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47 articles for “albino rats”
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Phytochemical Screening and Nephroprotective Activity of Citrus maximus
Abstract: Several plants with medicinal properties are used to treat diseases. Many people rely on traditional medicines, chiefly plant-based, for their major health care needs. The wide biological and medicinal properties, higher safety margins and affordability, make plant based medicines attractive for use in developing countries for primary health care. Citrus maxima belong to the family of Rutaceae; the phytochemical screening showed the presence of alkaloids, terpenoids, sterols, flavonoids and carbohydrates. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 3, 2019 · pp. 46–56 Read article
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Endosulfan-Induced Hepatotoxicity and its Amelioration by Administration of Bamboo (Dendrocalamus Strictus) Seed Extract in Rats
Abstract: Endosulfan is an important hepatotoxic agent that generates free oxygen radicals in liver and the incidence of toxic injury to the liver tissue in relation to its widespread has been reported. Bamboo is rich in phenolic components which possess various bioactivities and bamboo seed extract was found to have antioxidative properties. Hence, the present study has been designed to assess the protective role of bamboo seed extract against endosulfan induced …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 1, 2014 · pp. 1–7 Read article
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The Effect of Vitamin A Dose For Different Periods On The Spleen of White Rats: A Histological Study
Abstract: There are many detrimental effects of hypervitaminosis (A) on immune system function, growth, and reproduction. The main objective of the study was to evaluate the histological changes in the spleen of white rats given an excessive amount of vitamin A. The study was conducted from October 21, 2022, to December 12, 2022, at the College of Education's Animal House. (40) adult male albino rats, weighting between 200 and 220 grams …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 2, 2025 Read article
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Anti-hyperglycaemic Effect of Psidium guajava Extracts in Diabetes Mellitus: Systematic Review and Meta-analysis
Abstract: Introduction: Psidium guajava belonging to family Myrtaceae is traditionally used plant for the treatment of diabetes in many countries of the world. This systematic review was designed to determine level of evidence of on the anti-hyperglycaemic effect of Psidium guajava extracts from experimental trials. Methods: An electronic literature search from the database inception was performed since December 2014 with specified terms and defined outcome. We included only experimental study designs …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 1, 2019 · pp. 26–33 Read article
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Phytochemical Screening and Anticonvulsant Activity of Sebastiania chamaelae
Abstract: Epilepsy is one of the most common serious neurological conditions. Here, phytochemical screening and anticonvulsant activity of Sebastiania chamaelea evaluated. The present study was undertaken to screen anticonvulsant activity of Sebestiana chamelea. The drug was administered in the form of hydro-alcoholic extract orally and the effect was noted at two doses. The drug was found quite safe by the oral route as animals tolerated drug up to the dose of …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 6, Issue 3, 2019 · pp. 23–28 Read article
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Effects of Sub Chronic Dermal Exposure of Gasoline Blended with Varying Concentration of Benzene on Hepatic Mixed Function Oxidases in Rats
Abstract: Interaction of chemicals in a mixture, their biotransformation and adverse impact, if any, on environment and workroom atmosphere needs to be evaluated to identify the nature of potential toxic effects elicited by constituent chemical(s) in a mixture. The nature of chemical interaction(s) through which an individual chemical in a mixture undergoes metabolism and/or biotransformation in the target tissue could be helpful in evaluation of its toxic potential. Gasoline is a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 1, 2013 · pp. 1–5 Read article
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Antidiabetic Potential of Bryophyllum pinnatum: A Study on its Pharmacological Effects and Synergistic Action with Glibenclamide
Abstract: Diabetes is a long-term metabolic disorder that profoundly impacts an individual’s overall health, social interactions, and quality of life. While significant progress has been made in diabetes management with the use of medications such as insulin and oral hypoglycemic agents, the limitations of these existing treatments highlight the need for new therapeutic alternatives. Moreover, the high cost of current diabetes medications makes them inaccessible to many, particularly in rural areas …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 18–30 Read article
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Toxicological and Pharmacological Effect of Khadirarista in Animal Model
Abstract: AbstractThe objective of this study is to investigate the toxicological and pharmacological aspects of the popular Ayurvedic preparation Khadirarista (KDR). Khadirarista was administered orally to male albino rat. After 46 days of treatment period, animals were fasted for 18 h after the last administration. Biochemical studies including; total protein, serum albumin, blood urea nitrogen, bilirubin, creatinine, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were conducted. Triglyceride and creatinine levels were …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 2, Issue 2, 2013 · pp. 61–67 Read article
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Production, Characterization and Toxicological Evaluation of Eco-Friendly Flavolipid Biosurfactant
Abstract: At present majority of surfactants are chemically synthesized. Nevertheless, in recent years, much attention has been directed towards biosurfactants due to their broad range of functional properties, there are cheaper as they can be produced from alternative sources. They have applications in the fields, such as: oil recovery process, as an additive in food processing industry, pharmaceuticals preparations, energy saving technologies etc. As they are being microbial derivatives, it is …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 1, 2014 · pp. 16–21 Read article
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Antipyretic Effects of Whole Plant Extract of Nyctanthes arbortristis linn.
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} The antipyretic activity of Nyctanthes arbortristis linn extract is investigated for potential on normal body temperature and yeast-induced pyrexia in albino rats. The whole plant of Nyctanthes …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 1, 2011 · pp. 7–10 Read article
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Diuretic Activity of the Leaves of Crataeva nurvala
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Crataeva nurvala was used in the traditional medicine as diuretic. In the present study, an aqueous and ethanolic extract of leaves of Crataeva nurvala were evaluated for …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 1, 2011 · pp. 22–24 Read article
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Evaluation of Anti-ulcer Activity of Ethanolic Extract of Salacia fruticosa and Oldenlandia Umbellata
Abstract: In this present study the aerial and root parts of Salacia fruticosa and the entire herb of Oldenlandia umbellate were evaluated for its anti-ulcer property in Aspirin induced ulcer model and Pylorus ligation assays. Both plant materials were extracted with ethanol and given at the dose level of 200mg/kg orally after the LD50 studies to fix the dose. Ulcer index, free acidity and total acidity in pylorus ligated and aspirin …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 4, Issue 2, 2013 · pp. 1–5 Read article
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Laxative Activity of Root of Moringa pterygosperma
Abstract: Crude aqueous extract of root of Moringa pterygosperma (family: Moringaceae) at dose 100 and 200 mg/kg was investigated for laxative activity according to Cappaso et al. in albino rats that were compared with standard drug agar-agar (300 mg/kg, p.o.) in normal saline. The rats were fasted for 12 h before the experiment. After 8 h of drug administration, the faeces were collected and weighed. The extract was found to produce …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 2, Issue 3, 2012 · pp. 4–7 Read article
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Evaluation of Antipyretic Activity of Olax Scandens (Roxb.) Stem Bark
Abstract: Abstract:Traditionally, the decoction of Olax scandens (Roxb.) stem bark is used to cure fever and cough. The present experimental study was carried out to evaluate the antipyretic activity of stem bark of Olax scandens (Roxb.) on experimental animals. Brewer’s yeast was used as a pyrogen in Wistar strain albino rats for inducing pyrexia. The stem bark powder, at a dose of 540 mg/kg body weight of rat was suspended in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 1, 2015 · pp. 15–18 Read article
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Comparative Studies on Anti-inflammatory and Diuretic Activities of Alternanthera Bettzickiana, Alternanthera pungens, Alternanthera tenella and Digera muricata
Abstract: The Benzene and Alcholic extracts of four medicinal plants such as Alternanthera bettzickiana, Alternanthera pungens, Alternanthera tenella and Digera muricata were studied for antiinflammatory and diuretic activities in albino rats. Anti inflammatory test was performed against carrageenin induced paw oedema method by using diclofenac sodium as standard. The parameters measured for the assessment of diuretic activity were total urine volume, sodium, potassium and chloride concentration in urine.The results of each …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 1, Issue 1, 2011 · pp. 53–58 Read article
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Hepatoprotective Activity of Japanese Cedar (Cryptomeria japonica) against Carbon Tetrachloride Induced Toxicity
Abstract: Liver is a vital organ which plays a major role in metabolism and excretion of xenobiotics from the body. Liver injury or liver dysfunction is a major health problem that challenges not only health care professionals but also the pharmaceutical industry and drug regulatory agencies. Liver cell injury caused by various toxic chemicals and excessive alcohol consumption and microbes is well studied. The available synthetic drugs to treat liver disorders …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 6, Issue 2, 2016 · pp. 6–9 Read article
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Effect of Processing On Bioavailability of Macronutrients and Minerals in Complementary Food Formulated From Cereals and Supplemented With Legumes
Abstract: Low bioavailability of protein and minerals in plant-based foods has contributed to malnutrition challenge confronting young humans in developing settings. Therefore, roasting, germination, fermentation and boiling were investigated as possible household processing methods that could improve bioavailability of a cereal-based complementary food supplemented with soy bean and groundnut. Standard methods were adopted in evaluating the bioavailability of these nutrients in male weaning albino rat model. The results obtained showed that …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 10, Issue 1, 2021 · pp. 7–14 Read article
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Locomotion Inhibitory Activity of Lagerstroemia speciosa Hydroalcoholic Root Extract
Abstract: Presently, it has been found from the medical databases such as PubMed, Scopus, Google Scholar, etc. that no locomotion inhibitory activity has been explored by any research group so far for the hydroalcoholic extract of Lagerstroemia speciosa (Family: Lythraceae) root. The present study involved filling the above gap by exploring the locomotion inhibitory activity (actophotometer-based) in Swiss albino rats. The investigation showed promising therapeutic perspectives (as compared to standard drug …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 11, Issue 1, 2021 · pp. 8–11 Read article
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Acute Toxicity and Histopathological Evaluation of Polyherbal Formulations of Annona Squamosa, Zingiber Officinalis and Triticum Aestivum in Wistar Rats
Abstract: The relationship between dose and its effects on the exposed organism is of high significance in toxic evaluation. The present study was aimed for the safety assessment of methanolic extract of Annona squamosa, Zingiber Officinalis and Triticum aestivum as polyherbal formulations at different ratios in albino Wistar rats. Sighting study was conducted in one female rat by administering 300 mg/kg body weight of polyherbal formulation through oral gavage. There were …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 1–7 Read article
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Determination of Gastric Irritation Inducing Effect of Iron-Containing Unani Compound Formulations In Animals
Abstract: AbstractBackground: Iron is the most commonly used metal for human welfare on earth and also a vital element for sustenance of life.Iron deficiency is a common affliction of human beings all over the globe and presents as iron deficiency anaemia. Most effective and preferred treatment of iron deficiency is replenishment of iron by oral administration. Successful completion of treatment depends on tolerance of the prescribed drug by a patient. Oral …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 9, Issue 3, 2022 · pp. 27–30 Read article