Search
130 articles for “Genetic research”
-
Climate-Induced Infertility in Dairy Cows: Pathways, Challenges, and Solutions for Sustainable Dairy Development
Abstract: Climate change has emerged as a significant challenge to dairy production, with profound implications for reproductive performance in dairy cows. The interplay of rising temperatures, fluctuating rainfall patterns, and increased frequency of extreme weather events disrupts key physiological, nutritional, and behavioral processes essential for fertility. Heat stress alters hormonal balance, impairs oocyte and embryo quality, reduces estrus expression, and affects pregnancy outcomes. Concurrently, climate-induced nutritional deficits, immune suppression, and increased …
Published in International Journal of Climate Conditions · Vol. 2, Issue 2, 2025 Read article
-
Diet-Gene Interactions in Farm Animals: Molecular Dynamics, Gene Expressions, Signalling Pathways and Precision Nutrition for Sustainable Productivity
Abstract: Diet-gene interactions represent a central mechanism through which nutrition influences growth, health, and productivity in farm animals. Recent advances in molecular biology and genetics have revealed that nutrients act not only as metabolic substrates but also as signalling molecules capable of modulating gene expression, cellular pathways, and epigenetic regulation. This review synthesizes current knowledge on the molecular dynamics of nutrient utilization in farm animals, with emphasis on nutrigenomic responses, nutrient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
-
Balancing Welfare-Productivity Trade-Offs: Logical Frameworks and Strategic Approaches for Sustainable Dairy Development
Abstract: Balancing animal welfare and productivity remains a critical challenge in modern dairy farming. This study explores diverse frameworks for evaluating the welfare-productivity trade-offs essential for achieving sustainable dairy systems. Key approaches are categorized into six thematic areas: animal-centric frameworks, management-oriented models, environmental assessments, economic and policy perspectives, technological innovations, and holistic methodologies. Each framework offers unique metrics and evaluation tools, including behavioral assessments, physiological indicators, precision livestock farming, cost-benefit analyses, …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 2, 2025 · pp. 16–24 Read article
-
Review Paper of the Rich Floral and Faunal Diversity in Chhattisgarh, India
Abstract: Chhattisgarh, a state in central India, is renowned for its rich biodiversity, encompassing a wide variety of plants and animals. This review highlights the critical role that sacred groves—small, often isolated forest patches preserved by local communities—play in maintaining this biodiversity. These groves are repositories of genetic diversity and serve as sanctuaries for numerous species, many of which are threatened by habitat loss and fragmentation. However, the integrity of these …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 3, 2024 · pp. 23–38 Read article
-
Immunological Mechanisms Underlying Autoimmune Disorders: Recent Advances and Therapeutic Implications
Abstract: A diverse range of illnesses known as autoimmune disorders are typified by dysregulated immune responses against self-antigens, which result in tissue damage and persistent inflammation. Understanding the genetic, epigenetic, and environmental variables that contribute to autoimmune pathogenesis has advanced significantly during the last ten years. Current disease models have been transformed by new understandings of immunological tolerance mechanisms such as the functions of regulatory T cells, cytokine networks, and the …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 21–25 Read article
-
Pharmacogenomics: Unlocking the Genetic Basis of Drug Response for Precision Medicine
Abstract: Pharmacogenomics, a fusion of pharmacology and genomics, explores how genetic variations influence individual responses to medications. This field is revolutionizing modern medicine by moving away from a one-size-fits-all approach toward personalized treatment strategies. By identifying specific genetic markers, pharmacogenomics aims to enhance drug efficacy, minimize adverse drug reactions, and improve overall patient outcomes. Key methodologies in this discipline include candidate gene analysis, genome-wide association studies, and haplotype analysis, all of …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
-
Assessing the impact of lifestyle factors on autoimmune risk and survival outcomes: A Population-based Study
Abstract: This study investigated the interplay between lifestyle factors and genetic regulation in autoimmune diseases, focusing on the role of human T-cell metabolic and proliferative control through C-REL gene transcription. This study combined CRISPR-Cas9 manipulation of C-REL in human T-cells with a longitudinal cohort of 100 adults (autoimmune patients and controls), investigating metabolic and proliferation dynamics via flow cytometry and assays. It assessed lifestyle impacts through surveys and medical records, ensuring …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
-
Epidermolysis Bullosa and Its Role in Cervical Cancer: An Overview
Abstract: Epidermolysis Bullosa is a group of uncommon genetic disorders that primarily affect the skin and mucous membranes. It is marked by severe skin fragility and the formation of blisters even after minor trauma. Traditionally, the focus of Epidermolysis Bullosa research has been on its dermatological manifestations, which include recurrent blistering, scarring, and the potential for infections due to the compromised skin barrier. However, recent advancements in Epidermolysis Bullosa research have …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 14–18 Read article
-
Gene Therapy in Modern Medicine: Promises and Challenge in Treating Genetic Diseases
Abstract: Gene therapy is a medical approach that focuses on altering or adjusting an individual’s genes to treat or prevent illnesses. The aim is to repair faulty genes or insert new ones into the body to combat diseases. Gene therapy can involve directly introducing modified or new genes into a patient’s cells or altering the genes already present in the patient’s body. This approach shows potential for treating a range of …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 27–32 Read article
-
Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
-
The Efficacy of Fig Extract on Some Candida spp.
Abstract: The study was conducted in Al-Amin Laboratory by preparing the alcoholic extract of fig leaves, which were collected from the garden of a house in Najaf Governorate / Al-Shuara’a during the month of December 2023 for the purpose of testing its inhibitory effectiveness against two isolates of the fungus Candida albicans and Candida dubliniesis taken from Al-Amin Scientific Research Laboratory, where serial concentrations of the extract were prepared (12,9,6,3) mg/ml., …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 2, 2024 · pp. 19–23 Read article
-
An Overview of Gene Therapy
Abstract: Gene therapy is a revolutionary technique in medical science that seeks to cure or stop illnesses by means of introducing, altering, or quieting genes inside a patient's cells. Advancements in molecular biology, genetics, and biotechnology have propelled this field forward markedly changed over the last few decades. The underlying idea of gene therapy is to introduce genetic material into target cells via viral or non-viral vectors to rectify faulty genes, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 89–105 Read article
-
How Scientists Look for New Pathogens Before They Spread
Abstract: Emerging infectious illnesses are a persistent danger to global health. They often come from unexpected places, such wildlife reservoirs, changes in the climate, or human activities. Finding new diseases before they create epidemics is one of the biggest problems in modern epidemiology. This article talks about how scientists use genetic monitoring, field sampling, and real-time data processing to find, track, and describe new infectious organisms in a way that works …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 11–17 Read article
-
Genetic Authentication of Acacia Senegal (L.) Wild
Abstract: A study was carried out to ascertain the taxonomic identity and phylogenetic lineage of three presumed Acacia senegalensis using molecular markers. Three (3) varieties of seeds presumed to belong to Acacia spp. were collected from the Rubber Research Institute of Nigeria (RRIN) Benin City and three BP haplotypes (A, B, and C) was used as control for the analysis. These seeds were processed at the Applied Biotech International Laboratory Nigeria …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 33–39 Read article
-
Biopharmaceuticals: A Review of Biopolymeric Drugs and Accessibility Challenges in India
Abstract: Advances in biotechnology have allowed us to produce biosynthesized proteins that have therapeutic benefits. The drug products having biotechnology derived proteins, i.e. Biopharmaceuticals, have evolved the treatment of several diseases. knowledge about biological systems have been explored scientifically, there have been significant efforts to utilize them for improving human lives. These biopharmaceutical products have a rapidly growing market which needs to be closely monitored to avoid any potential risks. This …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 32–38 Read article
-
A Review on Solar Multilevel Inverter for the Production of Free Energy Due to the Structure with Long-life Feature
Abstract: Multilevel inverters play a major role in medium voltage, high power and renewable applications. It is also used in certain applications where high switching frequency, and high output voltage gain are required. The switching transient period of a MOSFET should be minimal because a high dv/dt rate could result in permanent damage to the MOSFET. The harmonics present could cause many problems and so it has to be minimized. The …
Published in Journal of Nuclear Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 13–18 Read article
-
Wiskott-Aldrich Syndrome: A Comprehensive Guide
Abstract: Wiskott-Aldrich Syndrome (WAS) is an uncommon genetic disorder inherited through the X chromosome, marked by a combination of immune system deficiencies, eczema, and low platelet counts. This syndrome primarily affects males, leading to significant morbidity and mortality due to recurrent infections, bleeding complications, and autoimmune diseases. Mutations in the WAS gene disrupt the production of the Wiskott-Aldrich Syndrome protein (WASp), crucial for the functioning of immune cells and platelet formation. …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 39–46 Read article
-
AI-Accelerated Development of Gradient Polymer Nanocomposite Thin Films
Abstract: Gradient polymer nanocomposite thin films are an active field of materials research due to the fact that it enables scientists to de-facto regulate the optical, electrical, and mechanical properties of a film by merely altering its composition on a layer-by-layer basis. This type of control opens the gate to the improved flexible electronics, long lasting protective coats, and the new smart gadgets. The problem is, though, that it is a …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 456–469 Read article
-
Codal Validation and Optimization of Gantry Girders Under Variable Wheelbase and Impact Loads: A Review of Analytical, Numerical, and Codal Approaches
Abstract: Gantry girders serve as critical structural elements in industrial facilities such as steel plants, workshops, and heavy manufacturing units, where electric overhead traveling (EOT) cranes operate. The design of these girders is governed by stringent codal provisions to ensure safety under bending, shear, and deflection. However, discrepancies between codal predictions, analytical formulations, and finite element analysis (FEA) results, particularly under variable wheelbase and dynamic impact loads, have been widely reported. …
Published in Journal of Offshore Structure and Technology · Vol. 12, Issue 3, 2025 · pp. 23–29 Read article
-
FMR1 Key Biomarker in Fragile X Syndrome- A Comprehensive Review
Abstract: Fragile X Syndrome (FXS) is a complicated neurodevelopmental condition that causes intellectual disabilities, behavioural issues, and a variety of physical symptoms. Central to understanding FXS is the Fragile X Mental Retardation 1 (FMR1) gene, pivotal in the disorder's pathogenesis. This review examines FMR1 as a key biomarker in FXS, drawing on recent research insights. The FMR1 gene, situated on the X chromosome, encodes the fragile X mental retardation protein (FMRP), …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 8–18 Read article