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389 articles for “Bio-agents”
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Exploring Phytochemicals from Ricinus Communis for Potential Therapeutic Applications in Rheumatoid Arthritis: An in-Silico Approach
Abstract: Aim: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by the immune system mistakenly attacking the joints, leading to swelling, discomfort, and joint deformities. Current management strategies include anti-rheumatic drugs and biologics, which have limitations. This study aims to explore the therapeutic potential of Ricinus communis (castor bean plant) phytochemicals as plant-based therapies for autoimmune conditions, like RA. Methods: Phytochemicals from Ricinus communis were retrieved using the IMPPAT database, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 32–41 Read article
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Excoecaria agallocha Extract from Leaves Encounters Antifungal, Antibacterial, and Cytotoxic Activity – In Vitro Studies
Abstract: Mangroves contain a wide range of bioactive substances, certain of and these have been used as solutions for a variation of conditions for thousands of years. Excoecaria agallocha leaf application components have been extracted in the presence of organic solvents along with water-based with a Soxhlet apparatus and antibacterial research properties employing diffusion agar well assays towards nine different kinds of culture infectious agents, six clinical trials isolated compounds, as …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 2, 2025 · pp. 1–7 Read article
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Biochemical Changes due to Various Environmental Pollutants Affecting the Therapeutic Potentialities of Certain Medicinal Plants
Abstract: ABSTRACTMedicinal herbs have been an essential part of human society since the civilization started. They are boon of nature to cure a number of ailments of human beings. Herbal medicines are a major component in all traditional medicine systems since all practitioners of Ayurveda, Homeopathic, Siddha and Unani systems of medicine regularly employ a large number of Indian medicinal plants as antibiotic agents. In the present study, various plant species …
Published in Research & Reviews : Journal of Botany · Vol. 1, Issue 1, 2012 · pp. 22–27 Read article
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Anticancer Potential and Other Therapeutic Activities of Curcumin & Its Derivatives
Abstract: Curcumin, a compound isolated from turmeric, is used in the management of various diseases due to its extensive medicinal properties. Curcumin, the principal polyphenol isolated from Curcuma longa (turmeric), has garnered immense scientific interest for its extensive medicinal properties, including potent anti-inflammatory, antioxidant, and anticancer activities demonstrated in preclinical models. An expanding body of research indicates broad therapeutic promise in managing diverse pathologies, from various cancers to chronic inflammatory, metabolic, …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 19–28 Read article
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Synthesis and Characterization of Polyvinyl alcohol film incorporated with Tridax procumbens leaf extract
Abstract: Active film materials are prepared by incorporation of natural antimicrobial and antioxidant agents. These materials have attracted growing interest in wound dressing and food packaging process. In this study, active films were developed by incorporation of Tridax procumbens (T. procumbens) leaf extract into Polyvinyl Alcohol (PVA) matrix. T. procumbens leaves have been accounted for their biomedical and nutritional properties. The impact of T. procumbens leaf extract on the physical, mechanical …
Published in Journal of Polymer & Composites · Vol. 11, Issue 2, 2023 · pp. 40–51 Read article
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Formulation and Development of Gastroretentive Hydrogels of Glipizide
Abstract: The aim of the present study was to develop a pH sensitive gastroretentive drug delivery system for an antidiabetic drug glipizide, based on gas formation technique using 32-factorial design, in order to prolong the gastric residence time and increase the overall bioavailability of the dosage form, since the absorption is erratic in diabetic patients. The system consists of the drug, glycol chitosan (5% w/w) and aqueous PVA solution (10% w/w) …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 1, 2017 · pp. 1–7 Read article
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Pharmaceutical Activity of Mirabilis Jalapa and its Biogenesis of Nanocrystals
Abstract: Bio friendly green modest synthesis of nanoparticles are the present research in nanotechnology. This study has been undertaken to explore the determinants of copper nanoparticles from 1 mM CuSO4 solution through profuse concentration of aqueous flower extract of Mirabilis jalapa reducing besides immobilizing agent. The attribute of copper nanoparticles was studied by using UV-VIS spectroscopy SEM and XRD. The XRD spectrum of the copper nanoparticles established the presence of elemental …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 56–65 Read article
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Mechanical and Sustainable Enhancement of Epoxy Composites using Tamarind Seed Powder
Abstract: The investigation examines how tamarind seed powder affects epoxy-based materials for the development of waste-based useful products. The research examines the mechanical behavior of epoxy resin composites which contain tamarind seed powder in increasing percentages spanning from 10% to 40%. The team utilized the hand layup method to produce the composites which then fulfilled the ASTM guidelines for specimen fabrication for mechanical tests. The study examined fundamental mechanical parameters by …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 797–806 Read article
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Studies on the Antioxidant Content and Antimicrobial Activity of Cucumber (Cucumis sativus) Peels Collected from Bagmari, Kolkata, West Bengal, India
Abstract: Cucumber (Cucumis sativus) is widely consumed across the globe, yet its peels are commonly discarded as waste, despite possessing a wealth of bioactive compounds. Recent studies have highlighted that these peels contain substantial amounts of antioxidants, antibacterial, anti-inflammatory, and anticarcinogenic properties, making them a promising candidate for value-added applications. In this study, methanolic extracts (80% v/v) of cucumber peels were systematically analyzed to assess their total phenolic content (TPC), total …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 · pp. 6–14 Read article
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Studies on the antioxidant content and antimicrobial activity of cucumber (cucumissativus) peel collected from bagmari, kolkata, west bengal, india
Abstract: Cucumber (Cucumis sativus) is widely consumed across the globe, yet its peels are commonly discarded as waste, despite possessing a wealth of bioactive compounds. Recent studies have highlighted that these peels contain substantial amounts of antioxidants, antibacterial, anti-inflammatory, and anti-carcinogenic properties, making them a promising candidate for value-added applications. In this study, methanolic extracts (80% v/v) of cucumber peels were systematically analyzed to assess their total phenolic content (TPC), total …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Investigating The Alkalizing Potential of Chandanasava For Restoring Acid-Base Homeostasis in Renal Tubular Acidosis: A Computational and In Silico Pharmacological Study
Abstract: Chandanasava, a traditional Ayurvedic formulation, is recognized for its potential alkalizing properties, which may help restore acid-base homeostasis in conditions such as renal tubular acidosis (RTA). This study aims to investigate the active components of Chandanasava and their interactions with key renal target proteins, Pendrin and Carbonic Anhydrase II, which are essential for maintaining acid-base balance. An in silico approach was utilized to explore the pharmacological potential of the phytochemicals …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 28–52 Read article
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Experimental Study on Cyanoacrylate as Wound Adhesive
Abstract: Cyanoacrylates (CAs) have been widely used as surgical glues; however, the high cost of medical CA-based glues limits their use in developing countries. Another possible alternative is the low cost α-CAs which are normally used in commercial glues. The lack of toxicity studies of such agents is considered the main obstacle in their medical application. In the present study, we have evaluated the toxicity profile of commercial glue in comparison …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 10–14 Read article
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A Review on Novel Emulsification Technique: A Nanoemulsion
Abstract: Kinetically stable and isotropic system of submicron size range is the nanoemulsion. In this system two immiscible liquids are mixed together to form a single-phase system with the identical concentration and ratio of surfactant and cosurfactant. Nanoemulsion droplet sizes fall typically in the range of 20- 200 nm. Some literature suggest this range below 100 nm with shows narrow size distribution. In this review, major focus is given on the …
Published in Trends in Drug Delivery · Vol. 3, Issue 2, 2016 · pp. 25–34 Read article
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A Brief Review On Nanoparticles Drug Delivery System Used In Cervical Cancer
Abstract: Among cervical tumor-related deaths worldwide, cervical cancer is a major cause. The limitations of traditional methods, such as chemotherapy and radiation therapy, stem from their adverse effects and increased susceptibility to medications. Despite being seen as innovative options, immune checkpoint inhibitors (ICIs) have rather low clinical response rates. Reliable treatments for patients with metastatic or recurring cervical cancer are currently lacking. Lately, nanomaterials including polymers, liposomes, and dendrimers have been …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 30–40 Read article
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Lipid Profile Analysis in Type 2 Diabetes Mellitus Patients Belonging to Kota South
Abstract: Background: Diabetes mellitus is a category of metabolic disorders marked by persistently high blood sugar levels and abnormalities in the metabolism of fats, proteins, and carbohydrates as a result of deficiencies in the secretion or action of insulin, or both. Diabetic dyslipidemia is characterized by elevated low-density lipoprotein cholesterol (LDL-C), reduced high-density lipoprotein cholesterol (HDL-C), and increased triglyceride (TG) levels. The objective of this study is to assess the lipid …
Published in Research and Reviews : A Journal of Immunology · Vol. 13, Issue 2, 2023 · pp. 38–41 Read article
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In vitro Antibacterial Activity of Averrhoa carambola Leaf Extracts
Abstract: The aim of the present study was to determine the phytochemical constituents and antimicrobial potential of Averrhoa carambola leaf extracts against three gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus and Streptococcus mutans) and three gram-negative bacteria (Klebsiella pneumoniae, Proteus vulgaris and Pseudomonas aeruginosa) which are some of the infectious bacteria. The A.carambola leaves were extracted in three different solvents of increasing polarities (hexane, ethyl acetate, and acetone). The phytochemical analysis showed …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 8, Issue 2, 2018 · pp. 27–32 Read article
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Molecular Docking-Based Analysis of Rauvolfia serpentina Alkaloids Targeting HPV E1 and L1 Proteins for Antiviral Therapeutic Potential
Abstract: Human papillomavirus (HPV) is a major cause of cervical cancer and other epithelial cancers. E1 and L1 proteins are crucial to the virus's lifespan. E1 is a viral helicase that is needed for HPV DNA replication, and L1 is the main structural capsid protein that builds the virion and infects target cells. Going after these proteins is a good way to stop viruses from spreading. In this case, Rauvolfia serpentina, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 100–113 Read article
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Cancer Treatment by Radionuclide Therapy
Abstract: Recently, pretargeted nuclear imaging and radiotherapy have gained tremendous attention for diagnosis and treatment of cancer with nanomedicines. Radionuclide therapy (RNT) is one of the rapidly growing fields of nuclear medicine which works on the mechanism of delivery of cytotoxic levels of radiation to the disease sites, sparing the normal cells. RNT targets diseases at the cellular level rather than on a topographic anatomical level when compared to conventional external …
Published in Journal of Nuclear Engineering & Technology · Vol. 8, Issue 2, 2018 · pp. 4–7 Read article
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Modulation of Receptor Proteins: A Recent Paradigm in Drug Discovery and Target
Abstract: The main aim in drug discovery is to design different ligands those work on specific drug targets. However, various effective drugs work through the modulation of many proteins than single target. Advancement in system biology are establishing a phenotypic strength and a network structure, which suggests that, the excellent selective compounds may be performed less than desired clinical efficacy in comparison to multi-target drugs. In this new appreciation of the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 14–24 Read article
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Exploring the Therapeutic Potential of Grapeseed Phytoconstituent Through Molecular Docking Analysis for Multiple System Atrophy Treatment
Abstract: Objective: Alpha-synuclein (α-Syn) aggregates are a common neurodegenerative disorder associated with Parkinson’s disease and multiple system atrophy (MSA). As a fruit that is extensively grown, grapes have several pharmacological advantages when it comes to reducing oxidative stress. Research has indicated that grape seed phytoconstituents have a major effect on α-Syn. The objective of this study is to inquire into the pharmacological characteristics and potential therapeutic applications of grape seed derivatives …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 14–26 Read article