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412 articles for “Gene targeting”
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Generation of Wind Power using Doubly Fed Induction Generator
Abstract: Due to independent controlling mechanism for the active and reactive power, doubly fed induction generator (DFIG) is still culled by the wind turbine companies. The control strategies are continuously advancing to manage the grid codes (i.e. reactive power compensation, low voltage ride-through operation). This paper focuses on the control strategies using combined reactive power compensation for power converters to maintain the optimized lifetime distribution under normal grid conditions. An advanced …
Published in Research & Reviews : Journal of Physics · Vol. 7, Issue 3, 2018 · pp. 73–78 Read article
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Oncolytic Viruses (OV) Mediated Targeted Therapy to Eradicate Chronic Myeloid Leukemia (CML): A Review
Abstract: With the recent advances in scientific scenarios globally, an innovative introduction of cancer vaccines and a much safer and more effective way to eradicate cancer has been evolved. The viruses that are not severely harmful to the humans and do not recognize the human as their natural host can be deployed as an oncolytic virus to eradicate the malignancy either by killing or lysing the oncogenic cells or indirectly stimulating …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 12, Issue 2, 2022 · pp. 27–36 Read article
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Monoclonal antibodies in targeted cancer therapy advances, resistance mechanisms, and next-gen formats (Bispesifics, ADCs)
Abstract: Breast cancer is one of the leading causes of cancer-related morbidity and death worldwide, which emphasizes the need for more effective and focused treatment strategies. antibody-mediated drug delivery techniques. Specifically, antibody–drug conjugates (ADCs) have emerged as a potential approach that combines the specificity of monoclonal antibodies with the potent cytotoxicity of anticancer drugs. By selectively targeting tumor-associated antigens, ADCs enhance drug accumulation within cancer cells while minimizing systemic toxicity associated …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 62–79 Read article
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Ovarian Cancer: Understanding Risk Factors, Diagnosis, and Advances in Treatment
Abstract: Ovarian cancer is a leading cause of cancer-related mortality among women worldwide, often diagnosed at advanced stages due to its subtle early symptoms. Ovarian cancer develops due to a combination of factors, including genetics, environmental influences, and hormonal changes. This article explores the pathophysiology of ovarian cancer, highlighting the genetic mutations, such as BRCA1 and BRCA2, that contribute to its development. It also discusses current diagnostic methods, including imaging techniques …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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A Potential Role of Ayurvedic Treatment in Tuberculosis
Abstract: According to the World Health Organization (WHO), tuberculosis (TB) is one of the top tencauses of death worldwide and verified as a global health problem. The main reason of globalhealth problem is generally the tremendous burden of disease. In the estimated survey of TB in2016, 10.4 million people suffered with TB and 1.7 million died with this disease. After a longperiod of neglect some new interventions are developed by various …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 1, 2019 · pp. 1–10 Read article
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Canopy Design and Fabrication for Reducing Noise Level Generated at Work Place without Affecting Equipment/Machine Performance
Abstract: Abstract Laws governing the safety and health of employed people exist in most countries of the world, the purpose being to create a suitable working environment and eliminate unsafe practices and processes. Work areas should be designed and laid out so that they are satisfactory both, from the environmental and safety points of view. In this connection, safety also implies that noise is kept at a level, which is not …
Published in Journal of Refrigeration, Air conditioning, Heating and ventilation · Vol. 3, Issue 3, 2016 · pp. 24–29 Read article
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Vaccination in the Era of Precision Medicine: Tailoring Immunization Strategies for Individual Risk Profiles
Abstract: The introduction of precision medicine has caused a paradigm change in the vaccine landscape. Conventionally, vaccination programmes have been homogeneous, targeting immunity at the population level without taking into consideration the individual differences in immune response and vulnerability to diseases that can be prevented by vaccination. However, a more individualised approach to immunisation has been made possible by current developments in genetics, immunology, and data analytics. Within the context of …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 32–47 Read article
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 · pp. 41–50 Read article
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Active Vision Approach for Controlling Educational Robotic Arm with Autonomous Object Manipulation
Abstract: This research presents an autonomous robotic framework for academic, vocational and training purpose. The platform is centred on a six-degree-of-freedom (DOF) serial robotic arm. Two on-board cameras developed a computer vision system for detection and autonomous object/target manipulation placed randomly on a target surface and controlling an educational robotic arm (ERA) to pick it up and move it to a predefined destination. Force sensitive resistor (FSR) has been used as …
Published in Journal of Advancements in Robotics · Vol. 1, Issue 3, 2014 · pp. 1–10 Read article
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A Review on Repurposing Drugs for Treatment of Covid-19
Abstract: The newly emerged 2019 novel coronavirus is named as severe acute respiratory syndrome 2(SARS CoV-2). Till date, 1,757,393 cases have been observed in India and 37,452 deaths. COVID-19 has been now declared as pandemic and new treatments are urgently needed as we enter a phase beyond containment. In the absence of approved marketed drugs against coronavirus, the treatment and management of novel COVID-19 disease worldwide is a challenge. Developing new …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 7, Issue 3, 2020 · pp. 16–22 Read article
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Molecular Docking of Nigella Sativa Phytocompound as Inhibitors of Transcription Factors NF-KB Implicated in Rheumatoid Arthritis
Abstract: Objectives: Nigella sativa, a plant considered around the world as the most treasured nutrient-rich herb for centuries together in different civilizations, is exceptionally known for its high levels of antioxidant properties. Free radical intensification due to oxidative stress plays a key role in the pathogenesis of rheumatoid arthritis by activating the NF-KB protein that regulates the expression of the genes involved in inflammation. Methods: This study involves in-silico approach to …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 42–55 Read article
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A Review: The Global Burden of Breast Cancer
Abstract: Breast cancer is most common invasive cancer and the second main cause of death in women. In breast cancer the cancerous cells break out from inside the ducts and invade nearby tissue and increasing the chances of spreading the cancer to other body parts. Out of every 100 breast cancer patient, presently 4% are in the age group 20-30, 16% are in 30–40, 28% are in 40–50. Breast cancer has …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 7, Issue 2, 2017 · pp. 8–16 Read article
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3D-QSAR and Molecular Docking Studies of Triazol-Cycloalkanol Derivatives Used as Potent 3-Dehydroquinase II Inhibitors Against Mycobacterium tuberculosis
Abstract: Tuberculosis is a life threatening infectious disease caused by gram positive bacteria mycobacterium tuberculosis. Emergence of drug resistance, multi drug resistance and extensively drug resistance strain of mycobacterium make the situation more worst. It increases the mortality rate of tuberculosis patient, time duration and cost of treatment. Various inhibitors and drug molecules are designed to combat this fatal disease. Enzymes of shikimate pathway are responsible for production of essential amino …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 3, 2015 · pp. 18–28 Read article
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SIMULATION OF THE PERFORMANCE OF PV/T (PV-PCM) SYSTEMS IN TRANSIENT STATE
Abstract: The paper describes the analysis of the thermal performance of a PCM unit attached to a PV panel configuring a PV/T system. Thermal performance has been analyzed from the transient process point of view considering the temperature evolution of the PCM with time dependent on ambient temperature and solar radiation. A specific algorithm for determining the time evolution of the PCM temperature has been developed. The model uses the DERIVE …
Published in Journal of Thermal Engineering and Applications · Vol. 10, Issue 1, 2023 · pp. 1–13 Read article
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The Unseen World Within: Decoding the Intricacies of Gut Microbiota and Its Impact on Human Health
Abstract: This comprehensive review delves into the multifaceted role of the gut microbiota in human health, elucidating its impact on diverse physiological processes, immune responses, and metabolic diseases. The intricate interplay of diet, genetics, and environmental factors is explored in shaping the composition and function of the gut microbiota, with consequential effects on conditions ranging from metabolic disorders to inflammatory bowel diseases and mental health. Therapeutic interventions, including probiotics, prebiotics, and …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 3, 2023 · pp. 12–21 Read article
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A Review on Applications of Nanoparticles in Cancer Treatment
Abstract: Cancer has become the leading cause of death. It is caused by disorder in the division and growth of cells. It can be treated after the confirmation of growth of cancerous cells. Conventionally it is done by x-rays or CT scans. Then the genes are destroyed or damaged or by controlling the blood supply to other genes. Now advancements in nanotechnology have enabled the physicians to treat the cancer. In …
Published in Research & Reviews : Journal of Physics · Vol. 7, Issue 3, 2018 · pp. 31–35 Read article
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A Contribution to the Study of Geographical Displacement of Crime using GIS–Kings Cross, London
Abstract: Displacement of crime is the specter that haunts crime prevention studies, in that, the crime problem does not go away but shifts from one location to another. The fact that crime is not reduced in an area but rather moves around means that trying to change the situation and circumstances surrounding the targeted area may not fully reduce crime. Research that has been previously carried out into the study of …
Published in Journal of Remote Sensing & GIS · Vol. 4, Issue 3, 2013 · pp. 12–25 Read article
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Supportive Therapy Play a Vital Role in the Treatment of Leukemia: A Review
Abstract: Leukemia is a major burden worldwide. The anomalous production of white blood cells (WBC) is responsible for producing leukemia; these cells are also known as blasts. A study indicated that thousands of patients are detected every year with leukemia risk worldwide. The risk factor including chemical exposure, ionizing radiations, cigarette smoking is the major causes for developing leukemia. There are four types of leukemia and number of genes involved are …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 3, 2018 · pp. 1–8 Read article
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In Silico Molecular Docking Studies of Phytoconstituents Identified in Curcuma zedoaria Rosc. on Acetylcholinesterase: An Enzyme Target for Anti Alzheimer’s Activity
Abstract: Alzheimer’s disease (AD) is a chronic, progressive and disabling organic brain disorder characterized by disturbances of multiple cortical functions. Acetylcholinesterase (AChE) inhibition is thought to be a promising approach towards the treatment of AD. The aim and objective of the present study is to perform in-silico docking analysis of the major active constituents identified in Curcuma zedoaria Rosc. against AChE for anti-Alzheimer’s activity. In this perspective, phytoconstituents like bisdemethoxy curcumin, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 3, 2019 · pp. 9–14 Read article
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A Review Paper on Friction Stir Processing on Aluminium Alloys
Abstract: Friction stir processing is a step from friction stir welding, targeted at surface modification through improving the local microstructure via localized plastic deformation. The tool consists of a rotating mechanism incorporating a shoulder and pin that are inserted into the material, traversing the designated area. When the tool's shoulder and the workpiece make contact, friction develops, generating heat that produces plastic deformation. This localized plastic deformation and heat impact result …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 1, 2024 · pp. 1–8 Read article