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1680 articles for “BCS Class II/IV drugs”
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Circadian Regulation of Lipid Peroxidation in the Brain: Linking Ferroptosis to Neurodegenerative Vulnerability
Abstract: The human brain operates through highly coordinated physiological and biochemical processes that regulate cognition, behavior, and neural adaptability. Central to these processes are mechanisms governing brain function, neurophysiology, and neuroplasticity, which are increasingly recognized to be influenced by circadian rhythms. Recent advances in cognitive neuroscience, neuroimaging, and behavioral neuroscience have revealed that disruptions in circadian regulation can significantly impact oxidative balance within the brain, particularly through enhanced lipid peroxidation. Lipid …
Published in International Journal of Brain Sciences · Vol. 3, Issue 2, 2026 · pp. 1–14 Read article
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Machine Learning–Guided Cognitive RF System with Dynamic FFT Resolution and Multiplier Reconfiguration for Adaptive Anti-Jamming Communication
Abstract: This paper presents a hierarchical adaptive RF communication system that integrates signal quality-based pre- processing with machine learning-driven signal classification to achieve robust and resource-efficient operation in dynamic, interference-prone environments. Unlike prior art that addresses adaptive RF, ML classification, or anti-jamming individually, this work uniquely combines real-time SNR/RSSI-based signal strength estimation with dynamic FFT size selection (64-, 256- , or 512-point) and arithmetic-level multiplier reconfiguration (CORDIC, Distributed Arithmetic, and hybrid …
Published in International Journal of Radio Frequency Innovations · Vol. 4, Issue 1, 2026 Read article
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Molecular Docking, QSAR Modeling, and ADMET Evaluation of Novel Pyrazolo-Pyrimidine Derivatives as Potential CDK-2 Inhibitors for Cancer Therapy
Abstract: Cyclin-dependent kinase-2 (CDK-2) is an essential regulator in cell cycle progression and is an important therapeutic target in cancer drug development. In the present study, an integrated computational approach involving molecular docking studies, QSAR modeling, ADMET prediction, and artificial intelligence-based analysis was used to identify pyrazolo-pyrimidine derivatives as potential CDK-2 inhibitors. Based on the molecular docking results, it was found that selected compounds exhibited high binding affinity towards the ATP …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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IoT-Based Real-Time Monitoring System for Temperature and Humidity Control in Pharmaceutical Manufacturing
Abstract: Environmental conditions, especially temperature and humidity, play a vital role in pharmaceutical manufacturing processes. Even minor fluctuations in these parameters can significantly influence the stability, potency, and overall effectiveness of drug formulations. In many cases, uncontrolled environmental variations may lead to chemical degradation, reduced shelf life, contamination risks, and substantial financial losses for manufacturers. Therefore, maintaining precise and consistent environmental conditions is essential to ensure product quality, regulatory compliance, and …
Published in International Journal of Mobile Computing Technology · Vol. 4, Issue 1, 2026 · pp. 32–37 Read article
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HPLC and Tandem MS Device for the Recognition of Emtricitabine and Tenofovir Alafenamide in K2EDTA Human Plasma Utilizing Emtricitabine 15ND2 Tenofovir D5 as an IS
Abstract: Developed very impressionable, discriminating, and exact extreme-efficiency liquid chromatographytandem bulk spectrometry form for measurement of Emtricitabine and Tenofovir Alafenamide in human plasma. Emtricitabine15ND2 Tenofovir D5 was used as a within the standard (IS). The samples were divided on Phenomenex Kinetex C18 5 μm 100A, 100*4.6 mm procession utilizing Acetonitrile: 0.2% formic acid, 60:40 V/V as movable state, the retention period of Emtricitabine: 1.36 minutes (±0.5 minutes), Emtricitabine 15ND2: 1.36 minutes …
Published in Research and Reviews: A Journal of Toxicology Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
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Pharmacoinformatic Based Screening Of Phytocompound Epigallocatechin Gallate To Identify As A Potential Bcl-2 Inhibitor
Abstract: Objectives: The B-cell lymphoma-2 (Bcl-2) is a protein that is particularly though to be involved in preventing apoptosis. Bcl-2 family members also essential for cancer survival, and its over expression has been linked to tumor genesis, development and resistance to anticancer treatments. The Bcl-2 family of members that inhibit apoptosis is a promising target for the creation of anticancer drugs. Methods: The study was based on computational approach using different …
Published in International Journal of Bioinformatics and Computational Biology Read article
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A Computational Study to Elucidate the Phytochemicals as An Antagonist Against Pruritis in Psoriasis
Abstract: Objective: Psoriasis is a chronic, non-contagious, auto-immune skin disorder that causes inflammation, pain, and itching in the affected areas. The etiology of this condition is not entirely understood, and while there are treatments available to manage the symptoms, there is currently no cure. The Transient receptor potential cation channel, subfamily Vanillin, member 3 (TRPV3), present in keratinocytes, allegedly had a part in the development of psoriasis-related pain and itching. Specifically, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 49–61 Read article
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Bone Fracture: Understanding, Therapies, and Rehabilitation
Abstract: Bone fractures are common injuries that can significantly impact an individual's quality of life. This article presents a comprehensive examination of bone fractures, encompassing their origins, categorization, and potential ramifications. This review of literature explores various therapeutic approaches and rehabilitation strategies employed in the management of bone fractures. Surgical interventions, non-surgical treatments, and rehabilitation techniques are discussed, highlighting their effectiveness in promoting healing, restoring function, and preventing complications. The article …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 24–28 Read article
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Card Fraud Detection Using Artificial Neural Network and Multilayer Perception Algorithm
Abstract: Fraud has posed a significant challenge for merchants, especially in the online business sector, over the course of many years. This is primarily due to the advancements in technology that have made credit card transactions a common method of payment. Credit card fraud refers to the unauthorized use of a credit card by an individual for personal purposes, without the owner's consent and with no intention of paying for the …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 1, Issue 1, 2023 · pp. 21–30 Read article
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ASL Mobile Translator with CNN Algorithm
Abstract: There are around 63 million people in India with speech and hearing disabilities, and the number goes all the way up to 300 million across the world. All of them face issues in their day-to-day life as they can only have conversations with gestures. American Sign Language (ASL) mobile translator with convolutional neural network (CNN) algorithm is an easy-to-use mobile application, which uses complex images and video recognizing models built …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 1, Issue 2, 2023 · pp. 31–38 Read article
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Antibiotics – Challenges in our Post-COVID Era
Abstract: Accidental discovery of the antibiotic properties of penicillin marked a watershed moment in healthcare, transforming the landscape of medicine and saving countless lives of injured and infected. Further research and awareness on the advantages of this “miracle drug” resulted in its bulk production in the 1940s, and played a crucial role in saving lives of thousands during World War II. Subsequent discoveries especially broad-spectrum antibiotics paved the way for further …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 1–5 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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A Review On Wonder Plant Aloe Vera
Abstract: For millennia, people have utilized and appreciated the health, aesthetic, therapeutic, and skin- care benefits of aloe vera plants. Aloe is a plant that grows in dry regions of Africa, Asia, Europe, and America. It has approximately 300 species. Aloe barbadensis miller is the botanical name of aloe vera. It is a perennial, xerophytic, succulent, shrubby or arborescent plant with pea-green hue that is a member of the Asphodelaceae (Liliaceae) …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 1, 2024 · pp. 1–9 Read article
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Formulation and Evaluation of Aqueous Azadirachta indica Phytosome
Abstract: A phytosome is a complex created through the union of a natural compound, typically a plant extract, with a phospholipid. Phospholipids play a crucial role in cell membranes, possessing a structure comprising a hydrophilic (water-attracting) head and hydrophobic (water-repelling) tails. This distinctive structure enables phospholipids to construct lipid bilayers, fundamental elements of cell membranes. Phytosome increases the bioavailability, and absorption of active chemical constituents in the extract with the help …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 1, 2024 · pp. 17–30 Read article
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Credit Card Fraud Detection Using Machine Learning Techniques
Abstract: Credit card fraud has become a significant concern in today's digital economy, with billions of dollars being lost annually to fraudulent transactions. Conventional rule-based approaches frequently prove inadequate in addressing the constantly changing strategies employed by fraudsters. Machine learning methods have emerged as robust solutions for detecting credit card fraud, presenting the capability to accurately identify fraudulent transactions promptly. In this study, we investigate the efficiency of three widely used …
Published in Journal of Open Source Developments · Vol. 11, Issue 1, 2024 · pp. 1–7 Read article
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Preparation of New Analytical Reagents and Study of Chromatographic Separation
Abstract: There are various types of diagnostic reagents in the laboratory, which involve many specializations in analytical chemistry and detection of pollution levels in river water and environmental pollution, as well as in the preparation of reagents that form as reagents and complexes with elements. Several techniques are shown here in an endless flow, and it is difficult Simply classify them according to a certain principle.; From a methodological point of …
Published in Emerging Trends in Chemical Engineering · Vol. 11, Issue 1, 2024 · pp. 44–58 Read article
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Aluminum based types of hydrophobic coatings for Engineering Materials: A Review
Abstract: Today's coating applications allow for the employment of a wide range of techniques and substances to safeguard products and structures from chemical and chemical harm. Coatings are now widely utilized in manufacturing across the globe to boost productivity and cut costs, both of which are crucial for maintaining the industry's profitability. Materials with coatings are stronger than those without coatings. Strong and hard metals, ceramics, bioglass, polymers, and plastic materials …
Published in Journal of Polymer & Composites · Vol. 12, Issue 1, 2024 · pp. 113–133 Read article
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Enhancing Security and Privacy in Smart Factory: A Blockchain Based Solution
Abstract: The manufacturing industry is currently experiencing a transformative shift due to the rise of smart factories, propelled by interconnected devices and automated systems. However, this integration of diverse technologies within smart factories introduces significant concerns regarding security and privacy. This research paper thoroughly investigates the vulnerabilities and threats prevalent in smart factory ecosystems, shedding light on the potential risks associated with centralized data storage and communication channels. The study emphasizes …
Published in International Journal of Wireless Security and Networks · Vol. 2, Issue 1, 2024 · pp. 13–20 Read article
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Anti-microbial Activity of Herbal Plant Extracts
Abstract: The Microbial resistance to major antibiotics due to overuse of them and problem observed rapidly during treatment of infectious diseases having a big challenge in health sector. Recently many researchers have been finding the solutions for come out these problems. There are many photochemical have been available, they have potential antimicrobial property against microbial species which occurs resistance against antibiotics. The present study is therefore an attempt for review on …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 2, 2024 · pp. 40–52 Read article