Solid Self Nanoemulsifying Tablets: Statistical Optimization by 23 Factorial Designs

Panner Selvam R; P. K. Kulkarni; Iswar Hazarika; Anusha Sudulaguntla; Vineeth Chandy

Abstract

The objective of the current research was to enhance the solubility of poorly water soluble drug i.e. atorvastatin calcium, by self nanoemulsifying drug delivery system (SES) and formulating it as tablets using 23 factorial designs. The prepared liquid SES were adsorbed onto aerosil which acts as carrier. The 23 factorial designs were employed to optimize the concentration of micro-crystalline cellulose, PVP and sodium starch glycollate. The observed values were in close agreement with the predicted values thereby validating the feasibility of the optimization procedure in developing self nanoemulsifying tablets. The drug release of the S SES and marketed product were 97.5 and 32.7percentage respectively. This confirms that the solubility of the drug has been increased leading to increase in the bioavailability of atorvastatin calcium. Keywords: Self nanoemulsifying drug delivery system, 23 factorial designs, bioavailabilityCite this ArticlePanner Selvam R, Kulkarni PK, Iswar Hazarika et al. Solid Self Nanoemulsifying Tablets Statistical Optimization by 23 Factorial Designs. Research & Reviews: A Journal of Drug Design & Discovery. 2017; 4(2): 1–7p