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833 articles for “Resistance”
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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Drug Resistance in Targeted Cancer Treatment: Clinical Difficulties, Molecular Mechanisms, and Emerging Strategies
Abstract: Targeted cancer therapy, which selectively inhibits the molecular mechanisms responsible for tumor growth and development, has revolutionized modern oncology. Targeted therapies have lower systemic toxicity and better therapeutic efficacy when compared to traditional chemotherapy. However, the emergence of medication resistance often limits the long-term efficacy of these treatments, ultimately resulting in treatment failure and disease progression. Drug resistance develops through a number of intricate biological processes and can be innate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 130–138 Read article
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Plant-Derived Antimicrobials as Next-Generation Solutions to Multidrug Resistance
Abstract: The steady rise of multidrug-resistant (MDR) pathogens is reshaping how clinicians, researchers, and policymakers think about infection control. When bacteria acquire the ability to survive exposure to three or more antibiotic classes at once—whether through efflux pumps, enzyme-mediated drug destruction, target modifications, or reduced membrane permeability—treatment options narrow dramatically, hospital stays lengthen, and mortality climbs. Conventional pharmaceutical pipelines have struggled to keep pace with this biological arms race, pushing the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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Antimicrobial Resistance and AI-Based Strategies for Rapid Pathogen Detection
Abstract: Antimicrobial resistance (AMR) has become a major global health threat, significantly reducing the effectiveness of antimicrobial therapies and increasing the burden of infectious diseases worldwide. The rapid emergence of multidrug-resistant pathogens has created an urgent need for faster, more accurate, and scalable diagnostic approaches to support timely treatment and effective infection control. Artificial intelligence (AI) has emerged as a promising technology capable of transforming pathogen detection and AMR surveillance through …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 · pp. 26–36 Read article
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High-Performance Thin Film Coatings for Corrosion Resistance in Extreme Environments
Abstract: Corrosion is a serious concern in industries such as aerospace, marine, and oil & gas, where materials are exposed to harsh environments. High-performance thin-film coatings have emerged as a critical solution to mitigate this issue, providing a protective barrier against harsh chemical and physical conditions. This review article highlights recent advancements in thin-film coatings designed to enhance corrosion resistance in such environments. The focus is on various coating materials, including …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 11, Issue 2, 2024 · pp. 20–25 Read article
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Dermatophytoses: Taxonomy, Pathogenesis, Diagnosis, Resistance, and Management.
Abstract: Dermatophytes, belonging to the family Arthrodermataceae, are keratinophilic fungi responsible for superficial mycoses. Dermatophytoses affect the skin, hair, and nails globally. Over the last few years, dermatophytic infections have seen a sharp rise in India, with the main causative agent being antifungal-resistant Trichophyton mentagrophytes genotype VIII. This review provides a detailed overview of dermatophytoses, including taxonomy, pathogenesis, epidemiology, diagnosis, and treatment. Dermatophytes belong to the kingdom Fungi, family Arthrodermataceae, with …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 28–37 Read article
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Influence of Antibiotic Promotion Practices on Pharmacovigilance and Resistance Reporting Patterns
Abstract: The global escalation of antimicrobial resistance (AMR) has emerged as a critical public health crisis, undermining decades of therapeutic advancements. While inappropriate prescribing and misuse of antibiotics are widely acknowledged contributors, the role of pharmaceutical promotion practices remains underexplored in influencing prescribing behaviors and downstream pharmacovigilance systems. This review critically examines how antibiotic promotion strategies – ranging from direct physician engagement to digital marketing – affect adverse drug reaction (ADR) …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 1–11 Read article
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Screening Some Sorghum (Sorghum Bicolor L. Moench) Genotypes for Yield and Resistance Against Stem Borer (Sesamia Calamistis) in Nigeria
Abstract: Sorghum is a staple crop with global significance, scientifically it’s known as Sorghum Bicolor, stands as one of the most important cereal crops globally, particularly in regions with arid and semi-arid climates. Sorghum remains a cornerstone of agricultural economies worldwide with its widespread cultivation and diverse applications; however, its production is often hindered by various biotic stresses, with stem borer (Sesamia calamistis) infestation being a significant concern. The stem borer …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 50–55 Read article
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Correlation Between Agronomic and Stem Borer (Sesamia Calamistis) Resistant Traits In Sorghum (Sorghum Bicolor (L.) Moench)
Abstract: Stem borer (Sesamia calamistis) infestation remains a significant challenge in sorghum (Sorghum Bicolor (L.) Moench) cultivation, leading to substantial yield losses in Nigeria. This study is aimed at investigating the interrelationship between agronomic and resistant traits of stem borer (Sesamia calamistis), and its influence on selection. The study was carried out at the research field of Plant Breeding Unit, Department of Agriculture Biotechnology, National Biotechnology Research and Development Agency. Forty …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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A study on Antibiotic Resistance: An Analysis of Molecular Mechanisms and Therapeutic Implications
Abstract: Antibiotic resistance (AR) represents one of the most critical existential threats to global public health, rapidly eroding the efficacy of established antimicrobial therapies and portending a return to the pre-antibiotic era. This analysis explores the intricate molecular landscape defining this crisis, focusing specifically on the primary mechanisms of action (MoA) utilized by major antibiotic classes—including cell wall inhibitors, protein synthesis inhibitors, and nucleic acid synthesis inhibitors—and the corresponding, diverse mechanisms …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 9–21 Read article
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A Review on Effect of Cryogenic Treatment on Wear Resistant Bearing Materials for Automotive Application
Abstract: Cryogenic processing has come as a successful supplementary process to common heat treatment, especially in improving the wear-resistant performance of materials employed in in-vehicle applications. This sub-zero processing is normally performed following quenching and before tempering, during which materials are subjected to extremely low temperatures, typically around -196°C, for prolonged periods of 24 hours. Cryogenic treatment, which involves subjecting materials to extremely low temperatures, has demonstrated promising results in changing …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1–11 Read article
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Mannan-Rich Fractions in Poultry Nutrition: A Sustainable and Defensive Strategy against Antimicrobial Resistance
Abstract: Antimicrobial resistance (AMR) has evolved to be a significant global threat, menacing worldwide health and food security. Its proliferation in poultry farming has spurred the search for sustainable, non-antibiotic alternatives. One promising alternative is Mannan-Rich Fractions (MRFs), which is derived from Saccharomyces cerevisiae. These bioactive compounds not only support poultry health but also aid in suppressing pathogenic bacteria without contributing to resistance. This review brings together current studies highlighting how …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 · pp. 1–16 Read article
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Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
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A Pilot Study on β-lactamase Producing Escherichia coli from Bovine Milk, West Bengal
Abstract: Drug resistant bacteria have become a significant global healthcare issue that requires close attention. With regards to antibiotic resistance, E.coli and its Enterobacteriaceae family are highly notorious for their ability to swiftly spread antibiotic resistance genes, thereby posing a major concern. In order to effectively address the spread of multi drug resistant bacteria, ongoing monitoring of the microflora in milk for the presence of drug resistant genes is essential. This …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 01–05 Read article
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Experimental Investigation of Micro-Hardness & Tribological Behavior of Composite Coating for Wear Resistance Application
Abstract: The author effectively created a composite coating with enhanced durability utilizing the HVOF technique in this investigation. The automobile business has encountered fierce worldwide rivalry, rapid technical breakthroughs, and strict regulatory regulations in recent year.. Producers of lubricants, gasoline additives, and worldwide original equipment manufacturers (OEMs) are striving to address the difficulties presented by changing consumer preferences and emerging energy conservation and environmental protection regulations. We have successfully created and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1097–1103 Read article
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Antibiotic Resistance in Microbes: History, Mechanisms, Therapeutic Approaches, and Strategies for Mitigation
Abstract: The global emergence of clinically significant antibiotic resistance is increasingly linked to the environment. Antimicrobials, metals, and biocides are just a few of the substances that are released into the environment through paths that are regulated by environmental regulators. Consequently, environmental regulators ought to be heavily involved in developing national and international antimicrobial resistance (AMR) measures. Antimicrobial compounds from pharmaceutical waste, agricultural runoff, and wastewater discharge contribute to the spread …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–11 Read article
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Effectiveness of PTFE-Based Nano-coatings in Improving Corrosion and Wear Resistance of Stainless Steel
Abstract: Polytetrafluoroethylene (PTFE) has emerged as a highly effective material for enhancing the durability and performance of metal surfaces, particularly in environments requiring superior corrosion resistance and low friction. This study investigates the application of PTFE coatings on various metallic substrates, with a focus on stainless steel and carbon steel, to improve their corrosion resistance, wear protection, and tribological performance. Utilizing advanced deposition techniques such as sol-gel and plasma spray, PTFE …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 2, 2024 · pp. 32–38 Read article
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Recombinant Proteins and Nested Gene Regulation: Nutrient Driven Immune Response and Disease Resistance in Livestock
Abstract: Livestock production systems are increasingly challenged by infectious diseases, metabolic disorders, and environmental stressors that reduce productivity and compromise animal health. Advances in molecular biology and animal nutrition now offer new opportunities to strengthen disease resistance through integrated strategies that combine recombinant protein technologies, gene regulatory mechanisms, and nutrient mediated immune modulation. This review examines how recombinant proteins and nested gene regulation interact to shape nutrient driven immune responses in …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Animated Transient Response of High Voltage Power Line Towers Equipped with Nonlinear Footing Resistances
Abstract: This study focuses, among other objectives, on the use of animation techniques for visualizing the electromagnetic transients in high voltage power line towers. The model includes parameters such as the tower’s footing resistance and its location-dependent surge impedance. It describes the governing algebraic/partial differential equations expressed in terms of the current and voltage distributions as functions of time and location. The transients are assumed initiated by a lightning discharge of …
Published in Trends in Electrical Engineering · Vol. 14, Issue 1, 2024 · pp. 44–52 Read article
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Assessment of Fire Resistance of Offshore Structures under Special Environmental Loads: Emphasizing Structural Integrity and Safety Measures for Extreme Conditions
Abstract: Offshore structures are exposed to a myriad of environmental challenges, including high temperatures and fire hazards, necessitating robust fire resistance measures to ensure structural integrity and the safety of personnel and facilities. This study aims to evaluate the fire resistance of offshore structures under special environmental loads, with a focus on the structural integrity and safety measures in place to withstand extreme conditions. The research methodology includes a comprehensive review …
Published in Journal of Offshore Structure and Technology · Vol. 11, Issue 1, 2024 · pp. 1–9 Read article