IN SILICO SCREENING AND EVALUATION OF SOME METABOLITES FROM MOMORDICA CHARANTIA IN THE TREATMENT OF PEPTIC ULCERS

D.S.V.G.K. Kaladhar; Akhilesh Tiwari; Shristi Sharma

Abstract

Peptic ulcers are also called as or duodenal ulcers or gastric ulcers that are open sores generally develop in the lining of the stomach due to food and climatic factors. H. pylori infections are potentially the most dangerous and are linked to several diseases like diabetes, cancer, cardiovascular diseases, etc. In the present study, in silico screening and evaluation of some metabolites from Momordica charantia like Momorcharin, Momordicin, Metformin, Pioglitazone, Glipizide, Gliclazide and Glibenclamide in the treatment of peptic ulcers has been conducted. Vacuolating cytotoxin autotransporter (VacA) causes ulceration and gastric lesions is interacting with Urease subunit alpha (ure a), Outer membrane protein-adhesin(babA), Acid-activated urea channel (ureI; rapidly enhances the production of ammonia) and Cytotoxicity-associated immunodominant antigen (CagA). CagA is directly interacting with Serine/threonine-protein kinase CtkA and Cag island protein (virD4). Glibenclamide, Glipizide and Momorcharin has shown good results with Vac A and CagA involved in peptic ulcer. The present study has shown that Glibenclamide is found as effective molecule in the control of peptic ulcer.

Abstract

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