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1499 articles for “1Alu (IL-6)”
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Fatigue Analysis of the FSAE Vehicle's Front Wheel Hub
Abstract: This study illustrates the design and analysis of the FSAE vehicle's front wheel hub. Because wheel hubs are subjected to cyclic loads on a continuous basis, there is a risk of fatigue, which leads to material failure. The start and spread of cracks in a material as a result of cyclic loading is known as fatigue. The brake discs could not be easily removed since the disc is positioned between …
Published in Journal of Automobile Engineering and Applications Read article
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Computational Molecular Docking Studies to Design Novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)-1H- indol-5-ol Derivatives for Estrogen Receptor Alfa in AF-2 Domain
Abstract: The present manuscript describes the designing of novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)- 1H-indol-5-ol derivatives as specific estrogen receptor alfa modulators and their screening by docking studies to determine the binding interaction for the best-fit conformations in the binding site of the ERα receptor. Based on the results of docking studies, the selected ligands reveal the all- important functional groups of the ligands that interact with active amino acid residues in the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 15–49 Read article
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A Comprehensive Review on COVID-19 Evolution and Development
Abstract: The emerging pandemic causing flu-like symptoms in patients is caused by the novel Coronavirus that was previously called 2019-nCoV. The mutated gene of SARS-CoV was transformed to SARS-CoV-2 in animals and further transmitted to humans in the month of December 2019 in Wuhan city of China. Eventually, the novel coronavirus spread all around the globe as a highly contagious disease. COVID-19 (the illness caused by coronavirus) has affected 213 countries …
Published in Research and Reviews : A Journal of Life Sciences Read article
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An Approach towards in Management of Chronic Kidney Disease
Abstract: The current international guidelines define and classify the chronic kidney disease (CKD) as decreased kidney function shown by decreased glomerular filtration rate (GFR). Glomerular filtration rate of 60 ml/min/1.73 m 2 for at least 3 months is a marker for kidney damage. The underlying causes for chronic kidney disease are proteinuria and hypertension. It is the main cause of CKD in many high-, middle- and low-income countries. In different countries, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 1, 2025 · pp. 9–15 Read article
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AQUASOMES: A Vesicular, Self-assembled Ceramic Nanoparticulate Drug Carrier
Abstract: Nano-biopharmaceutics involves delivery of biopharmaceutical product through different biomaterials like multi-functional nanoparticles, quantum dots, aquasomes, super-paramagnetic iron oxide crystals, and liposomes dendrimers. Aquasomes are considered as one of the most recently developed delivery systems for bioactive molecules like peptides, proteins, hormones, antigens and genes to specific sites. Aquasomes have a spherical shape and a particle size of 60–300 nm. These are three layered self-assembled nano-particulate carrier system. This three-layered structure …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 1–14 Read article
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Assessment of Groundwater Quality in Rumuodara, Rivers State, Nigeria
Abstract: The assessment of groundwater quality from selected borehole in Rumuodara, Rivers State, Nigeria was evaluated. The results of the physicochemical parameters revealed that pH ranged from 6.57-6.60, temperature: 26.10-28.54oC, turbidity: 1.57-2.96NTU, conductivity: 41.24-68.44 μS/cm, salinity: 26.10-50.37mg/l, total dissolved solid: 18.9-63.14mg/l, total hardness: 38.21-48.30mg/l, alkalinity: 55.30-70.17mg/l, chloride: 28.40-75.14mg/l, sulphate: 21.50-30.60mg/l, nitrate: 1.50-3.04mg/l, phosphate: 59.24-65.40mg/l, calcium: 37.81-45.27mg/l, Iron: 0.133-0.190mg/l, sodium: 16.70- 21.13mg/l, copper: 0.22–0.50mg/l, total suspended solid: 2.94-3.60mg/l, Lead: < 0.01mg/l-2.27mg/l, zinc: …
Published in Research & Reviews : Journal of Ecology Read article
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Assessing the Baking Characteristics of Mozzarella and Pizza Cheeses
Abstract: Mozzarella/Pizza cheese is considered an important specialty cheese since it can be consumed directly or as an ingredient in other food products. It exhibits functional properties inclusive of baking properties such as Shred ability, meltability, fat leakage, stretchability, browning, etc. during their end use application in food. Assessing such properties of cheese is of significance since the cheese users at the restaurants and even the varied connoisseurs of cheese have …
Published in Research and Reviews : Journal of Dairy Science and Technology Read article
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Ground Water Contamination in Shallow Aquifer of Punjab State With Special Reference to Uranium
Abstract: In Punjab State ground water is in general suitable for drinking uses except at few places in the southern and south western parts where it is not suitable due to high EC or high fluoride or nitrate or combination of all. Almost all ground waters are suitable for irrigation for growing crops like wheat, mustard, rice, barley and maize etc. However, at few places where EC of ground water goes …
Published in Research & Reviews : Journal of Ecology Read article
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Modeling the Novel Coronavirus Disease (COVID-19) as Hidden Markov Chains
Abstract: The Hidden Markov Model has over the years been an appropriate method for modeling diseases such as HIV AIDS, heart failure, and so on. With the ongoing pandemic affecting Nigeria by being responsible for 2,745 death cases out of 207,616 confirmed cases as of October 10, 2021, the need to study an important parameter of COVID-19, the case fatality rate by building a model and estimating the case fatality rate …
Published in Research & Reviews : Journal of Statistics Read article
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Basic Concept and Role of Memory Enhancer (Muqawwi- E-Hafiza) Unani Drugs in the Management of Alzheimer’s Disease (Nisyaan-E-Shekhukhi): A Review
Abstract: Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline, defined as a dementing illness in which anterograde amnesia is a dominant symptom and is the most common cause of Dementia in the elderly. There is no direct mention of this condition in classical Greek literature, but Alzheimer's disease is almost always associated with forgetfulness or fasaad-e-takhayy’ul. Although the etiology is …
Published in Research & Reviews : Journal of Herbal Science Read article
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Molecular Characterization of Circulating Rota Viral Strain causing infantile diarrhoea in Tripura, North East India
Abstract: Introduction: North Eastern India is geographically distinct from rest of India and the trend of Rota viral diarrhoea among children below 5 years of age group is not well studied yet. The Government of India introduced the oral rotavirus vaccine (ROTAVAC) in 2016 as part of the Universal Immunization Programme in different parts of India. Objective: (1). To determine the proportion of circulating Rotavirus strains causing acute viral gastroenteritis (AGE) …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 3, 2021 · pp. 6–13 Read article
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Effect of Initial Temperature and Diameter of Ethanol Droplet on Evaporation Dynamics in Convective Air Medium
Abstract: Ethanol is a suitable biofuel as it has fewer toxic emissions and higher-octane numbers. For spray combustion applications, the gas phase motion must be considered while numerically investigating the fundamental aspects of droplet evaporation and combustion processes. Hence, we have numerically simulated the evaporation dynamics of an isolated spherically shaped ethanol droplet under a forced convective air environment in the absence of gravity. The momentum transfer between two phases is …
Published in Journal of Polymer & Composites Read article
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Experimental Analysis of Nano-carbon Doped Alumina for Industrial Applications
Abstract: The use of nano-carbon metal matrix composites can provide a solution to the enduring issue of optimal material selection and optimization for getting metal-insulator transition (MIT) behavior at a particular frequency at ambient temperature. Other substances, like two-dimensional (2D) transition metal dichalcogenides (TMD), vanadium oxide (VO2), and germanium telluride (Ge-Te), have difficult challenges in achieving effectively the MIT property at a given frequency and temperature. It is also difficult to …
Published in Journal of Polymer & Composites Read article
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Distinctive Approaches for Improving the Aqueous Solubility of BCS Class II Drugs
Abstract: The most difficult feature of many novel chemical entities is their solubility behaviour, as 60 percent of new promising products suffer solubility limitations. This is the most common reason for novel medicine compounds failing to reach the market or performing to their full potential. The proportion of the aqueous phase when the solution is in equilibrium with the pure substance in its normal phase is referred to as aqueous solubility. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 52–56 Read article
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Radon Estimation in Some Lakes and Fraser River Water of British Columbia, Canada using LR-115 Type II Alpha Track Detector
Abstract: Radon activity levels were measured in the five Lakes and Fraser River water samples collected from different locations of British Columbia in Canada. The purpose of this study was to compare Radon activity levels in all six sources of water. Water was collected in air tight bottles and stored for two weeks before investigation. LR-115 Type II nuclear track detectors of 1.2 cm2 were used for recording radon alpha tracks. …
Published in Research and Reviews: A Journal of Toxicology Read article
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HPLC and Tandem MS Device for the Recognition of Emtricitabine and Tenofovir Alafenamide in K2EDTA Human Plasma Utilizing Emtricitabine 15ND2 Tenofovir D5 as an IS
Abstract: Developed very impressionable, discriminating, and exact extreme-efficiency liquid chromatographytandem bulk spectrometry form for measurement of Emtricitabine and Tenofovir Alafenamide in human plasma. Emtricitabine15ND2 Tenofovir D5 was used as a within the standard (IS). The samples were divided on Phenomenex Kinetex C18 5 μm 100A, 100*4.6 mm procession utilizing Acetonitrile: 0.2% formic acid, 60:40 V/V as movable state, the retention period of Emtricitabine: 1.36 minutes (±0.5 minutes), Emtricitabine 15ND2: 1.36 minutes …
Published in Research and Reviews: A Journal of Toxicology Read article
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An Overview of Spam Detection Techniques
Abstract: Spam is also known as unsolicited commercial email (UCE) has become a major worry for the internet's and worldwide commerce's long-term viability. Fake emails and other forgeries, such as phishing, are examples of spam emails. Which aim to collect confidential personal information about users on the network or to act illegally against authority. Spam produces a variety of issues, which can result in financial losses. Spam creates bottlenecks and traffic …
Published in Journal of Advancements in Robotics Read article
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Support of Knowledge-oriented Business Processes through Workflow Management Systems
Abstract: A major challenge in implementing business process-related knowledge management is to encourage employees to participate in knowledge processes. On the one hand, the educational work should be integrated harmoniously into the work context and, on the other hand, information must be presented and actively distributed as needed. In order to be able to introduce systematic knowledge management in companies, the design dimensions that a knowledge management project encompasses must first …
Published in E-Commerce for Future & Trends Read article
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In Silico Drug Design for Mycobacterium tuberculosis and Development of Host–Pathogen Interaction Network and Molecular Docking Procedures
Abstract: Objective: A leading cause of illness is the contagious disease tuberculosis (TB), this infection with Mycobacterium tuberculosis complex (MTBC) particularly M. tuberculosis and M. africanum, is what causes tuberculosis. Diverse receptor proteins (mycobacterial proteins) with various 3D structures and functions were evaluated to access the multi-domain antimycobacterial action of ligands. The specific receptor proteins PDB ID: 3PTY, PDB ID: 4OW8, PDB ID: 5KWA, and PDB ID: 3ZXR, were opted for …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 1–19 Read article
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology Read article