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240 articles for “binding”
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Melanoma Skin Cancer Detection Using Deep Learning
Abstract: Cancer as one of the major diseases rank in the World is still very challenging to diagnose and treat hence need for the technological advancements. Chemotherapy, radiation, as well as surgery therapies have several drawbacks including non-selective action, damage to healthy tissues, and multi-drug resistance. Smart nano-theranostics, an advanced integration of nanotechnology with diagnostic and therapeutic modalities, offers a next-generation approach for precision oncology. Thus, the development of multifunctional nanoparticles …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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A Brief Review on Herbal Excipients
Abstract: Natural or herbal excipients are significantly more advantageous than their synthetic equivalents because they are readily available, non-toxic, and less expensive. The pharmaceutical industries are becoming more interested in using these herbal excipients – mainly polymers of natural origin – in formulation development because of growing knowledge of them. The purpose of this study is to provide light on the possibility of using natural excipients, which are biocompatible and able …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 2, 2025 · pp. 5–14 Read article
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Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications
Abstract: The present study explores the synthesis and characterization of polymer-supported benzamide derivatives, focusing on their potential biomedical applications. The use of polymer-supported synthesis offers several advantages, including improved reaction efficiency, ease of purification, and reusability of the support material, making it an environmentally friendly and cost-effective approach. The synthesis involved a stepwise reaction sequence, with polymeric supports facilitating controlled functionalization and ensuring high product purity. These materials have been widely …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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A Review on Kaempferol Eye Drops for the Glaucoma Treatment
Abstract: One of the main causes of permanent blindness, glaucoma is defined by gradual damage to the optic nerve, mostly brought on by oxidative stress, neuroinflammation, and high intraocular pressure (IOP). The investigation of herbal alternatives is necessary since current synthetic therapies, such as beta-blockers and prostaglandin analogs, frequently result in ocular discomfort, systemic toxicity, and poor patient compliance. Clitoria ternatea contains kaempferol, a bioactive flavonoid that has shown anti-inflammatory, antioxidant, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 110–121 Read article
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Bedaquiline: An In-Depth Exploration into Its Antitubercular Significance
Abstract: Tuberculosis is still a leading infectious disease and a major threat to public health. Although there has been a slow decrease in the incidence over years, its “hard to kill nature” is responsible of about 2 million deaths in HIV infected individuals annually. Bedaquiline, a Diaryl-Quinoline drug was fast-track approved as an orphan drug to combat drug resistance. It shows potent activity against Mycobacterium tuberculosis by interfering with the production …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 06–14 Read article
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Soil Stabilized Road
Abstract: This research examines the suitability of soil-stabilized roadways for light vehicular movement, offering an economical and practical alternative for areas with limited infrastructure development. Stabilizing soil involves improving its engineering properties by incorporating additives such as cement, lime, or other binding materials. Through stabilization, the treated soil can achieve a compressive strength of approximately 5 N/mm², or 500 tonnes per square meter (t/m²), which is sufficient to support loads imposed …
Published in Journal of Geotechnical Engineering · Vol. 12, Issue 2, 2025 · pp. 38–42 Read article
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Molecular Docking Analysis of Berberis aristata Phytocompounds as Potential Growth Factor Receptor Blockers in Cancer Therapy
Abstract: Middle-aged and older women are susceptible to breast cancer (BC), a potentially fatal condition. When breast cancer is diagnosed, the median age is 62. Breast cancer diagnoses in women under 45 are comparatively uncommon, whereas the bulk of breast cancer diagnoses occur in women 62 and older. Growth factor receptors are interesting therapeutic targets because of their critical role in the pathophysiology of cancer. Vascular endothelial growth factor receptors (VEGFR-2) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 1–10 Read article
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Drug Utilisation and Cost Analysis in End-Stage Renal Disease Patients: A Prospective Observational Study
Abstract: Chronic Kidney Disease (CKD) is a condition in which the kidneys are damaged and unable to efficiently remove waste and excess fluid from the blood. Dialysis serves as a treatment for CKD by artificially carrying out the kidney’s filtering functions. This prospective observational cross-sectional study was conducted to evaluate drug utilization patterns, economic burden, and health-related quality of life (HRQoL) among patients with end-stage renal disease (ESRD) undergoing dialysis. Over …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 2, 2025 · pp. 1–12 Read article
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In silico Molecular Docking Analysis of Stephania glabra phytocompounds Targeting Thymidylate Kinase for potential Antituberculosis Activity
Abstract: Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis. It mainly affects the lungs and spreads through the air when a person with active TB in their lungs coughs, sneezes, or spits. This study investigates several bioactive compounds derived from plants to forecast how effective plant-based ligands will be at preventing tuberculosis. The purpose of the study was to use computational techniques to assess the effectiveness of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 Read article
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Polymer-Nanowire Hybrid Composites Based on PEDOT: PSS and AgNWs for High-Performance Conductive Films in Flexible Devices
Abstract: The growing demand for flexible photovoltaic and wearable optoelectronic devices has intensified research into polymer-based conductive composites that provide transparency, flexibility, and electrical efficiency. In this work, we report the fabrication and characterization of a hybrid polymer nanocomposite electrode comprising silver nanowires (AgNWs) embedded within a PEDOT:PSS matrix, deposited on flexible polyethylene terephthalate (PET) substrates. The PEDOT:PSS polymer phase, modified with 5 vol% dimethyl sulfoxide (DMSO) and 0.1 vol% Zonyl …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 236–250 Read article
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Investigation of Sulphate, Alkali and Carbonation Chemical attack in GGBS-Based Geopolymer Concrete and OPC Concrete
Abstract: This study presents a comparative evaluation of the durability of GGBFS-based Geopolymer Concrete (GPC) and OPC concrete in rapid carbonation, sulphate, and alkali environments. All samples were subjected to three severe conditions are carbonation at 4% CO₂, 25°C and 60% relative humidity, exposure to a 10% sodium sulphate (Na₂SO₄) solution, and immersion in a 10% sodium hydroxide (NaOH) solution for alkali resistance. The durability characteristics were evaluated by the compressive …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 13–35 Read article
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The Effect of Quicklime on The CBR Value of Soft Soil Stabilized with Nickel Slag and Aluminium Hydroxide
Abstract: The construction of road structures on soft soils is prone to structural damage due to the low bearing capacity of the soil under the load imposed by vehicles. Chemical stabilization is a popular method used to increase the bearing capacity of soft soils. This study aims to examine the effectiveness of soft soil stabilization using a mixture of lime, nickel slag, and aluminium hydroxide to enhance soil bearing capacity. The …
Published in Journal of Geotechnical Engineering · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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Develop Compassion for Peaceful Existence
Abstract: Compassion is the source of creating an affectionate world. The essence of the human soul remains the same, regardless of racial or ethnic differences. Compassion is the key element which binds them together. Even one, if he thinks beyond horizon, birds and animals also experience compassion toward each other. A feeble old bird was being fed by a younger one; the sight was truly heartwarming. Monkey holding the baby in …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 3, 2025 · pp. 1–5 Read article
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Comprehensive Review of Kojic Acid and Its Derivatives: Biological Activities, Safety, and Therapeutic Potential in Depigmentation
Abstract: There are several uses for kojic acid in human medicine, particularly in depigmentation. Additionally, derivatives of it are suggested to enhance efficacy, avoid side effects, and stop chemical degradation. With an eye toward human use and an attempt to clarify the action mechanisms, the goal of this study was to review the most recent scientific literature regarding the biological activities and safety information of kojic acid or its derivatives. During …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 45–53 Read article
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Extraction, Stability, and Application of Natural Dye from Spathodea campanulata Flower: A Study on Shelf Life, Yield, and Fabric Dyeing Potential
Abstract: The growing demand for sustainable and eco-friendly alternatives to synthetic dyes has led to increased interest in natural dye sources. Spathodea campanulata, commonly known as the African Tulip Tree, is a potential source of natural dye due to its vibrant floral pigments. This study focuses on the extraction, yield, stability, and application of the dye obtained from Spathodea campanulata flowers. The dye was extracted using an aqueous method, and its …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 3, 2025 · pp. 8–15 Read article
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Design, Synthesis, and Evaluation of Novel Quinazoline Derivatives as Anti-Inflammatory Agents
Abstract: Novel quinazoline derivatives are well-known heterocyclic scaffolds that are renowned for having a wide range of biological functions. A new quinazoline derivative was synthesized from anthranilic acid through a multi-step sequence involving amide formation, cyclization, and aromatic group substitution. The structure of the methoxy- and chloro-substituted final compound was confirmed by IR and 1H NMR spectroscopy. Evaluation of synthesized molecules anti-inflammatory activity using paw edema caused by carrageenan paradigm in …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 01–09 Read article
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Comparative Analysis Between Librosa and OpenSMILE
Abstract: This research work focuses on comparative study of Librosa, a python-based library, and openSMILE, a C++ toolkit, with python bindings used in audio speech analysis. Librosa is ideal for beginners due to its simple structure and flexibility with strong integration with machine learning frameworks like TensorFlow and PyTorch. On the other hand, OpenSMILE is ideal for speech-centric tasks like speech-emotion recognition or paralinguistic studies, offering a wide range of pre-defined …
Published in Journal of Open Source Developments · Vol. 12, Issue 3, 2025 · pp. 06–10 Read article
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Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking Approach
Abstract: Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking ApproachGlioneuronal tumors and gliomas are grade I tumors classified by the World Health Organization (WHO). They typically grow slowly and primarily affect infants, children, and teenagers, but can also occur in adults. They mostly cause seizures caused by gangliomas. Most current treatments include surgery and radiotherapy. Since this disease affects children, the current treatments may cause complications. Andrographis paniculata …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 82–93 Read article
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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Investigation of Bio-Physical Interaction and Electrophoretic Properties of Fe3O4/DNA Nanocomposite and Colloids for Biomedical Application
Abstract: In recent years, research on magnetic nanoparticles has gained significant attention. The core concept behind their physics lies in their interaction with biomolecules such as hemoglobin, DNA, and RNA. This study examines the fundamental forces involved in these interactions, including van der Waals attractions, electrostatic repulsion, thermal effects, and magnetic coupling between nanoparticles and biological molecules. To describe these interactions quantitatively, parameters such as zeta potential, magnetic moment density, and …
Published in Research & Reviews : Journal of Physics · Vol. 14, Issue 3, 2025 · pp. 20–32 Read article