Development and Characterization of Selfnanoemulsifying Drug Delivery System

Shashi Kiran; Suman Khurana

doi:10.37591/tdd.v9i3.1235

Abstract

AbstractNanotechnology has presented a novel perception of human knowledge and led to innovation in the field of biological sciences including diagnostics, food, drug delivery, biomaterials for implants or prostheses, and the production of biomimetics appropriate for applications in the field of medicine. With their pinpoint accuracy and minuscule size, nanomaterials is rising in importance. Nanoscale formulations have a size range of 100–10,000 times lesser than that of the cell of a human. The use of various nanoscale carriers to improve medications' therapeutic efficacy has been a recent area of research. In this investigation, an attempt has been done to improve pharmacodynamic potentials of poorly water-solublesdrug(s) rosuvastatin and candesartan. Rosuvastatin is prescribed to patients with excessive cholesterol as a means of lowering their risk of heart disease. After administration, rosuvastatin, a prodrug is hydrolyzed to rosuvastatin acid an active β- hydroxyacid form. Rosuvastatin inhibits HMG-CoA (3-hydroxy-3-methylglutarylcoenzyme A) reductase. Rosuvastatin is practically insoluble in water, BCS class-II drug and exhibits extensive first-pass hepatic metabolism. The availability of the drug in general circulation is low (<20%). Its innovator product i.e. Crestor 5, 10, 20, 40 and 80 mg tablets is conventional tablets with low bioavailability. Keywords: Drug Delivery System, Emulsification, SLN.Citation: Shashi Kiran, Suman Khurana. Development and Characterization of Self-nanoemulsifying Drug Delivery System. Trends in Drug Delivery. 2022; 9(3): 1–18p.