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97 articles for “Stem cell”
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Rheumatoid Arthritis and Stem Cell Therapies Perspectives for It
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by systemic inflammation, primarily affecting synovial joints, leading to joint destruction and systemic complications. The pathogenesis involves immune system dysregulation, autoantibody production, and enzymatic imbalances. Enzymes, including matrix metalloproteinases (MMPs), serine proteases, and kinases, play crucial roles in these processes. Their dysregulation contributes significantly to disease progression through the imbalance of pro-inflammatory cytokines, oxidative stress, and extracellular matrix (ECM) degradation. MMPs, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 · pp. 20–28 Read article
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Hematopoietic Stem Cells: Sources and Therapeutic Potential for Autoimmune Diseases and Cancer
Abstract: Hematopoietic stem cells (HSCs) are a group of multipotent adult stem cells that are responsible for lifelong production of all types of functional blood cells comprising myeloid (monocytes, macrophages, granulocytes), megakaryocytes/platelets, red blood cells (erythrocyte), T-cells, B-cells, natural killer (NK) cells, mast cells and dendritic cells (DCs). HSCs have the capacity for self-renewal and differentiation into various tissues. These remarkable properties of HSCs make them an ideal tool for tissue …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 3, 2012 · pp. 6–14 Read article
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Effect of Bone Marrow Derived Autologous Stem Cell Transplantation on Cerebral Metabolism of a 20-year-old Autistic Patient
Abstract: Autism is a neurodevelopmental disorder characterized by clinically significant impairment in social, occupational and other important areas of normal functioning. The autistic brain shows altered neurochemical metabolism, such as decreased glucose uptake, increased concentrations of lactate and reduced concentrations of N-acetyl-aspartate. Besides behavioral therapies and medications for autism-associated conditions such as seizures and gastrointestinal distress, there are no U.S. FDA approved pharmacological therapies to treat Autism’s core pathology. Stem cell …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 3, Issue 3, 2013 · pp. 14–20 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 · pp. 15–22 Read article
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Hematopoietic stem progenitor cells reduce the proliferation of Tregs via regulation of IL-12/STAT4 signaling during chronic stress
Abstract: Abstract. Physical or psychological chronic stress mediates the impaired immune response by inducing the proliferation of regulatory T cells (Tregs). Our recent studies showed that hematopoietic stem progenitor cells (HSPCs) significantly modulated the immune system. HSPCs prevented stress-induced lymphocyte apoptosis, exerting a protective effect in chronic stress-induced immune responses. Thus, whether HSPCs could prevent the proliferation of Tregs in conditions of chronic stress was assessed in the present study. Injection …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 3, 2022 · pp. 1–10 Read article
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Single-Cell Genomics and its Impact on Understanding Cellular Heterogeneity
Abstract: Single-cell genomics has transformed how we study the differences between individual cells, helping scientists uncover the detailed variety within tissues that traditional methods could not reveal. Traditional methods, such as RNA sequencing, average gene expression across many cells, thereby missing subtle yet important cellular variations. Single-cell technologies, such as single-cell RNA sequencing (scRNA-seq), DNA sequencing, and epigenomics, allow researchers to study individual cells in extraordinary detail like never before. This …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 1–5 Read article
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Wiskott-Aldrich Syndrome: A Comprehensive Guide
Abstract: Wiskott-Aldrich Syndrome (WAS) is an uncommon genetic disorder inherited through the X chromosome, marked by a combination of immune system deficiencies, eczema, and low platelet counts. This syndrome primarily affects males, leading to significant morbidity and mortality due to recurrent infections, bleeding complications, and autoimmune diseases. Mutations in the WAS gene disrupt the production of the Wiskott-Aldrich Syndrome protein (WASp), crucial for the functioning of immune cells and platelet formation. …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 39–46 Read article
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A Review: Uses of Thalidomide in Cancer Treatment
Abstract: Thalidomide is an anti-angiogenetic agent, which was widely used in early 1950s and 1960s for the treatment of morning sickness in pregnant women. The drug has been banned in1960 as it caused severe birth defects in children whose mothers had used thalidomide during pregnancy. Though it caused severe adverse effects the drug has found to be effective in the treatment of leprosy and multiple myeloma. These days thalidomide has been …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 1, 2018 · pp. 1–5 Read article
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The Dental Pulp: Vital Core of Tooth Functionality
Abstract: Dental pulp, an intricately specialized mesenchymal tissue, possesses limited regenerative capabilities attributable to the unique anatomical arrangement and the post-mitotic nature of odontoblastic cells. The process of complete pulp amputation, subsequent disinfection of the pulp space, and the insertion of synthetic materials results in the substantial loss of dentin, leading to enduring consequences such as a non-vital and structurally weakened tooth.Nevertheless, a beacon of hope emerges in the form of …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 1, 2024 Read article
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Protective Effects of Phellinus linteus Polysaccharides Against Radiation-Induced Hematopoietic Damage in Bone Marrow of Mice
Abstract: Chemotherapy and radiation therapy, which are standard methods of treatment for various cancers, often result in suppression of hematopoiesis accompanied by reduction in the number of hematopoietic stem cells and their progeny. We investigated a clinically potential use of Phellinus linteus polysaccharide in the treatment of various cytopenias induced by radiotherapy. Mice were administered Phellinus linteus polysaccharide orally at a dosage of 100 mg/kg once daily for + consecutive days, …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 1, 2024 · pp. 12–17 Read article
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The Current State of Huntington's Disease Treatment: An Overview of Palliative Care and Symptom Management
Abstract: Huntington's disease (HD) is a neurodegenerative ailment that adversely affects the basal ganglia and the cortex of the brain. Although there is no recognized cure for HD, symptomatic relief and therapeutic management of the condition have improved over the course of time. This review paper provides an up-to-date overview of the current treatment options and symptom management strategies utilized in the care of HD patients. Additionally, it highlights the existing …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 35–52 Read article
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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Extranodal NK/T-Cell Lymphoma; Dilemma in Diagnosis and Management: A Review of Literature
Abstract: Natural killer (NK) cell neoplasms are rare malignancies. They are classified as extranodal NK-cell lymphoma, nasal type, and aggressive NK-cell leukaemia. Clinically they can be classified as nasal type, non-nasal type, and aggressive lymphoma/leukaemia. Stage I/II Nasal NK-cell lymphoma are treated by combined chemotherapy and radiotherapy. In case of stage III/IV nasal NK-cell lymphoma, as well as non-nasal and aggressive lymphomas/leukaemias, chemotherapy is the main treatment. In selected cases, allogenic …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 3, Issue 3, 2014 · pp. 4–12 Read article
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Potential Role of Blood, Platelet-rich Plasma and Fibrin Concentrates in Regenerative Endodontics
Abstract: This article will review the new concept of regenerative endodontics in salvaging immature permanent teeth. The potential role of blood and platelet concentrates – platelet-rich plasma and platelet-rich fibrin in regeneration protocol will be discussed. MEDLINE and EMBASE computer databases were searched up to June 2011 using the following keywords – immature teeth, dental stem cells, growth factors, regenerative endodontics and platelet concentrates. It appears that stem cells, growth factors, …
Published in Research and Reviews: A Journal of Dentistry · Vol. 3, Issue 1, 2012 · pp. 38–44 Read article
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Recent Development Technique in Management of Cancer
Abstract: Cancer develops when a change in one's genetic makeup leads to the development of tumour cells. These clusters of malignant cells eventually develop into tumours. Tumours can shed cancerous cells, which can then travel through the lymphatic system or the circulatory system to other organs. In the medical field, this occurrence is referred to as metastasis. Cancer cells proliferate even when they have no instructions to do so. Despite the …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 25–41 Read article
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The Quiet Intruder: An Insidious Presentation of Primary Plasma Cell Leukemia and a Literature Review on Current Treatment Strategies
Abstract: Introduction: Primary plasma cell leukemia (pPCL) is a rare and aggressive plasma cell dyscrasia, defined by ≥5% circulating plasma cells, with poor prognosis and rapid progression. Case Presentation: A 66-year-old African–American female with no prior medical history presented with one week of fatigue, dehydration, and polydipsia. Laboratory evaluation revealed leukocytosis, severe thrombocytopenia, acute kidney injury (creatinine 4.03 mg/dL), and hypercalcemia (13.0 mg/dL) with suppressed PTH. Imaging showed intra-abdominal lymphadenopathy without …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 1–5 Read article
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In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia
Abstract: Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 38–53 Read article
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Nanotechnology Application in Neural Growth Support System
Abstract: With its ability to transfer electric impulses, make contact with neurons, and mimic the environment of neurons, carbon nanotubes have been intriguing candidates for the development of scaffolding that could promote neuronal growth and division. In order to encourage the growth and development of human brain cells, the researchers developed biodegradable composite scaffolding comprised of interconnected carbon nanotubes dispersed in the poly-L-lactic acid substrate. To imitate the guiding inputs of …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 24, Issue 2, 2022 · pp. 47–55 Read article
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Epitopes of Enzymes Involved in Sialylation with Special Reference to Lung Cancer
Abstract: Environmental pollutants, poor air quality, urban growth, deforestation, burning of fuel and indoor air pollution lead to different respiratory diseases including lung cancer with fatal consequences. Almost 2 million people die every year due to harmful effects of indoor air pollutants. Especially an enormous number of children are being affected. Environment pollution is not only reported to affect the lungs but also damage the stem cells and their niche thus …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 8, Issue 2, 2018 · pp. 11–19 Read article
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A review on the effects of Indian medicinal spices on age related molecular and cellular pathways in light of geriatric muscle loss
Abstract: Biological aging is an enigmatic and progressive process, which can be affected by various mechanisms - genetic alteration, deregulated nutrient sensing, proteostasis, cellular degeneration and stem cell dysfunctioning. Indian spices are an underexplored repository of phytoactives with a medicinal potential. Especially spices like cumin (Cuminum-cyminum) and fennel seeds (Foeniculum vulgare) are central to the Indian diet as well as a part of numerous traditional recipes and formulations with medicinal implications. …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 12, Issue 3, 2024 · pp. 1–10 Read article