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116 articles for “variants”
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Retrieval of nouns and verbs in Persons with Aphasia
Abstract: A grammatically correct sentence is comprised of two parts, a subject (noun or pronoun) and a predicate (verb). The noun represents the names of a particular person, place or thing. The verb, on the other hand, represents actions, states, processes or relations. Nouns and verbs, differ in the linguistic dimensions, such as word frequency, imageabilty, and lexical semantic variables. These varying dimensions have been explored in individuals with Aphasia and …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 9, Issue 1, 2019 · pp. 24–28 Read article
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Unveiling Actionable Pathogenic Genes for Precision Oncology in Brain Cancers: Glioblastoma and Astrocytoma
Abstract: Glioblastoma (GBM) and astrocytoma are aggressive primary brain tumors characterized by significant molecular heterogeneity, complicating effective treatment. This study employed targeted next-generation sequencing of 529 cancer-associated genes on matched tumor-normal pairs from GBM and astrocytoma patients. Somatic variants were identified using a rigorous bioinformatic pipeline adhering to GATK Best Practices, with variant allele frequencies (VAF) calculated to assess clonal dominance. Functional annotation and driver mutation classification were performed using Ensemble …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 · pp. 43–59 Read article
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In Silico Assessment of Demethoxycurcumin: Molecular Docking and Computational Insights into its various therapeutic Potential
Abstract: Natural compounds are increasingly explored for their therapeutic potential in medical research. Here, we focused on demethoxycurcumin (DMC), a polyphenolic bioactive compound extracted from Curcuma longa, commonly found in turmeric. DMC, with a chemical formula of C20H18O5 and a molecular weight of 340 g/mol, possesses two aromatic ring systems, each featuring a β-diketone moiety connected by a seven-carbon chain. This unique structure allows DMC to engage in tautomerism, which is …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 9–15 Read article
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Improving Plastic Bottle Waste Management System of India using RVMs
Abstract: India is ranked first as the most populous country in the world, and plastic waste management has been a major ongoing concern for India. With the growing economy and population, the growth of plastic waste generation has been exponential but plastic waste management has been underachieved. The excess utilization and mishandling of single-use plastic have depreciated the performance of the plastic waste management system of India. This study emphasizes on …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 14, Issue 3, 2024 · pp. 31–41 Read article
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Targeting PTPN22 in Arthritis: Molecular Docking and Pharmacokinetic Evaluation of Artemisia vestita Compounds
Abstract: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by inflammation of the synovial membrane, commonly resulting in swelling, pain, stiffness, and overall fatigue. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been identified as a risk factor linked to various autoimmune diseases, including RA. In the PTPN22 gene, two missense Single nucleotide polymorphisms (SNPs) are associated with autoimmune conditions. The R620W (C1858T, rs247660) variant in exon 14 has been …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 20–31 Read article
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Genomic Medicine Revolutionizes Heart Care: A New Standard of Practice
Abstract: The integration of genomic and precision medicine into cardiovascular healthcare represents a transformative advancement in addressing the global burden of cardiovascular diseases (CVDs). Precision medicine leverages genomic, proteomic, and metabolomic data to provide personalized care, optimizing treatment outcomes while minimizing adverse effects. Over the past decade, extensive research has highlighted its potential to revolutionize the management of major CVDs, including myocardial infarction, hypertension, and heart failure, which significantly contribute to …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 30–37 Read article
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Randomized Latent Vectors for Enhanced Reinforcement Learning Exploration
Abstract: This paper investigates Random Latent Exploration (RLE), a novel reinforcement learning technique that enhances exploration using randomized latent vector conditioning. I evaluate RLE’s performance across various environments, including discrete control tasks (FourRoom), continuous control (IsaacLab), and complex visual domains (Atari games). The core approach augments traditional reward functions with intrinsic rewards, calculated as the dot product between state features and periodically resampled latent vectors. The policy and value networks are …
Published in Current Trends in Signal Processing · Vol. 15, Issue 3, 2025 · pp. 19–25 Read article
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Performance Evaluation of Kevlar-Sisal-S-Glass Hybrid Composites with Ceramic Fillers for Structural Applications
Abstract: This study examines the mechanical properties of hybrid composite laminates reinforced with Kevlar, sisal, and S-glass fibers, and incorporating ceramic fillers—silicon carbide (SiC) and aluminum oxide (Al2O3)—within an epoxy matrix. The hand lay-up method was utilized to produce the laminates, ensuring a uniform fiber stacking sequence and including 10% filler material. Two composite variations were synthesized: one incorporating SiC and the other Al₂O₃, and both underwent tensile, flexural, hardness, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1308–1322 Read article
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Assessing the Effectiveness of Machine Learning Algorithms in Simulating Malware Detection Processes
Abstract: On the information system comprehends, computer virus attacks play a very important role and, by undermining regionally and globally, are considered one of the most critical threats. The traditional malware detection methods, more varied, being based on signature, are incapable of providing sufficient coverage over malicious programs in a short time. This is due to the speed of evolution and growing complexity of malware variants. This situation, in turn, requires …
Published in Journal of Electronic Design Technology · Vol. 14, Issue 3, 2023 · pp. 11–20 Read article
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Turners Syndrome in a girl with an unknown marker chromosome in Karyotype: A Case Study
Abstract: Abstract Turners syndrome is an X-linked chromosomal disorder, in which nucleus possesses only 45X chromosomes i.e. 22 pair of autosomes and a sex chromosome XO. Absence of Y chromosome resembles female. There are some variants in which mosaic of X0/XX or even X0/XY are present. They have characteristic appearance like short stature, sexual infantilism, ovarian agenesis or gonadal dysgenesis, pattern of major and minor malformations. Patient comes with complaints of …
Published in Research and Reviews: A Journal of Health Professions · Vol. 10, Issue 2, 2020 · pp. 44–48 Read article
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Sentence Judgment and Correction Abilities in Persons with Anomic and Conduction Aphasia
Abstract: Persons with aphasia posses’ difficulty in syntactic judgment, regardless of the aphasia type. Even persons with milder variants with aphasia such as conduction aphasia and anomic aphasia do exhibit deficits on syntactic judgment. The syntactic judgment ability is tested through a judgment task where the participants have to speculate the response if the sentence presented to them is correct or incorrect. In order to counteract this variable, sentence correction task …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 8, Issue 2, 2018 · pp. 23–26 Read article
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The effective therapeutic strategies to fight against COVID-19 in India
Abstract: In December 2019, the global pandemic coronavirus infection (COVID-19) was first detected in Wuhan, Hubei Province, Central China. It is caused by coronavirus-2, which causes severe acute respiratory syndrome (SARS-CoV-2). This was declared by World Health Organization on 11th March 2020. In India, the first case of COVID-19 infection was reported in Kerala on January 27,2020 of a 20 yr old female presented to an Emergency Department in General Hospital, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 12, Issue 1, 2022 · pp. 43–49 Read article
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Comparison of Various Load Balancing Algorithms in Cloud Computing
Abstract: The components associated with distributed computing are customers, datacenter and appropriated server. One of the principal issuesin distributed computing isload adjusting. Adjusting the heap intends to circulate the outstanding task at hand among a few hubs uniformly so no single hub will be over- burden. Burden can be of any kind that is it very well may be CPU load, memory limit or system load. Right now, introduced a design …
Published in Recent Trends in Parallel Computing Read article
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Formulation Development and In Vitro Evaluations of Trimetazidine and Clopidogrel Bilayered Tablets
Abstract: The Bilayered tablets consisting of Trimetazidine SR as well as Clopidogrel IR were efficiently prepared by damp granulation technique as well as straight compression approach specifically. The prepared powdered mix (SR) were also preserved the physiochemical residential or commercial properties of tablet computers such as thickness, firmness, weight variant, friability and drug material. The enhanced formula consists of the average thickness of 3.1 ± 0.034, average firmness of 4.2 ± …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 3, 2023 · pp. 29–40 Read article
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Human Age and Gender Determination Using Fingerprints
Abstract: We present a review of technologies to determine human age and gender using fingerprints. Broadly two methodologies are reviewed i.e. Ridge based human age and gender determination and Image based human age and gender determination. Ridge based techniques uses ridge information with its variant statistics measures for classification of a human fingerprint into different classes of age groups and male/female distinction. These methods do not involve separate classifiers for classification …
Published in Journal of Advancements in Robotics Read article
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Multiple Sclerosis: A Systematic Review of a Neurological Disorder
Abstract: The inflammatory illness known as multiple sclerosis (MS) is brought on by outside influences that affect a biologically vulnerable host. It has 3 separate diagnostic phases: the pre-clinical phase, which can only be discovered by MRI; the relapsing-remitting (RRMS) phase, which again is defined by bouts of neurological malfunction accompanied by remission; and the progressing phase, which often develops from either the relapse phase. Unfortunately, the majority of relapse MS …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 53–71 Read article
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From Ancient DNA to Modern Livestock: Paleogenomics
Abstract: Paleogenomics, an interdisciplinary blend of paleontology and genomics, has revolutionized our understanding of ancient DNA and its applications across various fields. In Animal Genetics and Breeding, this field has emerged as a pivotal tool providing invaluable insights into the historical genetics of domesticated animals. By reconstructing and analyzing the genomes of long-extinct organisms, paleogenomics sheds light on genetic diversity, evolutionary dynamics, and adaptations of ancient species. Paleogenomics significantly impacts animal …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 1–6 Read article
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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Advancements in Energy-Efficient Electrical Motor Design: A Comprehensive Review
Abstract: The rapid growth in energy demand poses a fundamental challenge for the whole power industry in fulfilling the increased demand. An exhaustive energy audit recommends substituting energy-efficient gadgets with conventional ones, which function with low efficiency and waste a significant amount of electricity. Electric motors are quite common in contemporary life, providing energy to a wide range of devices, including both domestic and industrial machinery. Nevertheless, they bear the responsibility …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 1, Issue 1, 2023 · pp. 29–35 Read article
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Revolutionizing Geopolymer Composites: Unveiling Intelligent Wall Facades and Precision PZT Sensors for Vibration Analysis
Abstract: Evaluating the mechanical performance and environmental benefits of geopolymer composites is imperative for sustainable alternatives in construction. This study presents an innovative circular PZT-based sensor that effectively captures transient vibrations within concrete structures, demonstrating its validity in comparison to standard surface-mounted accelerometers. The research also elucidates the influence of sensor orientation on capturing various vibrational modes of concrete. Furthermore, the embedded PZT sensors provide valuable insights into the evolving mechanical …
Published in Journal of Polymer & Composites · Vol. 11, Issue 13, 2023 · pp. 59–73 Read article