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116 articles for “variants”
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Stretching Boundaries: A Comprehensive Review of Ehlers-Danlos Syndrome and its Subtypes
Abstract: The Ehlers-Danlos syndromes (EDS) encompass 13 inheritable disorders affecting connective tissue. These conditions arise from genetic alterations impacting the structure of connective tissue. Every variant of Ehlers-Danlos syndrome (EDS) exhibits distinct features and has specific diagnostic criteria. While certain traits such as joint hypermobility, skin hyperextensibility, and tissue fragility are common across all types of EDS. The range of clinical presentations spans from minor skin and joint looseness to severe …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 44–57 Read article
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IT Security and Intrusion Detection Systems: An Introduction
Abstract: This article deals with the current status of IT security in an industrialized country and one of the many approaches. The emphasis is on what are known as intrusion detection systems. These enable users to detect suspicious behavior and attacks in daily IT operations by analyzing data, resources, and network flows. Based on previous research, the different variants, available detection types, and their working methods are briefly explained and presented. …
Published in Journal of Computer Technology & Applications · Vol. 15, Issue 1, 2024 · pp. 10–17 Read article
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Exploring High-Strength Self-Compacting Concrete: An Investigative Study
Abstract: Presently, Self-Compacting Concrete (SCC) emerges as a cutting-edge variant within the concrete landscape. This type of concrete opens a new horizon in construction industries, as the concrete may flow on its own weight and does not require external vibration for compaction. For this reason, it reduces the labor costs, energy, and time required for placement It has the capability to smoothly spread into the intricate spaces of the formwork and …
Published in Recent Trends in Civil Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 20–28 Read article
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Unraveling Metagenomics: A Comprehensive Diagnostic Approach for COVID-19
Abstract: The COVID-19 pandemic has brought attention to the need for rapid, accurate, and scalable diagnostic techniques. Metagenomics, a powerful technique that enables the comprehensive analysis of genetic material from complex microbial communities, has emerged as a promising diagnostic approach for COVID-19. This article elucidates the principles of metagenomic sequencing, highlighting its ability to detect viral RNA directly from clinical samples without prior knowledge of the pathogen. Furthermore, we discuss the …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 2, 2024 · pp. 19–28 Read article
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Hidradenocarcinoma: A Rare Skin Disease
Abstract: Hidradenocarcinoma (HAC) also known as ‘‘sweat gland tumor” is an aggressive, uncommon, highly malignant, adnexal tumor derived from the intradermal duct of eccrine sweat glands. It is said to be aggressive as it has a high risk of local recurrence (50%–75%) and a high potential to metastasize to nearby lymph nodes or to other distant sites. Hidradenocarcinoma has other recognized variants which are known by different names such as Malignant …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 1–12 Read article
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Effectiveness of Temporins for the Treatment of HPV Infections
Abstract: Objectives: Human papillomavirus (HPV), especially high-risk variants like type-16 have been linked to the formation of malignant tumors. HPV-16 has been implicated in most cases of cervical cancer in women. This study aims to assess the effectiveness of three types of temporin molecules, i.e., antiviral peptides secreted by certain frog species, for the inhibition of the viral L1 protein. Methods: In the present study, various computational tools were used to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 41–53 Read article
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Viral Chronicles: The Ever-Evolving Saga of COVID-19
Abstract: Coronaviruses, belonging to the family of RNA viruses, have recently captured global attention owing to their remarkable ability to infect a diverse array of species, ranging from animals to humans. These viral agents, recognized by their characteristic crown-like morphology when observed through electron microscopy, have a historical association with zoonotic diseases. Previous examples include Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The term "Corona" …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 16–25 Read article
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Ransomware Detection and Prevention Using Honeypot
Abstract: The significance of network security and explores the details of ransomware attacks, highlighting the crucial parameters essential to fortifying defences against this pernicious cyber threat. Network security involves safeguarding computer networks against unauthorized access, data breaches, and cyberattacks. Ransomware attack, a specific type of cyberattack, entail malicious software encrypting a computer system, making them unavailable to use in return attacker asks for ransom in form of cryptocurrency like Bitcoin or …
Published in Recent Trends in Electronics Communication Systems · Vol. 11, Issue 1, 2024 · pp. 8–13 Read article
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Mechanical and Morphological Analysis of Jute/Manila Hemp Hybrid Composites for Enhanced Structural Performance
Abstract: Natural fiber composites are renowned for their lightweight, strength, corrosion resistance, and high strength-to-weight ratio, often surpassing traditional metals. Despite challenges such as poor fiber-matrix adhesion and moisture susceptibility, hybridizing composites present a viable solution by enabling tailored properties for optimal performance. This study investigates hand-lay-up processed natural fiber composites, specifically woven jute/epoxy, non-woven manila hemp/epoxy, and their hybrid variants. Extensive testing was conducted on mechanical properties including hardness, flexural …
Published in Journal of Polymer & Composites · Vol. 12, Issue 8, 2024 · pp. 1–11 Read article
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Association of Vitamin D Binding Protein BP rs2282679 Gene Polymorphism and Serum Levels of Vitamin D in Patients with Vitiligo
Abstract: For vitamin D to have an impact, the vitamin D receptor (VDR) must be expressed and activated in the nucleus. The VDR has several known genetic variants. Biological impacts can be caused by changes in DNA sequences known as "polymorphisms" that are common in the population. Vitiligo is a disease that causes loss of skin color in patches, and it is a chronic (long-lasting) autoimmune disorder loss of color. The …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 45–52 Read article
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An Overview of Fanconi Anemia: A Genetic Disorder
Abstract: Fanconi Anemia (FA) is a rare genetic disorder caused by DNA repair defects due to pathogenic variants in one of 21 genes. It is the primary cause of inherited bone marrow failure, marked by pancytopenia. Clinically, Fanconi Anemia (FA) is associated with congenital malformations in multiple systems, resulting in progressive bone marrow failure and heightened cancer risk, especially in the urogenital region and the head and neck. There are approximately …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 19–25 Read article
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The Power of Genetic Engineering in Revolutionizing Vaccines
Abstract: Genetic engineering techniques, including recombinant subunit, viral vector, and nucleic acid vaccines have transformed the landscape of vaccine development. These novel approaches offer precise antigen design, enhanced safety profiles, and rapid adaptability to emerging pathogens. Key advantages include improved efficacy through targeted immune responses, increased safety due to the absence of live pathogens, and the ability to modify vaccines to address new variants or diseases quickly. Notable success stories, such …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 18–27 Read article
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SiRNA-Based Multivalent Vaccines: A Systematic Review of Potential Risks, Benefits, and Future Applications
Abstract: Background: Small interfering RNA (SiRNA) technology represents a promising innovation in vaccine development, especially for multivalent vaccines that can target multiple pathogens or antigenic variants simultaneously. siRNA-based vaccines offer a unique mechanism to induce specific immune responses, presenting an adaptable and potentially powerful tool for tackling infectious diseases and cancer. Methods: This systematic review synthesizes recent studies on siRNA multivalent vaccines, focusing on their immunogenicity, safety, and effectiveness. We reviewed …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 43–49 Read article
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Efficient Malware Detection in Cybersecurity: Leveraging Advanced Data Structures for Enhanced Threat Identification
Abstract: The cybersecurity landscape is constantly changing with more advanced malware creating major challenges for detection systems. To address these challenges effectively, advanced data structures have become essential in optimizing how data is managed, processed, and analyzed for malware detection. This review paper delves into the role of several cutting-edge data structures—bloom filters, tries, hash tables, graphs, decision trees, and suffix trees—in enhancing the efficiency and accuracy of malware detection mechanisms. …
Published in International Journal of Data Structure Studies · Vol. 2, Issue 2, 2024 · pp. 32–40 Read article
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Urban Smart Living: Home IoT Technology
Abstract: The practice of self-sufficiently regulating home appliances using various control system approaches is known as IoT smart city home automation. Many control strategies may be utilized to control the electrical and electronic appliances in the house, including the windows, refrigeration units, fans, lights, fire alarms, kitchen timers, and so on. Sync thousands of products to automate everyday tasks and create a home hub. With live cams, you can see how …
Published in Journal of Mechatronics and Automation · Vol. 11, Issue 3, 2024 · pp. 26–32 Read article
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Machinability of Metal Matrix Composites using Wire Electric Discharge Machining: A Review
Abstract: Metal Matrix composites [MMCs] are increasingly being applied in the automotive and aerospace industries as high-performance substitutes for traditional materials. Due to these properties, namely, high strength-to-weight ratio, outstanding fracture toughness, and low density, a vast array of uses is feasible. We can control the properties of MMCs directionally as well, which makes them the perfect choice for military uses and marine and sports equipment. The machining of MMCs plays …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 303–311 Read article
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From Theory to Practice: The Mathematical Foundations of Secure Blockchain Transactions
Abstract: The rise of blockchain technology has transformed the method of conducting secure and decentralized transactions across multiple industries. At its core, blockchain relies on a robust mathematical foundation to ensure data integrity, transparency, and immutability. This paper delves into the theoretical underpinnings that make secure blockchain transactions possible, including cryptographic algorithms, distributed consensus protocols, and mathematical proofs of security. We begin by exploring the role of cryptography, particularly public-key encryption, …
Published in Journal of Advanced Database Management & Systems · Vol. 12, Issue 1, 2025 · pp. 13–20 Read article
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Statistical Models for Predicting Genetic Variability and Disease Susceptibility
Abstract: Differences in genetics are key to understanding why some individuals are more prone to certain diseases than others. Recent advancements in genomic research, combined with statistical modeling techniques, have made significant strides in predicting disease risk based on genetic factors. This review explores the application of statistical models for predicting genetic variability and their role in disease susceptibility. We discuss traditional methods like linear regression and genome-wide association studies (GWAS), …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 30–34 Read article
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Leveraging Genome-Wide Association Studies for Precision Medicine in Cardiovascular Diseases
Abstract: Cardiovascular diseases (CVDs) are the leading cause of death globally, with complex etiologies involving genetic, environmental, and lifestyle factors. Genome-wide association studies (GWAS) have significantly advanced the understanding of genetic underpinnings of CVDs by identifying numerous risk loci and variants associated with various cardiovascular conditions. This review explores the potential of GWAS to drive precision medicine in cardiovascular diseases by linking genetic data with clinical outcomes, providing insights into disease …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 35–39 Read article
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Role of Carbohydrates and Herbal Plants in the Management of Diabetes Mellitus
Abstract: This extensive review explores the intricate relationship between carbohydrates and diabetes mellitus, integrating historical perspectives, biochemical foundations, and modern therapeutic approaches. The article delves into the chemistry of carbohydrates, elucidating their structural diversity and metabolic significance in relation to diabetes pathophysiology. It traces the evolution of diabetes, understanding from ancient civilizations to contemporary molecular insights, highlighting pivotal discoveries such as insulin’s identification. They critically examined various forms of diabetes, including …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 34–60 Read article