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218 articles for “Drug toxicity”
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Current Tumour Immunotherapy strategies and their molecular basis
Abstract: AbstractStudying cancer and devising techniques to combat the deadly disease has witnessed a paradigm shift, from conventional toxic treatments of radiation and chemotherapy, to a more specific, and biologically significant immunotherapy and molecular targeted therapy. This can be seen in the global immunotherapy market, which is dominated by North America region valued about $45.9 billion in 2017 that is estimated to reach about $115.9 billion by 2025, and is closely …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 1–18 Read article
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Use of Advanced (i.e., Membrane) Technology for the Wastewater Treatment of Coke Ovens
Abstract: Coke plants produce gas, and coke for metallurgical purposes and also supply the raw materials for the manufacture of dyes, drugs, and high explosives. Naturally found coal is converted into coke in coke ovens. A large quantity of water is used for quenching hot coke and for washing gas. After quenching the wastewater contains high-suspended solids, high biochemical oxygen demand (BOD) (600–1300 mg/L), chemical oxygen demand (COD) (1500–3000mg/L), phenols(500–650 mg/L), …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 2, Issue 1-3, 2012 · pp. 114–126 Read article
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Cytotoxic, Anthalmintic and Analgesic Activities of the Methanol Extract of Ricinus communis (Family: Euphorbiaceae)
Abstract: The aim of this study was to evaluate the phytochemical screening, cytotoxicity, anthelmintic activity and analgesic properties of the methanol extract (leaves) of Ricinus communis (Family: Euphorbiaceae). The methanol extract of the leaves showed mild cytotoxic activity with the LC50 value 6.456 µg/mL compared to vincristine sulfate (LC50 0.812 µg/mL) using brine shrimp lethality bioassay. The anthelmintic activity was performed by observing the time of paralysis and the time of …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 1, 2015 · pp. 27–35 Read article
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Antimicrobial Activity of Alcoholic and Aqueous Extracts of Tinospora cordifolia
Abstract: 1024x768 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} The success of chemotherapy lies in the continuous search for new drugs to counter the challenge posed by resistant strains. Ethanolic and aqueous extracts of plant Tinospora …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 1, 2011 · pp. 1–6 Read article
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Advancing Breast Cancer Treatment: Harnessing the Potential of Diverse Inorganic Nanoparticles
Abstract: Nanotechnology provides promising avenues for diagnostics, tumor imaging, and targeted drug delivery in breast cancer treatment. This article examines the potential of inorganic nanoparticles in breast cancer theragnosis, specifically Supramagnetic nanoparticles, gold nanoparticles, and quantum dots. It applies a scoping review approach to address the existing challenges and prospects of nanotechnology in managing breast cancer and to propose directions for future research. The findings from the review suggest that critical …
Published in Journal of Nuclear Engineering & Technology · Vol. 13, Issue 2, 2023 · pp. 21–41 Read article
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Personalized Medicine: the impact of ferrofluids, clinical procedures, strategies, applications,challenges, current trends, and reseach opportunities.
Abstract: Personalized medicine has shown progressive development and evolution in health care systems. It is considered as transformative emerging medicine encorporating advanced technologies including genomics, AI as thinking partner, and nanotechnology in a greater extent. The quest for painless injection, lesstoxicity, rapid cell separation, and gene sequencing make ferrofluid the focus of personalized medicine. Currently, magnetic nanoparicles and ferrofluides are becoming driving force of personalized medicine. However, contronlling and managing nanoscale …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 Read article
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INVESTIGATING PHYTOCHEMICAL INHIBITORS OF PSEUDOMONAS AERUGINOSA'S AHL SYNTHASE LASI: A PATH TOWARD NOVEL THERAPEUTIC AGENTS
Abstract: Objectives: This study intended to explore the potential of phytochemicals from Allium sativum to inhibit AHL synthase LasI, a critical protein of the Quorum Sensing (QS) pathway in Pseudomonas aeruginosa, with the ultimate objective of developing therapeutic agents for managing P. aeruginosa infections. Methods: The physicochemical properties, toxicity, aggregation ability and binding potential of phytochemicals from Allium sativum to the protein AHL synthase LasI were determined. Physicochemical properties, toxicity and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 40–54 Read article
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Evaluation for Diuretic Activity of Abutilon indicum and Amaranthus spinusus Leaves Extracts
Abstract: The diuretic activity of Abutilon indicum and Amaranthus spinusus leaves was studied. The fractions of ethanol and methanol showed significant increase in the urine elimination, while ethyl acetate fraction does not show diuretic activity. All the groups were compared to the control group; frusemide was used as reference standard drug in this screening activity. The phytochemical screening study showed the presence of flavonoids, saponins, terpenoids, and steroid content in both …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 12–15 Read article
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Biopolymer Hydrogels: Patent Insights and Emerging Technological Trends
Abstract: Hydrogel biopolymers have become a valuable resource for next-generation functional materials due to their inherent properties, including compatibility with biological systems, environmental degradability, and minimal toxicity. Intelligent gels that respond to changes in temperature, pH, or ionic strength have various applications across industries like pharmaceuticals, biomedical engineering, and the food sector. This review systematically compiles findings from patent disclosures and non-patent literature to highlight recent trends in biopolymer-based hydrogel research, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 916–924 Read article
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Formulation, Evaluation and Development of Multipurpose Cream Containing kokum Butter
Abstract: The creation of the multipurpose polyherbal crack-healing cream, which shields the skin from cracks and can also serve as a multifunctional cream to shield the skin from other skin issues. The polyherbal cosmetic formulation can be used to give skin a protective barrier and is safe to use. Over the course of the study, this multipurpose polyherbal cream demonstrated good homogeneity, pH, consistency, spreadability, and lack of phase separation. This …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 78–89 Read article
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Discovery of Curcumin: Miraculous Activity as Anticancer
Abstract: AbstractCancer is the second most life-threatening disease and one of the main public health problems worldwide now a day. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Curcumin is an active ingredient of the Curcuma longa plant, has received great attention over …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 29–38 Read article
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A Brief Review on Herbal Excipients
Abstract: Natural or herbal excipients are significantly more advantageous than their synthetic equivalents because they are readily available, non-toxic, and less expensive. The pharmaceutical industries are becoming more interested in using these herbal excipients – mainly polymers of natural origin – in formulation development because of growing knowledge of them. The purpose of this study is to provide light on the possibility of using natural excipients, which are biocompatible and able …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 2, 2025 · pp. 5–14 Read article
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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In Silico Molecular Docking Studies of Phytocompounds from Melissa officinalis Against MPXV Poxin Target
Abstract: Objectives: This study aimed to evaluate the inhibitory potential of phytocompounds of Melissa officinalis against the MPXV poxin protein target, a key virulence factor in monkeypox infection. Methods: Molecular docking performed using PyRx, a virtual screening software, was conducted to predict the binding affinities of the compounds to MPXV poxin. Prior to docking, the compounds were subjected to comprehensive analysis, including Lipinski's rule of five, evaluation of physicochemical properties, pharmacological …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 25–38 Read article
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Development and Evaluation of a Cost-Effective UV-Protective Cream Containing Para-Aminobenzoic Acid and Aloe Vera for Indian Climatic Conditions.
Abstract: The increasing incidence of ultraviolet (UV) radiation-induced skin disorders has heightened the demand for effective, affordable photoprotective agents, especially in countries with high sun exposure such as India. This study aimed to develop a cost-effective and efficient UV-B protective cream formulation suitable for populations in Indian latitudes. Para-aminobenzoic acid (PABA) was selected as the primary sunscreening agent due to its high UV-B absorption efficiency, low toxicity, and affordability compared with …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 2, 2025 · pp. 7–18 Read article
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Artificial Intelligence In Transfusion Medicine And In Our Mission To “BEAT- COVID”
Abstract: The key objectives of this manuscript are: 1] Demystifying the buzzword of Artificial Intelligence [AI] and comparing neuronal networkings similarity of machines with some mammals; 2] Exploring, from outside sources, the breath of some computerized procedural data generated in laboratory and clinical areas of medicine, by robotic tools in the cutting age of transfusion medicine; 3] Expressing views on the variabilities of covid- associated long lasting microcirculatory disseminated pathogenic autoimmune …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 7, Issue 3, 2020 · pp. 10–21 Read article
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Development of PLLA-based Bio Inks Applicable in the Medical Field
Abstract: Some synthetic polymers, such as Poly (L-lactic acid) (PLLA), are interesting to use in 3D bioprinting because they can have adaptable and resilient mechanical properties that also facilitate bioprinting processes. PLLA is a biocompatible polymer which makes it very interesting for medical applications, it is an aliphatic polyester obtained from α-hydroxy acids in different ways: ring-opening polymerization, and direct polycondensation. The use of one path over the other depends on …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 24, Issue 2, 2022 · pp. 38–46 Read article
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Network Pharmacological Studies in Biological Interactions of Thymoquinone
Abstract: Thymoquinone, a bioactive phytochemical compound belonging to the class of benzoquinones, is prominently present in the plant Nigella sativa. Despite its widespread use, the precise molecular mechanisms underlying its beneficial effects remain elusive. To address this gap, we employed network pharmacology to investigate the actions of Thymoquinone (TQ). Our methodology encompassed the utilization of diverse bioinformatic tools to scrutinize this molecule of interest comprehensively. Initially, we retrieved the chemical structure, …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 12, Issue 3, 2023 · pp. 18–25 Read article
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Antibacterial Activity of Pongamia pinnata Leaf and Callus Extracts against Microorganisms Causing Periodontal Diseases
Abstract: Some specific microorganisms have been identified as etiologic agents of periodontitis. The main goal of treatment is to control the spread of infection. Depending on the extent of the gum disease, treatment varies. Therapeutic antibiotic along with surgery are the most opted form of treatment. But, due to high costs of antibiotics, the disastrous side effects and emergence of multi drug resistant strains of these pathogenic bacteria, a safe alternative …
Published in Research and Reviews: A Journal of Dentistry · Vol. 3, Issue 2, 2012 · pp. 1–7 Read article
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Phytochemistry and Antimicrobial Potential of Apang (Achyranthes aspera L.): An Update Review
Abstract: Normal 0 false false false EN-US X-NONE X-NONE With the increase of synthetic antibiotic resistance and severe side effects, the pharmaceutical industry is interested in finding new drugs from natural sources with fewer or no side-effects. The present review deals with the phytochemical and antimicrobial aspects of Achyranthes aspera- a commonly used folk medicinal plant in Bangladesh and other tropical countries. Different parts of this plant (leaf, root, stem and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 2, 2012 · pp. 1–8 Read article