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478 articles for “ADME”
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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Exploring the Bourne Again Shell (Bash)
Abstract: The Bourne Again Shell (Bash) is a popular command-line interpreter and scripting language, created as a free software alternative to the original Bourne Shell (sh). Developed as part of the GNU Project, Bash extends the functionality of its predecessor by incorporating features from the C Shell (csh) and KornShell (ksh), making it more versatile and powerful. Bash offers robust command-line editing, job control, and support for functions and variables, enabling …
Published in Journal of Advances in Shell Programming · Vol. 12, Issue 1, 2025 · pp. 01–09 Read article
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Fingerprint and Face Recognition Based Attendance System for Exams
Abstract: In educational institutions, managing attendance efficiently and accurately is pivotal for ensuring academic integrity and administrative effectiveness. Traditional attendance tracking techniques, including human roll calls or barcode scanning, are laborious, error-prone, and vulnerable to fraud. Traditional methods of keeping track of attendance, including sign-in sheets and physical roll calls, are often time-consuming, prone to errors, and lack the security measures needed in many contemporary settings. Modern biometric technologies have made …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 11, Issue 3, 2024 · pp. 26–33 Read article
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Tomato Food Delivery
Abstract: Tomato food delivery systems face numerous challenges, such as duplicate documents, lack of security, and insufficient transparency. This paper proposes a solution using the MERN (MongoDB, Express.js, React, Node.js) stack to address these issues by creating an electronic public administration system that ensures secure, transparent, and efficient record-keeping. Leveraging MongoDB, the proposed system, automates the maintenance of records and registration documents, utilizing a consensus-based contract for streamlined loan settlement processes …
Published in Journal of Web Engineering & Technology · Vol. 12, Issue 1, 2025 · pp. 12–19 Read article
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A Descriptive Study to Assess Knowledge Regarding POSH Act Among Staff of Chirayu Medical College and Hospital, Bhopal, Madhya Pradesh
Abstract: Introduction: Sexual harassment is a significant health issue with severe effects on employees’ self-respect, physical mental health, and dignity. This descriptive study aimed to assess knowledge scores regarding the POSH (Prevention of Sexual Harassment) Act among staff of Chirayu Medical College and Hospital. A convenience sampling method was employed, and data were gathered using a self-designed knowledge questionnaire. The findings indicated that 41% of the staff had poor knowledge, while …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 1–10 Read article
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Review on Clinical Safety and Efficacy of Giant Calotropis in the 21st Century
Abstract: Calotropis gigantea, a highly valued plant in traditional Indian pharmacology, has emerged as a promising candidate for therapeutic innovation. This review delves into the clinical safety and efficacy of C. gigantea in the 21st century, examining its historical use, phytochemical composition, and pharmacological properties. While traditional medicine has long utilized C. gigantea for various ailments, modern research has sought to validate these claims through scientific investigation. This review critically analyzes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 26–34 Read article
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Effects of Boko Haram and Environmental Hazard on the People of Borno and Adamawa State, Nigeria
Abstract: This study focuses on the effects of environmental hazards and Boko harams on the people of Borno and Adamawa State. Environmental hazards and Boko haram disasters especially, those that occur as a result of natural phenomena as one of the greatest threats to humanity and economic development. Causes and the effect of Boko Haram and the Environmental hazard were studied. Man-made disasters such as conflicts, crisis and wars also use …
Published in International Journal of Climate Conditions · Vol. 2, Issue 1, 2025 · pp. 35–42 Read article
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A Brief Review On Nanoparticles Drug Delivery System Used In Cervical Cancer
Abstract: Among cervical tumor-related deaths worldwide, cervical cancer is a major cause. The limitations of traditional methods, such as chemotherapy and radiation therapy, stem from their adverse effects and increased susceptibility to medications. Despite being seen as innovative options, immune checkpoint inhibitors (ICIs) have rather low clinical response rates. Reliable treatments for patients with metastatic or recurring cervical cancer are currently lacking. Lately, nanomaterials including polymers, liposomes, and dendrimers have been …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 30–40 Read article
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Treatment of Hepatotoxicity
Abstract: An instantaneous or prolonged response to a synthetic or natural substance is known as drug-induced liver injury, or drug-induced hepatotoxicity (DILI). There are two distinct pathways that lead to hepatotoxicity: the more unpredictable idiosyncratic mechanism and the dose-dependent intrinsic mechanism. Several pathways, some known and others speculated, may be involved in the emergence of drug-induced damage. Drug-induced liver impairment can have several causes, and elevated liver tests are one of …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 1, 2025 · pp. 31–37 Read article
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Morphine: A Pharmacological Perspective on Its Cancer Pain Management
Abstract: Morphine continues to be a key treatment in managing cancer pain because of its strong pain-relieving effects and established clinical history. Despite the emergence of alternative opioids and pain management therapies, morphine continues to be widely prescribed, particularly in palliative care settings. However, its use has been accompanied by concerns regarding tolerance, dependence, and adverse effects, which complicate long-term administration. This review explores the pharmacological aspects of morphine in cancer …
Published in Trends in Drug Delivery · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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The Clean Water Act: Legal Analysis and Implementation Challenges
Abstract: The Clean Water Act is one of the most far-reaching environmental laws in the United States; it was enacted with express purposes for the protection and restoration of the country's waters. For many years, though, numerous logistical, administrative, and legal challenges have beset its implementation. This paper will undertake a detailed legal review of the CWA, discussing its foundational principles, major amendments, and evolving interpretations by courts. It does so …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 1, 2025 · pp. 1–9 Read article
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FDA Drug Approvals 2024: A Comprehensive Review
Abstract: The year 2024 has been pivotal for the pharmaceutical industry, with the U.S. Food and Drug Administration (FDA) granting approval to a diverse array of new drugs. These approvals highlight significant strides in therapeutic innovation, targeting a spectrum of diseases from rare genetic disorders to prevalent chronic conditions. This article provides a detailed examination of the FDA-approved drugs of 2024, focusing on their therapeutic indications, mechanisms of action, and the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 28–46 Read article
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Targeting PTPN22 in Arthritis: Molecular Docking and Pharmacokinetic Evaluation of Artemisia vestita Compounds
Abstract: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by inflammation of the synovial membrane, commonly resulting in swelling, pain, stiffness, and overall fatigue. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been identified as a risk factor linked to various autoimmune diseases, including RA. In the PTPN22 gene, two missense Single nucleotide polymorphisms (SNPs) are associated with autoimmune conditions. The R620W (C1858T, rs247660) variant in exon 14 has been …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 20–31 Read article
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Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound
Abstract: Black seed (Nigella sativa) has been celebrated for centuries for its remarkable therapeutic properties. Among its bioactive compounds, thymoquinone (TQ) has gained significant attention in pharmacological research due to its diverse health benefits. This review delves into the pharmacokinetic (PK) and pharmacodynamic (PD) properties of black seed compounds, with a particular emphasis on TQ, the most extensively studied component. The PK of TQ includes the parameters of absorption, distribution, metabolism, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 36–43 Read article
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Comprehensive Approaches to Seizure Control: Home Care & Hospital Care
Abstract: Seizures show up as sudden, uncontrollable brain electrical abnormalities. Those afflicted by this health issue can suffer greatly and usually call for quick and thorough treatment. Examining several facets of seizure control, including disease epidemiology, etiology, clinical presentation, categorization, as well as acute and long-term therapy techniques, this review. Furthermore, emphasized in the review are several new trends that might help with seizure control. Factors including CNS infections, metabolic abnormalities, …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 1, 2024 · pp. 30–34 Read article
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AI Activity to Enhance Productivity, Creativity, and Sustainable Development of AI in Healthcare
Abstract: The application of artificial intelligence (AI) in healthcare is revolutionizing the industry by fostering both productivity and creative approaches to patient care and medical research. This study explores how artificial intelligence (AI) is reshaping healthcare by streamlining workflows, improving diagnostic precision, and supporting personalized treatment plans. AI-powered technologies are reshaping the way medical professionals approach patient care, providing tools that not only automate routine administrative and clinical tasks but also …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 1, 2025 · pp. 21–29 Read article
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AI: Revolutionizing Pharmacy Practice and Enhancing Patient Care and Safety
Abstract: The use of artificial intelligence (AI) in pharmacy is transforming medication management, improving patient care, and boosting safety. By leveraging cutting-edge technologies, such as machine learning, natural language processing, and predictive analytics, AI enables pharmacists to develop personalized treatment plans and anticipate possible adverse drug reactions. AI-driven systems enhance operational efficiency by streamlining inventory management, prescription processing, and administrative duties, allowing pharmacists to devote more time to patient care. Additionally, …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 1, 2025 · pp. 13–20 Read article
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Assay of the Antitrypanosomal Activity of Ziingiber Officinale Extract in Wister Rats
Abstract: This research investigated the antitrypanosomal effects of Zingiber officinale in rats infected with Trypanosoma brucei brucei. Twelve adult rats, 7 weeks old and of both sexes, were randomly divided into six groups (1 through 6), with each group consisting of two rats. All six groups (1–6) were intraperitoneally injected with 0.1 ml of blood containing 10⁶ Trypanosomes/ml. Groups 1–4 received daily intraperitoneal doses of the plant extract at concentrations of …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 1, 2025 · pp. 32–37 Read article
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Innovative Approaches in Pediatric Drug Formulation Catering to Specialized Need: Review Article
Abstract: This detailed article review examines innovations in pediatric drug formulation, highlighting developments that cater to children’s specific healthcare needs. It covers pediatric pharmacology and advanced solutions like nanoparticle drug delivery and taste-making techniques, focusing on improving the safety, effectiveness, and acceptability of medications for young patients. The review highlights the benefits for patients, including improved adherence to treatment, fewer side effects, and better overall treatment outcomes. It also addresses regulatory …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 35–43 Read article
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Application Henderson's Need Theory on a Case of Esophageal Cancer
Abstract: Cancer is a broad term that refers to the uncontrolled growth of abnormal cells, which can invade or spread to other areas of the body. Cancer encompasses over 150 different types, each presenting unique challenges. Patients with cancer often require specialized healthcare to manage their condition and the treatments involved. This case report discusses a 55-year-old female diagnosed with esophageal cancer, who was admitted for chemotherapy. Throughout her treatment, nursing …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 12–17 Read article