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32 articles for “Autoimmune disease”
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Psoriasis: Latest Trends in Treatment, Diagnosis and Management in Medical Science
Abstract: Psoriasis is a common chronic inflammatory and autoimmune skin disease that primarily affects the skin. It affects about 2–4% of the world populations. It is clinically characterized by skin rashes, highly inflamed red scale itchy plaque. Abundant therapeutic agents are accessible for the treatment of psoriasis. Wide range of therapeutic mediators such as coal tar, topical corticosteroids, anthralin, retinoid, calcineurin inhibitors, methotrexate, cyclosporine are proven to be effective in treating …
Published in Research and Reviews : A Journal of Biotechnology Read article
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Role and impact of Dietary Antioxidants on Aging and Lifespan: A Review
Abstract: The effect of an antioxidant-rich diet on aging and lifespan has attracted significant scientific attention, primarily through the lens of the free radical theory of aging (FRTA). This theory suggests that oxidative stress caused by an accumulation of reactive oxygen species (ROS), accelerates aging and contributes to cellular damage. The accumulation of free radicals and the oxidative damage that is induced significantly contribute to the aging process. This imbalance plays …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 2, 2025 · pp. 60–70 Read article
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Assessment of Vitamin D Levels Among Hashimoto and Hypothyroidism Disease in Iraq, A Comparative Study
Abstract: The thyroid gland is a small gland that regulates the body’s metabolism. It secretes the hormones that the body needs to maintain this process. People of different ages may be afflicted with thyroid diseases, including Hashimoto disease and hypothyroidism. The current study aimed to compare the levels of vitamin D among patients with Hashimoto’s disease and hypothyroidism coming to the Diabetes and Endocrinology Center in Al-Sadr Medical City in Najaf …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 77–83 Read article
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Multiple Sclerosis: A Brief Overview of the Disease, Its Pharmacotherapy
Abstract: Multiple Sclerosis is an autoimmune disorder mostly affecting individuals aged between 20-40. In this disorder, the optic, vertebral, and central nervous system nerves are primarily impacted. It is a neurological condition that worsens over time and is characterized by inflammation and the breakdown of the sheath that surrounds and shields the nerve fiber. Common symptoms may include muscle weakness, numbness, tingling, fatigue, vertigo, tremor, vision complications, pain, Lhermitte sign, sexual …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 13–18 Read article
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Immunological Mechanisms Underlying Autoimmune Disorders: Recent Advances and Therapeutic Implications
Abstract: A diverse range of illnesses known as autoimmune disorders are typified by dysregulated immune responses against self-antigens, which result in tissue damage and persistent inflammation. Understanding the genetic, epigenetic, and environmental variables that contribute to autoimmune pathogenesis has advanced significantly during the last ten years. Current disease models have been transformed by new understandings of immunological tolerance mechanisms such as the functions of regulatory T cells, cytokine networks, and the …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 21–25 Read article
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Association of Vitamin D Binding Protein BP rs2282679 Gene Polymorphism and Serum Levels of Vitamin D in Patients with Vitiligo
Abstract: For vitamin D to have an impact, the vitamin D receptor (VDR) must be expressed and activated in the nucleus. The VDR has several known genetic variants. Biological impacts can be caused by changes in DNA sequences known as "polymorphisms" that are common in the population. Vitiligo is a disease that causes loss of skin color in patches, and it is a chronic (long-lasting) autoimmune disorder loss of color. The …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 45–52 Read article
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Nutritional Influence on Gut Health and Immune Function: An Integrative Perspective
Abstract: The study of nutrition, gut health, and immune function is fast changing and has major implications for disease prevention and management. A varied microbiome in the gut regulates immune responses. A balanced diet with fiber, polyphenols, and important nutrients maintains a healthy gut flora, which regulates immune function and inflammation. Dysbiosis, an imbalance in the gut microbiota, is connected to autoimmune, allergic, and inflammatory bowel illnesses. New research reveals that …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 2, 2025 · pp. 30–44 Read article
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Rheumatoid Arthritis and Stem Cell Therapies Perspectives for It
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by systemic inflammation, primarily affecting synovial joints, leading to joint destruction and systemic complications. The pathogenesis involves immune system dysregulation, autoantibody production, and enzymatic imbalances. Enzymes, including matrix metalloproteinases (MMPs), serine proteases, and kinases, play crucial roles in these processes. Their dysregulation contributes significantly to disease progression through the imbalance of pro-inflammatory cytokines, oxidative stress, and extracellular matrix (ECM) degradation. MMPs, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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Targeting TNFSF4 in the Management of Systemic Lupus Erythematosus
Abstract: Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder that remains a significant challenge for both healthcare providers and researchers. Despite advances in understanding its mechanisms, finding effective therapies is still difficult. This review highlights a potential therapeutic target in SLE research: tumor necrosis factor superfamily member 4 (TNFSF4), also referred to as OX40L. We explore how TNFSF4 contributes to SLE development, looking at its role in immune system regulation …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 3, 2024 · pp. 6–14 Read article
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Treatment of Hepatotoxicity
Abstract: An instantaneous or prolonged response to a synthetic or natural substance is known as drug-induced liver injury, or drug-induced hepatotoxicity (DILI). There are two distinct pathways that lead to hepatotoxicity: the more unpredictable idiosyncratic mechanism and the dose-dependent intrinsic mechanism. Several pathways, some known and others speculated, may be involved in the emergence of drug-induced damage. Drug-induced liver impairment can have several causes, and elevated liver tests are one of …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 1, 2025 · pp. 31–37 Read article
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The Effects of Steroids on One’s Health
Abstract: The widespread use of steroids for both medicinal and non-medical purposes is a significant issue in contemporary culture. This article examines the considerable impact of steroids on human health, focusing on the therapeutic benefits and the adverse side effects associated with their consumption. In the treatment of conditions, such as inflammation, autoimmune disorders, and hormone imbalances, steroids, are frequently prescribed, providing significant relief from symptoms. However, the abuse of these …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 47–63 Read article