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837 articles for “Clinical”
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Quantitative Image-Based Assessment of Degradation Patterns in Polymer-Based Medical Implants
Abstract: Polymer-based medical devices are widely used in clinical practice, where long-term material degradation can compromise performance and patient safety. Traditional polymer degradation studies predominantly rely on laboratory-based experiments, which often fail to capture real-world operational and usage conditions. In this study, a multimodal, data-driven framework is proposed for the quantitative assessment of degradation patterns in polymer-based medical devices using publicly available clinical failure data. Structured operational parameters, including cumulative usage …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1510–1518 Read article
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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The Early Brain Hemorrhage Prediction System Using Machine Learning
Abstract: Brain hemorrhage is a critical medical emergency that requires immediate attention, as delays in diagnosis can result in severe neurological damage or death. The condition involves bleeding within or around brain tissues, leading to increased intracranial pressure and disruption of normal brain function. Although imaging techniques such as CT scans and MRI provide accurate diagnosis, their availability is limited in emergency and rural settings. In recent years, machine learning has …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 2, 2026 Read article
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A Cross-sectional Study to Analyse Level of Stress among Nursing Students of Christ College of Nursing, Jagdalpur, Chhattisgarh
Abstract: Nursing education combines rigorous academic training with demanding clinical responsibilities, exposing students to multiple stressors that may affect their psychological well-being, academic performance, and professional growth. Assessing stress levels and their association with socio-demographic variables is essential for developing effective support strategies. This study aimed to assess the level of stress among nursing students and determine its association with selected socio-demographic characteristics. A descriptive cross-sectional study was conducted among 150 …
Published in Journal of Nursing Science & Practice · Vol. 16, Issue 1, 2026 · pp. 1–10 Read article
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Photonic Diagnostics: Harnessing Optical Sensing for Non-Invasive Assessment of Coronary Obstruction
Abstract: Cardiovascular diseases (CVDs) remain the leading cause of mortality globally, with coronary artery blockages primarily atherosclerosis representing a critical challenge. The gold standard for diagnosing coronary artery disease remains invasive coronary angiography, a procedure that, while precise, carries inherent patient risks, high costs, and logistical burdens. Optical sensors, leveraging the principles of light-tissue interaction, offer real-time, high-resolution insights into vascular health, paving the way for early detection of arterial stenoses …
Published in International Journal of Optical Innovations & Research · Vol. 4, Issue 1, 2026 · pp. 25–30 Read article
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Recent Advancements in Nanobiocomposite-Based Wound Healing and Tissue Regeneration
Abstract: Haemostasis, inflammation, proliferation, remodeling, and other highly coordinated cellular and molecular activities are all part of the complex biological processes of wound healing and tissue regeneration. Following an injury, these stages cooperate to restore tissue integrity and function. However, this normal process is disturbed in many clinical circumstances, especially chronic wounds such diabetic ulcers, burns, and pressure sores. Prolonged inflammation, chronic microbial infection, diminished angiogenesis, and impaired extracellular matrix production …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 297–318 Read article
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Physicochemical Transitions and Polymerization Dynamics in Multi-Generational Dentin Adhesives: A Critical Review of the Resin-Dentin Composite Interface
Abstract: Adhesive dentistry has undergone a transformative refinement over the past three decades, transitioning from technique-sensitive, multi-step etch-and-rinse protocols to streamlined universal formulations. This narrative review critically synthesizes evidence from thirty peer-reviewed investigations to evaluate the evolution of dentin bonding agents from the fourth through the eighth generations. The analysis places particular emphasis on the physicochemical dynamics of the resin-dentin interface, including interfacial bond strength metrics, marginal integrity, and microleakage behavior. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 209–228 Read article
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Assessment of Polycystic Ovarian Syndrome with Emphasis on Imaging Modalities
Abstract: Polycystic Ovarian Syndrome (PCOS) is a higly prevalent hormonal disorder that affects women during their reproductive age. It is linked to a wide range of health concerns ,including disturbances in reproductive functions, metabolic abnormalities and an increased risk of cardiovascular diseases. Ultrasonography plays a crucial role in identifying polycystic ovarian morphology, which constitutes one of the key diagnostic criteria under the Rotterdam consensus. This prospective cross-sectional observational study was conducted …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 1, 2026 Read article
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Post Covid-Sequela: Novel-Inception of DM: A Review
Abstract: As patients recovers from COVID 19 pandemic, a subset of the covid patients experienced a post covid condition with long term symptoms, few weeks after their discharge or recovery from the (SARS-CoV-2) infection. Hence, we tried to prove the hypothesis whether diabetes mellites is an afresh possible sequala of covid infection by systematically evaluating the consistently changing glucose level of the post covid patients. The databases PubMed and Google Scholar …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 Read article
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Autonomous Calibration of Medical Devices Using Synthetic Biosignals and Adaptive Learning
Abstract: The accuracy and reliability of modern biomedical diagnostic devices are critically dependent on effective calibration mechanisms capable of handling dynamic physiological and environmental variations. Conventional calibration approaches, which rely on static reference signals and manual adjustments, are inadequate in addressing challenges such as sensor drift, noise interference, motion artifacts, and long-term performance degradation. To overcome these limitations, this research proposes an innovative AI-driven adaptive biosignal simulation and calibration architecture for …
Published in Journal of Instrumentation Technology & Innovations · Vol. 16, Issue 2, 2026 Read article
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Pharmacokinetics of Levothyroxine and Factors Influencing Its Therapeutic Efficacy in Hypothyroidism: A Comprehensive Review
Abstract: Levothyroxine (LT4) remains the standard therapy for hypothyroidism due to its effectiveness in restoring normal thyroid hormone levels and improving physiological functions. However, its pharmacokinetic profile exhibits considerable variability, which may influence therapeutic outcomes in clinical practice. This review aims to comprehensively evaluate the pharmacokinetics of levothyroxine, including its absorption, distribution, metabolism, and elimination, along with factors affecting its therapeutic efficacy. A structured literature search was conducted using electronic databases, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 Read article
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pH-Triggered In-Situ Nasal Gel Systems for Migraine Therapy: A Review
Abstract: Intranasal drug delivery has gained considerable attention as a non-invasive route for delivering drugs to both systemic circulation and the central nervous system, particularly for the treatment of migraine. Traditional nasal formulations such as sprays and drops often show poor therapeutic performance due to rapid mucociliary clearance and limited retention within the nasal cavity. To overcome these challenges, in-situ gel systems have been designed, which transform from a liquid to …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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The Role of Artificial Intelligence and Machine Learning in Redefining Global Healthcare Systems and Advancing Medical Innovation
Abstract: Health Services are being revolutionized with AI and ML through improved accuracy, efficiency and accessibility in the delivery of health care. With AI and ML, it is now possible for health care professionals to assess varying amounts of complex clinical data in a relatively short amount of time, therefore, creating opportunities for early detection of disease, increasing the odds of accurate diagnosis, and improving the ability to make informed clinical …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 14–19 Read article
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The Evolution of Asthma Management: A Comprehensive Analysis of GINA 2024 Guidelines, Endotype-Driven Diagnosis, and Targeted Biologic Intervention
Abstract: Asthma remains a substantial global public health challenge, characterized by heterogeneous airway inflammation leading to variable airflow obstruction. Recent advances in personalized medicine and guideline revisions, notably the Global Initiative for Asthma (GINA) 2024 update, mandate a profound paradigm shift from reliance on short-acting beta2-agonists (SABA) to antiinflammatory reliever (AIR) strategies utilizing inhaled corticosteroid (ICS)-formoterol. This report provides an exhaustive analysis of current asthma epidemiology, molecular pathogenesis distinguishing between Type …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 Read article
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Ayurvedic Management of Vatika Pakshavadha (Hemiplegia): A Case Study
Abstract: Background: Pakshavadha, described in Ayurveda under the category of Vāta Vyādhi, is a neurological disorder caused by aggravated Vāta doṣa affecting one half of the body. Clinically, it is correlated with hemiplegia or post-stroke neurological deficits, particularly following ischemic cerebrovascular accidents. Stroke remains a leading cause of mortality and disability worldwide, often leaving patients with residual weakness, gait disturbances, and impaired speech despite modern rehabilitation. Ayurveda offers a holistic approach …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 2, 2026 Read article
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Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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RNA- Based Drug Delivery, Current Advances, Pharmaceutical Applications, and Future Perspectives
Abstract: RNA-based therapeutics have emerged as a transformative approach in modern medicine due to their ability to regulate gene expression with high specificity and precision. Advances in molecular biology, RNA chemistry, and nanotechnology have accelerated the development of diverse RNA modalities, including messenger RNA (mRNA), small interfering RNA (siRNA), microRNA (miRNA), antisense oligonucleotides (ASOs), and RNA aptamers. These therapeutics offer promising strategies for the treatment of cancer, genetic disorders, infectious diseases, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Evaluation of Drug Utilization Patterns and Prescription Trends in Patients with Hypothyroidism and Hyperthyroidism in a Tertiary Care Hospital
Abstract: Background: Endocrine disorders affecting the thyroid gland represent some of the most frequently encountered conditions globally, necessitating prolonged therapeutic intervention and vigilant clinical surveillance. The evaluation of Drug utilization patterns (DUE) serves an essential function in examining prescriptive behaviours and promoting appropriate pharmaceutical management. Objective: To evaluate drug utilization patterns, prescribing trends, and rationality of therapy in patients with hypothyroidism and hyperthyroidism. Methods: A prospective, cross-sectional observational investigation was performed …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 2, 2026 · pp. 1–5 Read article
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 Read article
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Role of the Surgical-Ward Nurse in Identifying, Escalating, and Managing Postoperative Anastomotic Leak in Colorectal Patients: A Narrative Synthesis in an Australian Nursing Perspective
Abstract: Purpose: Postoperative colorectal anastomotic leak (AL) is one of the most feared complications after colorectal surgery because of its association with sepsis, reoperation, mortality, prolonged hospital stay, delayed adjuvant therapy, and permanent stoma formation. This narrative practice review outlines the frontline role of surgical-ward nurses in the early identification, escalation, and interim management of AL within the Australian acute-care context. Methods: A narrative synthesis of contemporary consensus statements, systematic reviews, …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 1, 2026 · pp. 7–12 Read article