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Research & Reviews: A Journal of Drug Design & Discovery

A Comprehensive Study on Protein-Protein Interaction in Drug Development: Future Prospective and Challenges

  1. Pankaj Malhotra
  2. Simran Rai
  3. Deepika Yadav
  4. Ankit .

Abstract

Protein-protein interactions (PPIs) play important roles in various cellular processes and have become a major area in drug development. Most of the studies which are related to Protein-protein interactions (PPIs) are correlated with different types of diseases including infectious diseases, Cancer and Neurodegenerative disorders. Therefore, targeting PPIs constitutes a therapeutic avenue for disease and an essential strategy for new drug development. In the last 10 years, PPI has been an emerging field of the study of drug intervention and it's the most difficult task for drug discovery. In recent years most PPI modulators have not only been developed but clinical trials have also been carried out on them for the investigations there potential to treat a particular disease, those that have been approved from an industrial point of view have been suggested by the experts that they have a broad future in drug discovery. In this study, we focus on summarizing recent advances in the field of PPI, including computational analysis, its types, detection methods, and the future perspectives for the design of type new drugs targeting PPIs in the future.

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