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146 articles for “Drug utilization studies”
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Molecular Docking Study: Targeting mycobacterium leprae ML2640 Protein Using Active Compounds from Coscinium fenestratum
Abstract: Objectives: Leprosy is an infectious disease in skin, peripheral nerve and mucosa of upper airway. Around 70% of this infection is caused by Mycobacterium leprae, which was discovered during1873. Multi drug therapy is used for the treatment, still multiple drug resistance and reactions has been reported among patients. Hence, this work focused on identifying bioactive compounds from Coscinium fenestratum that can target mycobacterium leprae ML2640 protein by in-silico approach. Method: …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 21–33 Read article
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To Assess the Level of Knowledge of Drug Abuse Among Adolescents in Government Higher Secondary School, Vilavancode at Kanyakumari District with a View to IEC Material Preparation: A Study
Abstract: In this study, adolescents at Vilavancode Government Higher Secondary School had their knowledge of drug abuse tested. This study used a descriptive design as its method. 30 research samples were chosen using the purposive sampling technique. The tool used in this research has two parts: Demographic characteristics by interview approach utilizing a questionnaire, and Self Structured Knowledge Questionnaire to the participants to measure the level of knowledge related adolescent drug …
Published in Journal of Nursing Science & Practice · Vol. 12, Issue 3, 2022 · pp. 31–36 Read article
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Innovative Antifungal strategies: Terbinafine hydrochloride in Niosomal carriers
Abstract: Onychomycosis, an infection caused by fungi that affects fingernails or toenails, causes the nails to grow, separate from the nail bed, and become discoloured. While anybody can get, those with weakened immune systems, children and the elderly are especially susceptible. Present study was related to formulate an effective nail lacquer that would treat onychomycosis by utilizing Terbinafine hydrochloride. In this study, niosomes of a medication called terbinafine hydrochloride, an antifungal …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 · pp. 1–16 Read article
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Enhancement of Bioavailability of Clopidogrel Using Different Solubility Enhancement Techniques
Abstract: Bioavailability is the key determinant of a drug for its therapeutic effectiveness, which in turn depends upon the solubility of that drug in gastro intestinal fluid. Clopidogrel is a BCS class II drug. Drugs of this category have low solubility and high permeability, so their bioavailability is less. This can be overcome by doing pharmaceutic modifications on it. In the present study, three different modifications, namely, complexation, solvent deposition and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 2, 2016 · pp. 25–39 Read article
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A Preceptor Based Research Study and Report on Analysis of Doctor of Pharmacy/Clinical Pharmacy Services Duringclerkship and Internshipward Round Postings in Hospital
Abstract: Clinical pharmacy is the branch of Pharmacy which is concerned with the science and practice of Rational Medication Use. Clerkship and Internship ward rounds refers to the Practice of Clinical Pharmacy Practice principles by Pharm.D (Doctor of Pharmacy) students. Aim: The Aim of the present study is the preceptor based analysis and report of Doctor of Pharmacy /Clinical Pharmacy Services during the Clerkship and Internship Postings at ESI Hospital, Indiranagar, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 11, Issue 2, 2023 · pp. 19–31 Read article
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Zebrafish in Drug Research: Decoding Biological Mechanisms and Finding Novel Therapeutic Targets
Abstract: The zebrafish, scientifically known as Danio rerio, is a powerful model organism in biological research because of its favorable traits, which include rapid development, genetic tractability, and transparent embryos. Zebrafish were first identified for their use in studies of vertebrate development, but they have since spread to a variety of disciplines, such as pharmacology, clinical research as a disease model, and most notably, drug development. Zebrafish have emerged as a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 1–8 Read article
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Evaluation of Drug Utilization Patterns and Prescription Trends in Patients with Hypothyroidism and Hyperthyroidism in a Tertiary Care Hospital
Abstract: Background: Endocrine disorders affecting the thyroid gland represent some of the most frequently encountered conditions globally, necessitating prolonged therapeutic intervention and vigilant clinical surveillance. The evaluation of Drug utilization patterns (DUE) serves an essential function in examining prescriptive behaviours and promoting appropriate pharmaceutical management. Objective: To evaluate drug utilization patterns, prescribing trends, and rationality of therapy in patients with hypothyroidism and hyperthyroidism. Methods: A prospective, cross-sectional observational investigation was performed …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 2, 2026 · pp. 1–5 Read article
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A Research Study and Report on Clinical Pharmacy Services Provided by Doctor of Pharmacy during their Clerkship and Internship Postings to a Tertiary care teaching Hospital.
Abstract: Clinical pharmacy is defined as the area of pharmacy concerned with the science and practice of rational medication use. Aim: The study aims at implementing clinical pharmacy services by Doctor of Pharmacy during clerkship and internship postings to patients at different wards of Rajiv Gandhi Institute of Medical Sciences. Objective: Prescription study and analysis and preventing the medication related problems adverse drug reactions drug interactions, over dose), performing drug utilization …
Published in Research and Reviews: A Journal of Medicine · Vol. 8, Issue 1, 2018 · pp. 27–32 Read article
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Exploring Pharmacological Mechanism Of Pteridines And Its Derivatives Against Neurodegenerative Disorders Using Network Pharmacology And Molecular Docking Techniques
Abstract: Objectives: Pteridines have been identified via various research and shown therapeutic efficacy in Neurodegenerative disorders(ND) preclinical models. In the current study, a network pharmacology technique was applied to determine the underlying mechanism of the pteridines' protective effects on ND. Network pharmacology was utilised in order to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 1–13 Read article
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Compulsory Licensing – The Effect on Generics, Patents and Drug-Development in Indian Pharma
Abstract: The objective of the present study was to analyse the effect of compulsory licensing (CL) on Generics, Patents and Drug-Development in India. This analytical study was carried out by collection of the data with respect to research questions. The data were collected from WTO, research articles, journals, ICMR and DCGI guidelines, Drugs and Cosmetics Act, WHO guidelines, TRIPS agreement, Indian Patents Act. The results revealed that expiry of three years …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 5, Issue 1, 2014 · pp. 1–13 Read article
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Anatomical Descriptive Research Studies on the Young and Old Stems of Urena lobata Linn
Abstract: Urena lobata Linn (usually known as Caesar weed), which has a place with the group of Malvaceae, is dispersed all over India. This spice is stuffing in nature and goes under the bush classification (60 to 100 cm long). The plant contains flavonoids and flavonoid glycosides like, alkanes, β-sitosterol and shame sterol. Different concentrates of the leaves and roots are utilized in natural medication to treat various afflictions, for example, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 7, Issue 3, 2020 · pp. 1–6 Read article
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Bacterial DNA Gyrase (Topoisomerase) Inhibitory Potentials of Heterocyclic Natural Products: Investigations through Induced-Fit Molecular Docking Approach
Abstract: The study exclusively focuses on the exploration towards the hidden potential of heterocyclic natural products against bacterial DNA gyrase (topoisomerase) through induced-fit docking (IFD) by utilizing the Glide module of Maestro 9.1 software. The study will open new doors for the antibacterial drug discovery by the inhibition of imperative biological target. Keywords: antibacterial, DNA gyrase, heterocyclic compound, molecular docking, natural product, topoisomeraseCite this ArticleTomy Muringayil Joseph, Debarshi Kar Mahapatra. Bacterial …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 7–9 Read article
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In Silico Analysis and Molecular Docking Studies of COX-2 Inhibitors for Anti-Inflammatory Activity
Abstract: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat pain, lower fevers, and control inflammation, they frequently cause gastrointestinal side effects because they inhibit the COX-1 and COX-2 enzymes. Despite their effectiveness and lack of gastrointestinal side effects, selective COX-2 inhibitors have been linked to cardiovascular risks. To find new COX-2 inhibitors that are safer and more effective, this study uses in silico techniques, such as molecular docking and …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 38–55 Read article
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Innovative 3D Printed Cell Scaffolds with Magnetized Nanocomposites for Targeted Cancer Therapy Drug Delivery
Abstract: In recent years, scaffolds have gained increasing attention in the field of tissue engineering, especially in cancer treatment. Nanocomposite scaffolds have emerged as promising candidates for delivering drugs to cancer cells. 3D printing technology has enabled the fabrication of customized scaffolds with precise pore size and complex geometries. This study explores the development of 3D printed scaffolds of nanostructured made of graphene oxide and Poly-Caprolactone (PCL) nanocomposites, which can be …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 48–55 Read article
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Comparative Study of Medicinal Properties of Indigenous Drugs from Species of Strychnos L. and its Scope in the Field of Homoeopathy- a Pilot Study
Abstract: AbstractPlant kingdom is a rich source of drug. Different medical systems prepare drug from plants and employ them according to their own pharmacological principles. Genus Strychnos L. belongs to Loganiaceae family and contains many active principles like brucine, strychnine, icajine, toxiferine, loganine, etc. Modern medicine and AYUSH use genus Strychnos L. to prepare drug against several disease conditions like ulcers, neurological disorders, skin diseases, parasitic infestations etc. Work has been …
Published in Research & Reviews : Journal of Botany · Vol. 9, Issue 1, 2020 Read article
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Development and Fabrication of Biohydrogel for Targeted Delivery of Delafloxacin for Bacterial Skin Infections
Abstract: The escalating challenge of bacterial resistance necessitates innovative drug delivery systems to enhance the efficacy of antibiotics. This study focuses on the development and optimization of a biohydrogel formulation for the targeted delivery of Delafloxacin, aiming to improve its therapeutic outcomes against resistant bacterial strains. Utilizing a 3² factorial design, biohydrogel formulations incorporating Poly(N-isopropylacrylamide) (PNIPAM) and Genipin were synthesized. The optimization process was guided by Design Expert software, focusing on …
Published in Research & Reviews: A Journal of Drug Design & Discovery Read article
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Prescription Opioid Use, Misuse and Motivation for Misuse among patients admitted in a drug treatment center
Abstract: Background: Opioid misuse remains a significant public health concern in Nigeria and globally. The risk of misuse complicates opioid prescriptions, potentially leading to overdose and fatal outcomes if not promptly addressed. Objectives: To determine the prevalence of prescription opioid use, misuse, and the underlying motivations for misuse. Method: This study utilized a retrospective cross-sectional design to examine the prevalence and patterns of prescription opioid use and misuse. Data were collected …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article
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Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants
Abstract: Candesartan cilexetil, a BCS class II drug with low aqueous solubility and poor bioavailability (15%), poses challenges for oral delivery. To address this limitation, the present study focuses on polymer-based inclusion complexation and composite formulation strategies to enhance solubility and dissolution behavior. The drug was incorporated into β-cyclodextrin (β-CD), a cyclic oligosaccharide polymer, by the kneading method in different drug-to-carrier ratios. Among these, the 1:1 molar ratio complex exhibited the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 687–695 Read article
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Exploring Biomedical Innovations in the Formulation and Assessment of Medicated Hard Candy Lozenges Containing Metoclopramide Hydrochloride
Abstract: The objective of this study was to formulate and evaluate metoclopramide hydrochloride medicated lozenges for antiemetic action through buccal absorption by incorporating a polymer. All formulations were developed and assessed for in-vitro drug release, physical appearance, weight variation, thickness, hardness, moisture content, mouth-dissolving time, and drug content. The prepared lozenges exhibited uniformity in weight and thickness. The hardness of all formulations ranged between 7.3–15.50 kg/cm², falling within standard limits. The …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 50–62 Read article
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An Insightful Study on SMEDDS Challenges and Potential Strategies
Abstract: Self-microemulsifying drug delivery systems (SMEDDS) have gained attention as an effective approach to enhance the bioavailability of poorly water-soluble drugs. They are innovative lipid-based formulations designed to enhance the solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs. The development of SMEDDS involves systematic selection of components based on solubility and emulsification efficiency, followed by optimization of ratios using pseudo-ternary phase diagrams. The resulting formulations are evaluated for droplet size, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 311–334 Read article