Search
423 articles for “3-D”
-
In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
-
Investigating The Alkalizing Potential of Chandanasava For Restoring Acid-Base Homeostasis in Renal Tubular Acidosis: A Computational and In Silico Pharmacological Study
Abstract: Chandanasava, a traditional Ayurvedic formulation, is recognized for its potential alkalizing properties, which may help restore acid-base homeostasis in conditions such as renal tubular acidosis (RTA). This study aims to investigate the active components of Chandanasava and their interactions with key renal target proteins, Pendrin and Carbonic Anhydrase II, which are essential for maintaining acid-base balance. An in silico approach was utilized to explore the pharmacological potential of the phytochemicals …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 28–52 Read article
-
Optimization of Process Parameters for AISI 304 Using Micro-EDM Drilling Process Through Response Surface Method
Abstract: The increasing demand for micro-parts in high-tech products, such as micro-electromechanical systems (MEMS) applications and micro-electronic devices, has driven significant advancements in micromachining technologies. Among the various micromachining processes, the fabrication of accurate microholes and pins is critical for the performance and reliability of miniature components. Micro-hole drilling plays a vital role by enabling the production of deep holes with excellent straightness, roundness, and surface quality. It is widely used …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 1, 2025 · pp. 37–47 Read article
-
Bioremediation of TPH in Petroleum HydrocarbonContaminated Clay Soil with an Emerging Nutrient (Solpawa SBR-X TM)
Abstract: This research focuses on the bioremediation of total petroleum hydrocarbons (TPH) in petroleum hydrocarbon contaminated clay soil with an emerging nutrient (Solpawa SBR-XTM). A laboratory experiment was set up and successfully carried out in order to monitor TPH concentration among the various reactors (T1, T2, T3, and T4). This process was monitored for 7 days, 12 days, 22 days, 32 days, 42 days, and 52 days, respectively, for reactors 1, …
Published in International Journal of Pollution: Prevention & Control · Vol. 1, Issue 1, 2023 · pp. 9–16 Read article
-
Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
-
A study to assess the effect of nutritional supplementation on the hemoglobin level and the associated signs and symptoms of the students identified with anaemia in selected colleges of SNDT Womens’ University Mumbai
Abstract: The purpose of this study was to assess the effects of nutritional supplements on haemoglobin levels and related symptoms among students at SNDT Women's University in Mumbai who had been diagnosed with anaemia in a few particular institutions. Non-occurrence A sample of thirty anaemic students was selected via easy sampling. With a one-group pre-test-post-test methodology, the study used a descriptive evaluative design. Data collecting instruments included measurement devices, opinion questionnaires, …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 16–25 Read article
-
Molecular Docking Studies of Nyctanthes arbor-tristis Phytochemicals for Targeting TNF Receptor in Arthritis
Abstract: Rheumatoid Arthritis is an autoimmune disorder which results in inflammation. Tumor necrosis factor-alpha (TNF-α) is responsible for the progression of inflammatory arthritis by promoting immune cell activation and cytokine release. The present study explores the potential of bioactive compounds derived from Nyctanthes arbor-tristis (Parijat) in modulating TNF receptor activity through molecular docking. Computational methods were employed to evaluate the binding affinity of selected phytocompounds from N. arbor-tristis against the extracellular …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 11–21 Read article
-
Climate variability analysis over the state of Himachal Pradesh, India
Abstract: Longterm daily temperature and rainfall data (2000–2024) for thirty-five locations ranging from ~350 to >4000 m amsl were obtained from the NASA POWER database. The variability and trends in maximum, minimum temperature and rainfall were worked out by using different statistical tools and Mann-Kendal test trend analysis. The mean annual maximum temperature of the state was 20.3°C (CV = 3.9%), declining from 27.4°C in the low hills to 7.2°C at …
Published in International Journal of Climate Conditions · Vol. 3, Issue 1, 2026 · pp. 51–64 Read article
-
Use of NMR and Other Spectroscopy Techniques in Heterocyclic Oxadiazole Derivatives Studies: A Review
Abstract: It was possible to create a number of novel symmetrical 2,5-dialkyl-1,3,4-oxadiazoles with substituents including carboxymethylamino, isopropyloxycarbonylmethylamino, and bromine at the terminal positions of the alkyl groups. The multistep process that was devised used hydrazine hydrate, phosphorus oxychloride, and commercially available acid chlorides that varied in alkyl chain length and terminal substituent.Diisopropyliminodiacetate was an easy way to substitute the intermediate bromine-containing 2,5-dialkyl-1,3,4-oxadiazoles. This was followed by hydrolysis in an aqueous methanol …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 07–13 Read article
-
Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
-
Harnessing the Potential of Insectivorous Birds in Managing the Rice Leaf Folder, Cnaphalocrocis Medinalis in Paddy Ecosystems of Kerala
Abstract: This study evaluates the effectiveness of various treatments for managing leaf folder pests in rice crops during the maximum tillering stage, focusing on the role of insectivorous birds. The treatments included bird perches (T1), nylon nets (T2), Bt spray (T3), a combination of bird perch and Bt spray (T4), flubendiamide spray (T5), and a control group (T6). Results indicated significant differences in pest densities. T2 showed the highest mean density …
Published in International Journal of Insects · Vol. 1, Issue 2, 2024 · pp. 6–9 Read article
-
Efficient Fault Detection in Power Transmission: A Review of Three-Phase Line Fault Detection with Hybrid Energy using MATLAB
Abstract: In urban regions, the density of power demand has significantly increased recently. Large-scale subterranean power cable installations are beginning to take the place of overhead transmission lines everywhere in the world because of environmental concerns in highly populated areas. The present project's primary objective is to use MATLAB to create a simulation model that includes 3ph symmetrical and unsymmetrical defects. Some have proven to be effective in detecting errors while …
Published in International Journal of Electrical Power and Machine Systems · Vol. 1, Issue 1, 2023 · pp. 42–47 Read article
-
Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
-
Knowledge and Perception of the Ill Effects of Cosmetics Among Late Adolescent Girls
Abstract: The current research focused on examining the knowledge and attitude towards the negative effects of cosmetics among late adolescent girls studying at DM WIMS Pharmacy College in Meppadi, Wayanad. The study aimed to evaluate the level of knowledge and attitude toward the harmful effects of cosmetics among these girls and explore any potential associations between their knowledge, attitude and selected socio-demographic variables. To conduct the study, a quantitative approach using …
Published in International Journal of Women's Health Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 15–20 Read article
-
The Effect of Rare Earth (RE) Metal Doping of Zno, On Magnetic and Optical Properties of Zno Crystals Structure
Abstract: The magnetic and optical properties of magnetic semiconductors relays on the crystal structure, type and amount of dopant ions, and particle size. Then, the effect of rare earth metal (Dy, Eu, and La) doping on crystal structures, magnetic properties and optical properties are seen. It is revealed that the optical band gap of ZnO decrease down from 3.37eV up on doping with RE metals. Then, the Hamiltonian of the system …
Published in International Journal of Crystalline Materials · Vol. 2, Issue 2, 2025 · pp. 28–40 Read article
-
Effectiveness of A structured teaching program on Leucorrhoea and it's management for women of Reproductive age group at selected college in Honavar
Abstract: Leucorrhea, also known as leucorrhea, is a white, yellow, or green discharge from a woman's vagina, which may be normal or asign of an infection. Leucorrhea is common during pregnancy and is typically normal if the discharge is thin, white, and odorless.Physiological leucorrhea is a condition that occurs in young women several months to a year after the onset of menstruation. It sometimes occurs in newborn girls and usually lasts …
Published in International Journal of Women's Health Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 40–44 Read article
-
Comparative Study on the Growth and Yield of Ganoderma lucidium Mushroom Cultivated on African Peach (Nauclea diderrichii) and Bush Mango (Endospermum medullosum) Sawdust as Substrates
Abstract: This study was conducted to find out which substrate provides for the best artificial development of G. lucidium. Mango (Mangifera indica) leaves were added to the saw dusts of Nauclea diderrichii and Endospermum medullosum, which were both utilized as substrates for growing. The substrates were inoculated with Ganoderma spawn and then exposed and hydrated to start the fruiting process. Three replications of the process were carried out. It was observed …
Published in International Journal of Fungi · Vol. 2, Issue 1, 2025 · pp. 39–45 Read article
-
Multi-Sensor System for Underwater Pothole Detection to Enhance Road Safety During Monsoon Seasons
Abstract: Monsoon seasons across India and similar tropical regions severely compromise road safety by causing water accumulation that conceals dangerous potholes beneath stagnant pools, leading to frequent vehicle damage, tire punctures, and fatal accidents. Traditional detection methods relying on smartphone accelerometers, ultrasonic sensors, or machine vision fail under flooded conditions due to acoustic signal reflection at water surfaces and optical distortions from glare and turbidity. This research proposes an innovative multi-sensor …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 4, Issue 1, 2026 · pp. 25–32 Read article
-
Revolutionizing Artificial Organs: Next-Generation Membrane Technologies for Precision Medicine and Global Health
Abstract: Membrane technology has emerged as a cornerstone in the advancement of artificial organ systems, offering critical functionalities in selective molecular filtration, tissue scaffolding, and controlled therapeutic delivery. Recent innovations have propelled the field beyond traditional polymeric membranes to include nanostructured, biomimetic, and stimuli-responsive materials, significantly enhancing biocompatibility, selectivity, and durability. The integration of smart technologies, such as AI-driven membrane design, bioelectronic sensors, and personalized fabrication via 3D printing, is ushering …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 29–39 Read article
-
A Study to Assess the Knowledge and Practice of Self-Care Management Among Post-Operative Orthopaedic Patients in Selected Hospitals at K.G.F
Abstract: This study aimed to assess the level of knowledge and practice regarding self-care management among post-operative orthopedic patients using a non-experimental descriptive research design. A total of 60 post-operative orthopedic patients were selected through purposive sampling from a hospital in Kolar Gold Fields. Data were collected using a standardized checklist developed by Printz, Foster Kent, O’Leary, Robin, and Foster (1989), followed by an assessment of patients’ knowledge and practice related …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 1–6 Read article