In， inside roof of EAF is more severely affected by heat load than …
Published in Journal of Thermal Engineering and Applications · Vol. 11, Issue 3, 2024 · pp. 11–17 Read article
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Enhancing Compressive Strength of M25 Grade Concrete Using Ceramic Tiles Waste and Waste Fiber Metal: A Path Toward Sustainable Construction
Abstract: This study explores the use of Ceramic Tiles Waste and Waste Fiber Metal as partial replacements in M25 grade concrete, focusing on their impact on compressive strength. Various combinations of waste materials were tested to determine the optimal mix proportions. Compressive strength tests were conducted on concrete cubes incorporating 0.30%, 0.40%, and 0.50% Waste Fiber Metal with varying percentages of Ceramic Tiles Waste ranging from 20% to 50%. The results …
Published in Journal of Structural Engineering and Management · Vol. 11, Issue 3, 2024 · pp. 13–19 Read article
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Safety of Foundation of Building
Abstract: The design of a building's foundation requires careful consideration of the load intensity applied from the structure above. To ensure stability and safety, the foundation depth must be sufficient to support the loads effectively. For residential buildings, where the loads are relatively lower, a foundation base size of 2.5 × 2.5 meters or 3 × 3 meters is typically adequate. In contrast, for structures with significantly higher loads, such as …
Published in Journal of Structural Engineering and Management · Vol. 11, Issue 3, 2024 · pp. 51–60 Read article
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Effect of Pigment Particle Size of Offset Inks on Printability
Abstract: The pigment is the most expensive part of printing inks. The process of making ink involves physical processes that require even distribution of pigments in the surrounding vehicle. This process is known as "Dispersion". The quality of the final dispersion decides print parameters like dot gain, density, print contrast, and gloss. In this work, the aim was to study how the ink behaves on the printing press based on the …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 275–283 Read article
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Assessment of Vitamin D Levels Among Hashimoto and Hypothyroidism Disease in Iraq, A Comparative Study
Abstract: The thyroid gland is a small gland that regulates the body’s metabolism. It secretes the hormones that the body needs to maintain this process. People of different ages may be afflicted with thyroid diseases, including Hashimoto disease and hypothyroidism. The current study aimed to compare the levels of vitamin D among patients with Hashimoto’s disease and hypothyroidism coming to the Diabetes and Endocrinology Center in Al-Sadr Medical City in Najaf …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 77–83 Read article
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A Comprehensive Review of FinFet Technology: Advantages, Challenges and Applications
Abstract: This has been complemented by improvements on the new layers that have surpassed the manufactures planar transistor by the new FinFET (Fin Field-Effect Transistor), which enhance modern demands on high performance, small size and low power consumption. This review is for a timely information on the latest development on FinFET technology, such as by curbing leakage currents by 50 percent and enhancing its speed by 30 percent proving that FinFETs …
Published in Journal of Semiconductor Devices and Circuits · Vol. 11, Issue 3, 2024 · pp. 1–12 Read article
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A Study to Evaluate the Effectiveness of Sensory Stimulation Program (SSP) on Motor Function (MF) and Verbal Response (VR) Among Patients with Stroke in ICU of Selected Hospitals at Salem
Abstract: Introduction: Stroke is a medical emergency and can cause permanent neurological damage, complications and death. Objectives: (1)To develop and validate a Sensory Stimulation Program aimed at enhancing motor function (M.F) and vital signs recovery (V.R) in stroke patients. (2)To evaluate and compare the pre-test and post-test scores of M.F and V.R in stroke patients receiving routine nursing care. (3)To assess and compare the pre-test and post-test scores of M.F and …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 16–28 Read article
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An Evaluation of the Impact of a Structured Teaching Program on Staff Nurses' Knowledge of Low Back Pain Prevention in Intensive Care Units at Selected Hospitals in Bangalore
Abstract: The study aimed to assess the knowledge of ICU nurses concerning the prevention of low back pain (LBP), determine the effectiveness of a structured teaching program (STP) in improving their knowledge, and examine the relationship between pre-test knowledge levels and various demographic factors. A pre-experimental research design was utilized, featuring a one-group pre-test and post-test method. The study employed non-probability convenience sampling to recruit 60 ICU nurses for participation. Data …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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Investigation of Electronic Transport in Li2O and ZnO Nanoparticles Containing Polypyrrole Systems
Abstract: Polypyrrole systems having nanocrystalline ZnO and Li2O with different compositions (PPy50 + Li2Ox + ZnO(50-x), where x = 0, 2, 4, 6, 8, and 10) have been produced by ball milling. compositions of the type The temperature-dependent DC conductivity of each sample was determined in the temperature range of 313 K to 363 K. The conductivity studies show that Polaron hopping was the conducting mechanism in the material composites. The …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 88–95 Read article
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A comprehensive study on elemental analysis and sustainable integration of CETP (common effluent treatment plant) sludge as a substitute to sand in concrete
Abstract: This study examines the utilization of sludge from common effluent treatment plants (CETP) as a fractional substitute for sand in M20 concrete mixtures. Its aim is to address disposal challenges associated with CETP sludge while promoting sustainable use of natural resources. The research assesses the structural and microstructural attributes of concrete mixes containing varying percentages of CETP sludge (0%, 10%, 20%, 30%, 40%, and 50%). Tests conducted include compressive, flexural, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 49–59 Read article
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Water Absorption and Mechanical Behaviour of Bagasse Fibre and Particle-Reinforced Hybrid Composite Materials
Abstract: This study investigates the mechanical behaviour and water absorption characteristics of bagasse fibre and groundnut shell particle (GSP)-reinforced hybrid composites using a phenol-formaldehyde (PF) resin matrix. Varying weight fractions of GSP (5%, 10%, 15%, and 20%) were incorporated into the composites, with bagasse fibre content kept constant at 30% by weight. Tensile, flexural, and impact strengths were measured, and the water absorption behaviour was evaluated following ASTM standards.The results indicated …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 115–124 Read article
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Experimental Analysis of Residual Stress, Micro-Hardness and Corrosion Behavior of HVOF Sprayed Composite Coating
Abstract: The utilisation of non-traditional composite coating materials, enhanced lubrication, and surface geometry optimisation have all contributed to the tribological performance. Piston rings are among the most crucial engine parts since friction causes between 40 and 45 percent of all energy loss. Fuel efficiency, power loss, and exhaust pollutants are all strongly impacted by the piston assembly's tribological performance. The present study's primary goal was to develop composite coating by using …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 77–82 Read article
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New Generation Waste Material as Sustainable Ingredient in Concrete: An Experimental Approach
Abstract: E-waste, including devices like phones and computers, poses serious environmental risks. To mitigate these, the construction industry is exploring e-waste as a material to enhance concrete strength and durability. Hence, the present study assesses the performance of M40-grade high-strength concrete by replacing coarse aggregates with 0% to 30% e-waste plastics at various intervals. As the e-waste replacement increased, fresh concrete's workability decreased gradually. The mix containing 30% e-waste experienced the …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 141–156 Read article