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454 articles for “Disorder”
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A Review Article on Spice up the Solution of Inflammation Through Phytomedicines
Abstract: Inflammation is a complex, protective immune response essential for healing and combating infection. However, prolonged inflammation is associated with chronic diseases, such as arthritis, cardiovascular disorders, diabetes, and neurodegenerative conditions. Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids can exhibit adverse effects, particularly with chronic administration. This challenge has encouraged the exploration of natural alternatives. Among various natural anti-inflammatory agents, spices, such as ginger, garlic, turmeric, cardamom, and black pepper have …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 1, 2025 · pp. 1–10 Read article
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Awareness and Knowledge of Postpartum Psychosis Among Antenatal Women: A Call for Educational Intervention
Abstract: Postpartum psychosis (PP) is a rare yet critical mental health disorder that poses serious risks to the well-being of new mothers. This condition manifests through a range of acute symptoms, including manic episodes, depressive states, confusion, hallucinations, and delusions. Symptoms typically present abruptly within the first two weeks following childbirth, making it a medical emergency that necessitates urgent care. Left untreated, PP can lead to severe consequences, including self-harm or …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 125–134 Read article
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Epidermolysis Bullosa and Its Role in Cervical Cancer: An Overview
Abstract: Epidermolysis Bullosa is a group of uncommon genetic disorders that primarily affect the skin and mucous membranes. It is marked by severe skin fragility and the formation of blisters even after minor trauma. Traditionally, the focus of Epidermolysis Bullosa research has been on its dermatological manifestations, which include recurrent blistering, scarring, and the potential for infections due to the compromised skin barrier. However, recent advancements in Epidermolysis Bullosa research have …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 14–18 Read article
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The Intersection of Bioinformatics and Cellular Function in Disease Modeling
Abstract: The integration of bioinformatics and cellular biology has revolutionized our understanding of disease mechanisms, offering unprecedented opportunities to model complex biological systems. Bioinformatics is an interdisciplinary field that merges biology, computer science, and statistics, offering advanced tools to analyze vast biological datasets. Cellular functions, including gene expression, protein interactions, and metabolic pathways, form the foundation of physiological and pathological states. Disruptions in these processes can result in diseases like cancer, …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
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Computational Approaches to Understanding Cellular Signaling Pathways
Abstract: Cellular signaling pathways are fundamental in regulating vital processes, such as cell growth, differentiation, and apoptosis. The intricate and interconnected nature of these signaling networks requires sophisticated methods for their analysis. Computational approaches, including mathematical modeling, network analysis, and machine learning, have revolutionized the way researchers analyze and simulate cellular signaling. This article provides a comprehensive overview of computational strategies employed to model signaling pathways, with a focus on integrating …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 8–13 Read article
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Multi-Target Molecular Docking of Anantmul (Hemidesmus indicus) Compounds for Tay-Sachs Disease Treatment
Abstract: This research aimed to study the effects of the plant Anantmul (Hemidesmus indicus) in the treatment of Tay-Sachs disease using molecular docking studies. Tay-Sachs disease is a neurodegenerative autosomal recessive disorder caused due to accumulation of the molecule GM2 ganglioside which is caused due to lack of enzyme Beta Hexosaminidase which breaks down GM2 Ganglioside. Anantmul (Hemidesmus indicus) is a an ayurvedic plant used in the Indian subcontinent that has …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 61–69 Read article
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Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
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A Comprehensive review on phytomedicinal activity of chirchita (Achyranthes aspera): an Indian Rural Medicinal Plant
Abstract: Because it is used to treat many types of diseases. Native to India, Achyranthes aspera (Chirchita) has been used in rural medicine for generations.This review explores the phytomedicinal significance of Achyranthes aspera, focusing on its bioactive compounds and the pharmacological activities that support its use in treating various ailments. This plant is a useful tool in traditional and alternative medicine. Because it has anti-inflammatory properties Antioxidants Antibacterial, anticancer and liver …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 74–85 Read article
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Marine-Derived Pharmaceuticals: Unlocking the Ocean's Potential for Human Health
Abstract: The ocean, covering 70% of the Earth’s surface, is a rich source of unique bioactive compounds with potential therapeutic applications. This review aims to highlight the significance of marine-derived pharmaceuticals in human health, focusing on clinically approved and commercially available medications. The review covers various marine-derived compounds, their structural features, modes of action, and applications in treating diseases, such as cancer, diabetes, and neurodegenerative disorders. The review identifies several marine-derived …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 1–12 Read article
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A Comprehensive Review of Antioxidant Activity of Bhringraj (Eclipta alba) : An Indian Ancient Herb
Abstract: Eclipta alba, commonly known as Bhringraj, is an herb widely utilized in traditional Indian medicine (Ayurveda) for its diverse therapeutic properties, particularly in promoting hair growth, enhancing liver function, and improving overall health. Among its numerous biological activities, the plant’s antioxidant potential has garnered significant interest in modern phytochemistry. Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and the body’s antioxidant defenses, is a key contributor to …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 1, 2025 · pp. 12–21 Read article
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Phase-Specific Nutrient Requirements in Broilers: Implications for Behavior, Gut Health, Performance, Meat Quality, Welfare, and Economics
Abstract: The broiler industry plays an inevitable role in global food security, requiring optimal formulation strategies tailored to each growth phase, starter, grower, and finisher for sustainable production. This review explores phase-specific nutrient requirements and their implications for broiler performance, meat quality, welfare, and economics. During the starter phase (1–10 days), nutrition focuses on immune development, gut health, and skeletal growth, with high protein and low energy needs. In the grower …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 5–15 Read article
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Advances in Biological Systems Modeling for Predicting Drug Effects in Chronic Disease
Abstract: Biological systems modeling has emerged as a promising tool for understanding and predicting the effects of drugs in the treatment of chronic diseases. Chronic diseases, such as diabetes, cardiovascular diseases, and neurodegenerative disorders pose significant challenges to traditional drug development due to their complex, multifactorial nature. Systems biology approaches, which integrate computational modeling with experimental data, provide a holistic view of disease mechanisms and treatment responses. This review explores recent …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 17–22 Read article
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An Evidence Based Analytical Study on Capability of ChatGPT in Advanced AI Based Patient Drug Counseling
Abstract: The application of ChatGPT in providing drug counseling to patients offers the best approach to enhancing policies of healthcare support in decision-making. Aim and Objectives: The present study mainly involves an evaluation of the capability of ChatGPT in the management of drug counseling among patients suffering from various metabolic disorders. Methodology: The present study was a community-based interventional study conducted for a period of 12 months from October 2023 to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 8–13 Read article
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FDA Drug Approvals 2024: A Comprehensive Review
Abstract: The year 2024 has been pivotal for the pharmaceutical industry, with the U.S. Food and Drug Administration (FDA) granting approval to a diverse array of new drugs. These approvals highlight significant strides in therapeutic innovation, targeting a spectrum of diseases from rare genetic disorders to prevalent chronic conditions. This article provides a detailed examination of the FDA-approved drugs of 2024, focusing on their therapeutic indications, mechanisms of action, and the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 28–46 Read article
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Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound
Abstract: Black seed (Nigella sativa) has been celebrated for centuries for its remarkable therapeutic properties. Among its bioactive compounds, thymoquinone (TQ) has gained significant attention in pharmacological research due to its diverse health benefits. This review delves into the pharmacokinetic (PK) and pharmacodynamic (PD) properties of black seed compounds, with a particular emphasis on TQ, the most extensively studied component. The PK of TQ includes the parameters of absorption, distribution, metabolism, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 36–43 Read article
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Diurnal Variation of Tear Film Dynamics During Digital Device Use
Abstract: With a primary focus on their effects on tear dynamics and ocular health, this research effort addresses the hyperlink between pre and post digital screen usage, time of day, and tear dynamics. The desired outcomes of the eye health metrics divulge that post-digital screen exposure significantly reduces mean tear production values across all conditions (p < 0.05), with this impact intensifying as the day progresses. These observations show the interplay …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 1, 2024 · pp. 22–29 Read article
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Hearing, Speech, and Language Characteristics in a Case with Hemoglobinopathy Secondary to Beta Thalassemia Intermedia
Abstract: Background: Thalassemia is an inherited disorder characterized by a reduced amount or absence of hemoglobin, the oxygen-carrying protein inside the red blood cell. Thalassemia has its types called alpha and beta-thalassemia. Beta thalassemia is a condition in which there is a reduction or deficit in the synthesis of the beta-globin chain of hemoglobin molecules caused by a mutation in chromosome eleven. Beta thalassemia can be broadly categorized into three main …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 1, 2024 · pp. 1–5 Read article
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Advances in Total Knee Replacement: A Systematic Review of Clinical Outcomes and Complications
Abstract: Total Knee Replacement (TKR) is a widely used surgical intervention for patients with knee osteoarthritis and other degenerative knee disorders, offering significant improvements in pain relief, functional restoration, and quality of life. This systematic review synthesizes data from multiple clinical studies to evaluate the outcomes and complications associated with TKR. To find applicable research published in the last ten years, a thorough search of electronic databases was performed. Randomised controlled …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 1, 2024 · pp. 41–56 Read article
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Management of Varicose Veins: A Review of Literature
Abstract: Lower extremities venous insufficiency is a frequent disorder that can cause a variety of symptoms, such as ulceration, soreness, swelling, and bulging leg veins. Whereas there is many other treatment choices, the more recent endovascular treatments are simple, safe, rapid, and very effective at reducing symptoms. Foam sclerotherapy, thermal ablation, and mechanical chemical ablation are minimally invasive endovascular techniques commonly used in the treatment of varicose veins. This review article …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 1, 2025 · pp. 17–21 Read article
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Mind-Gut Connection: The Psychosomatic Effects of Stress and Emotions on Digestive System
Abstract: Stress, understood as an immediate disruption to bodily equilibrium, triggers an adaptive or allostatic response that impacts gastrointestinal function both in the short and long term. The enteric nervous system communicates in both directions with the brain through parasympathetic and sympathetic pathways, collectively forming what is known as the brain-gut axis. Unani scholars describe stress as a response to the loss of something valuable, such as an opportunity, a desired …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 11–14 Read article