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829 articles for “disorders”
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Progeria Syndrome Unveiled: A Scientific Odyssey into Premature Aging Mechanisms and Therapeutic Frontiers
Abstract: Progeria, or Hutchinson-Gilford Progeria Syndrome (HGPS), is a rare and fatal genetic disorder in childhood, exhibiting features akin to premature aging. Despite normal appearances in infancy, affected children face accelerated aging with distinct facial characteristics, including micrognathia, dental malformations, lower body weight, early hair loss, decreased joint mobility, lipodystrophy, etc. The cause of HGPS is a point mutation that occurs at the exon 11 of the LMNA gene which normally …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 2, 2024 · pp. 52–68 Read article
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Wiskott-Aldrich Syndrome: A Comprehensive Guide
Abstract: Wiskott-Aldrich Syndrome (WAS) is an uncommon genetic disorder inherited through the X chromosome, marked by a combination of immune system deficiencies, eczema, and low platelet counts. This syndrome primarily affects males, leading to significant morbidity and mortality due to recurrent infections, bleeding complications, and autoimmune diseases. Mutations in the WAS gene disrupt the production of the Wiskott-Aldrich Syndrome protein (WASp), crucial for the functioning of immune cells and platelet formation. …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 39–46 Read article
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Refining Retinal Layer Segmentation in OCT Imaging with Advanced Techniques and Clinical Applications
Abstract: Segmenting retinal layers from Optical Coherence Tomography (OCT) pictures entails locating and separating different retinal layers to offer comprehensive anatomical and pathological information. Age-related macular degeneration, diabetic retinopathy, and glaucoma are among the retinal illnesses for which this procedure is crucial for diagnosis and follow-up. By utilizing preprocessing techniques to improve image quality and applying advanced algorithms—such as intensity-based, gradient-based, and texture-based methods—alongside deep learning approaches, clinicians can accurately measure …
Published in Trends in Opto-electro & Optical Communication · Vol. 14, Issue 2, 2024 · pp. 01–06 Read article
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Visionary Companion: Revolutionizing Email Accessibility for the Visually Impaired
Abstract: The efficiency demands of technology have surged, particularly with the rise of virtual work, necessitating extensive communication resources. Email serves as a vital means for international communication and group messaging. While those with clear vision can easily utilize typing and emailing, individuals with color blindness or visual impairments face obstacles. Fortunately, numerous resources cater to those with visual disorders. This project aims to bridge this gap by creating a voice-based …
Published in Trends in Opto-electro & Optical Communication · Vol. 14, Issue 2, 2024 · pp. 21–28 Read article
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Early Detection of Alzheimer’s Disease Using Machine Learning Techniques
Abstract: Alzheimer's Disease (AD) is a progressive neurodegenerative condition impacting a large global population. Detecting AD early is critical for timely intervention and effective management. Conventional diagnostic approaches involve cognitive assessments and neuroimaging, which are often lengthy, costly, and prone to human error. In this paper, we propose a novel approach for early detection of AD using machine learning techniques applied to multimodal data, including neuroimaging, cognitive assessments, and biomarkers. Our …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 2, 2024 · pp. 32–43 Read article
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Metabolic Reprogramming in Carcinogenesis: An Overview
Abstract: Metabolic reprogramming is a crucial mechanism via which cells modify their metabolic pathways to adjust to changes in the environment and maintain growth, survival, and function. This phenomenon is of utmost importance in a wide range of physiological and pathological situations, specifically in cancer, immunological responses, and stem cell biology. In cancer, metabolic reprogramming facilitates fast cell growth and survival, as demonstrated by the Warburg effect, where cancer cells prioritize …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
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Platelets A Tiny Cell Fragments
Abstract: Platelets are disc-shaped, anucleate cells that are approximately 2-3 μm in diameter. Their primary function is to control hemostasis, or blood clotting, but they also play important roles in angiogenesis (the formation of new blood vessels) and innate immunity (the body's first line of defence against infection). With a diameter of just 2-3 microns, platelets are tiny, disc-shaped cells that lack a nucleus. While their main responsibility is to ensure …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 22–28 Read article
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Psychotherapeutic Approaches for Enhancing Perinatal Mental Health
Abstract: Pregnancy is a life turning event in a woman's life. Many women during pregnancy and after the birth of the child face mental health issues like anxiety, depression, and stress due to varied reasons. If not addressed properly, these can affect the mother-child bond, the lady's relationship with the entire family, and the child's cognitive and emotional development. As per WHO, “Globally about 10% of pregnant women and 13% of …
Published in International Journal of Behavioral Sciences · Vol. 1, Issue 2, 2024 · pp. 26–38 Read article
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Exploring Gender Differences in Mental Health: Attitudes towards Help-Seeking and Service Utilization
Abstract: Mental health is a complex topic that requires understanding of gender disparities in the use of mental health services and the behavior of seeking assistance. Development of legislation and initiatives aiming at raising awareness and availability of mental health care depends on this knowledge. Maintaining healthy relationships, limiting disease development, managing symptoms, increasing production, and fighting cultural prejudice all depend on mental health therapies. Gender expectations, socialising, stigma, and the …
Published in International Journal of Behavioral Sciences · Vol. 1, Issue 2, 2024 · pp. 10–17 Read article
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Health Implications of Electromagnetic Wave Exposure
Abstract: From low-frequency radio waves to high-frequency gamma rays, electromagnetic waves have a wide range of effects on human health. This diverse subject includes an extensive spectrum of waves. The non-thermal effects of low-frequency waves, such as microwaves, are not completely understood despite the fact that they predominantly represent thermal dangers, which could potentially lead to tissue heating and damage similar to those caused by heating. High-frequency radiation, such as gamma …
Published in Research & Reviews : Journal of Physics · Vol. 13, Issue 1, 2024 · pp. 9–13 Read article
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A Research Study on Navigating Medication Risks Through MFRS (Medication Fall Risk Score and Evaluation Tool) and DART (Drug Associated Risk Tool) Among Patients with Polypharmacy
Abstract: Background information: The advancements in medical science continue, but the safety of medication usage is still a question mark and has become a crucial area for researchers to focus on. In the need of the above, various scoring systems and tools have been developed in pharmacy practice research. Prior to the present work, we did a systematic review and meta-analysis and identified two such tools: the medication fall risk score …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 1–13 Read article
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Specialized Education in Enhancing Life Satisfaction Among Caregivers of Children with Autism
Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that significantly impairs a person's ability to communicate, engage in social interactions, and exhibit typical behavioral patterns. Raising a child with autism presents several difficulties for couples. Specialized education can be beneficial for children with autism. The study aims to identify the role of special education and satisfaction rates among autistic caregivers. The result shows that special education causes a 37.9 …
Published in International Journal of Children · Vol. 1, Issue 2, 2024 · pp. 38–42 Read article
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Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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Tinospora Cordifolia (Willd.) Hook.f. & Thomson: A Review on Herbal Formulations and Health Benefits
Abstract: India has a vast variety of medicinal plants utilised as natural medicines since prehistoric times. Herbal medicine was the main form of treatment earlier in the 20th century because neither antibiotics nor analgesics were readily available. Nowadays, natural plant products are becoming more significant in clinical research since they have no side effects and have greater pharmacological response than allopathic medications. Tinospora cordifolia (Giloy or Guduchi) is a climbing shrub …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 14–19 Read article
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Impact of Occupational Therapy on Fine Motor Skills Development of Cerebral Palsy Children
Abstract: Background:Deficits in fine motor skills typically co-occur with cerebral palsy (CP), a neurological disorder that affects movement and posture. Occupational therapy is crucial for treating cerebral palsy in children and improving their capacity for independent living. This thorough summary identifies areas that require more research and highlights the most recent advancements in cerebral palsy. Aim: The purpose of this review is to investigate the effects of occupational therapy treatments on …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 24–30 Read article
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Understanding Programmed Cell Death
Abstract: Recent studies emphasize the critical role of various types of programmed cell death (PCD) such as apoptosis, autophagy, pyroptosis, and necroptosis, as well as their respective signaling pathways. These processes are essential for regulating cellular balance, responding to stress, and triggering immune defenses. Apoptosis, commonly known as "cellular suicide," is a tightly controlled mechanism that allows cells to die without inducing inflammation. This process is key for tissue development, immune …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 42–50 Read article
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Host Interface of Cystic Fibrosis and P. aeruginosa
Abstract: A clash between microbial infection and host immunity can contribute to multiple diseases. Cystic fibrosis is one of those diseases. It’s an autoimmune disorder and hyperinflammatory disease, caused by pseudomonas aeruginosa, it’s the most predominant pathogen causing this disease. The progression of the lung infection cystic fibrosis is driven by host pathogen interface that focuses on the host and the bacterial factors. The disease has an interplay between the host, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 9–31 Read article
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PCOD and Ayurveda: Steering the Ailment Through Lifestyle Interventions
Abstract: Ayurveda is the science of life having myriad of means to attain a long and healthy life. The individualistic and holistic approaches of Ayurveda pose better ways to a healthier living. In the age of physical, mental, and environmental stressors, it’s important to make your health a priority. While arranging for the monetary wealth, whilst disregarding the health, lands to a disarrayed state of health. Numerous diseases spring about because …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 20–25 Read article
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Effective Ayurvedic Management of Dadru Kustha with Herbo- mineral Aushadhi yoga: A Single Case Study
Abstract: The skin, as the body's largest organ, is highly prone to various disorders due to its size and exposure to external factors. The majority of skin conditions are often the result of infections, including those caused by fungi or bacteria. In Ayurveda, skin diseases are grouped under the term 'Kustha' and are further categorized into MahaKustha and KshudraKustha. Among these, Dadru is a notable condition, classified as Raktapradoshaja Vikara, with …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 3, 2024 · pp. 26–31 Read article
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Pharmacological evaluation of Hepatoprotective activity of Indian medicinal plants Cordia Myxa and Canscora diffusa on wistar albino rats
Abstract: Two plants (Cordia myxa and Canscora diffusa), which were claimed to possess hepatoprotective activity, were selected. The Selected plants were authenticated by an expert botanist. In the current study, herbal extraction involving solvents of decreasing polarity (petroleum ether, ethyl acetate, and hydroalcoholic) was used to extract bioactive compounds from the plants of Cordia Myxa and Canscora diffusa in polyherbal preparations. A phytochemical evaluation was performed, including an acute toxicity study …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 31–44 Read article