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97 articles for “Stem cell”
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Biopolymer Degradation and Structure–Property Relationships in Ageing: A Polymer Science Perspective
Abstract: Ageing, as viewed from the polymer sciences perspective, is perceived as the gradual modification of the structure-property-function interrelationship of biopolymers such as proteins, polysaccharides, nucleic acids and their molecular aggregates. Such changes include structural organization, mechanical behavior, physicochemical stability and functional effectiveness. Ageing is an inevitable multifactorial polymeric process. Due to the growing aging population globally, more age-associated complications emerge, which are correlated with the molecular degeneration of biopolymeric complexes. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 479–489 Read article
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Improvement of Motor and Sensory–Motor Behaviors after the Human Amniotic Epithelial Cells Transplantation in 6-OHDA Lesioned Corpus Striatum of Wistar Albino Rats
Abstract: Deficits in apomorphine-induced rotation and rotarod in rat have been proposed as a nondrug-induced model of the akinesia associated with the Parkinson’s disease. In the present study, we examined the disabilities in the rotarod and apomorphine-induced rotations have been observed after the 6-hydroxydopamine-induced denervation in the striatum. These impaired activities have reversed after the Human Amniotic Epithelial (HAE) cells transplantation during long-term observation. The neuronal densities and diameter were reduced …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 4, Issue 2, 2014 · pp. 34–45 Read article
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The Interaction of Extracellular Matrix and Growth Factors
Abstract: The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. ECM assembly is regulated by the 3D environment and the cellular tension that is transmitted through integrins. The hematopoietic microenvironment is a complex structure in which stem cells, progenitor cells, stromal cells, growth factors, and ECM molecules each interact to direct the coordinated regulation of blood cell development. Hematopoietic growth factors are any of …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 6, Issue 3, 2016 · pp. 9–23 Read article
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Epigenetic Regulation and Plasticity in Human Diseases
Abstract: In normal human development as well as in the case of diseased development, epigenetic changes are involved. The role of plasticity is important and directed on the understanding feature of epithelial cell biology, and maybe a significant pathway for disease pathobiology and pathogenesis. During embryonic development, an epigenetic mechanism is important for the growth and development of genetically identical cells that are obtained from different outcomes. In this review study, …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 1, 2021 · pp. 12–20 Read article
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Regenerative Medicine: Areas of Opportunities and Inter-related Challenges
Abstract: Regenerative medicine and Human tissue engineering are the emerging fields in medicine. The concept of regenerative medicine is a promising multidisciplinary field to develop the way to advance the health and quality of life by restoring, maintaining or enhancing tissue and functions of the organs. They are such biomaterials that will provide the self-repairing of the damaged tissues and it assures for the improved treatment for the patients, faster recovery …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 2, 2015 · pp. 24–29 Read article
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Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release
Abstract: Biopolymer-based composite scaffolds have attracted significant attention as multifunctional platforms at the intersection of polymer science, regenerative medicine, and cancer nanotherapy. In this study, a dual-functional scaffold was developed for simultaneous osteosarcoma treatment and bone regeneration using poly (L-lactic acid) (PLLA) reinforced with bioactive glass (BG) and integrated with a glutathione-responsive platinum (IV) prodrug system (PDA@Pt). To improve interfacial adhesion, photothermal conversion efficiency, and tumor-specific activation, the Pt (IV) prodrug …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 351–361 Read article
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Therapeutic Effects of Metformin on Cancer: A Possible Option in Cancer Chemotherapy
Abstract: Metformin is being used for an elongated period of an antidiabetic medicine for type 2 diabetes. It is used moreover as a monotherapy or in mixture with additional antidiabetic medications. The drug derived into importance in diabetes and other circumstances with cardiovascular risk after the landmark study of 1995 by the United Kingdom Prospective Diabetes Study which highlighted its reputation. The usage of metformin, the usually given drug for type …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 46–68 Read article
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Metabolic Reprogramming in Carcinogenesis: An Overview
Abstract: Metabolic reprogramming is a crucial mechanism via which cells modify their metabolic pathways to adjust to changes in the environment and maintain growth, survival, and function. This phenomenon is of utmost importance in a wide range of physiological and pathological situations, specifically in cancer, immunological responses, and stem cell biology. In cancer, metabolic reprogramming facilitates fast cell growth and survival, as demonstrated by the Warburg effect, where cancer cells prioritize …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
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Bone Grafting in Dentistry: From Biological Principles to Contemporary Regenerative Applications
Abstract: Bone grafting plays a pivotal role in contemporary regenerative dentistry by enabling predictable reconstruction of alveolar bone defects resulting from periodontal disease, tooth extraction, trauma, or pathology. Adequate bone volume and quality are essential prerequisites for successful implant placement, periodontal regeneration, and long-term functional and esthetic outcomes. Bone graft materials act as biological or synthetic scaffolds that facilitate new bone formation through the primary mechanisms of osteogenesis, osteoinduction, osteoconduction, and …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 1, 2026 · pp. 6–13 Read article
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Revolutionizing Blood Cancer Treatment: Emerging Therapies and Future Perspectives
Abstract: Blood cancer inclusive of leukemia, lymphoma and multiple myeloma poses a significant threat in the world today because of its multifactorial process and its non-amenable to standard therapies. Some of such approaches are immunotherapy, gene-editing technology and targeted small molecule inhibitors that have altered the nature of treatments. CAR T cell therapy is a molecular targeted therapy for cancers and several clinical studies have reported a huge success. Also, the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 2, 2025 Read article
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Recent Advancements in Nanobiocomposite-Based Wound Healing and Tissue Regeneration
Abstract: Haemostasis, inflammation, proliferation, remodeling, and other highly coordinated cellular and molecular activities are all part of the complex biological processes of wound healing and tissue regeneration. Following an injury, these stages cooperate to restore tissue integrity and function. However, this normal process is disturbed in many clinical circumstances, especially chronic wounds such diabetic ulcers, burns, and pressure sores. Prolonged inflammation, chronic microbial infection, diminished angiogenesis, and impaired extracellular matrix production …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 297–318 Read article
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Supportive Therapy Play a Vital Role in the Treatment of Leukemia: A Review
Abstract: Leukemia is a major burden worldwide. The anomalous production of white blood cells (WBC) is responsible for producing leukemia; these cells are also known as blasts. A study indicated that thousands of patients are detected every year with leukemia risk worldwide. The risk factor including chemical exposure, ionizing radiations, cigarette smoking is the major causes for developing leukemia. There are four types of leukemia and number of genes involved are …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 3, 2018 · pp. 1–8 Read article
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Management of Thermal Burns over Breast – Our Experience
Abstract: The intricate challenge of restoring normal anatomy with minimal deformity in burns over the breast region has prompted the development of innovative tissue regeneration approaches. Addressing the complex nature of challenging wound patterns necessitates a multidisciplinary team with diverse expertise. In our concerted effort, we have successfully integrated advanced reconstructive techniques with regenerative medicine modalities to enhance outcomes in the intricate realm of complex breast reconstruction post-thermal burns. Our approach …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 1, Issue 2, 2023 · pp. 1–8 Read article
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Role of Functional Regenerative Trilaminar Scaffold Dressing in Wound Bed Preparation
Abstract: Advancements in wound healing have incorporated tissue regeneration therapy as a crucial tool for managing both acute and chronic wounds. Bio constructs designed to facilitate wound regeneration utilize natural, artificial, or hybrid materials, collectively referred to as regeneration scaffolds. The components of regeneration scaffolds play a crucial role in enhancing the skin's natural self-renewal abilities and accelerating the healing process. These scaffolds are designed to provide essential growth factors and …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 2, 2024 · pp. 70–75 Read article
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An Overview of Fanconi Anemia: A Genetic Disorder
Abstract: Fanconi Anemia (FA) is a rare genetic disorder caused by DNA repair defects due to pathogenic variants in one of 21 genes. It is the primary cause of inherited bone marrow failure, marked by pancytopenia. Clinically, Fanconi Anemia (FA) is associated with congenital malformations in multiple systems, resulting in progressive bone marrow failure and heightened cancer risk, especially in the urogenital region and the head and neck. There are approximately …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 19–25 Read article
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Towards smart cancer care - AI enhanced monitoring and intervention
Abstract: According to estimates from the World Health Organization (WHO) for 2022, cancer is one of the leading causes of mortality, accounting for roughly 16% of all deaths globally. The goal of the cancer community is to improve the lives of those who are impacted by cancer and to cut the cancer death rate in half during the next several years. If cancer is identified early and treated, its impact on …
Published in Journal of Microwave Engineering and Technologies · Vol. 12, Issue 1, 2025 · pp. 38–44 Read article
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Nano-Therapeutics in Diabetes Mellitus: Revolutionizing Diagnosis, Treatment, and Drug Delivery
Abstract: Diabetes mellitus is a chronic metabolic disorder in which blood glucose concentration remains high over an extended duration, resulting in significant lethal complications, including neuropathy, nephropathy and cardiovascular diseases. However, conventional diabetes management strategies, including insulin therapy and oral hypoglycemic agents, rarely exhibit poor bioavailability, high doses, off target delivery, etc. Nanotechnology has brought the rise of diabetes treatment revolution, by overcoming the challenges present in standard treatment, owing to …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 08–19 Read article
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Extra Philadelphia in CML Due to Isodicentric 22: A Case Report
Abstract: Introduction: Chronic Myelogenous Leukemia is a malignancy that affects the hematopoietic stems cells (HSC) of the bone marrow, leading to the rapid and continual proliferation of granulocytes and precursor blast cells. This is caused due to a reciprocal translocation that occurs between chromosomes 9 and 22, leading to the formation of derivative 22 also called as Philadelphia (Ph) chromosome. The Ph chromosome then encodes a fusion oncoprotein that functions as …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 18–22 Read article
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Study to Assess the Effectiveness of Teaching Program on Knowledge Regarding Management of Patients with Regenerative Orthopedics Procedures Among Orthopedic Nurses at Selected Orthopedic Departments
Abstract: Regenerative therapy is an emerging treatment approach in medical science. It focuses on the use of stem cell therapy, biological treatments, tissue engineering, platelet-rich plasma, prolotherapy, and nutraceutical supplements to replace or restore dysfunctional structures or organs. Regenerative therapy emphasizes the body’s natural healing process; it supports physiological healing mechanisms and repairs damaged tissues. It is a minimally invasive approach with expanding applications across various medical fields, including surgery, degenerative …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 7–11 Read article
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Paternal Pre-Pubertal Smoking: Small RNAs, Lasting Marks, and the Hidden Legacy of Early Exposure
Abstract: While the negative effects of maternal smoking during pregnancy are well-established, the lasting and transgenerational impact of paternal pre-pubertal smoking remains a critical, underexplored area. Emerging evidence in sperm epigenetics suggests that cigarette exposure during early male development may create persistent molecular imprints that can affect the health of future offspring. This phenomenon is rooted in the fact that heredity extends beyond the DNA sequence. Sperm carry a complex epigenetic …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 1, 2026 · pp. 1–5 Read article