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185 articles for “tablet.”
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Design and Assessment of Fixed Dose Combination Containing Fenofibrate and Pravastatin Sodium in Tablet Formulation: A Bioinformatics Approach
Abstract: The aim of this is study is to formulate and evaluate fixed dose combination of Fenofibrate and Pravastatin sodium in tablet dosage for the treatment of Dyslipidemia. For the formulation and optimization of fenofibrate layer, two factor three level factorial design was used as experimental design for optimization with a minimum of nine run. All the nine trial (F1–F9) has been formulated according to the experimental design by wet granulation …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 1–20 Read article
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Formulation Development and Evaluation of Floating Tablets of Venlafaxine Hydrochloride
Abstract: The aim of the present study was to formulate and evaluate gastroretentive floating tablets of an antidepressant drug, Venlafaxine HCl. The matrix tablets of Venlafaxine hydrochloride were prepared by employing low viscosity grade hydrophilic polymer HPMC E15LV in combination with any one of the high viscosity grades of HPMC (K4M, K15M, and K100M) as swelling polymers. Sodium bicarbonate was employed as gas generating agent. The tablets were formulated using direct …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 1, 2015 · pp. 7–15 Read article
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Validation of Caratol E Tablet for its Melanogenesis Effect—In Vitro Study
Abstract: Vitiligo is a skin disorder characterized by pale patches due to lack of melanin. Lack of melanin may be due to reduced melanogenesis, lack of melanocytes and decreased tyrosinase activity. In the present study, Caratol E tablet was evaluated for its melanogenesis effect. Melanocytes viability was evaluated by MTT assay and tyrosinase assay. Caratol E tablet showed positive effect in increasing the melanogenesis. Results are discussed in the present paper. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 3, 2018 · pp. 35–37 Read article
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In-Vitro Evaluation of Extended Release Atorvastatin Tablets by using Natural Gums
Abstract: The present research is the formulation of extended-release tablets Atorvastatin is used as a hypoglycemic agent; it is HMG CoA Reductase inhibitor. All the formulation were prepared with using different grades of xanthan gum, guar gum, sodium alginate, then all the formulations were subjected to pre-compression and post-compression parameters such as angle of repose, bulk density, tapped density, Carr’s index, Hausner's ratio, weight variation, thickness, hardness, friability and drug content. …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 55–62 Read article
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Design And Evaluation Of Meloxicam Tablet For Colon Cancer
Abstract: Meloxicam, recognized as a preferential COX-2 inhibitor, has emerged as a promising chemopreventive agent for colorectal cancer. Leveraging its local and targeted action on the colon, Meloxicam proves to be a formidable component in the prevention of colorectal malignancies. This study aims to innovate by formulating and evaluating a targeted tablet delivery system for Meloxicam, emphasizing site-specific and instant drug release in the colon, thereby maximizing its therapeutic efficacy in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 3, 2023 · pp. 1–7 Read article
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Solid Self Nanoemulsifying Tablets: Statistical Optimization by 23 Factorial Designs
Abstract: The objective of the current research was to enhance the solubility of poorly water soluble drug i.e. atorvastatin calcium, by self nanoemulsifying drug delivery system (SES) and formulating it as tablets using 23 factorial designs. The prepared liquid SES were adsorbed onto aerosil which acts as carrier. The 23 factorial designs were employed to optimize the concentration of micro-crystalline cellulose, PVP and sodium starch glycollate. The observed values were in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 2, 2017 · pp. 1–7 Read article
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Characterization of Tabletting Properties of Mango Gum
Abstract: The aim of the study is to elucidate the physical, thermal, sorption, and functional properties of a mango gum obtained from the stem of Mangifera indica were characterized viz. elemental analysis, Fourier transmittance infrared, particle size analysis, thermogravimetric analysis, differential scanning colorimetry, scanning electron microscopy, and X-ray powder diffraction. Mango gum had a glass transition temperature (Tg) and melting peak of 90 and 318.795°C, respectively. This material showed a 14.59% …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 1, Issue 2, 2014 · pp. 22–30 Read article
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In vitro Quality Control Testing: A comparative Study of Jan Aushadhi with Different Brands of Metformin Tablets Available in India
Abstract: Metformin hydrochloride is an oral anti-diabetic drug used mainly to treat type-II Diabetes Mellitus and it is widely available in different brands in the market, making it challenging to select the safe, effective and economic one. The endeavour of this experiment was to compare and assess the quality standard of the Jan Aushadhi medicine with a different brand of the metformin hydrochloride tablet available in India. For evaluation of the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 2, 2019 · pp. 32–37 Read article
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European Regulatory Perspective on Super-Generics: Antacid Orally Disintegrating Tablets (ODT)
Abstract: Super-generic is the general form of nomenclature for hybrid medicinal product in European Union (EU). The super-generic form of the medicinal product is one that considers changes in the form of active substance, therapeutic indications, strength, pharmaceutical form or route of administration. They rely partly on results of preclinical tests and clinical trials of an innovator product and also on new data with appropriate bioavailability and bioequivalence studies. Marketing authorization …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 31–37 Read article
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Advancements in Analytical Techniques and Validation Methods for Pharmaceutical Tablet Formulations Using HPTLC
Abstract: High Performance Thin Layer Chromatography (HPTLC) is a versatile analytical technique which has been effectively used for pharmaceutical quality control and cost effectively, rapidly, and high throughput analyzed tablet formulations. HPTLC is different from traditional chromatographic methods as multi sample analysis is possible in one run with low consumption of solvent, which are principles of green analytical chemistry. But existing HPTLC is limited in sensitivity, resolution and reproducibility and these …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 3, 2026 Read article
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Simultaneous Estimation of Irbesartan and Hydrochlorothiazide in Bulk and Tablet Dosage Form by UV-Spectrophotometry
Abstract: The present study describes a simple, accurate, precise and cost-effective UV Spectrophotometric method for the simultaneous estimation of irbesartan and hydrochlorothiazide in bulk and tablet dosage form. The solvent used was methanol and the absorption maxima for irbesartan and hydrochlorothiazide were found to be 250 nm and 270 nm respectively. A linear response was observed in the range of 4–20 µg/mL with a correlation coefficient of 0.998 for irbesartan and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 3, 2012 · pp. 9–17 Read article
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Development and Validation of HPLC Method for Simultaneous Estimation of Cilnidipine and Valsartan in Bulk and Tablet Dosage Form
Abstract: A simple, sensitive, accurate and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Valsartan and Cilnidipine. The purposed RP-HPLC method utilizes stationary phase and consists of symmetry C18 (250 × 4.6 mm, 5 μm in particle size) with a mobile phase comprising of Acetonitrile: Ammonium Acetate Buffer (75:25%v/v) pH 5.0 adjusted by Triethylamine at a flow rate of 1.0 mL/min, column temperature …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 2, 2015 · pp. 28–36 Read article
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Development and Validation of a New Stability-Indicating HPLC Method for the Determination of Rosiglitazone in Tablets
Abstract: Rosiglitazone (ROS) is an antidiabetic drug belonging to the thiazolidine class. A new stability-indicating high-performance chromatographic (HPLC) method was developed for the determination of ROS in pharmaceuticals, and validated for its suitability following the ICH guidelines. Chromatography was performed on a Chromatopack (250×4.6 mm; 5 µm particle size) column using phosphate buffer of pH 3.2 and methanol (70:30 v/v) as mobile phase pumped at a flow rate of 1 ml …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 1, 2017 · pp. 1–9 Read article
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Field Completion of the GIS database of Cameroon base map using the couple: tablet/GPS antenna
Abstract: The National Institute of Cartography of Cameroon (NIC) is currently establishing a1:10,000-scale National GIS data base, from which digital maps are being produced. A newmethodology for field completion, which is one of the key phases for the production of a basemap, has been implemented in other to meet the requirements of the new database. Thismethod is mainly based on the use of the couple tablet/GPS antenna for surveying, combinedwith android …
Published in Journal of Remote Sensing & GIS · Vol. 11, Issue 2, 2020 · pp. 29–34 Read article
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Formulation Evaluation and Optimization of Orodispersible Tablets of Pantoprazole Sodium by the using of Different Superdisintigrants
Abstract: The objective of this study was to formulate and optimize an orodispersible formulation of pantoprazole sodium using a 32 factorial design for optimized the superdisintigrant concentration. Various concentration (2%,4%,6%) of superdisintegrants (SSG, CP) were added in formulation, all processing steps are carried out at temperature below 250C and relative humidity less than 35%. Procedure to manufacture orodispersible tablets by direct compression was established. The results show that the presence of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 7, Issue 3, 2017 · pp. 11–20 Read article
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Formulation and Development of Ibuprofen Floating Tablet
Abstract: The investigation focused on optimizing a gastric floating drug delivery system (GFDDS) for Ibuprofen tablets. It employed polymers like HPMC K4M and Carbopol 940 to improve Ibuprofen's bioavailability and therapeutic effectiveness. GFDDS, with lower bulk density than gastric fluids, remains buoyant in the stomach, extending gastric residence time. Compatibility assessments, via DSC analysis, indicated harmony between the polymers used, with no observed interaction between the polymer and the drug. The …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 3, 2023 · pp. 24–29 Read article
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Formulation and Development of Iguratimod Film Coated Tablets 25 mg
Abstract: Iguratamide is chemically called as methanesulfonanilid for the treatment of rheumatoid arthritis. The present invention relates to the micron zing technology for insoluble polycrystal medicine Iguratimod, and the micronized Iguratimod has new crystallization and powder direct compression method for formulating tablets. The orally taken quick release preparation with micronized Iguratimod as active component, high efficiency super disintegrants like cross carmellose sodium, surfactants like sodium lauryl sulphate, diluents like MCC PH …
Published in Trends in Drug Delivery · Vol. 7, Issue 1, 2020 · pp. 25–31 Read article
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Sumatriptan Succinate Mucoadhesive Buccal Tablets: Formulation Design, Optimization and Evaluation
Abstract: The main aim of present investigation was to develop and study mucoadhesive buccal tablets of sumatriptan succinate using different bioadhesive polymer. Nine formulations were prepared by using direct compression method with varying concentration of polymer as HPMC (Metolose SR 90SH-15000), xanthan gum (XTGM) and sodium carboxy methyl cellulose (sodium CMC). Fourier transform infrared spectroscopy was used to identify drug excipient interaction. Micromeritic properties of lubricated blend, physical properties and chemical …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 2, 2022 · pp. 1–20 Read article
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Method Development and Validation for the Simultaneous Estimation of Ertugliflozin and Sitagliptin in Bulk and Tablet Dosage Form by using HPLC.
Abstract: A simple, Accurate, precise method was developed for the simultaneous estimation of the Ertugliflozin and Sitagliptin in bulk and tablet dosage form. Chromatogram was run through DIKMA Spursil C18 column (4.6 mm x 150mm, 3.0 µm). Mobile phase containing KH2PO4: Methanol (45: 55) was pumped through column at a flow rate of 1ml/min. Temperature was maintained at Ambient. Optimized wavelength for Ertugliflozin and Sitagliptin was 225 nm. Retention time of …
Published in Trends in Drug Delivery · Vol. 8, Issue 3, 2023 · pp. 40–49 Read article
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Formulation and Characterization of Bilayer Tablet of Anti-hyperlipidemic BCS Class II drug
Abstract: The main objective of work was to formulate co-loaded bilayer tablets of atorvastatin (ATV) and ezetimibe(EZM).ATV loaded in the immediate-release (IR) layer is an HMG CoA reductase inhibitor, while EZM, added in the immediate-release (IR) layer, is a lipid-lowering agent. The immediate release of BCS class II drugs atorvastatin and Ezetimibe, in a bilayer approach was achieved by wet granulation and fluid bed granulation followed by compression. The Preformulation studies …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 14, Issue 1, 2023 · pp. 1–18 Read article