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25 articles for “poorly soluble”
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Evaluation of Polyethylene Glycol (PEG)-Based Polymers for Improving Solubility and Bioavailability of Poorly Soluble Drugs
Abstract: A significant barrier to optimizing oral bioavailability is the inadequate water solubility of numerous pharmaceutical compounds. This study examined whether polymer systems utilizing polyethylene glycol (PEG) may enhance the solubility and bioavailability of a poorly soluble model drug. Multiple PEG polymers with molecular weights between 2,000 and 10,000 Da were utilized to produce PEGylated preparations. The formulations were subsequently evaluated for dissolution efficacy, medication loading capacity, particle size, and solubility …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 489–499 Read article
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Advances in Solubility Enhancement Strategies for Poorly Water-soluble Drugs: A Comprehensive Review
Abstract: Solubility enhancement holds significant importance in the field of pharmaceutical research as it aims to augment the solubility and bioavailability of drugs that possess low solubility. Poorly soluble drugs pose a considerable challenge in drug development due to their tendency to display inadequate absorption, bioavailability, and therapeutic efficacy. The advancement of solubility enhancement techniques encompasses a wide range of approaches, including physical and chemical methods, as well as innovative technologies …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 01–09 Read article
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Distinctive Approaches for Improving the Aqueous Solubility of BCS Class II Drugs
Abstract: The most difficult feature of many novel chemical entities is their solubility behaviour, as 60 percent of new promising products suffer solubility limitations. This is the most common reason for novel medicine compounds failing to reach the market or performing to their full potential. The proportion of the aqueous phase when the solution is in equilibrium with the pure substance in its normal phase is referred to as aqueous solubility. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 52–56 Read article
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Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants
Abstract: Candesartan cilexetil, a BCS class II drug with low aqueous solubility and poor bioavailability (15%), poses challenges for oral delivery. To address this limitation, the present study focuses on polymer-based inclusion complexation and composite formulation strategies to enhance solubility and dissolution behavior. The drug was incorporated into β-cyclodextrin (β-CD), a cyclic oligosaccharide polymer, by the kneading method in different drug-to-carrier ratios. Among these, the 1:1 molar ratio complex exhibited the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 687–695 Read article
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Advancements in Solubility Enhancement Through Liquisolid Compact Technology: A Comprehensive Review
Abstract: The study examines Liquisolid Compact Technology as an innovative approach for improving the bioavailability and solubility of drugs that are poorly soluble in water. Liquisolid systems, comprising solid carriers and liquid drugs, offer advantages such as improved drug release and bioavailability, reduced manufacturing costs, and controlled drug delivery. The technique involves dissolving or suspending the drug in non-volatile solvents, adding carrier materials, super disintegrants, and coating materials, and then compressing …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 25–34 Read article
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Exploring Type-II Diabetes Potential of Phyto-Derived Carbon Dots
Abstract: The integration of phytoconstituents with carbon dots (C-dots) presents a novel and sustainable approach to the development of nanotherapeutics for type 2 diabetes mellitus (T2DM). C-dots, zero-dimensional carbon-based nanomaterials, exhibit unique physicochemical properties including high fluorescence, tunable surface chemistry, biocompatibility, and low toxicity. Their ability to enhance the solubility, bioavailability, and targeted delivery of poorly soluble phytochemicals renders them highly suitable for biomedical applications. This study explores the synthesis of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 08–25 Read article
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Development and Optimization of Orally Disintegrating Tablets (ODTs) Containing Standardized Curcumin Extract for Enhanced Bioavailability and Patient Compliance
Abstract: This research centers on creating and perfecting orally disintegrating tablets with standardized curcumin extract to both increase its bioavailability and promote better patient adherence. Although curcumin has numerous therapeutic applications. It remains clinically ineffective due to its poor aqueous solubility and bioavailability constraints. The development of orally disintegrating tablets involved direct compression with various levels of superdisintegrants including sodium starch glycolate and cross povidone to address existing challenges. Research teams …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 1–06 Read article
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Advancing Capsule Technology: A Comprehensive Review of Formulation Strategies
Abstract: Capsules are a popular and versatile oral dosage form used in drug delivery, offering benefits such as ease of swallowing, taste masking, and improved stability of active pharmaceutical ingredients (APIs). They can be made from gelatin or non-gelatin materials like Hydroxypropyl Methylcellulose (HPMC), Polyvinyl Alcohol (PVA), and starch, catering to dietary, cultural, and sustainability needs. Capsules can be engineered for controlled, sustained, or targeted release, enhancing bioavailability, particularly for poorly …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 44–56 Read article
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Orally Dispersible Tablet of Mesalazine: Formulation and Evaluation
Abstract: Oral disintegrating tablets (ODTs) become increasingly more and more popular, particularly among elderly and paediatric patients who have difficulties with swallowing. The 5-aminosalicylic acid compound oral mesalazine, frequently referred to as mesalamine, is used to treat mild to severe ulcerative colitis and has a high percentage of success in causing and establishing response. Mesalazine has a topical therapeutic action at the location of the suffering colonic mucosa. The medication’s disadvantage …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 16–25 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Phyto-Entrapped Carbon Dots as Emerging Nanomaterials for Anti-Cancer Activity
Abstract: Phytoconstituent-loaded carbon dots (C-dots) represent an innovative approach in targeted cancer therapy, combining the therapeutic power of plant-derived compounds with the advanced capabilities of nanotechnology. These ultra-small, biocompatible nanostructures offer excellent fluorescence, tunable surface chemistry, and low toxicity, making them ideal for drug delivery, bioimaging, and theranostic applications. Traditional phytochemicals often face challenges like poor solubility, low bioavailability, and high first-pass metabolism barriers that C-dots help overcome. C-dots synthesized through …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 51–63 Read article
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Biodegradable Polymer Nano Composites for Enhanced Drug Bioavailability
Abstract: Polymer-based nanoparticles have emerged as a revolutionary approach in drug delivery systems, particularly in enhancing the bioavailability of poorly soluble and unstable drugs. These nanoparticles, composed of both natural and synthetic polymers, serve as effective vehicles for encapsulating a wide range of therapeutic agents. Their surface characteristics can also be modified to enable targeted drug delivery, increasing the concentration of drugs at the site of action while minimizing side effects. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 433–443 Read article
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Nanotechnology meet phytomedicine towards smarter drug delivery system.
Abstract: Using bioactive substances derived from plants, or phytomedicine, has long shown promise in treating a variety of illnesses with fewer adverse effects than synthetic medications. Nevertheless, a lot of phytochemicals have issues with inadequate targeting in vivo, low bioavailability, poor solubility, and chemical instability. By enabling encapsulation, controlled release, targeted delivery, and stimuli responsive behavior, nanotechnology provides effective tools to get around these restrictions. This review examines the intersection of …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 46–53 Read article
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Bioenhancer to Boost Herbal Drug Efficacy
Abstract: Bioenhancers are natural substances that significantly improve the absorption, bioavailability, and therapeutic efficacy of drugs when co-administered, without showing notable pharmacological activity of their own. In herbal medicine, the concept of bioenhancement has received growing attention as many phytoconstituents exhibit low oral bioavailability due to poor solubility, limited permeability, and extensive first-pass metabolism. The traditional Ayurvedic system first introduced this concept through the discovery of Piperine, the active alkaloid from …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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An Insightful Study on SMEDDS Challenges and Potential Strategies
Abstract: Self-microemulsifying drug delivery systems (SMEDDS) have gained attention as an effective approach to enhance the bioavailability of poorly water-soluble drugs. They are innovative lipid-based formulations designed to enhance the solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs. The development of SMEDDS involves systematic selection of components based on solubility and emulsification efficiency, followed by optimization of ratios using pseudo-ternary phase diagrams. The resulting formulations are evaluated for droplet size, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 311–334 Read article
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Swift Solutions: The Science and Innovation Behind Fast-Dissolving Tablets
Abstract: Swift solutions in the context of fast dissolving tablets (FDTs) represent an innovative breakthrough in pharmaceutical science, aiming to provide rapid and effective drug delivery for patients who face difficulty swallowing conventional dosage forms. The science and innovation behind FDTs are rooted in advanced formulation techniques, material science, and drug delivery mechanisms that prioritize speed, convenience, and patient compliance. These tablets are formulated to dissolve quickly in the mouth, removing …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 26–36 Read article
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Development and Characterization of a Solid Dispersion of an Anti-Diabetic Drug Using Pectin as a Natural Polymer
Abstract: Aim: The current study sought to improve the solubility and oral bioavailability of gliclazide by creating solid dispersions and oral dispersible tablets (ODTs) with enhanced physicochemical characteristics and maintained antidiabetic action. Methods: Preformulation studies were conducted to evaluate the physicochemical properties of gliclazide, including physical appearance, melting point, solubility, and partition coefficient. Solid dispersions were prepared using hydrophilic carriers-pectin and PVP K30, and subsequently characterized by Fourier Transform Infrared Spectroscopy …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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Recent Advances in Delivering Strategies of Domperidone Challenges and Opportunities
Abstract: Domperidone (DMP), a potent gastroprokinetic and antiemetic drug, exhibits poor aqueous solubility and limited oral bioavailability. Therefore, to develop oral preparations with optimized oral bioavailability, the pharmacokinetic parameters of DMP need to be controlled. The present review aimed to discuss the physicochemical characteristics of DMP causing its unfavorable oral delivery, to explore the viable oral formulation approaches, and to propose some recent formulation approaches that can mitigate the above mentioned …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 13–24 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article