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41 articles for “clinical manifestations”
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Unani Concepts of Brain Pathology: Humoral Mechanisms in Māddī Neurological Disorders
Abstract: Background The Unani System of Medicine (USM) considers the brain (Dimāgh) as the principal organ of Quwā Nafsāniyya (psychic faculties), responsible for sensation, cognition, memory, movement, and emotional regulation. According to Unani principles, health is maintained through equilibrium of Mizāj (temperament) and Akhlāṭ (humours), whereas disease develops when this balance is disturbed. Among neurological disorders, Sū’-i-Mizāj Māddī Dimāgh refers to pathological conditions of the brain associated with the accumulation of …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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Managing Chronic Diseases: Diabetes Mellitus
Abstract: Diabetes mellitus is one of the most prevalent chronic non-communicable diseases worldwide and represents a major public health challenge due to its long-term complications, increasing prevalence, and economic burden on individuals and healthcare systems. It is distinguished by chronic hyperglycemia brought on by deficiencies in either insulin action or secretion, or both. Diabetes causes increasing harm to several organ systems, including the kidneys, eyes, neurological system, and cardiovascular system, if …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 Read article
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What Does Location of Abdominal Pain Say, Anatomically and Homoeopathically
Abstract: Background and justification for the study: Every symptom is an indication of bodily derangements which a patient feels when sick. The medical personal has to recognize these derangements only by symptomatic study of the disease without making any hypothetical theories. Therefore, examining symptoms is the sole correct method for determining the presentation of a disease. In Homoeopathy, a complete symptom is that which covers location, sensation, modalities and concomitant symptoms. …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 1, 2024 · pp. 14–19 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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A Review on Applications of Artificial Intelligence (AI) in Parkinsons’s Disease Diagnosis and Treatment and Its Future Challenges
Abstract: Parkinson’s disease (PD) is a long-term, progressive neurodegenerative disorder that mainly occurs in people older than 60 years, affecting nearly 1% of this population. It is chiefly marked by the loss of dopaminergic neurons in the substantia nigra, a crucial brain region responsible for controlling motor functions. The resultant dopamine deficiency significantly disrupts motor control, manifesting in clinical symptoms such as tremors, bradykinesia, muscle rigidity, and postural instability. While PD …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 1–15 Read article
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Demodex spp. (Acari: Demodicidae) Infestation in Humans: Diagnostic Clues and Therapeutic Approaches to Primary and Secondary Demodicosis.
Abstract: Demodicosis represents an inflammatory dermatosis and adnexal disorder arising from pathologic overgrowth of Demodex mites, primarily Demodex folliculorum and Demodex brevis, which are ubiquitous human ectoparasites residing in pilosebaceous units and eyelid margins. Once regarded as benign commensals, these mites are now recognized as primary drivers or key cofactors in diverse clinical phenotypes, including papulopustular eruptions, pityriasis folliculorum, rosacea-like disorders, blepharitis, meibomian gland dysfunction, and exacerbations of comorbid dermatoses such …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 12–20 Read article
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An Overview of Fanconi Anemia: A Genetic Disorder
Abstract: Fanconi Anemia (FA) is a rare genetic disorder caused by DNA repair defects due to pathogenic variants in one of 21 genes. It is the primary cause of inherited bone marrow failure, marked by pancytopenia. Clinically, Fanconi Anemia (FA) is associated with congenital malformations in multiple systems, resulting in progressive bone marrow failure and heightened cancer risk, especially in the urogenital region and the head and neck. There are approximately …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 19–25 Read article
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The Prognostic Efficacy of Inflammatory Indicators in Determining the Cause of Multiple Sclerosis Exacerbation
Abstract: Multiple sclerosis (MS) is the most prevalent immune-mediated inflammatory disease affecting the central nervous system, presenting with diverse clinical symptoms and manifestations. This study investigates the diagnostic potential of the monocyte-to-lymphocyte ratio (MLR), red cell distribution width-to-lymphocyte ratio (RLR), and systemic immune-inflammation index (SII) in detecting MS attacks among relapsing-remitting MS (RRMS) patients seeking care in the emergency department (ED). The research focused on RRMS patients who presented to the …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 1, 2025 · pp. 1–8 Read article
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Unresolved and misdiagnosed of floating sensation in young man
Abstract: Persistent Postural-Perceptual Dizziness (PPPD) stands out as a prevalent peripheral vestibular disorder, earning its recognition in the International Classification of Vestibular Disorders in 2017. Characterized by chronicity, this condition manifests symptoms persisting for more than three months, encompassing a disconcerting array such as a floating sensation, unsteadiness, and dizziness. Notably, individuals afflicted with PPPD often report symptom exacerbation following prolonged standing, self-initiated motion, or exposure to dynamic visual stimuli. This …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 1–4 Read article
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Comparative Analysis of the Structural Integrity and Dimensional Stability of Additively Manufactured Biopolymers vs. Thermoformed PETG: A 1-Year Retrospective Study on Polymer Performance in Orthodontic Applications
Abstract: Objective: This study aimed to evaluate the long-term dimensional accuracy and structural performance of direct 3D-printed biopolymers compared to conventional vacuum-formed Polyethylene Terephthalate Glycol (PETG) composites. The investigation focused on how different polymer processing methods (additive manufacturing vs. thermoforming) influence material thinning and resistance to occlusal stress. Methods: A retrospective analysis was conducted on 60 cases (n = 60) of post-orthodontic maintenance. The sample was divided into two cohorts: Group …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 140–146 Read article
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Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in Philadelphia Chromosome-Positive Leukemias: An Overview of Mechanisms, Clinical Implications, and Management Strategies
Abstract: Tyrosine kinase inhibitors have greatly enhanced the outlook for individuals diagnosed with Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia and acute lymphoblastic leukemia. However, these therapeutic agents are associated with Cardiotoxicities and can manifest as left ventricular dysfunction, which may progress to heart failure, along with electrocardiographic abnormalities, dysrhythmias, hypertension, myocardial ischemia, and thromboembolic events. The unclear frequency of drug-induced cardiovascular complications, coupled with uncertainties regarding their reversibility and long-term …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 18–24 Read article
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Global Burden of Major Depressive Disorder: Prevalence, Diagnosis, and Impact: A Comprehensive review
Abstract: In this review, we will discuss about the major depressive disorders on the basis of neurobiological changes. MDD, a prevalent psychiatric condition, manifests as a complex interplay of genetic, environmental, and physiological factors with a substantial impact on individuals and societies globally. Here the clinical assessment is fully based on diagnosis and the statistical manual for mental disorder, 5th edition (DSM-5). The pathophysiology involves Diagnosis alterations in neurotransmitter systems, dysregulation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 54–62 Read article
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Unveiling the Synergy: Sciatica, Arthritis, and Their Integrated Approach to Wellness
Abstract: This comprehensive review delves into the intricate connection between sciatica and arthritis, unraveling the etymological roots of “sciatica” from its ancient Greek and Latin origins. Tracing the historical aspects of sciatica back to the teachings of Hippocrates, the fifth-century BC Hellenic physician, sets the stage for a contemporary exploration of the interplay between these conditions. The sciatic nerve, including nerve roots spanning from L4 to S3, stands out as the …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 22–31 Read article
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The Integration of Artificial Intelligence in Ophthalmology: Augmenting Clinical Decision or Clinical Dependency?
Abstract: The diagnostic accuracy of artificial intelligence (AI) algorithms for glaucoma and diabetic retinopathy screening is on par with or higher than that of skilled doctors. Their acceptance has accelerated due to regulatory clearances, practical implementation in telehealth networks, and growing proof of cost-effectiveness. However, this very success raises a question that the field has been reluctant to address: are we unintentionally undermining the clinical reasoning abilities of the upcoming generation …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 1, 2026 · pp. 31–34 Read article
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A Study to Assess the Awareness of the Breast Cancer Screening Among Teacher Training Students in Selected Teacher Training Institutions at Mysuru with the View to Conduct Educational Program
Abstract: Background: Cancer is one of the major causes of death both in developed and developing countries. Breast cancer is defined by the uncontrollable proliferation of cells within the breast, encompassing different forms of cancer that impact the breast tissue. The majority of breast cancer cases manifest as painless lumps, while a smaller percentage may exhibit additional symptoms. Breast cancer is amenable to almost complete care if detected in its early …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 17–31 Read article
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Ilaj bil-Ma’ (Hydrotherapy) as a Regimenal Modality in Pain Management: Conceptual Foundations in Unani Medicine and Modern Correlation
Abstract: Waja‘ (pain) is one of the most common clinical complaints encountered worldwide and remains a leading cause of disability, impaired functional capacity, and diminished quality of life. In the Unani system of medicine, pain is not considered merely a symptom but a significant manifestation of disturbed physiological balance. Classical Unani scholars describe pain as arising from derangement in Mizāj (temperament), imbalance of Akhlāṭ (humours), Sudad (obstruction within bodily channels), Waram …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 · pp. 12–19 Read article
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Stiff Person Syndrome: Advances in Understanding, Diagnosis, and Treatment of a Rare Autoimmune Disorder
Abstract: Stiff Person Syndrome (SPS) is a rare and complex autoimmune neurological disorder characterized by progressive muscle stiffness, rigidity, and painful spasms. This chapter provides a comprehensive overview of SPS, exploring its pathophysiology, clinical presentation, diagnostic challenges, and current treatment approaches. We discuss the latest research findings, including the role of autoantibodies, genetic factors, and environmental triggers in the development of SPS. The chapter examines various diagnostic methods, emphasizing the importance …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 35–43 Read article
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Unraveling Ulcerogenesis: A Comprehensive Delve of Enteric & Nonenteric Ulcers
Abstract: Enteric ulcers present a multifaceted landscape encompassing both peptic and non-peptic varieties, demanding a thorough exploration of their manifestations, causes, and pathophysiology. At the forefront of understanding lie pivotal factors such as Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs usage, lifestyle choices, and stress, each wielding significant influence over ulcer development and progression. The intricate interplay of these factors underscores the complexity of enteric ulcer etiology. Helicobacter pylori infection—a prevalent culprit—inflicts …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 1, 2024 · pp. 25–40 Read article
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Dental and Oral Health Challenges in Patients with Eating Disorders: An Updated Review
Abstract: Eating disorders are complicated psychiatric disorders with profound systemic and oral health implications that are often not identified in clinical practice. Dietary restriction, binge eating, and self-induced vomiting are disorders eating behavior that negatively impact the oral cavity via nutritional deficiency, exposure to acid, malfunction of salivary activities, and changes in immune and microbial. These processes lead to a wide spectrum of oral and dental effects such as dental erosion, …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 1, 2026 · pp. 25–34 Read article
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An Integrative Review of Male Sexual Disorders and the Therapeutic Role of Unani Aphrodisiacs
Abstract: Sexual health is a vital component of overall well-being, encompassing physical, emotional, and psychosocial dimensions. Male sexual dysfunction – including conditions, like erectile dysfunction, premature ejaculation, and low libido – can significantly impact quality of life and intimate relationships. Aphrodisiacs, derived from the Greek goddess Aphrodite, are substances that stimulate sexual desire and performance. Historically, natural aphrodisiacs have been used in various cultures and include plant-based substances such as Yohimbine, …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 3, 2025 · pp. 8–15 Read article