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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Advanced Techniques in Filler Layering for the Malar Region: Implications for Cellular Integrity and Long-Term Outcomes
Abstract: Objective: This review investigates advanced filler layering techniques for the malar region, focusing on cellular integration, collagen remodeling, hydration dynamics via aquaporin channels, genetic responses, and filler performance over time. Emphasis is placed on high-density HA fillers (Lyft, Voluma, Volift, and Volux), examining cellular-level mechanisms, genetic interactions, and the role of key pathways (TGF-β, ERK/MAPK, AQP3) in long-term outcomes. Methods: A systematic review was conducted, focusing on genetic, cellular, and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 10–19 Read article
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Green Synthesis of Cobalt Oxide Nanoparticles Using Delonix regia Leaf
Abstract: Green synthesis of nanoparticles offers a sustainable and eco-friendly alternative to conventional methods. This study explores the biosynthesis of cobalt oxide nanoparticles (Co3O4 NPs) using Delonix regia leaf extract as a reducing and stabilizing agent. The synthesized Co3O4 NPs were characterized by UV-visible spectroscopy, Fourier transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM), confirming their uniform spherical morphology with an average size of …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 1, 2025 · pp. 30–38 Read article
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Optimization Of Mechanical Properties Of 500/7 Grade Ductile Cast Iron (DCI) By Using SMAW: Applications In Reinforced Composites And Thermoplastics Through Taguchi & GRA
Abstract: Welding, a critical manufacturing process, is broadly engaged to join metals and thermoplastics using heat, pressure, or both. This study inspects the Shielded Metal Arc Welding (SMAW) method to optimize welding parameters and improve the mechanical properties of Ductile Cast Iron (DCI) grade 500/7, a material widely used in high-strength and thermal conductivity applications in aerospace and automotive sectors. Using an L9 OA (orthogonal array), experiments were conducted on nine …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 204–222 Read article
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Exploring the Effects of Yogic Meditation on Stress, Anxiety, and Cardiovascular Health: A Prospective Cross-Sectional Cohort Study at Desh Bhagat Hospital
Abstract: Background: Stress and anxiety are significant risk factors for cardiovascular disorders, with growing evidence suggesting that yogic meditation can mitigate these effects. This prospective cross-sectional cohort study was conducted to evaluate the impact of yogic meditation on stress, anxiety, and cardiovascular parameters among patients attending Desh Bhagat Hospital. Methods: A cohort of 350 patients was recruited, comprising individuals presenting with elevated stress, anxiety, or cardiovascular conditions. Participants underwent a guided …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 1, 2025 Read article
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An Evaluation of the Effectiveness of a Self-Instructional Module on First Aid and Safety Measures for School Children (Aged 11–14 years) at PDR VVP Vidyalaya, Loni
Abstract: Background: School children are active youngsters. India is home to nearly 500 million young individuals, with approximately 370 million being children under 15 years old, highlighting their crucial role as the future of the country. Young children often exhibit naughty, defiant, and impulsive behavior. According to the World Health Organization’s Global report, in the South-East Asia Region, road traffic accidents, drowning, burns, and other injuries are leading causes of child …
Published in Journal of Nursing Science & Practice · Vol. 15, Issue 1, 2025 · pp. 17–22 Read article
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Evaluation of Medication Adherence in Patients with Type 2 Diabetes Mellitus: A Mixed- Methods Approach
Abstract: Background: Medication adherence refers to how closely an individual follows the prescribed medication regimen. It is essential for achieving desired therapeutic outcomes and improving patient health. Inadequate adherence can result in the deterioration of health conditions, higher mortality rates, and increased healthcare expenses. Diabetes mellitus, being a chronic condition, demands ongoing medical care not only to prevent the onset of serious complications but also to manage them effectively once they …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 28–35 Read article
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Emerging Therapies for Diabetes Mellitus: Efficacy and Safety of USFDA-Approved Drugs and Late-Stage Clinical Trials
Abstract: This review provides a comprehensive analysis of drugs approved by the U.S. Food and Drug Administration (USFDA) for managing diabetes mellitus (DM) from 2013 to 2022, including emerging treatments from phase 3 clinical trials during this period. Over the past decade, the treatment landscape for diabetes has evolved significantly, with new therapies not only improving blood sugar control but also targeting broader health outcomes like heart and kidney health. In …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 11–23 Read article
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Exploring Psychotropic Trends of Medication Use in Psychiatric Outpatients: An Observational Study at a Tertiary Care Hospital
Abstract: Background: Psychotropic medications are essential in managing a wide range of psychiatric disorders, including depression, anxiety, bipolar disorder, and schizophrenia. Prescribing habits in outpatient clinics can differ a lot depending on things like the patient’s age, background, and medical conditions. Aim: This study aims to explore the trends in psychotropic medication use among psychiatric outpatients at a tertiary care hospital, with a focus on understanding prescribing patterns, demographic factors, and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 15–23 Read article
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Social Media Usage Among Youth in Punjab: Platform Preferences, Usage Habits, and Academic Impact
Abstract: Background: The role of social media in daily life and communication activities continues to grow, especially among young people. Given the shift towards more social interaction and engagement online, it is important to look at the preferences of the platforms, their habits of usage, and how they relate with academic engagement. This research study analyzes the social media utilization patterns of youth residing in Punjab, India with the aim of …
Published in Journal of Communication Engineering & Systems · Vol. 15, Issue 2, 2025 · pp. 21–30 Read article
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Comparison of Several Clinical Scoring Systems in Predicting the Outcome of Variceal Bleeding
Abstract: Background: Stratification of variceal bleeding patients into high-risk and low-risk group is very important to guide them through the suitable clinical pathway and to save the medical costs. We purposed to find out the best scoring system in the prediction of rebleeding and death after variceal bleeding by comparing four clinical scoring systems(clinical Rockall score, complete Rockall score, AIMS65 score, Child-Pugh score) which seemed to be applicable and simple. Method: …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 2, 2025 Read article
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The Role of Digital Detox in Improving Mental Health
Abstract: This study examines digital detox—the deliberate limitation of screen exposure—and its influence on mental health. A survey of 30 participants indicated that reducing screen time by at least two hours daily resulted in a 30% improvement in sleep quality, a 25% decrease in stress levels, and a 20% enhancement in overall mood stability. Statistical analysis (p < 0.05) confirmed these results. Additionally, participants following a structured digital detox plan reported …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 2, 2025 Read article
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Effects of Tendon Gliding Exercises on the Speed of Handwriting Among Female UG Students: Pilot Study
Abstract: Background: Handwriting is an intricate function which requires the combination of fine motor skills, visual and motor coordination abilities, and concentration. Handwriting involves two main movements: horizontal wrist motion and vertical finger movements, along with a rightward translation of the entire arm. Handwriting speed is an important factor in a student’s academic performance, particularly in fields such as statistics. The strength and flexibility of hand muscles can significantly influence writing …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Evaluation of Metal Coupons Corrosions in Fresh Water Environment at Different Water Depths Using Finite Element Analysis
Abstract: This research addressed the effects of water depths and quality on corrosion of submerged metal structures in the water body considering environmental conditions. The depths considered were 30cm to 150cm. Four different metal coupons were selected (Mild Steel, Copper Steel, Carbon Steel and Stainless Steel] Galerkin`s finite element techniques was applied to evaluate the relationship between diffusion and weight loss, also velocity and weight loss at different water depths. The …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 1, 2025 · pp. 27–50 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Mechanical Characterization of Hybrid Basalt Fiber Composites with Silicon Carbide Fillers
Abstract: Natural fiber composites (NFCs) have experienced significant growth and innovation in recent research because to their advantages over synthetic fiber composites, including their lower cost and environmental impact. This paper investigates the tension and compression properties of hybrid laminate composites composed of stainless-steel wire mesh, epoxy resin reinforced with basalt fibre, and silicon carbide (SiC) filler. Composites with varying weight percentages of SiC filler (0%, 1.5%, and 3%), were made …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 582–593 Read article
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Analyzing the Role of Fiber Composition in Drying Behavior: A Comparative and Predictive Approach
Abstract: This research presents a comprehensive analysis of the drying behavior and thermal response of three distinct fabric types: 100% Cotton, 100% Polyester, and a Polyester blend (65/35), under meticulously controlled environmental conditions. The Polyester blend (65/35) consists of 65% Polyester and 35% Cotton, combining characteristics of both fibers. The investigation focuses on understanding how fiber composition impacts drying time, moisture retention, and thermal characteristics. Experimental trials were conducted using standardized …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 1–11 Read article
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Bioanalytical Method Development and Validation for the Estimation of Levothyroxine in Human K₃EDTA Plasma by Using UPLC-MS/MS
Abstract: A rapid, sensitive, and highly selective UPLC-MS/MS method was developed and validated for the quantitative estimation of Levothyroxine in human plasma using Levothyroxine-D₃ as the internal standard (IS). Chromatographic separation was achieved on a Gemini NX-C18 column (50 × 3.0 mm, 3 µm) with a mobile phase consisting of acetonitrile and water (70:30, v/v) containing 0.015% formic acid at a flow rate of 0.5 mL/min. The total run time was …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 32–46 Read article
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Facile Synthesis and Characterization of Cd²⁺ Doped NiAl₂O₄ Nanoparticles for Advanced Polymer Composite Integration
Abstract: Ni1-xCdxAl2O4, where 0 ≤ x ≤ 0.5, was successfully synthesized using the chemical co-precipitation technique, a scalable and cost-effective route suitable for composite material applications. X-ray diffraction (XRD) analysis revealed a crystalline cubic spinel structure for the resulting nanoparticles, with determined crystallite sizes ranging from 36 to 12 nm for NiAl2O4 and Cd-doped NiAl2O4. The respective band gaps for the materials were found to be 3.51 and 4.18 eV. Infrared …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 59–72 Read article
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Generative AI for VR: Creating Physically Realistic Models
Abstract: Virtual Reality has revolutionized the traditional learning system by creating and interactive and engaging environment. However, its ability to show precise real-world experiences is limited due to lack of physical realism. This study investigates the potential of Generative Adversarial Network (GAN) in creating physically realistic 3D models. Proposed system incorporates deep learning techniques along with physics-based constraints to enhance model’s accuracy and usability. To achieve this, experiments were conducted on …
Published in Journal of Advancements in Robotics · Vol. 12, Issue 3, 2025 · pp. 14–22 Read article
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Optimizing Heat Dissipation: Analysis of Air Cooled Fins for Electronic Equipments
Abstract: This paper focuses on the thermal management of electronic components in modern technologies like RADAR electronics, UAV and Drone technologies,Automotive Electronic Components etc. The main objective of this research is to design and develop an efficient heat dissipation system, using fins, for an electronic component with dimensions of 80 x 300 mm, dissipating 30W heat. The process starts by calculating essential parameters for fin design, followed by modeling the fins …
Published in Recent Trends in Fluid Mechanics · Vol. 12, Issue 3, 2025 · pp. 26–50 Read article