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161 articles for “Sustain Release”
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Effect of Starch CMC Blend on the Drug Release from the Tablet
Abstract: Starch is frequently used as a binder and disintegrate for immediate release tablet formulation and is also used to prepare sustained release formulations. Starches from various sources show different functional characteristics; while combining with other excipients. When starch blend from various sources is used in the combination with carboxy methyl cellulose (CMC), it shows different release properties. The aim of the present work is to investigate the influence of starch-CMC …
Published in Trends in Drug Delivery · Vol. 5, Issue 1, 2018 · pp. 10–16 Read article
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Formulation and Evaluation of Gastroretentive Bilayered Floating Tablets of Famotidine: Effect of Formulation Variables and in vitro in vivo Evaluation
Abstract: The present investigation concerns the development of bilayered floating tablets of famotidine for prolongation of gastric residence time. An attempt was made to prepare bilayered floating tablets of famotidine by direct compression method. Two layered formulations were designed with an immediate release layer (IR) comprising of the drug, the super disintegrant Croscarmellose sodium along with the other diluents like microcrystalline cellulose and dicalcium phosphate. Three batches of immediate release layer …
Published in Trends in Drug Delivery · Vol. 2, Issue 3, 2015 · pp. 1–17 Read article
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Formulation and Development of pH Sensitive Drug Delivery Systems for Antihyperglycemic Drugs
Abstract: The aim of the present study was to develop a pH sensitive gastroretentive drug delivery system for an anti-diabetic drug pioglitazone HCl based on gas formation technique using 32 factorial design, in order to prolong the gastric residence time and increase the overall bioavailability of the dosage form, since the absorption is erratic in diabetic patients. The system consists of the drug loaded pellets which is coated with two different …
Published in Trends in Drug Delivery · Vol. 4, Issue 1, 2017 · pp. 8–17 Read article
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Design and Evaluation of Itraconazole Niosomes
Abstract: The present study was undertaken with an aim to fabricate and characterize and evaluate niosomes of Itraconazole, where the drug is released in a sustained manner for a period of 12 hours. Itraconazole is Class-2 drug having low solubility and have short half-life between 3–4 hours. Due to high first pass metabolism, the drug is rapidly excreted from the body indicating the need of sustained release delivery. To overcome these …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 62–68 Read article
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Formulation and Development of Gastroretentive Hydrogels of Glipizide
Abstract: The aim of the present study was to develop a pH sensitive gastroretentive drug delivery system for an antidiabetic drug glipizide, based on gas formation technique using 32-factorial design, in order to prolong the gastric residence time and increase the overall bioavailability of the dosage form, since the absorption is erratic in diabetic patients. The system consists of the drug, glycol chitosan (5% w/w) and aqueous PVA solution (10% w/w) …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 1, 2017 · pp. 1–7 Read article
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Sumatriptan Succinate Mucoadhesive Buccal Tablets: Formulation Design, Optimization and Evaluation
Abstract: The main aim of present investigation was to develop and study mucoadhesive buccal tablets of sumatriptan succinate using different bioadhesive polymer. Nine formulations were prepared by using direct compression method with varying concentration of polymer as HPMC (Metolose SR 90SH-15000), xanthan gum (XTGM) and sodium carboxy methyl cellulose (sodium CMC). Fourier transform infrared spectroscopy was used to identify drug excipient interaction. Micromeritic properties of lubricated blend, physical properties and chemical …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 2, 2022 · pp. 1–20 Read article
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The Utilization of Oil Entrapped Floating Alginate Beads in a Gastroretentive Delivery System is Intended to Improve the Bioavailbility of Telmisartan Incorporating Principles of Bioinformatics
Abstract: Oil entrapped floating calcium alginate beads of Telmisartan were successfully prepared using sodium alginate as polymer and two different oil phases of mineral oil and olive oil by emulsion gelation method. The FT-IR spectra of final optimized formulation confirms no drug- polymer incompatibility. The floating time of beads was found to be more than 12 hrs suggesting that the method used for prepration was effective. The floating time of optimized …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 21–38 Read article
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Development and Characterization of Mucoadhesive Microspheres Containing a Model Antidiabetic Drug
Abstract: The present work was envisaged to reduce the dosing frequency and improve patient compliance by designing and evaluating sustained release mucoadhesive (SRM) microspheres of metformin hydrochloride (MH) for an effective control of diabetes type-2. Microspheres were prepared by emulsification solvent evaporation method using sodium alginate, carbopol 934P (CP), and sodium carboxy methyl cellulose (SCMC) as a mucoadhesive polymers. The microspheres exhibits good mucoadhesive properties and showed high drug entrapment efficiency. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 2, 2015 · pp. 12–19 Read article
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 47–58 Read article
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Formulation Development and Evaluation of Floating Tablets of Venlafaxine Hydrochloride
Abstract: The aim of the present study was to formulate and evaluate gastroretentive floating tablets of an antidepressant drug, Venlafaxine HCl. The matrix tablets of Venlafaxine hydrochloride were prepared by employing low viscosity grade hydrophilic polymer HPMC E15LV in combination with any one of the high viscosity grades of HPMC (K4M, K15M, and K100M) as swelling polymers. Sodium bicarbonate was employed as gas generating agent. The tablets were formulated using direct …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 1, 2015 · pp. 7–15 Read article
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Development and Performance Evaluation of a Polyethersulfone–Graphene Oxide Ultrafiltration Membrane for Simultaneous Drug Delivery and Virus Removal: An Experimental Investigation
Abstract: The development of multifunctional ultrafiltration membranes for simultaneous controlled drug delivery and viral removal has gained considerable attention in biomedical engineering, pharmaceutical sciences, and water purification. Polyethersulfone (PES) membranes offer excellent thermal, chemical, and mechanical stability; however, their hydrophobicity can limit permeability, antifouling performance, and biocompatibility. This study proposes the fabrication of PES–graphene oxide (GO) ultrafiltration membranes using the phase inversion technique, with systematic variation of GO concentration to optimize …
Published in International Journal of Membranes · Vol. 3, Issue 2, 2026 Read article
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Analysis of Transdermal Patches: A Surgical Perspective
Abstract: In addressing the challenges associated with oral drug administration, the introduction of a transdermal drug delivery system has proven to be a valuable alternative. This system involves the application of a transdermal patch onto the skin, facilitating the controlled release of a specific medication through the skin and into the bloodstream. The primary objective is to enhance the healing process of the affected area of the body. Notably, the transdermal …
Published in Research and Reviews : Journal of Surgery · Vol. 12, Issue 3, 2023 · pp. 10–13 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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Recent Trends in Ocular Drug Delivery: Challenges and Approaches
Abstract: Drug topically regulation can be accessed most easily in the eye. When given topically as eye drops, medication ocular bioavailability is quite low. Drug entry into specific ocular locations is complicated by the complex anatomy and physiology of the human eye. Research has long been interested in the topical administration of successful treatments. To provide a suitable ocular penetration and extend the duration of drug residence is their challenging task. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 22–38 Read article
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Advanced Ointment Formulation: An Insightful Review of Innovation and Efficacy
Abstract: This review provides an in-depth exploration of the evolution of ointment formulations, particularly considering the increasing prevalence of fungal infections and the growing demand for effective antifungal treatments. Traditional ointment formulations, while useful, often face significant challenges, such as inadequate penetration into the skin, poor bioavailability, and undesirable textures that limit their efficacy. As a result, there has been a shift toward more advanced, innovative formulations that aim to address …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 14–23 Read article
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The Impact of Nanotechnology in Transforming Neuro-oncology - A Comprehensive Review
Abstract: The treatment of central nervous system (CNS) tumours, including aggressive malignancies like glioblastoma, faces significant challenges. The blood–brain barrier (BBB) blocks nearly 98% of small-molecule drugs from achieving therapeutic levels in the brain, and the heterogeneity of these tumours frequently contributes to treatment resistance and poor outcomes. Traditional approaches, including chemotherapy and radiotherapy, are hindered by systemic toxicity and inadequate drug penetration. Nanotechnology provides a promising alternative, as nanoparticles (NPs) …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 627–637 Read article
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Personalized Therapy Using Drug Delivery Devices
Abstract: The persistent challenge in modern medicine lies in inter-patient heterogeneity, rendering standardized drug dosing protocols suboptimal for many chronic conditions. Traditional pharmacokinetics fail to account for real-time biological fluctuations, leading to cycles of ineffective treatment or dose-limiting toxicity. This paper explores the critical intersection of advanced drug delivery devices (DDDs) and personalized medicine, positioning these technologies as the vital link translating genomic and biological data into tangible, patient- specific interventions. …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 1, 2026 · pp. 53–62 Read article
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Nanotechnology In Herbal Medicine
Abstract: Herbal medicine has been widely used for centuries as a natural and holistic approach to health care. However, many herbal compounds face challenges such as low solubility, low bioavailability, instability, and the lack of targeted delivery, which affect their efficacy. The integration of nanotechnology into herbal medicine has emerged as a promising strategy to overcome these challenges and enhance the pharmacological potential of plant-derived compounds. Nanocarriers such as liposomes, solid …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 1, 2025 · pp. 50–69 Read article
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Enhancing the Bioavailability of Polyphenols: A Comprehensive Review
Abstract: The polyphenolic compounds are abundantly found in different plant parts including fruits, leaves, stem and seeds, and are known for possessing a wide range of biological activities. These include antioxidant, antimicrobial, anti-inflammatory, anticancer, antidiabetic, cardioprotective, and neuroprotective effects. Their functional relation with their structure highlights the significant therapeutic potential. As a result, the polyphenols are being further being exploited for applications in functional foods, pharmaceuticals, and targeted drug delivery. Despite …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 37–51 Read article
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Synthesis, Crosslinking and Evaluation of Graft Polymer for Biomedical Use
Abstract: The objective of this research was focused on grafting of acrylic acid (AA) with hydroxypropyl methylcellulose (HPMC) to obtain copolymers of hydrogels with improved properties for ease of administration and reducing the dose frequency, improved patient compliance and comfort of sustained release medication. Water-absorbing polymers for hydrogels, the swellable polymeric materials have been widely investigated as the carrier for drug delivery system. These are the advanced polymer systems that hold …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 1, 2012 · pp. 37–45 Read article