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34 articles for “Cytotoxicity”
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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A Comprehensive Review of Therapeutic and Pharmacological Potential of Karafs (Apium graveolens)
Abstract: The history of the medicinal properties of plants and their use in various ailments is as old as the history of mankind. Karafs (Apium graveolens) is one of the important plants among them, belonging to the family Apiaceae/Umbelliferae. Its use in various ailments has been documented in Unani classical literature in detail. Every part of Karafs possesses wonderful medicinal properties. A series of studies conducted to evaluate its medicinal uses …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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Review on Unveiling the Shadow of Hyperpigmentation
Abstract: Natural products offer promising solutions for treating skin pigmentation disorders due to their non-toxic properties and effective mechanisms of action. Studies highlight their safety and efficacy through methods such as cytotoxicity tests, tyrosinase activity assays, and melanogenesis inhibition evaluations. Advanced delivery systems like liposomes and nanoparticles further enhance their performance by improving solubility and skin penetration. Skin pigmentation disorders, influenced by factors such as UV radiation, hormonal changes, and inflammation, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 59–66 Read article
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Engineered Polymer Composites for Non-Surgical Lip Posture Correction in Facial Paralysis
Abstract: Facial paralysis presents significant functional and aesthetic challenges, particularly through lip posture deficits such as drooping and drooling, often inadequately addressed by traditional surgical or drug-based interventions, especially in debilitated patients. This study explores the application of engineered polymer composites in a novel, non-surgical lip posture corrector designed to statically suspend and correct lip position without requiring surgical or dental support. The device utilizes a precisely formulated blend of polymethylmethacrylate …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Phytochemical Screening and Biological Activity of Pomegranate Extracts
Abstract: Pomegranates are renowned for their abundance of bioactive compounds that exhibit potent antioxidant, anti-inflammatory, and antimicrobial properties, making them a subject of growing interest in natural medicine. This study aimed to compare the biological activities of ethanolic extracts derived from different parts of the pomegranate plant—specifically, the bark, peel, and leaves. A comprehensive investigation was conducted to evaluate their phytochemical composition and assess their antimicrobial, antioxidant, and anticancer properties. The …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 64–79 Read article
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Predictive Modeling of Polymer Composites for Medical Implants Using Artificial Intelligence Techniques
Abstract: The use of polymers in biomaterials was now key to designing the next generation of medical implants, which need to be strong and also compatible with living tissue. Tests for biocompatibility, such as those done in the laboratory and by doing experiments on animals, require much time and many resources, so the need for computer-based approaches becomes clear. An artificial intelligence approach was provided in this study to determine how …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 665–692 Read article
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Comprehensive Review of Adenoid Cystic Carcinoma: Pathogenesis, Diagnosis, and Emerging Therapeutic Approaches
Abstract: Adenoid cystic carcinoma (ACC)is an infrequent neoplasm, highly malignant, that develops mainly in the salivary glands with the potential to exist in any secretory glandular sites, including the lacrimal glands, breast, and respiratory tract. ACC usually has a benign initial course, but conversely, it is notoriously aggressive in behavior with high incidence of perineural invasion, local recurrence, and distant metastasis, mostly to the lungs. The tumor’s molecular features are characterized …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–17 Read article
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Synthesis, Characterization, Antibacterial Evaluation and Study of Organic Separation Behavior for Five Membered Ring for Pyridine Derivatives
Abstract: Imidazoles can be prepared by condensation between amines and various aldehydes and ketones. Imidazole derivatives are important compounds due to their broad biological activity and pharmacological properties, such as antifungal, antioxidant, cytotoxic, anti-inflammatory, analgesic, anti-YFV (yellow fever virus), anti-tuberculosis, and antimicrobial activity. In recent years, many studies have been conducted on the preparation of biological imidazole derivatives, especially derivatives linked to heterogeneous rings containing nitrogen or any other donor atom. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 106–121 Read article
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Comprehensive Review of Kojic Acid and Its Derivatives: Biological Activities, Safety, and Therapeutic Potential in Depigmentation
Abstract: There are several uses for kojic acid in human medicine, particularly in depigmentation. Additionally, derivatives of it are suggested to enhance efficacy, avoid side effects, and stop chemical degradation. With an eye toward human use and an attempt to clarify the action mechanisms, the goal of this study was to review the most recent scientific literature regarding the biological activities and safety information of kojic acid or its derivatives. During …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 45–53 Read article
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Histological Effects of the Antibiotic Gentamicin on the Ovarian Tissue of Female White Laboratory Rats
Abstract: This study aimed to evaluate the histological alterations induced by Gentamicin in the ovarian tissue of white laboratory rats. A total of 12 adult female rats were used and randomly divided into two groups, with each group consisting of six animals. The experimental group received Gentamicin at a dose of 120 mg/kg body weight administered as an injection once daily, while the control group received an equivalent volume of normal …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article
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Cytogenotoxicity Assessment of Asphalt Plant Discharge Water using Plant Assay
Abstract: The Allium cepa assay test was used to evaluate cytogenotoxic effects of asphalt plant discharge water at the concentrations of 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100% (v/v) asphalt plant discharge water/distilled water. The distilled water served as the negative control. The analysis of the physicochemical properties and heavy metals concentrations showed that most parameters were higher than the established standards of WHO and FMENV. The …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 3, 2025 · pp. 100–110 Read article
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Spin Coated Polyvinylidene Difluoride / Ionic Liquid Nanocomposite Thin Films with Enhanced Dielectric and Piezoelectric Properties
Abstract: This study introduces a novel approach to enhance the piezoelectric and dielectric properties of polyvinylidene difluoride (PVDF) by incorporating 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF₄]) ionic liquid via a spin-coating method— a processing route that has been rarely reported for PVDF/ionic liquid composites. Structural and morphological analyses using X-ray diffraction (XRD), Raman spectroscopy, Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) confirm the successful integration of [BMIM][BF₄] into the PVDF matrix. The …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1190–1204 Read article
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Valorization of Human and Cattle Dental Waste into Functional Composite Biomaterials: A Detailed Comparative Analysis
Abstract: This study investigates the conversion of human and cattle (goat and cow) teeth into bioactive hydroxyapatite-based composites and presents a detailed comparative evaluation of these biogenic materials with laboratory-synthesised (synthetic) hydroxyapatite (HAp). In this work, hydroxyapatite was extracted from human and bovine teeth through controlled calcination and milling, while synthetic HAp was prepared using a standard wet chemical precipitation route. All materials were subsequently sintered at 900 °C and fabricated …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 340–354 Read article
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Solanum viarum Dunal: Ethnomedicinal Importance, Phytochemical Profile and Pharmacological Potential — A Comprehensive Review
Abstract: Solanum viarum Dunal, commonly known as tropical soda apple or Sodom apple, is a medicinally important plant belonging to the family Solanaceae. The plant has been widely utilized in traditional medicine systems for the treatment of fever, cough, skin disorders, inflammation, gastrointestinal ailments, and microbial infections. The present review comprehensively summarizes the ethnomedicinal importance, phytochemical profile, pharmacological activities, and pharmaceutical significance of S. viarum. Literature reports indicate that the plant …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 3, 2026 Read article