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288 articles for “Genetic”
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Leveraging Genome-Wide Association Studies for Precision Medicine in Cardiovascular Diseases
Abstract: Cardiovascular diseases (CVDs) are the leading cause of death globally, with complex etiologies involving genetic, environmental, and lifestyle factors. Genome-wide association studies (GWAS) have significantly advanced the understanding of genetic underpinnings of CVDs by identifying numerous risk loci and variants associated with various cardiovascular conditions. This review explores the potential of GWAS to drive precision medicine in cardiovascular diseases by linking genetic data with clinical outcomes, providing insights into disease …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 35–39 Read article
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Heterosis in Plants
Abstract: It refers to hybrid vigor or heterosis; herein, the offspring expressed better traits than one or both parent lines. This most often manifests in crop breeding as increased yield in F1 hybrids compared with their parents. Developing high-yielding hybrid cultivars across a wider range of crops represents an important strategy for addressing future food security. However, conventional hybrid breeding approaches are fraught with significant challenges in many self-pollinating crops, such …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 2, 2025 · pp. 21–31 Read article
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X - Chromosome Linked Rett Syndrome
Abstract: Rett Syndrome (RTT) is a genetic brain disorder which typically becomes apparent after 6 to 18 months of age in females synonymized as “Cerebroatrophic hyperammonemia”. It is due to genetic mutation of the MECP2 gene present on the X-chromosome. Develops as a new mutation with
Published in Research and Reviews: A Journal of Neuroscience Read article
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Stretching Boundaries: A Comprehensive Review of Ehlers-Danlos Syndrome and its Subtypes
Abstract: The Ehlers-Danlos syndromes (EDS) encompass 13 inheritable disorders affecting connective tissue. These conditions arise from genetic alterations impacting the structure of connective tissue. Every variant of Ehlers-Danlos syndrome (EDS) exhibits distinct features and has specific diagnostic criteria. While certain traits such as joint hypermobility, skin hyperextensibility, and tissue fragility are common across all types of EDS. The range of clinical presentations spans from minor skin and joint looseness to severe …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 44–57 Read article
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Vaccination in the Era of Precision Medicine: Tailoring Immunization Strategies for Individual Risk Profiles
Abstract: The introduction of precision medicine has caused a paradigm change in the vaccine landscape. Conventionally, vaccination programmes have been homogeneous, targeting immunity at the population level without taking into consideration the individual differences in immune response and vulnerability to diseases that can be prevented by vaccination. However, a more individualised approach to immunisation has been made possible by current developments in genetics, immunology, and data analytics. Within the context of …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 32–47 Read article
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A Review on Solar Multilevel Inverter for the Production of Free Energy Due to the Structure with Long-life Feature
Abstract: Multilevel inverters play a major role in medium voltage, high power and renewable applications. It is also used in certain applications where high switching frequency, and high output voltage gain are required. The switching transient period of a MOSFET should be minimal because a high dv/dt rate could result in permanent damage to the MOSFET. The harmonics present could cause many problems and so it has to be minimized. The …
Published in Journal of Nuclear Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 13–18 Read article
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Advancements and Challenges of Modern Breeding over Conventional Breeding
Abstract: Plant breeding dates back thousands of years, when people first deliberately bred plants based on visually pleasing characteristics. The domestication of wild plants aided this process, resulting in the evolution of numerous breeding strategies over time. Conventional breeding, which is distinguished by selective breeding based on superior performance, used procedures such as pure-line selections, mass selection, backcross breeding, recurrent selection, and hybridization. While effective, classical breeding procedures were time-consuming and …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 1, 2024 · pp. 1–5 Read article
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Current Perspectives of Prader -Willi Syndrome: A Multisystem Approach
Abstract: Prader-Willi syndrome (PWS) is a genetic disorder with multisystem involvement, caused by the lack of expression of genes on the paternally inherited chromosome 15q11.2-q13 region from paternal 15q11-q13 deletions (about 60%) or maternal uniparental disomy 15 or both. It is a complex and contiguous gene disorder which affects the multiple systems with many clinical presentations especially hypothalamic insufficiency. The clinical features are characterized by short stature position, developmental delay, cognitive …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 42–48 Read article
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Review Paper of the Rich Floral and Faunal Diversity in Chhattisgarh, India
Abstract: Chhattisgarh, a state in central India, is renowned for its rich biodiversity, encompassing a wide variety of plants and animals. This review highlights the critical role that sacred groves—small, often isolated forest patches preserved by local communities—play in maintaining this biodiversity. These groves are repositories of genetic diversity and serve as sanctuaries for numerous species, many of which are threatened by habitat loss and fragmentation. However, the integrity of these …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 3, 2024 · pp. 23–38 Read article
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Epidermolysis Bullosa and Its Role in Cervical Cancer: An Overview
Abstract: Epidermolysis Bullosa is a group of uncommon genetic disorders that primarily affect the skin and mucous membranes. It is marked by severe skin fragility and the formation of blisters even after minor trauma. Traditionally, the focus of Epidermolysis Bullosa research has been on its dermatological manifestations, which include recurrent blistering, scarring, and the potential for infections due to the compromised skin barrier. However, recent advancements in Epidermolysis Bullosa research have …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 14–18 Read article
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Genomic Medicine Revolutionizes Heart Care: A New Standard of Practice
Abstract: The integration of genomic and precision medicine into cardiovascular healthcare represents a transformative advancement in addressing the global burden of cardiovascular diseases (CVDs). Precision medicine leverages genomic, proteomic, and metabolomic data to provide personalized care, optimizing treatment outcomes while minimizing adverse effects. Over the past decade, extensive research has highlighted its potential to revolutionize the management of major CVDs, including myocardial infarction, hypertension, and heart failure, which significantly contribute to …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 30–37 Read article
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Enhancing Puberty in Dairy Heifers: Targeted Management Practices For Sustainable Development.
Abstract: Early attainment of puberty in dairy heifers is critical for improving reproductive efficiency and ensuring sustainable dairy production systems. This study explores targeted management practices that can accelerate puberty onset, contributing to enhanced productivity and economic viability in dairy farming. Key factors influencing puberty in heifers include nutritional management, genetic potential, health care, environmental factors, and behavioral interventions. Adequate nutrient supply, especially energy and protein, along with balanced mineral and …
Published in Research & Reviews : Journal of Ecology · Vol. 14, Issue 2, 2025 · pp. 28–35 Read article
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The Future of Camelids in South America: Recent Developments and Prospects
Abstract: Camelids, including llamas, alpacas, vicuñas, and guanacos, have been central to South American culture, economy, and ecosystems for centuries. Known for their adaptability to harsh Andean climates, these species provide valuable resources, such as luxurious fiber, nutritious meat, and durable leather. In modern times, their importance has grown due to increasing demand for sustainable and ethically sourced products, coupled with their minimal environmental impact and significant contributions to rural livelihoods. …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 2, 2025 · pp. 35–38 Read article
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Gene Drive Technology: Potential and Risks for Global Biodiversity
Abstract: Gene drive technology has emerged as a groundbreaking tool with significant potential to address critical global challenges, particularly in managing and preserving biodiversity. By enabling targeted alterations to the genetic makeup of species, gene drives could facilitate the control of invasive species, mitigate vector-borne diseases, and even aid in the restoration of endangered species. However, the rapid pace of development and deployment of gene drive technologies raises concerns about unintended …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 6–10 Read article
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Assessing the impact of lifestyle factors on autoimmune risk and survival outcomes: A Population-based Study
Abstract: This study investigated the interplay between lifestyle factors and genetic regulation in autoimmune diseases, focusing on the role of human T-cell metabolic and proliferative control through C-REL gene transcription. This study combined CRISPR-Cas9 manipulation of C-REL in human T-cells with a longitudinal cohort of 100 adults (autoimmune patients and controls), investigating metabolic and proliferation dynamics via flow cytometry and assays. It assessed lifestyle impacts through surveys and medical records, ensuring …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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A review on Design of Gene Therapy and Its Potential for Craniofacial Regeneration
Abstract: One of the most talked-about topics of the 21st century is gene therapy, which holds the promise of treating many diseases. Current gene therapy research explores a wide range of potential treatments, such as enhancing the body’s immune response to tumors, promoting the formation of new blood vessels in the heart to mitigate heart attacks, and preventing HIV replication in AIDS patients. Gene therapy involves the introduction, alteration, or replacement …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 6–12 Read article
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Zebrafish in Drug Research: Decoding Biological Mechanisms and Finding Novel Therapeutic Targets
Abstract: The zebrafish, scientifically known as Danio rerio, is a powerful model organism in biological research because of its favorable traits, which include rapid development, genetic tractability, and transparent embryos. Zebrafish were first identified for their use in studies of vertebrate development, but they have since spread to a variety of disciplines, such as pharmacology, clinical research as a disease model, and most notably, drug development. Zebrafish have emerged as a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 1–8 Read article
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Calf Mortality in the Tropics: Multidimensional Challenges and Implications for Sustainable Dairy Development
Abstract: Calf mortality remains a significant challenge in tropical dairy farming, posing threats to productivity and sustainability. This review explores the multifactorial factors contributing to calf mortality in the tropics, including environmental stress, infectious diseases, nutritional deficiencies, management practices, genetic factors, and social dynamics. Tropical climates, characterized by extreme temperature variations, humidity, and poor shelter, exacerbate stress and compromise calf health. Infectious diseases, such as bacterial, viral, and parasitic infections, coupled …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 3, 2025 · pp. 7–23 Read article
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Implementation of Anticipating Rainfall Using Machine Learning
Abstract: Rainfall forecasting is crucial for many aspects of our national economy and should help prevent major seasonal droughts. Since agriculture is a beloved profession in many states, some Asian countries are economically hooked to decline. Previous precipitation info is beneficial. Farmers are cancerous in managing their crops, resulting in economic progress for the country. downfall prediction is hard for earth science scientists because of unordering time and unordered quantity of …
Published in International Journal of Satellite Remote Sensing · Vol. 1, Issue 1, 2023 · pp. 1–8 Read article
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Recombinant Insulin
Abstract: Recombinant insulin, a revolutionary product of biotechnology, has transformed the landscape of diabetes treatment. Developed through genetic engineering techniques, recombinant insulin offers a safer, more consistent alternative to traditional animal-derived insulin. Its production involves the insertion of the human insulin gene into host organisms such as Escherichia coli or Saccharomyces cerevisiae, which serve as efficient factories for insulin synthesis. Recombinant insulin is used to treat diabetic patients who are allergic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 39–43 Read article