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32 articles for “entrapment efficiency”
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Development and Characterization of Mucoadhesive Microspheres Containing a Model Antidiabetic Drug
Abstract: The present work was envisaged to reduce the dosing frequency and improve patient compliance by designing and evaluating sustained release mucoadhesive (SRM) microspheres of metformin hydrochloride (MH) for an effective control of diabetes type-2. Microspheres were prepared by emulsification solvent evaporation method using sodium alginate, carbopol 934P (CP), and sodium carboxy methyl cellulose (SCMC) as a mucoadhesive polymers. The microspheres exhibits good mucoadhesive properties and showed high drug entrapment efficiency. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 2, 2015 · pp. 12–19 Read article
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Design and Evaluation Cefaclor Microspheres for Bioavailability Enhancement
Abstract: This study attempted to formulate microspheres for oral administration of Cefaclor by using different polymers like Hydroxypropyl methylcellulose (HPMC) K4M, (HPMC) K15M and Ethylcellulose (EC) which increases the gastric residence time and thereby the bioavailability. Solvent evaporation method was found to be the best due to its ease of fabrication without compromising the activity of the drug. Cefaclor is a second-generation cephalosporin antibiotic used to treat certain ear, lung, skin, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 3, 2019 · pp. 39–48 Read article
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Improved Intestinal Absorption and Bioavailability Enhancement of Rosuvastatin Calcium via Proliposome Powder
Abstract: The main objective of the present study was to develop proliposomal formulations to enhance the oral bioavailability of rosuvastatin calcium by improving solubility, dissolution and/or intestinal permeability. Proliposomal powder formulations were prepared with drug varying the Phospholipon 90H and cholesterol ratio in the range of 1:0 to 1:1 using pearlitol SD200 as carrier by film deposition method. The prepared proliposomal powder was filled into capsules. The bioavailability enhancement of proliposomes …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 7, Issue 3, 2020 · pp. 23–40 Read article
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Current Trends about Transfersomes: Formulations, Applications and Pharmacological Interventions.
Abstract: Transfersomes are one of the novel targeted drug delivery system which includes hydrophilic molecules. Transfersomes are a type of liposomes which consists of phosphodidylcholine and an edge activator. The elastic characteristics of Transfersomes enabling it to bend and penetrate through tiny holes that is much smaller than their own size. Transfersomes has various advantages like good solubility, greater bioavailability, and better penetration through the stratum cornea through intracellular route or …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 13, Issue 1, 2023 · pp. 10–26 Read article
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Design Approach based Formulation of Deformable Liposomes and their In vitro Skin Permeation
Abstract: Leukemia is the common cause of disease and its worldwide incidence is increasing. Cytarabine pyrimidine nucleoside analogs most widely used for the treatment of leukemia, but the major obstacles to existing treatments are adverse effect and poor patient’s compliances. To provide sustained drug release with minimum side effects and to develop more patients affable formulation, the authors investigated the transdermal delivery of cytarabine through deformable liposomes. The present work demonstrated …
Published in Trends in Drug Delivery · Vol. 4, Issue 3, 2017 · pp. 14–25 Read article
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Formulation Development, Characterization and in-vitro Evaluation of Nano-Lipid Carriers of Ropinirole HCl for Persistent Parkinsonian Management
Abstract: According to a report of World Health Organization (WHO) 2014, Parkinson's Disease (PD) is the second-most neurodegenerative dysfunction of the central nervous system (CNS) of human being effecting 7–10 million people worldwide. It is primarily due to the death of dopamine-generating cells in the substantia-nigra of midbrain. It is symptomatized by tremor, rigidity, bradykinesia, dementia, depression and falls or emerges with the progression of the disease. Ropinirole HCl is a …
Published in Trends in Drug Delivery · Vol. 6, Issue 1, 2019 · pp. 14–23 Read article
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A Novel Liquid Crystal Drug Delivery for Transdermal Application
Abstract: The present study was aimed at the formulation of liquid crystals of acyclovir that will be incorporated into a transdermal patch. Liquid crystals serve as drug carrier and have a good penetration-enhancer property, due to the extensive similarity of these colloidal systems with the intercellular lipids in the stratum corneum. The liquid crystals were prepared using tween 80 as emulsifier, cetosteryl alcohol as emulsion stabilizer and double-distilled water. Liquid crystals …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 28–37 Read article
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Design and Evaluation of Itraconazole Niosomes
Abstract: The present study was undertaken with an aim to fabricate and characterize and evaluate niosomes of Itraconazole, where the drug is released in a sustained manner for a period of 12 hours. Itraconazole is Class-2 drug having low solubility and have short half-life between 3–4 hours. Due to high first pass metabolism, the drug is rapidly excreted from the body indicating the need of sustained release delivery. To overcome these …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 62–68 Read article
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Evaluation of Oil-Sorption Properties of Kapok Fiber for Cooking Oils: A Potential Check for Oil-ridden Wastewater from Restaurants
Abstract: Abstract Sewage is one of the leading sources of water pollution. The untreated water released from restaurants is the major contributor of oil pollution having devastating impact on aquatic life. Oil in water clogs pipelines, pumps and treatment equipments, decreases the efficiency of the plant and also results in high maintenance and operation costs. The natural material, kapok fibers have the capability to significantly separate oil from water by entrapping …
Published in Journal of Water Pollution & Purification Research · Vol. 3, Issue 3, 2016 · pp. 15–22 Read article
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A New Computational Method for Dust and Gas Dynamics in Protoplanetary Discs
Abstract: The simultaneous evolution of dust and gas in protoplanetary discs regulates essential events in planet formation, such as dust accumulation, migration, and the initiation of gravitational instabilities. Nevertheless, precisely modelling this interaction continues to provide a significant computing problem owing to the extensive variety of spatial and temporal scales involved. In this study, we introduce an innovative computational framework for simulating dust-gas dynamics in protoplanetary discs, integrating a two-fluid hydrodynamical …
Published in International Journal of Universe · Vol. 1, Issue 2, 2025 · pp. 35–46 Read article
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Development of a Natural Fiber Sand–Carbon Composite Filter Using Agave sisalana for Sustainable Domestic Sewage Treatment
Abstract: This study presents an innovative approach to decentralized domestic sewage treatment by integrating Agave sisalana fibers as the core functional component within a composite filtration system. The filtration column was constructed using a vertical 1:3:1 layered configuration comprising silica sand (top), Agave sisalana fibers (middle), and activated carbon (bottom). Comprehensive experimental analyses were conducted to evaluate the system’s efficacy in removing key water quality parameters, including turbidity, total solids (TS), …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 43–51 Read article
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Enzymatic Transesterification using Immobilized Lipase in Production of Biodiesel from Nannochloropsis Oculata
Abstract: The microalgae have higher photosynthetic efficiency, higher biomass production and faster growth compared to other energy crops. The growth of Nannochloropsis oculata was enhanced in 300mg/l of nitrogen concentration and the optimum temperature for growth is 25â—¦C. 38% of microalgal oil was extracted and then converted to biodiesel by enzymatic transesterification using an immobilized lipase (triacyl glycerol acylhydrolase, EC 3.1.1.3). In this study, expensive to produce biodiesel because of the …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 1, Issue 1, 2011 · pp. 1–7 Read article