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837 articles for “Clinical”
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Unveiling the Synergy: Sciatica, Arthritis, and Their Integrated Approach to Wellness
Abstract: This comprehensive review delves into the intricate connection between sciatica and arthritis, unraveling the etymological roots of “sciatica” from its ancient Greek and Latin origins. Tracing the historical aspects of sciatica back to the teachings of Hippocrates, the fifth-century BC Hellenic physician, sets the stage for a contemporary exploration of the interplay between these conditions. The sciatic nerve, including nerve roots spanning from L4 to S3, stands out as the …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 22–31 Read article
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Unraveling Ulcerogenesis: A Comprehensive Delve of Enteric & Nonenteric Ulcers
Abstract: Enteric ulcers present a multifaceted landscape encompassing both peptic and non-peptic varieties, demanding a thorough exploration of their manifestations, causes, and pathophysiology. At the forefront of understanding lie pivotal factors such as Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs usage, lifestyle choices, and stress, each wielding significant influence over ulcer development and progression. The intricate interplay of these factors underscores the complexity of enteric ulcer etiology. Helicobacter pylori infection—a prevalent culprit—inflicts …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 1, 2024 · pp. 25–40 Read article
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Marchiafava Bignami Syndrome: A Review
Abstract: Marchiafava-Bignami syndrome (MBS) is a rare neurological disorder characterized by demyelination and necrosis of the corpus callosum, which is the main bundle of nerve fibers connecting the two hemispheres of the brain. MBS primarily affects individuals with chronic alcoholism, although cases unrelated to alcohol consumption have also been reported. The corpus callosum is affected in almost a pathognomonic way. The clinical presentation is based on neurological impairment, motor abnormalities, seizures, …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 1, 2024 · pp. 21–25 Read article
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A Narrative Review on an Insight of Herbal Origin Drugs and Their Traditional Medicine Formulations for the Treatment of Nephrolithiasis
Abstract: Ethnopharmacological relevance. There is no satisfactory treatment at present to cure or prevent kidney stone recurrences using predictable medicines. There are several marketed formulations in Ayurveda, Unani and Homeopathic Traditional Medicines (TM) have potential lithotriptic effects and clinical applications. In India, prevalence rates of complementary and alternative medicine (CAM) for the treatment of nephrolithiasis are being estimated at 63.9%. Aim of the review This review article intended to scientifically documented …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 1, 2024 · pp. 14–30 Read article
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Periodontitis and Rheumatoid Arthritis
Abstract: This comprehensive review delves into the complex interplay between Periodontitis and Rheumatoid Arthritis, aiming to unravel the underlying mechanisms and shared inflammatory pathways that connect these seemingly distinct conditions. The review examines a wealth of current research, exploring how chronic periodontal inflammation may contribute to the development and progression of RA and vice versa. Furthermore, the review critically evaluates the clinical implications of this interrelation, emphasizing the need for interdisciplinary …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 1, 2024 · pp. 31–39 Read article
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A Review on Diagnosis and Management of Conjunctivitis
Abstract: Conjunctivitis, typically recounted as crimson eye, is a super ocular circumstance affecting men and ladies of all ages. This abstract aims to summarize the findings of a comprehensive study that delves into the pathogenesis, clinical manifestations, and management strategies for conjunctivitis. A multifaceted approach was employed, including a systematic literature review of conjunctivitis-related studies, clinical observations, and interviews with leading ophthalmologists. The various cases were analysed to assess demographic patterns, …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 35–46 Read article
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Unraveling Metagenomics: A Comprehensive Diagnostic Approach for COVID-19
Abstract: The COVID-19 pandemic has brought attention to the need for rapid, accurate, and scalable diagnostic techniques. Metagenomics, a powerful technique that enables the comprehensive analysis of genetic material from complex microbial communities, has emerged as a promising diagnostic approach for COVID-19. This article elucidates the principles of metagenomic sequencing, highlighting its ability to detect viral RNA directly from clinical samples without prior knowledge of the pathogen. Furthermore, we discuss the …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 2, 2024 · pp. 19–28 Read article
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Iron Deficiency Anaemia_A Evidence-Based Literature Review
Abstract: Iron deficiency anaemia represents a medical condition characterised by a reduction in the concentration of haemoglobin in the bloodstream below a defined level, according to the World Health Organization. The condition presents itself in two forms: functional IDA and absolute IDA. The former is characterized by normal or elevated total body iron stores, but insufficient iron supply to the bone marrow. At the same time, the latter occurs when total …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 17–28 Read article
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Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity
Abstract: Over the past few decades, significant advancements have been made in the development of heterocyclic derivatives, leading to the production of numerous novel agents, both synthetic and natural in origin. Because of its numerous biological properties, including antibacterial, antiviral, and antifungal properties, thiazole is a special five-membered heterocyclic motif among heterocyclic compounds. It is utilized as a fundamental building block in many pharmaceutically significant compounds. To the best of our …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 62–67 Read article
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Evaluating Linezolid: A Comprehensive Analysis
Abstract: Treatments for infections caused by Gram-positive bacteria, such as methicillin-resistant staphylococci and VRE, including skin and soft tissue infections, community-acquired pneumonia, and other infections treated with linezolid, an oxazolidinone antimicrobial agent that functions by specifically inhibiting protein synthesis. Even while antibiotic resistance is becoming more frequent in many nations, linezolid resistance among these pathogens is still low, typically less than 1%. Thus, the emergence of resistance in clinical isolates should …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 11–16 Read article
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Editorial: Advancements in Movement Analysis for Understanding Neurological Disorders
Abstract: Neurological disorders pose a significant challenge, demanding innovative approaches for accurate diagnosis, effective treatment, and deeper understanding. Movement analysis emerges as a powerful tool, offering a quantitative window into the complexities of motor function. This editorial delves into the transformative impact of movement analysis on neurological research and clinical practice. Traditional diagnostic methods, reliant on subjective observations, often miss subtle motor impairments, particularly in early disease stages. Movement analysis tackles …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 28–32 Read article
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Assessing the Efficacy of Carica Papaya Leaf Extract in Preventing Thrombocytopenia: A Review
Abstract: A clinical condition known as thrombocytopenia is characterized by a low platelet count (less than 150 × 103/μL) in the blood, which leads to an imbalance in hemostasis and can result in multiple deadly consequences. Although the exact causes are not always known, they always lead to death by interfering with the formation of platelets and encouraging their destruction. Research demonstrates that Carica papaya leaf has special medicinal and therapeutic …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 2, 2024 · pp. 25–33 Read article
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Comprehensive Analysis of MRSA Peptides Via Maldi
Abstract: The present study employed Matrix-Assisted Laser Desorption/Ionization Time-of-Flight mass spectrometry to analyze methicillin-resistant Staphylococcus aureus peptides, focusing on various parameters associated with mass-to-charge (m/z) values. Through systematic data collection and analysis, including time, intensity, signal-to-noise ratios, quality factors, resolutions, areas under the peaks, relative intensities, full widths at half maximum, Chi-squared values, and background peaks, comprehensive insights into the spectral characteristics of methicillin-resistant Staphylococcus aureus peptides were obtained. Methicillin-resistant Staphylococcus …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 98–101 Read article
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Role of Low Level Laser Therapy (LLLT) in Healing of Electric Burns
Abstract: The objective of this case study is to evaluate the effectiveness of low-level laser therapy (LLLT) in treating scalp wounds caused by electric burns. A thorough examination of the scalp wound was conducted both before and after administering LLLT. The findings suggest that LLLT plays a beneficial role in the healing process of superficial ulcers. Specifically, the application of LLLT (as depicted in Figure 1) demonstrated promising results in facilitating …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 39–44 Read article
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Current Perspectives of Prader -Willi Syndrome: A Multisystem Approach
Abstract: Prader-Willi syndrome (PWS) is a genetic disorder with multisystem involvement, caused by the lack of expression of genes on the paternally inherited chromosome 15q11.2-q13 region from paternal 15q11-q13 deletions (about 60%) or maternal uniparental disomy 15 or both. It is a complex and contiguous gene disorder which affects the multiple systems with many clinical presentations especially hypothalamic insufficiency. The clinical features are characterized by short stature position, developmental delay, cognitive …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 42–48 Read article
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Wiskott-Aldrich Syndrome: A Comprehensive Guide
Abstract: Wiskott-Aldrich Syndrome (WAS) is an uncommon genetic disorder inherited through the X chromosome, marked by a combination of immune system deficiencies, eczema, and low platelet counts. This syndrome primarily affects males, leading to significant morbidity and mortality due to recurrent infections, bleeding complications, and autoimmune diseases. Mutations in the WAS gene disrupt the production of the Wiskott-Aldrich Syndrome protein (WASp), crucial for the functioning of immune cells and platelet formation. …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 39–46 Read article
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An Overview of Fanconi Anemia: A Genetic Disorder
Abstract: Fanconi Anemia (FA) is a rare genetic disorder caused by DNA repair defects due to pathogenic variants in one of 21 genes. It is the primary cause of inherited bone marrow failure, marked by pancytopenia. Clinically, Fanconi Anemia (FA) is associated with congenital malformations in multiple systems, resulting in progressive bone marrow failure and heightened cancer risk, especially in the urogenital region and the head and neck. There are approximately …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 19–25 Read article
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Rethinking Type-1 Diabetes Treatment: Emerging Medicines Based on AAT Therapy and C-peptide Preservation Therapy
Abstract: The increasing number of cases, especially in the younger age group, along with the lack of accessible clinical solutions, make Type-1 Diabetes (T1D) a growing global health concern. While gene therapy and transplantation approaches are promising avenues, their excessively high costs and logistical difficulties make them inaccessible to the majority and can impose a financial burden on those suffering from it, adding to the challenges already faced by these advanced …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 19–29 Read article
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The Evaluation of the Light Parameters and Pleural Fluid Cholesterol to Determine the Differences Between Exudative and Transudative Pleural Discharge
Abstract: Background: Pleural effusion occurs when an imbalance between pleural fluid production and absorption leads to the accumulation of excess fluid in the pleural cavity. Pleural effusions are commonly classified into two types: transudative or exudative, depending on the underlying mechanism of fluid formation. While transudates typically result from systemic factors like heart failure or liver cirrhosis, exudates are usually caused by local factors such as infection, malignancy, or inflammation. Differentiating …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 30–35 Read article
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Stiff Person Syndrome: Advances in Understanding, Diagnosis, and Treatment of a Rare Autoimmune Disorder
Abstract: Stiff Person Syndrome (SPS) is a rare and complex autoimmune neurological disorder characterized by progressive muscle stiffness, rigidity, and painful spasms. This chapter provides a comprehensive overview of SPS, exploring its pathophysiology, clinical presentation, diagnostic challenges, and current treatment approaches. We discuss the latest research findings, including the role of autoantibodies, genetic factors, and environmental triggers in the development of SPS. The chapter examines various diagnostic methods, emphasizing the importance …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 35–43 Read article