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484 articles for “optimization strategies”
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Innovations in Targeted Drug Discovery for Personalized Medicine
Abstract: Personalized medicine is revolutionizing modern healthcare by custoizing treatment plans to match an individual’s genetic makeup, protein expression, and metabomlic characteristics. Also referred to as precision medicine, this approach seeks to improve therapeutic outcomes, reduce adverse effects, and make efficient use of healthcare resources. The incorporation of various omics technologies—including genomics, proteomics, transcriptomics, metabolomics, and epigenomics—has greatly advanced our ability to understand disease biology and molecular variations specific to each …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 19–41 Read article
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Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
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Microstructural Design and Functional Properties of Polycrystalline Materials
Abstract: Polycrystalline materials, composed of an aggregate of crystallites or grains, are foundational to modern engineering applications due to their versatile functional properties. The microstructural design—encompassing grain size, shape, orientation, phase distribution, and grain boundary characteristics—plays a pivotal role in determining mechanical, thermal, electrical, and magnetic behavior. This abstract explores the intricate relationship between microstructure and functionality, emphasizing how tailored processing techniques such as thermomechanical treatments, sintering, and additive manufacturing can …
Published in International Journal of Crystalline Materials · Vol. 2, Issue 2, 2025 · pp. 16–20 Read article
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Renewable Solar Energy Prediction in India : 2025-2030
Abstract: As India endeavors to realize its objective of achieving 500 GW of renewable energy capacity by the year 2030, the precise forecasting of solar power generation is rendered increasingly essential. This scholarly article conducts a comprehensive review of the utilization of machine learning (ML) methodologies in the prediction of solar energy across diverse Indian states, underscoring their potential to address the complexities associated with the variability of solar irradiance. Conventional …
Published in Journal of Power Electronics and Power Systems · Vol. 14, Issue 3, 2024 · pp. 41–46 Read article
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Advancements in Nanotechnology and Biosensor Integration for Detection and Treatment of Alice in Wonderland Syndrome
Abstract: Alice in Wonderland Syndrome (AIWS) is an uncommon neurological condition characterized by profound distortions in perception. Individuals with AIWS experience altered body image and spatial awareness, often perceiving objects, surroundings, or even their own body as being unusually large, small, or distorted. The condition presents a unique challenge for both diagnosis and management due to its elusive and varied symptoms. This paper explores how advancements in nanotechnology and biosensor integration …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 3, 2024 · pp. 1–12 Read article
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Investigation of High reliable electric vehicles drive with fast charging system
Abstract: Per capita, India has the world's biggest battery electric vehicle market. For the last several years, there has been a lot of discussion about the challenges and prospects of integrating electric vehicles (EV) with an electric grid. A battery model of an EV should have suitable control mechanisms to interact with an electric grid. The growth of and accessibility of fast-charging technology is one of the many technological concerns being …
Published in Trends in Electrical Engineering · Vol. 15, Issue 1, 2025 · pp. 44–50 Read article
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Understanding Food Spoilage: Mechanisms, Shelf-Life Determination, and Safety Standards
Abstract: Food spoilage poses significant challenges to the global food industry, impacting both food safety and economic sustainability. The main causes of food quality deterioration are microbial and non-microbial spoiling. Microbial spoilage primarily results from the activity of bacteria, yeasts, and molds, which thrive under favorable environmental conditions. These microorganisms can lead to food poisoning and spoilage through the production of off-flavors, discoloration, slime formation, and the accumulation of harmful toxins. …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 14, Issue 1, 2025 · pp. 6–9 Read article
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AI-Empowered Space Traffic Management: Challenges and Strategies
Abstract: Space traffic management (STM) has emerged as a critical field of study due to the rapid expansion of space activities, including satellites, debris, and future crewed missions. This research paper delves into the multifaceted issues and challenges associated with STM and explores innovative strategies, specifically focusing on integrating artificial intelligence (AI). It examines the pressing problems of space debris proliferation, collision avoidance, spectrum congestion, and the need for international cooperation. …
Published in Research & Reviews : Journal of Space Science & Technology · Vol. 14, Issue 1, 2025 · pp. 20–28 Read article
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Gut Microbiome Dysbiosis During Metabolic Disorders: Diabetes
Abstract: Understanding the intricate interplay between gut microbiome dysbiosis and diabetes is crucial due to the escalating prevalence and impact of diabetes mellitus globally. This comprehensive review examines the current understanding of this relationship, elucidating how alterations in the gut microbiome composition contribute to diabetes pathogenesis by influencing metabolic homeostasis, immune regulation, and insulin resistance. Dysregulation of gut microbial communities leads to shifts in diversity and abundance, exacerbating chronic low-grade inflammation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 56–75 Read article
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An Examination of Energy-Saving Techniques for UAV Communication
Abstract: Unmanned aerial vehicles (UAVs), or drones, have become essential in various industries due to their low deployment costs and exceptional versatility. As a result, they are widely used in industries like mining, agriculture, logistics, and search and rescue. The effectiveness of UAV applications is largely dependent on robust communication technology, which is crucial for control, data transmission, and coordination. However, the limited capacity of the low-power batteries used in UAVs …
Published in International Journal on Drones · Vol. 1, Issue 1, 2025 · pp. 1–7 Read article
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Drug-Induced Liver Injury: Hepatotoxicity and Treatment - A Literature Review
Abstract: Drug-induced liver injury (DILI) is a major clinical and regulatory challenge, posing risks to patient safety and drug development worldwide. As the primary organ responsible for xenobiotic metabolism, the liver is particularly susceptible to toxic injury from prescription drugs, over-the-counter medications, herbal products, and dietary supplements. Drug-induced liver injury (DILI) accounts for a substantial proportion of acute liver failure cases and remains a leading cause of post-marketing drug withdrawal. Its …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 1–17 Read article
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Egg Quality in Laying Hens: Optimizing Genetic, Nutritional, Environmental and Management Factors for Sustainable Layer Farming
Abstract: This review paper provides a comprehensive analysis of the critical factors affecting egg quality in laying hens, focusing on the integration of genetic, environmental, nutritional, and management practices. Egg quality, including shell strength, albumen consistency, and yolk pigmentation, is a key determinant of both production efficiency and marketability. Genetic factors, such as selection for desirable traits, like shell integrity and yolk color, have a significant impact on the overall quality …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 2, 2025 · pp. 1–15 Read article
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Assessment of Several Feed Varieties in Carp Polyculture
Abstract: This six-month aquaculture study evaluated the effects of four distinct feeding treatments on the production and development of a five-species polyculture system comprising common carp (Cyprinus carpio), grass carp (Ctenopharyngodon idella), Rohu, Katla, and Mrigel. The experiment utilized the total volume for eight ponds, each with a volume of 150 m3 is 1200 m3 (cubic meters) to compare: T1 (finely chopped Dubo grass and mash feed), T2 (sinking pellet), T3 …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 1, 2026 · pp. 1–6 Read article
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Enhanced Multimodal Disease Prediction Using Hybrid Ensemble Learning and AutoML Techniques
Abstract: The integration of hybrid ensemble learning and automated machine learning (AutoML) is revolutionizing disease prediction by addressing the complexity, imbalance, and high dimensionality inherent in medical datasets. This paper proposes an advanced pipeline that combines diverse ensemble learning models with AutoML-based optimization to predict chronic diseases such as kidney diseas-e, Parkinson’s disease, and lung cancer. Publicly available datasets from UCI and PhysioNet repositories were preprocessed using outlier removal, normalization, and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 1, 2026 Read article
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The Role of Optimism in Reducing Psychological Distress Amongst Women in Urban Areas
Abstract: This paper aims to explore the role of optimism in reducing psychological distress among women living in urban areas. Psychological distress, encompassing anxiety, depression, and chronic stress, has become increasingly prevalent due to the fast-paced and demanding nature of urban life. Women, in particular, face unique stressors including work-life imbalances, financial pressures, safety concerns, and societal expectations, which contribute significantly to elevated levels of mental strain. Finding healthy coping strategies …
Published in International Journal of Trends in Humanities · Vol. 2, Issue 2, 2025 Read article
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Adaptive E-Learning Algorithms and Heutagogy: A Systematic Analysis
Abstract: The proliferation of artificial intelligence (AI) and machine learning (ML) technologies has transformed the digital education landscape by enabling adaptive e-learning systems capable of personalizing content and optimizing learning paths. This study provides a systematic analysis of adaptive e-learning algorithms within the framework of heutagogy, an educational paradigm that emphasizes learner autonomy, self-direction, and capability development. The convergence of adaptive technologies with heutagogical principles offers new avenues for creating more …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 3, 2025 · pp. 33–38 Read article
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Enhancing Peptic Ulcer Therapy: Innovations in Mucoadhesive Drug Delivery
Abstract: Peptic ulcer disease is still a sincere gastrointestinal demand makes medication administration difficult because of the harsh and changing stomach environment. This paper investigates the potential of using mucoadhesive drug delivery devices to improve the accuracy and effectiveness of peptic ulcer therapies. Due to the inherent characteristics of mucoadhesive drug delivery systems, localized and sustained drug release is made possible by their extended contact and adherence to the gastrointestinal tract's …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 62–76 Read article
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Effect of Drilling Process Parameters on Surface Roughness of LM6/B4C/Fly Ash Hybrid Composites
Abstract: This research seeks to assess the effect of process variables such as feed rate (FR), spindle speed (SS), drill material (DM) and reinforcement (R%) on surface roughness (SR) when drilling LM6/B4C/Fly ash hybrid composites. The stir casting process was used to fabricate the LM6/B4C/Flyash hybrid composites utilizing LM6 aluminum alloy as the matrix material and B4C/Fly ash as strengthening materials. Experiments were carried out using an L18 orthogonal array (OA) …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 898–906 Read article
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Enhancing Surface Roughness of Polylactic Acid (PLA) 3D-Printed Parts Using CO₂ Laser Scanning: An Experimental Study on Parameter Optimization
Abstract: Fused deposition modeling (FDM) of polylactic acid (PLA) often suffers from poor surface finish due to the inherent layer-by-layer deposition process, limiting its use in high-precision applications. This study investigates CO₂ laser scanning as an efficient post-processing technique to reduce the surface roughness (Ra) of PLA parts while maintaining structural integrity. Specimens (100 × 80 × 5 mm) were fabricated with varying infill densities (35%, 70%, and 100%) to assess …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 503–511 Read article
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Enhancing Chatter Resistance in Deep Hole Boring Through Modified Tool Design: A Study on Impact of Length-To-Diameter (L/D) Ratio
Abstract: Deep hole boring is a specialized machining process crucial for creating precise bores with high length-to-diameter (L/D) ratios, particularly vital in aerospace, automotive, and oil and gas industries. The L/D ratio is pivotal for stability and performance. Chatter, a detrimental vibration phenomenon, is a significant concern in deep hole boring, influenced by the L/D ratio. Higher L/D ratios increase chatter, leading to poor surface finish and reduced tool life. Longer …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 2, Issue 2, 2024 · pp. 24–33 Read article