Search
73 articles for “clinical translation”
-
Nanoparticle and Lipid-Based Vaccine Delivery Systems: A Systematic Review of Platforms, Stability, Pharmacokinetics, and Immune Modulation
Abstract: The rapid evolution of vaccine technologies over the past decade has highlighted the transformative role of nanoparticle (NP) and lipid-based delivery systems in modern immunization practices. These platforms – including polymeric nanoparticles, lipid nanoparticles (LNPs), liposomes, nanoemulsions, and solid lipid nanoparticles (SLNs) – enable enhanced antigen stability, improved cellular uptake, targeted antigen delivery, and potent immune activation. This systematic review critically examines the physicochemical foundations, manufacturing approaches, stability challenges, pharmacokinetic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 18–36 Read article
-
Biopolymer Hydrogels: Patent Insights and Emerging Technological Trends
Abstract: Hydrogel biopolymers have become a valuable resource for next-generation functional materials due to their inherent properties, including compatibility with biological systems, environmental degradability, and minimal toxicity. Intelligent gels that respond to changes in temperature, pH, or ionic strength have various applications across industries like pharmaceuticals, biomedical engineering, and the food sector. This review systematically compiles findings from patent disclosures and non-patent literature to highlight recent trends in biopolymer-based hydrogel research, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 916–924 Read article
-
Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
-
Recent Advancements in Nanobiocomposite-Based Wound Healing and Tissue Regeneration
Abstract: Haemostasis, inflammation, proliferation, remodeling, and other highly coordinated cellular and molecular activities are all part of the complex biological processes of wound healing and tissue regeneration. Following an injury, these stages cooperate to restore tissue integrity and function. However, this normal process is disturbed in many clinical circumstances, especially chronic wounds such diabetic ulcers, burns, and pressure sores. Prolonged inflammation, chronic microbial infection, diminished angiogenesis, and impaired extracellular matrix production …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 297–318 Read article
-
Machine Learning in Nuclear Medical Applications: A Review of Research Frontiers
Abstract: Nuclear medicine, encompassing PET, SPECT, and targeted radionuclide therapy, generates high-dimensional, quantitative data uniquely suited for machine learning (ML) analysis. This review synthesizes current research applications of ML across six key domains. Positron emission tomography (PET), single-photon emission computed tomography (SPECT), and targeted radionuclide therapy are examples of nuclear medicine modalities that generate high- dimensional, quantitative datasets that are particularly well-suited for machine learning (ML)-driven analysis. These imaging methods provide …
Published in Journal of Nuclear Engineering & Technology · Vol. 16, Issue 1, 2026 · pp. 19–24 Read article
-
Extracellular Vesicle-Based Liquid Biopsies: Decoding the Tumor Microenvironment for Precision Oncology
Abstract: The tumor microenvironment (TME) plays a pivotal role in cancer initiation, progression, and therapeutic response. Decoding the TME is, therefore, essential for advancing precision oncology. Extracellular vesicles (EVs), including exosomes and microvesicles, are nanoscale lipid bilayer particles secreted by tumor and stromal cells. They transport a wide range of bioactive molecules, such as DNA, RNA, proteins, lipids, and metabolites, which reflect the dynamic state of the TME. Recent advances in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 43–62 Read article
-
Nano‑Enabled CT for Cancer Imaging: From Molecular Targeting to Image‑Guided Therapy
Abstract: Nano‑enabled computed tomography (CT) exploits high‑atomic‑number (high‑Z) nanomaterials engineered with targeting ligands and therapeutic payloads to enhance contrast, enable molecular imaging, and support image‑guided interventions in oncology. Tumor‑specific nanoprobes such as RGD‑modified gold nanorods, polymer‑coated bismuth nanoparticles, and peptide, antibody, or aptamer‑functionalized platforms can intensify tumor conspicuity, allow early lesion detection and staging, and provide real‑time treatment monitoring. Integration of CT visibility with photothermal, photodynamic, chemo‑, radio‑, and immunotherapeutic functions …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 1, 2025 · pp. 40–49 Read article
-
Early Autism Diagnosis: Machine Learning Models and Their Effectiveness
Abstract: Diagnosis is of utmost importance for timely intervention and support. However, traditional diagnosis methods, which are based on subjective assessment, are delayed. This project explores the role that machine learning techniques might play in enhancing the accuracy and effectiveness of ASD detection. Several state-of-the-art classification algorithms were benchmarked using a dataset from Kaggle. Logistic Regression, XG Boost, Random Forest, Decision Tree, and Gradient Boosting were taken into consideration. Other performance …
Published in Journal of Instrumentation Technology & Innovations · Vol. 14, Issue 2, 2024 Read article
-
Revolutionizing Artificial Organs: Next-Generation Membrane Technologies for Precision Medicine and Global Health
Abstract: Membrane technology has emerged as a cornerstone in the advancement of artificial organ systems, offering critical functionalities in selective molecular filtration, tissue scaffolding, and controlled therapeutic delivery. Recent innovations have propelled the field beyond traditional polymeric membranes to include nanostructured, biomimetic, and stimuli-responsive materials, significantly enhancing biocompatibility, selectivity, and durability. The integration of smart technologies, such as AI-driven membrane design, bioelectronic sensors, and personalized fabrication via 3D printing, is ushering …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 29–39 Read article
-
Epigenetic Modifications in Health, Disease, and Precision Therapeutics (From Genome to Epigenome)
Abstract: Introduction: Epigenetic alterations play a crucial role in regulating gene expression in both normal physiological and disease states. These reversible modifications—such as DNA methylation, histone acetylation, phosphorylation, ubiquitination, and chromatin remodelling—are increasingly implicated in complex diseases including cancer and neurodegenerative disorders. Despite advances in standard therapeutic approaches, patient responses remain variable, largely due to genetic heterogeneity and epigenetic dysregulation. This highlights the need for incorporating epigenetic understanding into personalized medicine. …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 Read article
-
Formulation Challenges in Long-acting Injectable Small Molecules: Emerging Strategies and Perspectives
Abstract: Long-acting injectable (LAI) formulations represent a transformative approach in pharmacotherapy, particularly for conditions demanding sustained drug exposure over weeks to months. Although biologics have dominated this space historically, the adaptation of LAI technology to small molecules presents a distinct and complex set of challenges rooted in physicochemical properties, manufacturing scalability, and regulatory expectations. This review systematically addresses the principal formulation barriers encountered in developing LAI small-molecule products, including aqueous solubility …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
-
STRUCTURAL–EPIGENOMIC ATLAS: CNV/SV- DRIVEN PROGNOSTIC REFINEMENT ACROSS CANCERS
Abstract: Structural genomic alterations, including copy number variations (CNVs) and structural variants (SVs), play a central role in cancer initiation and progression. These alterations extend beyond gene dosage effects and interact dynamically with epigenomic mechanisms such as DNA methylation, histone modifications, and three-dimensional chromatin organization. Recent pan-cancer studies have demonstrated that CNV burden and SV signatures reflect key oncogenic processes including chromothripsis, homologous recombination deficiency, enhancer hijacking, and extrachromosomal DNA (ecDNA) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
-
Comparative Proteomics: From Cell Lines to Clinical Samples
Abstract: Comparative proteomics is a powerful tool for understanding the molecular differences between various biological samples. It entails identifying and measuring proteins in complex biological samples to assess their abundance, modifications, and interactions under various conditions. This approach plays a crucial role in advancing biomedical research, especially in disease understanding, biomarker discovery, and therapeutic development. While cell lines are widely used for proteomic studies due to their controlled environments and reproducibility, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 30–34 Read article
-
Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article
-
Understanding Leukemogenesis: Challenges and Advancements in Diagnostic Approaches
Abstract: Leukaemia development, or leukemogenesis, is a multifactorial process driven by a complex interplay of environmental, genetic, and epigenetic factors. Despite substantial advancements in technology and medicine, which have enhanced our understanding of the contributing factors, early and accurate diagnosis remains a major challenge due to the overlapping clinical features shared by the various leukaemia subtypes. This study explores the molecular and cellular mechanisms underlying leukemogenesis, while also addressing the difficulties …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 1, 2025 · pp. 11–22 Read article
-
Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
-
Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: Pathogens have evolved a wide repertoire of virulence strategies that allow them to invade host tissues, establish infection, and circumvent immune responses. From the initial steps of adhesion and colonization to complex molecular mimicry, antigenic variation, and immunomodulation, pathogens display remarkable adaptability. While traditional research has emphasized host cell entry and toxin production, emerging evidence highlights subtler and more dynamic strategies such as manipulation of host signaling pathways, subversion of …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
-
Physicochemical Transitions and Polymerization Dynamics in Multi-Generational Dentin Adhesives: A Critical Review of the Resin-Dentin Composite Interface
Abstract: Adhesive dentistry has undergone a transformative refinement over the past three decades, transitioning from technique-sensitive, multi-step etch-and-rinse protocols to streamlined universal formulations. This narrative review critically synthesizes evidence from thirty peer-reviewed investigations to evaluate the evolution of dentin bonding agents from the fourth through the eighth generations. The analysis places particular emphasis on the physicochemical dynamics of the resin-dentin interface, including interfacial bond strength metrics, marginal integrity, and microleakage behavior. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 209–228 Read article
-
A Study of Clinical Education Practice of Clinical Instructors Accompanying Nursing Students of Kashmir Division, Deployed for Clinical Posting in SKIMS Soura
Abstract: Introduction: Clinical education also called clinical teaching, is one of the practical based approaches whereby the students are exposed to natural and practical settings. Clinical education refers to the process of educating and training healthcare professionals, such as medical students, nurses, or other allied health professionals, in a real-world clinical setting. This form of teaching is crucial for translating theoretical knowledge into practical skills and fostering the development of clinical …
Published in Journal of Nursing Science & Practice · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
-
The Role of Natural Products in Antiviral Drug Discovery: Insights into Mechanisms and Therapeutic Potential
Abstract: Drug discovery has always relied heavily on natural sources, especially when it comes to creating antiviral medications. This review explores the therapeutic potential of various natural products, including plant extracts, marine compounds, and microbial metabolites, in the fight against viral infections. We examine the mechanisms of action by which these natural compounds exert their antiviral effects, including direct inhibition of viral replication, modulation of host immune responses, and interference with …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 36–47 Read article