Therapeutic Effect of PEGylated Phytosomes Loaded with Herbal Drugs for Treating Paediatric Leukaemia

Sanchita Mandal; Shibangi Mukhopadhyay

doi:10.37591/nanotrends.v24i3.1395

Abstract

To treat pediatric leukemia, this study evaluated a co-encapsulated pegylated phytosome system based on herbal anti-cancer medications. In this study, herbal drug-soy lecithin complex-loaded phytosomes were prepared as drug carriers to overcome the limitations of natural drugs like poor absorption, low oral bioavailability, poor aqueous solubility, and so on. This is a targeted nano-drug delivery that enhances the absorption and bioavailability of the herbal drug used. In this study, herbal drug-soy lecithin complex-loaded phytosomes were further surface-functionalized with PEG as drug carriers to overcome these limitations and achieve reduced toxicity and a superior herbal drug-mediated therapeutic effect. PEGylation can help the phytosomes avoid rapid clearance from the systemic circulation by the reticuloendothelial system (RES) and increase their passive targeting effectiveness. To do this, a postinsertion approach was used to inject PEG into the lipid moiety of the phytosomes. The generated PEG-functionalized drug-loaded phytosomes feature spherical shapes, steady zeta potential values, very low PDI values, and sustained drug release while improving the therapeutic action of herbal drugs.