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1365 articles for “Target”
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Therapeutic Effect of PEGylated Phytosomes Loaded with Herbal Drugs for Treating Paediatric Leukaemia
Abstract: To treat pediatric leukemia, this study evaluated a co-encapsulated pegylated phytosome system based on herbal anti-cancer medications. In this study, herbal drug-soy lecithin complex-loaded phytosomes were prepared as drug carriers to overcome the limitations of natural drugs like poor absorption, low oral bioavailability, poor aqueous solubility, and so on. This is a targeted nano-drug delivery that enhances the absorption and bioavailability of the herbal drug used. In this study, herbal …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 24, Issue 3, 2022 · pp. 48–69 Read article
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Protein-Tyrosine Phosphatase-1B (PTP-1B) Inhibitory Perspectives of Hydroxylated Chalcones: Exploration through Docking Studies
Abstract: The current research emphasized on exploring the Protein-Tyrosine Phosphatase-1 B (PTP-1B) inhibitory potentials of hydroxylated chalcone derivatives against PDB ID: 4I8N (PTP-1B in complex with an inhibitor [(4-{(2s)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid) by molecular docking approach using the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The current molecular docking analysis of some hydroxylated chalcone derivatives have presented a profound inhibition of the antidiabetic target PTP-1B by interacting with the amino acid residues …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 6, Issue 1, 2019 · pp. 4–8 Read article
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Analysis and Treatment of Greywater by Using Natural and Chemical Coagulants
Abstract: This project consists of collecting the data related to greywater treatment and analysis. The quality of greywater generated in different, especially, developing countries, constituents found in greywater, some treatment systems and natural materials for treatment, some reuse strategies and public perception regarding greywater reuse. The review shows that generation rates are mostly influenced by lifestyle, types of fixtures used and climatic conditions. Contaminants found in greywater are largely associated with …
Published in Journal of Water Pollution & Purification Research · Vol. 7, Issue 3, 2020 · pp. 1–5 Read article
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A Review on Drug Delivery Systems Using Microfluidics
Abstract: AbstractMicrofluidics is undoubtedly an influential technology that is currently revolutionizing the chemical and biological studies by replicating laboratory benchtop technology on a miniature chip-scale device. In the area of drug delivery science, microfluidics offers advantages, such as accurate dosage, ideal delivery, target-precise delivery, sustainable and controlled release, several dosing, and slight side effects. These helps bring significant assets to the drug delivery systems. Microfluidic technology has been increasingly used for …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 10, Issue 1, 2020 · pp. 1–10 Read article
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SATELLITE IMAGE CLASSIFICATION USING MACHINE LEARNING
Abstract: Satellite imagery is used in for various applications such as disaster management, defence, surveys, and environmental understanding. Earlier, manual processing was applied to do analysis. These methods are not accurate to detect the target and classify the object. Hence, in this work machine learning is explored. Now a days deep learning has gain prominence to automate target detection and classification. Convolutional Neural Networks (CNN) are playing vital role in deep …
Published in Journal of Remote Sensing & GIS · Vol. 12, Issue 2, 2021 · pp. 10–18 Read article
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Solar Energy Potential Assessment and Solar Farm Suitable Site Selection: A case in Oromia Special Zone, Ethiopia
Abstract: In this century throughout the world an increased energy demand, global warming and other environmental problems have brought severe challenges. As a result, countries have taken different measures and alternatives to fulfill their energy demands friendly with the environment. Many of them targeted to generate their energy need from renewable energy sources. In this regard, the government of Ethiopia has set targets to improve the share of renewable energy in …
Published in Journal of Remote Sensing & GIS · Vol. 12, Issue 2, 2021 · pp. 19–39 Read article
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CRISPR/CAS9 Technology and its Application in Food
Abstract: Advances in the editing technology of genome or genes and also availability for the genome sequence for several crops has developed possibility for the researcher to precisely target the desired phenotype. Such therapy is possible due to CRISPR editing technology, which involves various cloning methods. After proving this concept in certain plants or crops which were used for the demonstration, thus targeting and improving the specific working of CRISPR/CAS9 technology. …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 8, Issue 2, 2021 · pp. 38–42 Read article
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Exploration and Advancement of Drugs Within the Field of Bioinformatics: A Review
Abstract: After selection, research objectives fall under the supervision of either the pharmaceutical industry or pertinent academic institutions. The initial approach involves identifying drug molecules possessing the essential qualities necessary for the synthesis of targeted medications. Drug development constitutes the subsequent phase following the discovery of a drug and unfolds as a meticulous process aimed at introducing novel pharmaceuticals to the market. This intricate journey from discovery to market availability encompasses …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 10, Issue 3, 2023 · pp. 15–21 Read article
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The Need for Regulations against Abandoned Fishing Gear
Abstract: Ghost fishing resulting from abandonment of fishing gear has remained an increasing challenge in the oceans. A significant amount of these gears is made up of plastic materials; this has caused countless problems to aquatic life resulting in mortality in most cases. One of the ongoing causes of gear abandonment is conflict. Fishing gear is frequently discarded due to the nature of the fishing grounds and other environmental factors, such …
Published in Research & Reviews : Journal of Ecology · Vol. 12, Issue 2, 2023 · pp. 43–46 Read article
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System Design for High Speed Trajectory Changing of A Solar Sail
Abstract: Solar sails were created as a new form of satellite propulsion which uses the radiation pressure of the light from the stars or a laser to push ultrathin mirrors to high speeds. The new design incorporates ablative laser propulsion for trajectory changing of the probe at a desired point in space to be maneuvered towards the desired object. The design provides a combination of sail propulsion and laser propulsion systems …
Published in Research & Reviews : Journal of Space Science & Technology · Vol. 3, Issue 2, 2014 · pp. 22–27 Read article
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A Review on Applications of Nanoparticles in Cancer Treatment
Abstract: Cancer has become the leading cause of death. It is caused by disorder in the division and growth of cells. It can be treated after the confirmation of growth of cancerous cells. Conventionally it is done by x-rays or CT scans. Then the genes are destroyed or damaged or by controlling the blood supply to other genes. Now advancements in nanotechnology have enabled the physicians to treat the cancer. In …
Published in Research & Reviews : Journal of Physics · Vol. 7, Issue 3, 2018 · pp. 31–35 Read article
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Current Prospective of NLCs in Parkinson’s Disease: An Outlook
Abstract: Parkinson's disease (PD) is 2nd most a neuro-degenerative disorder of the central nervous system affecting 7–10 million people of worldwide as the report of WHO 2014. It occurs due to the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. It is characterized by tremor, rigidity, bradykinesia, dementia, depression and falls or emerges with the progression of the disease. Ropinirole Hydrochloride is a drug of choice …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 18–29 Read article
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In Silico Designing of Triazolothiadiazine as Anticancer Agents
Abstract: Cancer is irregular growth of cells and formation of tumor. There are approximately 9.6 million death reported globally. It is caused by physical or genetic factor. There are various targets for the inhibition of growth of cancerous cells. Inhibition of colchicines binding site of tubulin is promising target in field of cancer management. In this study, we designed 25 novel thiazole and triazolothiadiazine derivatives as colchicine binding site inhibitors and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 10–20 Read article
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Drug Discovery and Development: An Overview from the Regulatory Prospective
Abstract: The improvement of medication from an underlying plan to its entrance into the market is an extreme process which can take around 5–10 years and cost $1.7 billion. The thought for another advancement can originate from an assortment of sources which incorporate the flow necessities of the market, new rising infections, good clinical research, business part, and so on. Once an objective for revelation has been picked, the pharmaceutical businesses …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 1–9 Read article
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Effect of Polyherbal Compound (Low Cost) in Management of Insulin Dependent Diabetes Mellitus
Abstract: Diabetes mellitus is chronic ailment associated with life threating target organ damage. The present approach of treatment is to maintain glycaemic level within physiological normal level with different means, which may favour angiopathic changes even with normal blood sugar. Ayurveda believes that Medas i.e. lipid metabolism is important pathological change observed in DM that ends up presentation of elevated level of peripheral blood sugar. The quest is to come with …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 31–34 Read article
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Recent Trends in Drug Repositioning for Discovery of New Anticancer Drugs
Abstract: Drug repositioning, the process of finding new uses of existing drugs, has been gaining popularity in recent years. The availability of several established clinical drug libraries and rapid advances in disease biology, genomics and bioinformatics has accelerated the pace of both activity-based and in silico drug repositioning. Drug repositioning has attracted particular attention from the communities engaged in anticancer drug discovery due to the combination of great demand for new …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 35–38 Read article
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Exploring Phytochemicals of Ficus religiosa against Corona Virus Protein using Molecular Modeling Techniques
Abstract: The current worst pandemic situation is brought about by novel Severe acute respiratory syndrome coronavirus 2 causing Covid-19 disease. The world fights against it with vaccines, self-sanitation techniques and drugs like ribavirin, beta-interferon and remdesivir which has not solved the problem to the desired extent. With technical and scientific developments in molecular biology field, though the genome and proteome of the organism is explored, potent drugs against it is still …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 2, 2023 · pp. 18–26 Read article
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A Comprehensive Study on Protein-Protein Interaction in Drug Development: Future Prospective and Challenges
Abstract: Protein-protein interactions (PPIs) play important roles in various cellular processes and have become a major area in drug development. Most of the studies which are related to Protein-protein interactions (PPIs) are correlated with different types of diseases including infectious diseases, Cancer and Neurodegenerative disorders. Therefore, targeting PPIs constitutes a therapeutic avenue for disease and an essential strategy for new drug development. In the last 10 years, PPI has been an …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 2, 2023 · pp. 25–31 Read article
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Graphene Oxide: A Potential Drug Carrier for Cancer Therapy—Review
Abstract: Graphene oxide (GO) is a single or few layer’s sheet derived from graphite using strong oxidizing agents. Graphene oxide possesses outstanding aqueous processability, amphiphilicity, functionalizability, surface enhanced area and fluorescence ability. Hydrophilicity is an important property for mixing the material with ceramic or polymer matrixes while trying to improve their electrical and mechanical properties. Acquiring a promising application in the biomedical area, graphene molecules undergo complex interactions with the biological …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 21–31 Read article
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Review: Prodrug Concept in Drug Design
Abstract: AbstractIn the world of drug discovery and development, prodrugs have become a powerful method for improving biopharmaceutical, physicochemical or pharmacokinetic properties of pharmacologically active agents. The purpose of this review is to provide some types of prodrugs which are bioreversible derivatives of drug molecules that undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then exert the desired pharmacological effect. The target of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 1, 2018 · pp. 22–28 Read article