Search
100 articles for “Tuberculosis Tuberculosis”
-
Nanoparticle-Based Early Diagnostic Tools for Tuberculosis and Malaria in Rural India
Abstract: Malaria and Tuberculosis continue to be two major public health challenges in rural India. The interplay between an inefficient health care system, late diagnosis, and under-identification of cases contributes to the high morbidity and mortality associated with TB and Malaria. Conventional methods, such as sputum microscopy for TB, microscopy and rapid diagnostic tests (RDTs) for malaria, have a higher benchmark of sensitivity that requires a certain amount of time, skilled …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 45–51 Read article
-
Chest Wall Tuberculosis: A Case Report
Abstract: Chest wall tuberculosis is a very rare form of tuberculosis. Its presentations often misguide the clinician for early diagnosis and produce a diagnostic dilemma. High index of suspicion and exposure to literature reports may be helpful for early diagnosis and treatment. Here, such a case of chest wall tuberculosis which was preliminary managed by many clinicians with variety of empirical diagnosis has been reported. Even the FNAC report from the …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 3, 2014 · pp. 6–8 Read article
-
Statistical Analysis of Spatial Distribution of Tuberculosis in Ethiopia
Abstract: Tuberculosis is the world’s number one cause of death from an infectious disease. In the year 2018 Ethiopia registered 146,172 cases of TB. Among these, 139,261 were new cases; 46,132 new smear-positive (33.1%); 49,037 new smear-negative (35.2%); 44,092 new extra-pulmonary TB (31.6%). The main objective of this study is to assess the spatial distribution of TB in Ethiopia by using spatial statistical methods. Spatial clustering of Tuberculosis was explored using …
Published in Research & Reviews : Journal of Statistics · Vol. 9, Issue 3, 2020 · pp. 36–48 Read article
-
RECENT STUDIES OF DRUGS IN TUBERCULOSIS
Abstract: The infectious disease tuberculosis (TB), which is brought on by a particular type of bacteria, typically affects the lungs. When infected individuals cough, sneeze, or spit, the virus is disseminated through the air. There are ways to prevent and treat tuberculosis. According to estimates, the TB pathogen has infected around a quarter of the world's population. A cough that lasts longer than three weeks, together with the possibility of phlegm …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 1, 2023 · pp. 14–22 Read article
-
Evaluating Ma-ul-Shae’er (Barley Water) as a Nutritional Supplement in Pulmonary Tuberculosis: A Randomised Controlled Trial
Abstract: Background: Tuberculosis (TB) stands as a persistent global health challenge, imposing significant burdens on societies across the world. Despite its profound medical, social, and economic implications, there exists a critical gap in understanding interventions that could improve the quality of life for individuals afflicted by TB.Objective: This study aims to fill this void by investigating the impact of barley water on the quality of life of TB patients, providing a …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 3, 2023 · pp. 29–38 Read article
-
Innovations in Tuberculosis Management: Advancements in Drug-Resistant TB Treatment and Rapid Diagnostics
Abstract: Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, exacerbated by the increasing prevalence of drug-resistant strains, such as multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). Despite advancements in first-line and second-line treatments, resistance to conventional antibiotics has complicated therapeutic strategies, necessitating novel approaches. This mini review explores emerging advancements in TB treatment, including gene editing technologies, such as CRISPR, which offer potential for precise targeting of drug-resistant bacterial …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
-
In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
-
Tuberculosis Treatment Outcomes among TB Patients at FenoteSelam District Hospital, West Gojjam Zone, Amhara, Northwest Ethiopia
Abstract: Introduction: Tuberculosis is a major public health problem throughout the world. One third of the world’s population is estimated to be infected with bacilli and hence at risk of developing active disease. It is the second leading cause of death from an infectious disease worldwide after HIV, which caused an estimated 1.8 million deaths. The main reason for this is the high rate of death as an unsuccessful outcome. Incomplete …
Published in Research and Reviews: A Journal of Medicine · Vol. 6, Issue 3, 2016 · pp. 1–8 Read article
-
Family Burden of Tuberculosis on Female Patients
Abstract: Tuberculosis (TB) affects mostly economically active populations in underdeveloped and developing countries, therefore TB can have far-reaching economic and social consequences among infected people and other members of their family. TB is the second leading reason behind death worldwide amongst communicable diseases. TB kills approximately 1 million women in a year and is chargeable for more deaths in women within the reproductive people. The burden assessment schedule (BAS) has been …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 10, Issue 1, 2021 · pp. 7–13 Read article
-
Colorimetric Redox Indicator assay for rapid detection of multidrug-resistant Mycobacterium tuberculosis in South Gujarat region
Abstract: Tuberculosis (TB) has affected humans since antiquity. The burden of TB particularly with multi-drug-resistance (MDR) is increasing worldwide and has become a major public health concern. This study aims to perform Colorimetric Redox Indicator (CRI) assay for rapid detection of multidrug-resistant Mycobacterium tuberculosis in South Gujarat region. Total 234 samples were collected from South Gujarat region and were subjected for microscopy examination, culturing on Lowenstein-Jensen (LJ) medium and drug susceptibility …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 3, 2018 · pp. 65–70 Read article
-
A Study to Assess the Effectiveness of Information Booklet Regarding DOTS Therapy among the Tuberculosis Clients in a Selected Primary Health Centre
Abstract: The purpose of the study was to assess the effectiveness of information booklet regarding DOTS therapy among the tuberculosis clients in a selected primary health centre. The design used for this study was quasi experimental one group pre-test without control group with evaluative approach. Simple random sampling technique was used to select the sample for the study. The data were collected by using structured questionnaire from 60 tuberculosis clients before …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 4, Issue 3, 2017 · pp. 29–33 Read article
-
In Silico Drug Design for Mycobacterium tuberculosis and Development of Host–Pathogen Interaction Network and Molecular Docking Procedures
Abstract: Objective: A leading cause of illness is the contagious disease tuberculosis (TB), this infection with Mycobacterium tuberculosis complex (MTBC) particularly M. tuberculosis and M. africanum, is what causes tuberculosis. Diverse receptor proteins (mycobacterial proteins) with various 3D structures and functions were evaluated to access the multi-domain antimycobacterial action of ligands. The specific receptor proteins PDB ID: 3PTY, PDB ID: 4OW8, PDB ID: 5KWA, and PDB ID: 3ZXR, were opted for …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 1–19 Read article
-
Postprandial Elevation of Body Temperature – A Diagnostic Tool for Diq (Tuberculosis)
Abstract: AbstractDiq (tuberculosis) is one of the oldest diseases. The writings from different civilizations represent its clues. The man has been striving to know, to identify, to diagnose, to cure, to prevent and to eradicate this emaciating disease. All renowned Unani physicians have paid due attention towards the description of this disease. They are of the opinion that Diq is a condition in which Hararat Ghair Tabayee (abnormal heat) is associated …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 2, Issue 2, 2013 · pp. 37–44 Read article
-
Effect of Glycemic Control on Sputum Conversion at the End of Intensive Phase of Category I DOTS Therapy among Patients with Pulmonary Tuberculosis
Abstract: India is an endemic country of tuberculosis and diabetic capital of the world. A patient with diabetes has more chance of occurrence tuberculosis. Many studies pointed out the merging epidemic of diabetes and tuberculosis. Rifampicin and Isoniazid are the most prominent drugs in anti-TB treatment. These drugs disrupt the metabolism of many anti-hypoglycemic agents and lower the plasma levels, leading to hypogycemia. In non-diabetics, it impairs the release and action …
Published in Journal of Nursing Science & Practice · Vol. 10, Issue 1, 2020 · pp. 13–17 Read article
-
Tuberculosis Epidemiology and its Diagnostic Modality
Abstract: Tuberculosis (TB) remains a global health emergency, with India being the epicenter, recording 2.23 million cases and approximately 4.53 lakhs deaths in 2021. Despite efforts by the National Tuberculosis Eradication Program (NTEP), the anticipated decrease in the incidence and prevalence of TB has not been actualized. This paper examines the persistently high rates of TB in India, identifying critical risk factors such as male gender, marital status, overcrowding, socioeconomic disadvantages, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 3, 2023 · pp. 7–11 Read article
-
Study on Efflux Pump Inhibition Activity of Marine Actinomycetes against Oflaxcin Resistsnt M. tuberculosis
Abstract: Studies were conducted to isolate marine actinomycetes active against oflaxcin resistant M. tuberculosis. Out of 25 actinomycetes isolates designated as ECRMP 4 showed potent antimycobacterial activity against all three tested Mycobacterial strains. Representative bioactive isolate was characterized using phenotypic property and identified as Micropolyspora sp. The zone of inhibition was 20 ± 0.1 mm (62% RIZD) against M. tuberculosis and 18 ± 0.6 mm (100% RIZD) against OFLR M. tuberculosis. …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 4, Issue 2, 2014 · pp. 25–30 Read article
-
3D-QSAR and Molecular Docking Studies of Triazol-Cycloalkanol Derivatives Used as Potent 3-Dehydroquinase II Inhibitors Against Mycobacterium tuberculosis
Abstract: Tuberculosis is a life threatening infectious disease caused by gram positive bacteria mycobacterium tuberculosis. Emergence of drug resistance, multi drug resistance and extensively drug resistance strain of mycobacterium make the situation more worst. It increases the mortality rate of tuberculosis patient, time duration and cost of treatment. Various inhibitors and drug molecules are designed to combat this fatal disease. Enzymes of shikimate pathway are responsible for production of essential amino …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 3, 2015 · pp. 18–28 Read article
-
A Potential Role of Ayurvedic Treatment in Tuberculosis
Abstract: According to the World Health Organization (WHO), tuberculosis (TB) is one of the top tencauses of death worldwide and verified as a global health problem. The main reason of globalhealth problem is generally the tremendous burden of disease. In the estimated survey of TB in2016, 10.4 million people suffered with TB and 1.7 million died with this disease. After a longperiod of neglect some new interventions are developed by various …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 1, 2019 · pp. 1–10 Read article
-
Unani Concept of Tadarrun-e-Revi (Pulmonary Tuberculosis): A Review
Abstract: In Unani system of medicine, pulmonary tuberculosis is known as Tadarrun-e-Revi. Unani physicians also called it Diq or humma-e-diq or tap-e-diq. The ulcer which is formed in lungs due to tuberculosis is called sil. The word Diq means thinness or debility. In Diq, the increased temperature of body destroys the body fluid, because of which, the body of affected person becomes thin and dry. Hence the disease is called Humma-e-diq. …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 5, Issue 2, 2018 · pp. 32–36 Read article
-
Anti-tuberculosis Effects of the Extracts from Humulus japonicus and Humulus lupulus in in vitro and ex-vivo TB Models
Abstract: AbstractObjectives: Anti-tuberculosis effects of Humulus japonicus and Humulus lupulus were evaluated in in vitro direct killing ability and in ex-vivo indirect killing ability through human macrophages. Methods: H37Rv or XDR strain or NTM was treated with Crude extracts of Humulus japonicas and Humulus lupulus to estimate the MIC(Minimal Inhibitory Concentration) or MKC(Minimal Killing Concentration). Results: The MIC or MKC of the extracts of Humulus japonicus was 31.2 µg/ml for H37Rv …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 3, 2022 · pp. 40–49 Read article