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92 articles for “Inflammatory cells”
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Lactoferrin: An Overview
Abstract: Lactoferrin (Lf) is an iron-binding glycoprotein synthesized predominantly in mammary glands of animals. Lf is majorly found in milk and colostrum of livestock and mouse. The presence of Lf in indigenous breeds of cattle has a significant role in exerting immunoprotection. Studies have highlighted the significant activities of Lf viz., anti-parasitic, antioxidant, anti-cancer, anti- inflammatory, antimicrobial, and growth factor activator in cell cultures. The capacity of Lf to bind to …
Published in Research and Reviews : Journal of Dairy Science and Technology Read article
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Understanding Kameela's Importance In The Unani System Of Tibb: A Detailed Perspective
Abstract: Kameela or Kamala, a renowned Unani medicine, has been utilized by Unani physicians for centuries to effectively address Amraze Jildiya, commonly known as skin diseases. Its medicinal properties have been extensively documented in classical Unani texts. These perennial shrubs or small trees are widely distributed in tropical and subtropical regions, typically found at altitudes below 1,000 m. The pharmacological activities of Kameela encompass a broad spectrum, owing to its diverse …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 10, Issue 3, 2023 · pp. 16–22 Read article
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Discovery of Curcumin: Miraculous Activity as Anticancer
Abstract: AbstractCancer is the second most life-threatening disease and one of the main public health problems worldwide now a day. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Curcumin is an active ingredient of the Curcuma longa plant, has received great attention over …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 29–38 Read article
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Comprehensive Review of Kojic Acid and Its Derivatives: Biological Activities, Safety, and Therapeutic Potential in Depigmentation
Abstract: There are several uses for kojic acid in human medicine, particularly in depigmentation. Additionally, derivatives of it are suggested to enhance efficacy, avoid side effects, and stop chemical degradation. With an eye toward human use and an attempt to clarify the action mechanisms, the goal of this study was to review the most recent scientific literature regarding the biological activities and safety information of kojic acid or its derivatives. During …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 45–53 Read article
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Neural Sheath Liposarcoma: A Case Report
Abstract: Liposarcoma is a malignant mesenchymal tumor of the adipose tissue [1]. Liposarcomas most frequently arise from the deep-seated stroma rather than the submucosal or subcutaneous fat [2]. The most recent World Health Organization classification of soft tissue tumors recognizes five categories of liposarcomas: (1) well differentiated, which includes the adipocytic, sclerosing, and inflammatory subtypes; (2) de differentiated; (3) myxoid; (4) round cell; and (5) pleomorphic [2–4]. The anatomical distribution of …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 2, Issue 3, 2012 · pp. 8–10 Read article
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Alopecia Areata: Complex Roots and Potential Cures
Abstract: Autoimmunity is when the healthy organs of an individual’s body are attacked by its own immune system, leading to illness or functional abnormalities. The hair follicles (HFs) are wrongly destroyed by the immune system in a condition known as Alopecia Areata and results in chronic non-cicatricial hair loss discernible by spherical patches. It’s a severely worsening or relapsing malady that can be permanent during severe falling out of hair. In …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 41–54 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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Comprehensive Evaluation of Herbal Plants for Cancer Prevention
Abstract: Since cancer continues to be a major cause of morbidity and death globally, effective prevention measures are desperately needed. As the world’s cancer burden increases, interest in alternative cancer prevention methods, particularly the use of herbal medicine, is also increasing. With their rich history and diverse phytochemical composition, medicinal plants provide a great opportunity for the development of disease prevention strategies. This review explores the potential of various plants, including …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 01–07 Read article
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DRUG INDUCED IMMUNE MEDIATED NEPHRITIS: MOLECULAR MECHANISM , PATHWAYS AND CLINICAL IMPLICATIONS
Abstract: Drug-induced immune-mediated nephritis (DI-IMN) has become a more widely known cause of acute kidney injury (AKI), with the potential for development to chronic kidney disease if not detected and treated promptly. T-cell hypersensitivity to pharmaceuticals, such as antibiotics, proton pump inhibitors, nonsteroidal anti-inflammatory drugs, and immunological drugs, are the major causes for it. Beyond clinical burden, DI-IMN reflectsintricate molecular interactions that sustain interstitial inflammation and tubular injury. These interactions include …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 13–29 Read article
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Role of Protease in Virulence of Periodontal Bacteria
Abstract: Periodontitis is a polymicrobial, multifactorial disease with the most toxic protease that aids in emigration and the degradation of the host. Unattended bacterial contamination leads to periodontitis, and extreme gum problems may also bring about missing teeth and also bleeding. Major microorganisms associated with periodontitis are p.gingivalis, t. Forsythia, p.aeruginosa and t. Denticola. Virulence plays a major role in microbial contamination where different proteases released by microorganism aids in spreading …
Published in Research and Reviews: A Journal of Dentistry · Vol. 13, Issue 2, 2022 · pp. 9–15 Read article
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Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 · pp. 16–30 Read article
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A Promising Approach Towards Arthritis: Bacopa Monnieri
Abstract: Joint inflammation, pain, and a progressive loss of function are the hallmarks of arthritis, a chronic and crippling condition that frequently results in disability and a lower quality of life. The need for safer options is highlighted by the fact that while current therapy approaches, such as NSAIDs, corticosteroids, and disease-modifying antirheumatic medications, give symptomatic relief, they are usually linked to serious adverse effects. In this regard, the wellknown Ayurvedic …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 76–91 Read article
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Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking Approach
Abstract: Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking ApproachGlioneuronal tumors and gliomas are grade I tumors classified by the World Health Organization (WHO). They typically grow slowly and primarily affect infants, children, and teenagers, but can also occur in adults. They mostly cause seizures caused by gangliomas. Most current treatments include surgery and radiotherapy. Since this disease affects children, the current treatments may cause complications. Andrographis paniculata …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 82–93 Read article
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The Prognostic Efficacy of Inflammatory Indicators in Determining the Cause of Multiple Sclerosis Exacerbation
Abstract: Multiple sclerosis (MS) is the most prevalent immune-mediated inflammatory disease affecting the central nervous system, presenting with diverse clinical symptoms and manifestations. This study investigates the diagnostic potential of the monocyte-to-lymphocyte ratio (MLR), red cell distribution width-to-lymphocyte ratio (RLR), and systemic immune-inflammation index (SII) in detecting MS attacks among relapsing-remitting MS (RRMS) patients seeking care in the emergency department (ED). The research focused on RRMS patients who presented to the …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 1, 2025 · pp. 1–8 Read article
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Recent Advancements in Nanobiocomposite-Based Wound Healing and Tissue Regeneration
Abstract: Haemostasis, inflammation, proliferation, remodeling, and other highly coordinated cellular and molecular activities are all part of the complex biological processes of wound healing and tissue regeneration. Following an injury, these stages cooperate to restore tissue integrity and function. However, this normal process is disturbed in many clinical circumstances, especially chronic wounds such diabetic ulcers, burns, and pressure sores. Prolonged inflammation, chronic microbial infection, diminished angiogenesis, and impaired extracellular matrix production …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 297–318 Read article
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An Overview of a Study on the Formulation of Herbal Facewash Tablets
Abstract: The global industry is seeing an increase in demand for herbal formulations due to the fact that natural medicines are safer than synthetic ones. People are starting to realize that using plants can help them achieve the key goal of having attractive, healthy skin. Reetha provides antibacterial and cleaning qualities that make it appropriate for treating acne, eliminating dead skin cells, and encouraging clear skin. Clitoria ternatea has also been …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 53–66 Read article
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Nutraceuticals Unveiled: Exploring the Science, Benefits, and Future of Functional Food
Abstract: The rapidly developing subject of nutraceuticals is critically examined in this review, with a focus on its scientific basis, proven health advantages, and possible future applications in the functional food industry. Key bioactive ingredients that contribute to the therapeutics effectiveness of functional foods, including flavonoids, polyphenols, carotenoids, probiotics, and essential fatty acids, have been identified and characterized as a result of recent developments in nutritional science. Both experimental and clinical …
Published in International Journal of Nutritions · Vol. 2, Issue 2, 2025 Read article
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Formulation And Evaluation of Peel Off Mask From Custard Apple
Abstract: Herbal cosmetics have a long history of use aimed at enhancing cosmetic appearance and mitigating skin conditions such as acne, pigmentation, dryness, and wrinkles. These products provide various health benefits, including anti-acne, anti-inflammatory, moisturizing, antioxidant, and anti-aging effects, while also minimizing the risk of adverse reactions. Herbal formulations have gained global popularity and acceptance due to their natural origin, safety, and effectiveness in maintaining skin health. Traditional Indian herbs, like …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 1, 2026 · pp. 6–15 Read article