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478 articles for “ADME”
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Expanding Hicks Contraction Theory, Multi-Valued Mappings in Generalized b-Menger Spaces
Abstract: This paper extends the Hicks contraction theory to multi-valued mappings within generalized b-Manger spaces, a class of metric-like structures that accommodate more flexible distance functions. By introducing new definitions, such as generalized admissibility conditions and weak compatibility in the multivalued sense, we provide a comprehensive analysis of how these contractions behave in broader topological and metric contexts. Our approach systematically generalizes classical contraction principles by relaxing conventional constraints, thereby broadening …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 12, Issue 1, 2025 · pp. 1–05 Read article
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Tobacco and COVID-19: Molecular Interactions and Public Health Challenges – A Review
Abstract: Tobacco use exacerbates health risks, making it a significant concern during the COVID-19 pandemic. Smoking has been implicated in the upregulation of ACE2 receptors, critical for SARS- CoV-2 entry, and contributes to immune dysregulation and oxidative stress, worsening clinical outcomes. Methods: This review synthesizes evidence on the molecular mechanisms linking tobacco and COVID-19, assesses risk factors, such as smoking status and comorbidities, and explores public health challenges in managing the …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 1–6 Read article
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Personalized Medicines in Pharmaceutics: Drug Delivery System
Abstract: Pharmaceutics personalized medicine is a developing area that seeks to customize medical interventions for specific patients. Instead of a one-size-fits-all approach, personalized medicine focuses on developing treatments that consider a person’s unique characteristics, such as their genetic makeup, environment, and lifestyle. This allows for more effective treatment outcomes, as drugs are specifically designed to work best for each patient, reducing side effects and improving therapeutic results. In pharmaceutics, this involves …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 11–22 Read article
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Shell Programming in Computer Programming: Application and Techniques
Abstract: Shell programming is writing scripts with shell commands to automate tasks in an OS. Well, the shell is what enables users to reach the kernel, the program that controls the kernel, which actually enables the users to execute commands, manage files and run processes efficiently. The examples are Bourne Shell (Sh), Bourne Again Shell (Bash), Korn Shell (Ksh), C Shell (Csh), Z Shell (Zsh), etc. Of these, Bash is the …
Published in Journal of Advances in Shell Programming · Vol. 12, Issue 1, 2025 · pp. 17–21 Read article
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Role of Generative AI for Advanced Shell Language Design
Abstract: This study explores the emerging field of applying Artificial Intelligence (AI), specifically generative AI, to enhance shell scripting, a crucial skill for system administration and automation. While the formal design of entirely new shell languages using AI remains a long-term prospect, the current focus is on augmenting how existing shell languages are used for improving the scripting experience. This involves leveraging AI for tasks like automated script generation, intelligent code …
Published in Journal of Advances in Shell Programming · Vol. 12, Issue 1, 2025 · pp. 22–27 Read article
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A Community Awareness Project on Monkeypox (Mpox) and Enhanced Nursing Care for Patients: A Comprehensive Review
Abstract: Monkeypox (Mpox), a rare viral infection transmitted from animals to humans by the monkeypox virus, has attracted increasing attention due to its ability to spread between humans and its clinical similarities to other poxvirus diseases, including smallpox and chickenpox. Enhancing nursing care for monkeypox patients is imperative to manage and contain its spread effectively. On 15th October 2024, B.Sc. Nursing Interns of Holy Family College of Nursing, University of Delhi, …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 11–15 Read article
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Assessing Thyroid Disorder Awareness Among Pregnant Women: A Hospital-based Study in Kottayam
Abstract: The current study was carried out at Caritas Hospital to evaluate the knowledge of pregnant women regarding thyroid disorders. The study aimed to assess the level of knowledge about thyroid disorders among pregnant women and to explore the relationship between knowledge levels and selected demographic factors. A total of 194 pregnant women attending the obstetrics and gynecology outpatient department at Caritas Hospital in Kottayam were included using a convenience sampling …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 16–22 Read article
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Comprehensive Evaluation of Herbal Plants for Cancer Prevention
Abstract: Since cancer continues to be a major cause of morbidity and death globally, effective prevention measures are desperately needed. As the world’s cancer burden increases, interest in alternative cancer prevention methods, particularly the use of herbal medicine, is also increasing. With their rich history and diverse phytochemical composition, medicinal plants provide a great opportunity for the development of disease prevention strategies. This review explores the potential of various plants, including …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 01–07 Read article
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Synthesis, Spectral Characterization and Computational Studies of Hydrazine Derivative
Abstract: (E)-1-(2,3-dimethoxy benzylidene)hydrazine (2,3-DMBH) is synthesized by condensation reaction. FT-IR, ¹H NMR, ¹³C NMR spectra were recorded for this compound. The synthesized compounds were evaluated as potential drug candidates through ADME analysis and Lipinski’s rule verification. Molecular docking studies against six proteins using AUTO DOCK software showed promising results. Among them, 2,3-DMBH exhibited strong binding affinities, particularly with 3ERT (-5.44 kcal/mol), followed by 5F90, 7E9B, and 3EWD. These findings suggest that …
Published in Emerging Trends in Chemical Engineering · Vol. 12, Issue 2, 2025 · pp. 1–17 Read article
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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Improving Healthcare Outcomes with RF-enabled Health Information Systems
Abstract: Health Information Technology (HIT) plays a crucial role in improving healthcare by making medical data more accessible, accurate, and efficient. Using radio frequency (RF) technology, HIT enables the wireless sharing of important health information—like patient records, and treatments—between patients, doctors, and other healthcare providers. This helps reduce paperwork, cut costs, and improve the quality of care. By reducing the reliance on paper-based records, RF-based HIT helps streamline administrative processes, cut …
Published in International Journal of Radio Frequency Innovations · Vol. 3, Issue 1, 2025 · pp. 8–13 Read article
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Effectiveness of Moist Heat Application on Elderly Orthopedic Clients at Selected Urban Community Area, Bengaluru
Abstract: Pain is a distressing sensory and emotional experience that arises from actual or potential tissue damage. It is a multifaceted phenomenon that extends beyond physical discomfort, encompassing emotional and psychological aspects as well. Individuals who recognize that pain management not only enhances comfort but also accelerates the healing process are more inclined to seek or administer appropriate treatment. In order to educate the elderly orthopedic clients, this study was conducted …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 18–22 Read article
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Internship Management System Using MERN-Stack
Abstract: Internships are the key for the student who wants to get hands-on experience in the industry. IMS (Internship Management System) is a centralized platform that helps students to shape their careers. Our platform aims to provide different internship opportunities to the students. IMS includes a Admin login, student login and includes features like a resume builder which will provide a user-friendly experience to the students. IMS going to give the …
Published in Journal of Advanced Database Management & Systems · Vol. 12, Issue 2, 2025 · pp. 12–17 Read article
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Pharmacogenomics in Anesthesia: Individualized Drug Responses
Abstract: Pharmacogenomics is the study of how a person’s genes influence how they react to medications. Pharmacology, the study of medications, and genomics, the examination of genes and their functions, merge in this field to develop safe, effective drugs that can be prescribed based on an individual’s genetic makeup. Pharmacogenomics examines how an individual’s unique genetic makeup can influence their responses to certain drugs. In anesthesia, where individual responses to pain …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 83–95 Read article
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Emerging Therapies for Diabetes Mellitus: Efficacy and Safety of USFDA-Approved Drugs and Late-Stage Clinical Trials
Abstract: This review provides a comprehensive analysis of drugs approved by the U.S. Food and Drug Administration (USFDA) for managing diabetes mellitus (DM) from 2013 to 2022, including emerging treatments from phase 3 clinical trials during this period. Over the past decade, the treatment landscape for diabetes has evolved significantly, with new therapies not only improving blood sugar control but also targeting broader health outcomes like heart and kidney health. In …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 11–23 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Effectiveness of structured teaching programme on knowledge regarding Prophylactic vaccination against cervical cancer among adolescent girls
Abstract: Background: Adolescent health encompasses the variety of methods used to prevent, identify, or treat the health and wellness of young people. Adolescent health also includes the sexual and reproductive health of children and young adults. Women of all ages are susceptible to HPV infection. The human papillomavirus is the cause of cervical cancer . The HPV vaccine is an important main preventive measure against cervical cancer . Thus, it is …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 Read article
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Enhancing Sustainability and Safety in India's Process Industry Through Targeted Innovations
Abstract: The process industry operates within a highly intricate and high-risk environment, necessitating well-structured strategies to safeguard workers, maintain safety standards, and preserve environmental integrity. This study explores the impact of diverse safety interventions designed to enhance health, safety, and environmental performance. It evaluates multiple approaches, including engineering solutions, procedural controls, protective gear, and behavioral adjustments, aimed at mitigating risks such as chemical spills, fires, explosions, equipment failures, and occupational health …
Published in Journal of Industrial Safety Engineering · Vol. 12, Issue 1, 2025 · pp. 22–36 Read article
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Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models
Abstract: Chemotherapy remains a cornerstone of cancer treatment, yet severe side effects, including cardiotoxicity often limit its clinical application. Doxorubicin, a widely used anticancer drug, is particularly associated with dose-dependent toxicities that impact the heart, liver, and kidneys. In search of complementary approaches to mitigate these adverse effects, this study evaluates the protective potential of hydro-alcoholic extracts from Phyllanthus amarus and Sida acuta, two medicinal plants with known antioxidant and anti-inflammatory …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article