Search
175 articles for “Lead compound.”
-
Soursop Phytocompounds as Potential Anticancer Agents: A Molecular Docking Study
Abstract: Objective: According to tumor statistics, there will be a total of approximately 1,958,310 new malignancy cases, that balances to nearly 5,370 cases day by day. Without any questions its clearly evident that cancer is considered as one of the deadliest diseases of mankind. The course of this study emphasizes on computational approach for finding new drug for potential target proteins Bcl-2 (4MAN) and Mcl-1(5FDO) by docking against soursop (Annona Muricata …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 18–39 Read article
-
Phytoconstituents of Ticanto crista (L.) R. Clark & Gagnon (Caesalpiniaceae): A Review
Abstract: Ticanto crista (L.) R. Clark & Gagnon (= Caesalpinia crista L.), a member of the Leguminosae family, is a medicinally important plant traditionally used in various systems of medicine, including Ayurveda, for treating a wide range of ailments. It has attracted increasing scientific interest due to its rich phytochemical profile and therapeutic potential. This review serves as a comprehensive index of the chemical structures of common and medicinal compounds isolated …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 3, 2025 · pp. 38–59 Read article
-
Thermal Adsorption Processing of Hydrocarbon Residues
Abstract: The raw materials of secondary catalytic processes must be pre-refined. Among these refining processes are the deasphalting and demetallization including their thermo-adsorption (or thermo-contact adsorption) variety. In oil processing, four main processes of thermo-adsorption refining of hydrocarbon residues are used—Asphalt Residual Treating- residues deasphaltizing (ART), Discriminatory Destructive Distillation (3D), developed in the US; Adsorption-Contact Treatment (ACT) and Express Thermo-Contact Cracking (ETCC), developed in Russia. ART and ACT are processes with …
Published in Journal of Catalyst & Catalysis · Vol. 4, Issue 1, 2017 · pp. 6–10 Read article
-
INVESTIGATING PHYTOCHEMICAL INHIBITORS OF PSEUDOMONAS AERUGINOSA'S AHL SYNTHASE LASI: A PATH TOWARD NOVEL THERAPEUTIC AGENTS
Abstract: Objectives: This study intended to explore the potential of phytochemicals from Allium sativum to inhibit AHL synthase LasI, a critical protein of the Quorum Sensing (QS) pathway in Pseudomonas aeruginosa, with the ultimate objective of developing therapeutic agents for managing P. aeruginosa infections. Methods: The physicochemical properties, toxicity, aggregation ability and binding potential of phytochemicals from Allium sativum to the protein AHL synthase LasI were determined. Physicochemical properties, toxicity and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 40–54 Read article
-
Brain GST Inhibition, An Additional Mode of Action Following Beta-Cyfluthrin Intoxication in Albino Rat
Abstract: The aim of the study was to reveal the neurotoxic effect of an orally administered beta-cyfluthrin, a type-II pyrethroid in albino rats on the basis of activity of brain GST (Glutathione-s-transferase), AChE (acetylcholinesterase) and of total proteins level at different doses 35.48 and 5.06, 2.53, 1.68, 1.27 mg/kg body weight, for acute (1 day) and sub-acute (7, 14, 21 and 28 days) treatments respectively. Results reveal that beta-cyfluthrin administration inhibits …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 3, 2014 · pp. 30–36 Read article
-
Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
-
Using Artificial Intelligence for The Design of Polymeric Drug Delivery Systems
Abstract: AI is cost effective and time efficient process. Artificial intelligence is a method which uses high speed calculation, the improvement regarding algorithm along with collection about biological and chemical features in pharmaceutical exploration and development .Present day because continuous progress towards machine learning (ML),Artificial intelligence an effective statistics analysing technology might have been broadly utilized in drug design .In pharmaceutical exploration and research employ of AI in target identification, compound …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1018–1027 Read article
-
In silico potential drug target identification against 4-aminobutyrate aminotransferase for Huntington diseases
Abstract: Huntington disease, HD is a progressive neurodegenerative disorder. Some excitatory chemicals released like glutamate which causes the cell damage and the neuron die due to over accumulation of the glutamate in Huntington diseases (HD), which is regulated by the GABA also known as gamma- amino butyric acid, it is a major inhibitory neurotransmitter of the nervous system. Here we are targeting the pyridoxal dependent enzyme which degrades the GABA neurotransmitter, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 1–5 Read article
-
Bioactive Compounds in Ethanolic Extract of Strychnos innocua Root Using Gas Chromatography and Mass Spectrometry (GC-MS)
Abstract: Medicinal plants are of great relevance with endless pharmaceutical and therapeutic properties. They are source of wide array of secondary metabolites or bioactive compounds/phytochemicals (phenols, alkaloids, flavonoids, terpenoids, tannins, steroids and saponins) which can discharge numerous biological functions (antimicrobial, antioxidant, antiviral, antifungal, anti-fibrotic, immune-modulatory, cytotoxic, antipyretic, antitumor, antihelminthic, antiprotozoal, antibacterial, and so on). The use of gas chromatography and mass spectrometry analysis in identifying the bioactive compounds in the ethanolic …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 9–14 Read article
-
Extraction of Copper from Electronic Waste (E-Waste): A Review
Abstract: The issue of electronic waste, or e-waste, is indeed a significant global concern with far-reaching environmental and health implications. As technology continues to advance and become more integrated into our daily lives, the disposal of obsolete or broken electronic devices has become a pressing issue. This waste not only contains valuable metals but also toxic substances, posing significant challenges for disposal and management. Improper disposal of e-waste is a significant …
Published in Journal of Materials & Metallurgical Engineering · Vol. 14, Issue 1, 2024 · pp. 14–27 Read article
-
Review on the Effects of Chemical Compounds Toxicity on Workers in Chemical Laboratories.
Abstract: Chemical laboratories are considered high-risk work environments due to the wide range of chemicals that workers handle, which may be toxic, corrosive, or flammable. Improper handling of these substances can lead to serious health problems, ranging from mild irritation to death in cases of exposure to chemical compounds such as phenols and amines, which cause various types of lung and laryngeal cancers and respiratory diseases in laboratory workers who are …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 2, 2026 · pp. 17–26 Read article
-
Effects of Germination on the Bioactive Compounds and the Flour Physicochemical Properties of Sorghum Grains
Abstract: Sorghum, being used as a staple food with many kinds of bioactive compounds, is one of the four types of used cereal around the world. Sorghum is also an important raw material for the food industry, such as a brewing material. Germination can lead to a change of bioactive compounds, and then change the biological activities and flour physicochemical properties of sorghum grains. This review aims to analyze and summarize …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 12, Issue 1, 2024 · pp. 15–25 Read article
-
The use of Genetics and Proteomics in the Finding of Therapeutic Targets
Abstract: Gene medicine is overcoming long-standing health issues that have confounded humanity. To fully comprehend and apply gene medicine, it is vital to grasp how it works at the molecular level. Currently, various technologies may be utilized to find pharmacological targets; the two most prominent are genomic and proteomic methods. In this paper, we go over how to use genomic and proteomic approaches to find pharmacological targets in depth. These materials …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 1, 2022 · pp. 9–12 Read article
-
Ab Initio Investigation on Half-Heusler Compounds CoVZ (Z = P, Bi, Sb, As): Understanding Structural, Electronic, Magnetic, and Elastic Behavior
Abstract: The structural, electrical, mechanical, and magnetic properties of Half-Heusler CoVZ (Z= P, Bi, Sb, and As) compounds have been studied using the ab initio method. Here, we use the full potential linearized augmented plane wave (FP-LAPW) method, which is implemented by WIEN2k. The compounds CoVZ (Z= P, Bi, Sb, and As) are near to the Fermi level as implemented in the WIEN2k algorithm, exhibiting 100% spin polarization with finite band …
Published in Journal of Microelectronics and Solid State Devices · Vol. 10, Issue 3, 2023 Read article
-
Role of Reactive Extraction in Removal of Phenol from Wastewater
Abstract: Phenol is one of the most common organic water pollutants as it is highly toxic even at low concentration. Also, its presence in natural water can lead to the formation of substituted compounds during disinfection and oxidation processes. Reactive extraction method is found to be a capable alternate for separation of medium (300–3000 mg/l) to high (3000–6000 mg/l) concentration of phenol. The degree of extraction depends on nature of extractant, …
Published in Emerging Trends in Chemical Engineering · Vol. 3, Issue 1, 2016 · pp. 19–25 Read article
-
Impact of Storage Methods and Duration on Sugar and Starch Content and Ethanol Yield of Sweet Potatoes [Ipomoea batatas (L.) Lam]
Abstract: Previous studies have shown that ‘industrial’ sweet potatoes can be an excellent feedstock for ethanol production as compared to corn, sorghum and other potential feedstocks. However, starch content can be affected by cultivars as well as storage conditions. Ideally, it is practical that sweet potato storage roots be processed for ethanol production as close to harvest as possible, but this may not always be the case and some amount of …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 7, Issue 1, 2016 · pp. 23–29 Read article
-
Experimental Setup for the Measurement of Low Temperature Seebeck Coefficient of Single Crystal and Bulk Materials
Abstract: A differential thermopower setup is fabricated for both the single crystal and bulk materials in the temperature range of 16–320 K. One advantage of this apparatus is that the sample separation can be changed according to the requirement between 2 and 5 mm. In this setup silver paint is used for the improvement of thermal and electrical conductivity between copper (thermocouple) leads and material. Seebeck coefficients are measured using a …
Published in Journal of Control & Instrumentation · Vol. 5, Issue 2, 2014 · pp. 25–30 Read article
-
A Review about Scope of Traditional Medicinal Plants in a New Drug Discovery
Abstract: ‘AYUSH’ is the most important traditional system of medicine, which has been practised since thousands of long years by our ancestors. AYUSH has a very good healing power for so many problems by using both traditional and natural medicine. The new drug discovery is taking long time to produce its products and thus there is a reduction in number of new drug approvals due to different issues like legal problems …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 7, Issue 2, 2017 · pp. 1–3 Read article
-
Computational Analysis of Tinospora Cordifolia Phytochemicals as Potential Inhibitors of BRCA1-BRCT Domain Interaction in Breast Cancer
Abstract: Breast cancer is a leading cause of cancer-related deaths worldwide, accounting for a significant proportion of mortality rates among women. Despite current therapeutic approaches, the disease remains characterized by molecular heterogeneity, making it challenging to develop effective treatments. This study explores the potential of Tinospora cordifolia, a medicinal plant, in breast cancer therapy. Guduchi, scientifically known as Tinospora cordifolia, boasts a centuries-long history of use in traditional medicine, with a …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 27–37 Read article
-
Design and Development of a Sanitary Napkin Incinerator
Abstract: Improper disposal of menstrual waste presents serious health and environmental risks, especially in rural areas with limited access to proper sanitation and waste management systems. Without adequate facilities, used menstrual products are often discarded in open spaces, water bodies, or burned, leading to pollution, foul odors, and the spread of infections. The lack of awareness, infrastructure, and stigma surrounding menstruation further worsens the issue, making it crucial to promote safe, …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 15, Issue 2, 2025 · pp. 19–31 Read article