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55 articles for “Alpha”
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Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
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Flaxseed and Diabetes Management: A Comprehensive Review of Recent Studies and Potential Mechanisms
Abstract: Diabetes mellitus, a condition characterized by chronic hyperglycemia, has become a significant global health challenge, leading to substantial morbidity and mortality rates. Dietary techniques are crucial for the effective control of diabetes, including both pharmaceutical and non-pharmacological therapies. Flaxseed (Linum usitatissimum) is one of the functional foods that has attracted a lot of interest because of its abundance of bioactive components, including lignans, dietary fiber, and alpha-linolenic acid (ALA). The …
Published in International Journal of Nutritions · Vol. 2, Issue 1, 2025 · pp. 24–32 Read article
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Strategy to Accelerate the Biopharmaceuticals Production Using Komogataella phaffii (Pichia pastoris)
Abstract: Revenue generation has been the primary goals for nations as well as the industries worldwide. Biopharmaceutical verticals have become potential revenue generators as they are the industrial workhorses and the economic engines that drive the upcoming biopharmaceutical industries with advances in DNA recombinant technology. A breakthrough in the indusrial biotechnology for the production of biopharmaceuticals using Pichia pastoris is awaited. Ablynx NV, Recombinant proteins (RP), HSA-pFSH beta, antibodies, borosin, N-glycoprotein, …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
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Targeting PTPN22 in Arthritis: Molecular Docking and Pharmacokinetic Evaluation of Artemisia vestita Compounds
Abstract: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by inflammation of the synovial membrane, commonly resulting in swelling, pain, stiffness, and overall fatigue. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been identified as a risk factor linked to various autoimmune diseases, including RA. In the PTPN22 gene, two missense Single nucleotide polymorphisms (SNPs) are associated with autoimmune conditions. The R620W (C1858T, rs247660) variant in exon 14 has been …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 20–31 Read article
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Assessing the impact of lifestyle factors on autoimmune risk and survival outcomes: A Population-based Study
Abstract: This study investigated the interplay between lifestyle factors and genetic regulation in autoimmune diseases, focusing on the role of human T-cell metabolic and proliferative control through C-REL gene transcription. This study combined CRISPR-Cas9 manipulation of C-REL in human T-cells with a longitudinal cohort of 100 adults (autoimmune patients and controls), investigating metabolic and proliferation dynamics via flow cytometry and assays. It assessed lifestyle impacts through surveys and medical records, ensuring …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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Effect of Steam Flash Explosion Conditions on Preparation of Reed Pulp
Abstract: The effects of different steam explosion conditions on preparation of reed pulp by steam flash explosion were analyzed. Because the main factors affecting steam explosion are steam pressure, retention time and liquid-to-reed ratio, so that the effects of these conditions on the steam explosion pretreated reed straw, and constituent of reed pulp were analyzed. Reed straw samples, 2~3cm in length, were loaded into a 5L stainless steel reactor and treated …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 115–128 Read article
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Quantitative Mass Balance Modelling for the Synthesis and Production of Ten High-Volume Insecticides
Abstract: This study presents a detailed quantitative mass balance analysis for the industrial synthesis and production of ten high-volume insecticides: acequinocyl, acetamiprid, acynonapyr, alpha-cypermethrin, benzpyrimoxan, bifenazate, bifenthrin, bistrifluron, broflanilide, and bromofos, focusing on material flows, process efficiencies, and environmental implications. These compounds, spanning diverse chemical classes like neonicotinoids, pyrethroids, and meta-diamides, are essential for crop protection but pose challenges due to resource-intensive syntheses and waste generation. For each insecticide, standardized manufacturing …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 3, 2025 · pp. 36–55 Read article
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In Silico Screening and Molecular Docking of Cynodon dactylon phytochemicals against COPD-Associated Proteins
Abstract: Chronic Obstructive Pulmonary Disease or COPD is a pulmonary disease that obstructs airways and alveoli accompanied by respiratory issues like emphysema and bronchitis. This disease is caused mainly by inflammatory responses of the body to foreign particles that enter the respiratory path including tobacco smoke, air pollutants and irritants. The hallmark of COPD is excessive inflammation caused by imbalance in protease anti-protease activity. Proteases like elastase breakdown the ECM of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Machine Learning in Nuclear Medical Applications: A Review of Research Frontiers
Abstract: Nuclear medicine, encompassing PET, SPECT, and targeted radionuclide therapy, generates high-dimensional, quantitative data uniquely suited for machine learning (ML) analysis. This review synthesizes current research applications of ML across six key domains. Positron emission tomography (PET), single-photon emission computed tomography (SPECT), and targeted radionuclide therapy are examples of nuclear medicine modalities that generate high- dimensional, quantitative datasets that are particularly well-suited for machine learning (ML)-driven analysis. These imaging methods provide …
Published in Journal of Nuclear Engineering & Technology · Vol. 16, Issue 1, 2026 · pp. 19–24 Read article
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Consumer Misuse of Cosmeceuticals and Its Role in Adverse Skin Reactions
Abstract: Cosmeceuticals represent a rapidly expanding category of products positioned between cosmetics and pharmaceuticals, offering both aesthetic and therapeutic benefits. However, their widespread availability, aggressive marketing, and perception as inherently safe have contributed to increasing instances of consumer misuse. Misuse includes over-application, inappropriate combinations, prolonged unsupervised use, and use of high-potency active ingredients without dermatological guidance. Such practices have been strongly associated with a broad spectrum of adverse cutaneous reactions ranging …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 2, 2026 · pp. 1–16 Read article
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In Silico Screening and Evaluation of Some Metabolites from Momordica charantia in the Treatment of Peptic Ulcers
Abstract: Peptic ulcers are also called as or duodenal ulcers or gastric ulcers that are open sores generally develop in the lining of the stomach due to food and climatic factors. H. pylori infections are potentially the most dangerous and are linked to several diseases like diabetes, cancer, cardiovascular diseases, etc. In the present study, in silico screening and evaluation of some metabolites from Momordica charantia like Momorcharin, Momordicin, Metformin, Pioglitazone, …
Published in Research and Reviews : Journal of Computational Biology Read article
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Study of Cost Overrun in Repair & Rehabilitation Projects in India
Abstract: In broad sense, the word "rehabilitation" suggested putting a building back to how it was before. The specialized area of repair and rehabilitation engineering necessitates knowledge and skills that go beyond those needed for design and construction engineering. Repair and rehabilitation projects are significantly more challenging and more complicated than new construction projects. It is vital to take a methodical approach to structural deterioration, and technology management and economics should …
Published in International Journal of Architectural Design and Planning Read article
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Hand Gesture Recognition Systems: A Review of Vision-based and Sensor-based Approaches
Abstract: With many real-world uses, such as sign language translation and human-computer interaction, hand gesture detection is a crucial area of study in the science of computer vision. In this study, we propose a Convolutional Neural Network (CNN) model that uses real-time camera images to recognise hand gestures. A collection of hand motion photographs spanning the English alphabet (A-Z) was gathered, and the images were pre-processed to exclude any backdrop and …
Published in International Journal of Optical Innovations & Research · Vol. 1, Issue 1, 2023 · pp. 15–20 Read article
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Advancements in Reinforcement Learning: A Comprehensive Analysis of Algorithms, Applications, and Future Directions in Artificial Intelligence
Abstract: This work provides an overview of Reinforcement Learning (RL), an important field of artificial intelligence (AI) aims to provide the long-term benefits by learning a relating with a given environment. It spells out everything, what agents and environments do, to how rewards, states, and behaviours. It spent lot of time on looking the most usable RL algorithms, like DQN, SARSA, and Q-Learning. These studies provide a clear view of RL. …
Published in E-Commerce for Future & Trends · Vol. 11, Issue 1, 2024 · pp. 17–22 Read article
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Rheological behaviour analysis of prepared nano-cutting fluids from Al2O3 and TiO2
Abstract: In this research paper, an attempt has been made to characterize and analyse the rheological properties of two samples of nano-cutting fluids. Nanoparticles of Al2O3 and TiO2 were characterized by SEM and EDS. The high peaks showed the respective presence of aluminium, oxygen for alumina and titanium and oxygen for titanium dioxide. The two samples of nano-cutting fluids were prepared. Alpha alumina, α-Al2O3 nanoparticles were used for the preparation of …
Published in Journal of Polymer & Composites · Vol. 12, Issue 1, 2024 · pp. 329–338 Read article
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Relationship Between Mental Health, Competitive Aggression and Anger Rumination with Regard to the Role of Mental Health of Martial Arts Athletes in Gilan Province
Abstract: Due to the phenomenon of championship in sports, athletes are always very thirsty to achieve the championship and go on the podium, and this factor can cause negative behaviors by athletes, one of which is competitive aggression. Therefore, the main purpose of this study is to investigate the relationship between mental health, competitive aggression and anger rumination with regard to the role of mental health of martial artists in Gilan …
Published in Recent Trends in Sports · Vol. 1, Issue 1, 2024 · pp. 1–10 Read article
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Global Burden of Major Depressive Disorder: Prevalence, Diagnosis, and Impact: A Comprehensive review
Abstract: In this review, we will discuss about the major depressive disorders on the basis of neurobiological changes. MDD, a prevalent psychiatric condition, manifests as a complex interplay of genetic, environmental, and physiological factors with a substantial impact on individuals and societies globally. Here the clinical assessment is fully based on diagnosis and the statistical manual for mental disorder, 5th edition (DSM-5). The pathophysiology involves Diagnosis alterations in neurotransmitter systems, dysregulation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 54–62 Read article
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An in-silico toxicity study of the phytocompounds found in Pongamia pinnata leaves using the ProTox-II web server
Abstract: The aim of the current study was to determine the Insilco toxicity of the phytocompound present in the leaves of Pongamia pinnata. The leaves of Pongamia pinnata have long been used in traditional medicine for their therapeutic properties. Nowadays, herbal toxicity is a common problem caused by incorrect dosage. The FDA reviews the safety and effectiveness of herbal products only in response to patient or health care provider complaints—problems with …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 1, 2024 Read article
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Integrating Deep Learning and Computer Vision for Recognizing American Sign Language
Abstract: The only way the hearing-impaired community can exchange ideas is by utilizing non-verbal communication. The main challenge, however, is that the non-impaired community, which may not comprehend non-verbal communication, would struggle to communicate effectively with this group, and vice versa. The project is purposely devised to admit unwilling and dumb societies to transport ideas and connect with the organization. It aims to bridge the gap between the hearing- and speech-impaired …
Published in Current Trends in Information Technology · Vol. 14, Issue 3, 2024 · pp. 10–17 Read article
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The Regulatory Role of Food Spices Against Lipid Peroxidation in Meat Products
Abstract: Spices are plant-based materials used for enhancing the flavor, taste and aroma of meat and have been employed in cooking and meat processing for many decade. Interestingly, some of these spices have found relevance in meat preservation as they not only enhance the flavor and taste of meat product but can also reduce meat spoilage. One of the major causes of meat spoilage outside those induced by microbes is Lipid …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 13, Issue 3, 2024 · pp. 21–25 Read article