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512 articles for “Anti – infective”
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IN SILICO SCREENING AND EVALUATION OF SOME METABOLITES FROM MOMORDICA CHARANTIA IN THE TREATMENT OF PEPTIC ULCERS
Abstract: Peptic ulcers are also called as or duodenal ulcers or gastric ulcers that are open sores generally develop in the lining of the stomach due to food and climatic factors. H. pylori infections are potentially the most dangerous and are linked to several diseases like diabetes, cancer, cardiovascular diseases, etc. In the present study, in silico screening and evaluation of some metabolites from Momordica charantia like Momorcharin, Momordicin, Metformin, Pioglitazone, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 1, 2021 · pp. 5–13 Read article
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3D-QSAR and Molecular Docking Studies of Triazol-Cycloalkanol Derivatives Used as Potent 3-Dehydroquinase II Inhibitors Against Mycobacterium tuberculosis
Abstract: Tuberculosis is a life threatening infectious disease caused by gram positive bacteria mycobacterium tuberculosis. Emergence of drug resistance, multi drug resistance and extensively drug resistance strain of mycobacterium make the situation more worst. It increases the mortality rate of tuberculosis patient, time duration and cost of treatment. Various inhibitors and drug molecules are designed to combat this fatal disease. Enzymes of shikimate pathway are responsible for production of essential amino …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 3, 2015 · pp. 18–28 Read article
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In silico analysis of Abrus precatorius L. as a potential agonist of PPARγ : A novel approach to the treatment of diabetes
Abstract: Diabetes mellitus is a chronic disorder that is characterized by a lack of insulin secretion by the pancreas or a defect in insulin action, or both. If diabetes is not controlled, over time it can cause damage to blood vessels and nerves, leading to life-threatening complications such as, kidney damage, heart disease and vision impairment. It can also weaken the immune system, making patients more prone to infection. Although treatments …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 13–24 Read article
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A Step towards Malaria Vaccine DBP Engagement with DARC of Erythrocyte
Abstract: Plasmodium vivax is causative agent of malaria. In Plasmodium vivax Duffy binding protein (DBP) is most ligand for merozoite invasion of human erythrocyte surface by DARC. Thus, it is most suitable protein for development of vaccine. Initial infection can stop threw malaria vaccine DBP has great role of a family of related proteins found in different malaria species that are found in host cell invasion. There is only reason of …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 3, 2017 · pp. 19–26 Read article
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Identification of Specificity Determining Positions through Phylogenetic Studies and Molecular Modeling of ICP27 as a Drug Target of Herpes Simplex Virus-1
Abstract: An ever-growing effort to apply computational power to the combined chemical and biological space in order to streamline drug discovery, design, development and optimization can be achieved through computational approaches. Herpes simplex is an infection that is caused by a herpes simplex virus (HSV), and is one of the most common human infections transmissible to a body site. Infection with HSV can result in several diseases ranging from apparent infections …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 1, 2015 · pp. 32–43 Read article
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Viral Elimination Strategies for Musa spp.
Abstract: Banana is one of the major crops in tropical parts of the world. The banana plant is susceptible to many diseases due to the less genetic diversity in its popular cultivars. Particularly viral diseases can severely destruct quantity and quality of the crop. Four major banana infecting viruses doing the damage- banana bunchy top virus, banana streak virus, banana bract mosaic virus, cucumber mosaic virus; two other viruses- banana mild …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 1, 2018 · pp. 7–14 Read article
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Garlic and Onion Extracts Enhance the Yield of T2 Bacteriophage in E. coli
Abstract: It has been demonstrated that garlic and some of its components have anti-bacterial and/or anti-viral activity for viruses of humans in vitro. Increasing concentrations of garlic extract have no effect on the replication of E. coli cultured in nutrient broth. Increasing concentrations of garlic extract inhibit the replication of T4 Bacteriophage in E. coli but, surprisingly, E. coli cells treated with garlic extract produced a yield of T2 Bacteriophage up …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 2, 2015 · pp. 8–16 Read article
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A Comprehensive Review on Monkeypox Infection
Abstract: Monkeypox represents a zoonotic viral affliction instigated by the monkeypox virus, which is classified within the Poxviridae family and is distinct from the virus that causes chickenpox. Initially recognized in 1958, this infection has recently attracted international scrutiny due to its escalating incidence beyond traditional endemic territories. This review delivers an exhaustive examination of monkeypox, encompassing its epidemiology, viral morphology, modes of transmission, pathogenesis, clinical presentations, and therapeutic interventions. The …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 23–32 Read article
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Tuberculosis Epidemiology and its Diagnostic Modality
Abstract: Tuberculosis (TB) remains a global health emergency, with India being the epicenter, recording 2.23 million cases and approximately 4.53 lakhs deaths in 2021. Despite efforts by the National Tuberculosis Eradication Program (NTEP), the anticipated decrease in the incidence and prevalence of TB has not been actualized. This paper examines the persistently high rates of TB in India, identifying critical risk factors such as male gender, marital status, overcrowding, socioeconomic disadvantages, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 3, 2023 · pp. 7–11 Read article
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Wiskott-Aldrich Syndrome: A Comprehensive Guide
Abstract: Wiskott-Aldrich Syndrome (WAS) is an uncommon genetic disorder inherited through the X chromosome, marked by a combination of immune system deficiencies, eczema, and low platelet counts. This syndrome primarily affects males, leading to significant morbidity and mortality due to recurrent infections, bleeding complications, and autoimmune diseases. Mutations in the WAS gene disrupt the production of the Wiskott-Aldrich Syndrome protein (WASp), crucial for the functioning of immune cells and platelet formation. …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 39–46 Read article
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Exclusion of Seed Sprouts Salmonella Pathogens Through Bacteriophages
Abstract: Foodborne pathogens are contamination in foods; it results in poisoning conditions that reach to the consumers. Food poisoning responsible microbial inhabitants are progressive within a short duration and it is difficult to control their ascendancy. In practice, many chemical-based antimicrobial agents are used to control the foodborne pathogenic bacteria, subsequently with some drawbacks. Hence, we urgently need an attractive alternative to reduce bacterial food contamination. The lytic bacteriophages are the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 73–80 Read article
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An Immuno-informatics Approach for the Design of Subunit Vaccine for Non-human Homolog Proteins of A.aegypti Species
Abstract: Mosquito borne diseases account for a major fraction of vector-borne diseases that account for significant morbidity amongst the population worldwide. The prevalence rate of mosquitoes in the common habitable area is so high that even after the implementation of several eradication programs their disease-causing rate is still quite significant. A.aegypti and A.albopictus are two prominent species of genus Aedes, which transmit viruses causing several infectious diseases such as dengue, zika …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 9, Issue 3, 2022 · pp. 1–8 Read article
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Inhibitory Action of Sodium Tellurite on Uropathogenic Bacteria
Abstract: The objective of the present study was to predict the toxic properties of sodium tellurite against selected uropathogenic bacteria. A group of nine clinical isolates of different uropathogenic bacteria isolated from urine in suspected cases of urinary tracts infection Enterococcus faecalis, Staphylococcus aureus, Acinetobacter baumannii, Citrobacter freundii, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa were collected and utilized for screening tests. The spectrum of toxic properties …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 2, 2018 · pp. 6–10 Read article
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Assessment of Malaria Prevalence and Evaluation of Therapeutic Efficacy of Artemether/Lumefantrine (Coartem®) against Uncomplicated Falciparum Malaria in Wondogenet Woreda, SNNPR, Ethiopia
Abstract: Normal 0 false false false EN-US X-NONE X-NONE AbstractThe study was conducted to assess malaria prevalence and to evaluate therapeutic efficacy of Coartem® for the treatment of uncomplicated falciparum malaria in Wondogenet Woreda, Sidama Zone, Ethiopia. Since the spread of Plasmodium falciparum, parasite resistance to almost all antimalarial monotherapies is a serious impediment to malaria control. Artemether-lumefantrine (Coartem®) therapy has been in use as the first-line treatment for uncomplicated falciparum …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 2, 2015 · pp. 26–34 Read article
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Zika Virus E-Protein In Silico Approach and Drug Repurposing
Abstract: The mosquito borne, one of the flavivirus family, called Zika virus is a positive, single stranded RNA. ZIKV infected humans are affected by neurological disorders, birth defects and other small pain, rash etc. To relieve from these disease, the target protein of ZIKV disease is to be determined. Here, the envelope protein is taken as a target to prevent Zika virus entry in to the cells. 3D structure of ZIKV …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 2, 2017 · pp. 8–16 Read article
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Candida auris—Behaviour and Prognosis
Abstract: The genus Candida contains around two hundred different species. For over a decade, health authorities and institutions around the world have been on edge due to the unprecedented rise of Candida auris as a multidrug-resistant fungal pathogen, which poses a serious global threat due to its potential to cause nosocomial outbreaks and deep-seated infections with staggering transmissibility and mortality. The Centers for Disease Control and Prevention and other international organisations …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 1, 2023 · pp. 1–6 Read article
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Recombinant Proteins and Nested Gene Regulation: Nutrient Driven Immune Response and Disease Resistance in Livestock
Abstract: Livestock production systems are increasingly challenged by infectious diseases, metabolic disorders, and environmental stressors that reduce productivity and compromise animal health. Advances in molecular biology and animal nutrition now offer new opportunities to strengthen disease resistance through integrated strategies that combine recombinant protein technologies, gene regulatory mechanisms, and nutrient mediated immune modulation. This review examines how recombinant proteins and nested gene regulation interact to shape nutrient driven immune responses in …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 84–97 Read article
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Mucormycosis: Review on the basis of Diagnosis Treatment, Preventive Measures, and Recent Research Approach
Abstract: Mucormycosis is a fungal infection called an angio-invasive disease due to invasion of fungi of the order Mucorales and zygomatic species which causes tissue infarction and necrosis. The main aim and purpose of this review are related to the overview of Etiopathogenesis of Mucormycosis, mortality due to various types of Mucormycosis, recent advances in diagnostic and treatment methods, and their diagnostic preventive measures. It shows serious and worrying mortality and …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 10, Issue 3, 2021 · pp. 51–62 Read article
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Liver Patient Analysis Using Machine Learning
Abstract: Liver, a critical inside organ of the human body whose chief errands are to take out created squander delivered by our life form, digest food, and safeguard nutrients and energy materials. The liver problem can cause different deadly infections, including liver malignant growth. Early conclusion, and treating the patients are necessary to diminish the gamble of those deadly sicknesses. As the finding of liver illness is costly and refined, various …
Published in Journal of Instrumentation Technology & Innovations · Vol. 12, Issue 2, 2022 · pp. 29–35 Read article
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Isolation of Lactobacillus Acidophilus with A High Acid-Producing Capacity and Its Common Characteristics
Abstract: Some strains of lactobacilli like spore Lactobacillus offer good merits in normalizing intestinal micro biota, resisting selectively to intestinal pathogens, exerting resistance to heat, acid and antibiotics, and are of good storage stability. This research work has been conducted in order to isolate a certain strain of Lactobacillus that offers high resistance to the gastric acid, bile and pathogens, and mutualistic symbiosis with useful intestinal microbes, and identifying its characteristics …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 3, 2023 · pp. 1–6 Read article