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26 articles for “Hormonal therapy”
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Evaluating Pain and Quality of Life Improvement in Endometriosis: A Prospective Interventional Study
Abstract: Background: World-wide about 10% of reproductive-age women affects with endometriosis, drastically reducing their quality of life. This study assessed the effectiveness of a combination medicinal and lifestyle intervention approach in controlling endometriosis-related pain and enhancing quality of life. Methods: A prospective interventional study was conducted with 350 women diagnosed with endometriosis between August 2022 to September 2024. Participants received a structured intervention combining hormonal therapy, pain management, and lifestyle modifications. …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 1, 2025 · pp. 38–45 Read article
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Towards smart cancer care - AI enhanced monitoring and intervention
Abstract: According to estimates from the World Health Organization (WHO) for 2022, cancer is one of the leading causes of mortality, accounting for roughly 16% of all deaths globally. The goal of the cancer community is to improve the lives of those who are impacted by cancer and to cut the cancer death rate in half during the next several years. If cancer is identified early and treated, its impact on …
Published in Journal of Microwave Engineering and Technologies · Vol. 12, Issue 1, 2025 · pp. 38–44 Read article
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Nurse’s Responsibility and Liability in Chemotherapy Formulation: Legal and Ethical Considerations
Abstract: Each year, over 16 million new cancer cases are diagnosed globally. Cancer causes cells to grow uncontrollably, potentially leading to the formation of tumors, immune system damage, and other debilitating effects that can be fatal. Common cancer treatments include surgery to remove tumors, chemotherapy, radiation therapy, hormonal therapy, and immunotherapy. Among these, chemotherapy plays a significant role, accounting for nearly half of the overall treatment approach. Chemotherapy drugs can be …
Published in International Journal of Oncological Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 15–20 Read article
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Assessing Supportive Care Needs Among Breast Cancer Survivors: A Cross-Sectional Study
Abstract: Breast cancer poses a significant global health challenge and ranks among the primary causes of cancer-related morbidity and mortality worldwide. The objective of this study was to evaluate the supportive care needs of survivors of breast cancer and examine how these needs are related to various background factors. To accomplish this, a cross-sectional study was carried out with 116 breast cancer survivors, selected using a convenient sampling method. Data were …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 39–42 Read article
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Non -Invasive Ways to Detect Cancer
Abstract: Cancer is a diverse group of diseases characterized by uncontrolled cell growth and division, affecting millions worldwide and being a leading cause of death. The disease typically involves genetic alterations that disrupt the normal balance of cell growth, leading to the formation of tumors. Tumors can be benign, posing no threat as they do not spread, or malignant, capable of invading nearby tissues and metastasizing. There are more than 100 …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 2, 2024 · pp. 59–67 Read article
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Stingless Honeybee’s Rare Sugar and PCSK 9 - LDLR Interaction, A New Hope for Hormone Dependent Breast Cancer Patients – An In-silico Study
Abstract: Hypercholesterolemia is a lipid disorder characterized by elevated levels of low-density lipoprotein (LDL), commonly known as "bad" cholesterol. This condition is a significant risk factor in the development and progression of hormone-dependent breast cancer, as well as in the emergence of resistance to hormonal therapy. One of the key regulators of cholesterol metabolism is the proprotein convertase subtilisin/kexin type-9 (PCSK9) protein, which facilitates the degradation of the LDL receptor (LDLR) …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Current Perspectives of Prader -Willi Syndrome: A Multisystem Approach
Abstract: Prader-Willi syndrome (PWS) is a genetic disorder with multisystem involvement, caused by the lack of expression of genes on the paternally inherited chromosome 15q11.2-q13 region from paternal 15q11-q13 deletions (about 60%) or maternal uniparental disomy 15 or both. It is a complex and contiguous gene disorder which affects the multiple systems with many clinical presentations especially hypothalamic insufficiency. The clinical features are characterized by short stature position, developmental delay, cognitive …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 42–48 Read article
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Deciphering the Roles of Estrogen Receptors and 27-Hydroxycholesterol in BC Progression
Abstract: Breast cancer (BC) ranks among the top causes of cancer-related deaths in women worldwide. Many risk factors of BC are linked to estrogen. Experiments of Beatson in 1896 show the role of steroid hormones as major determinant in BC. Action of steroid hormones is mediated by their receptors including Estrogen receptors (ERs). ERs are part of a subfamily of ligand-regulated transcription factors. Their primary role is to translate hormone signals …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 18–26 Read article
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Molecular Docking of Abroma augusta Phytocompounds Against Estrogen Receptor Alpha (Er-Α) for the Treatment of Menstrual Disorders
Abstract: Menstrual disorders, including dysmenorrhea (painful menstruation), amenorrhea (absence of menstruation), and irregular menstrual cycles, significantly impact women’s reproductive health and overall well-being. These conditions often arise from hormonal imbalances, inflammation, and uterine dysfunction, necessitating effective therapeutic interventions. Current treatments, such as hormonal therapies (oral contraceptives, progestin-only pills), NSAIDs, and surgical procedures (endometrial ablation, hysterectomy), provide relief but often target symptoms rather than addressing the underlying causes. Consequently, there is a …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 1–12 Read article
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The Hidden Struggle: Premenstrual Depression its Impact on Women’s Health and Management Strategies: A Narrative Review.
Abstract: Background: Premenstrual depression, including Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD), represents a significant yet underrecognized contributor to women’s mental health burden. Hormonal fluctuations during the luteal phase interact with neurotransmitter systems, particularly serotonin and GABA, leading to affective and somatic symptoms that impair daily functioning. Objective: This systematic review synthesizes evidence on the prevalence, pathophysiology, psychological impact, and management strategies of premenstrual depression among reproductive-aged women, with particular …
Published in International Journal of Nutritions · Vol. 3, Issue 1, 2026 · pp. 21–32 Read article
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Drug Resistance in Targeted Cancer Treatment: Clinical Difficulties, Molecular Mechanisms, and Emerging Strategies
Abstract: Targeted cancer therapy, which selectively inhibits the molecular mechanisms responsible for tumor growth and development, has revolutionized modern oncology. Targeted therapies have lower systemic toxicity and better therapeutic efficacy when compared to traditional chemotherapy. However, the emergence of medication resistance often limits the long-term efficacy of these treatments, ultimately resulting in treatment failure and disease progression. Drug resistance develops through a number of intricate biological processes and can be innate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 130–138 Read article
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Emerging Therapies for Diabetes Mellitus: Efficacy and Safety of USFDA-Approved Drugs and Late-Stage Clinical Trials
Abstract: This review provides a comprehensive analysis of drugs approved by the U.S. Food and Drug Administration (USFDA) for managing diabetes mellitus (DM) from 2013 to 2022, including emerging treatments from phase 3 clinical trials during this period. Over the past decade, the treatment landscape for diabetes has evolved significantly, with new therapies not only improving blood sugar control but also targeting broader health outcomes like heart and kidney health. In …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 11–23 Read article
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Pharmacokinetics of Levothyroxine and Factors Influencing Its Therapeutic Efficacy in Hypothyroidism: A Comprehensive Review
Abstract: Levothyroxine (LT4) remains the standard therapy for hypothyroidism due to its effectiveness in restoring normal thyroid hormone levels and improving physiological functions. However, its pharmacokinetic profile exhibits considerable variability, which may influence therapeutic outcomes in clinical practice. This review aims to comprehensively evaluate the pharmacokinetics of levothyroxine, including its absorption, distribution, metabolism, and elimination, along with factors affecting its therapeutic efficacy. A structured literature search was conducted using electronic databases, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 Read article
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Polycystic Ovarian Syndrome and Its Management in Unani System of Medicine – A Comprehensive Review
Abstract: Polycystic ovarian syndrome (PCOS) is a prevalent endocrine disorder that significantly impacts women’s reproductive and metabolic health. It often leads to anovulation and infertility, creating distress for those affected. Additionally, PCOS increases the risk of developing diabetes and other long-term health complications. Recognizing and addressing PCOS is crucial, as early intervention can improve quality of life and prevent serious health issues. Common symptoms are polymenorrhea, oligomenorrhea, amenorrhea, hirsutism, acne, weight …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 2, 2025 · pp. 13–24 Read article
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Comprehending and Managing Restless Leg Syndrome
Abstract: An need to move that arises during rest or is made worse by rest, that happens in the evening or at night, and that goes away or gets better with movement is the hallmark of restless legs syndrome (RLS), a frequent sensorimotor disease. The degree, frequency, and age of start of symptoms vary greatly; severe types can impair mood, quality of life, and sleep. Periodic leg movements are common in …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 1–6 Read article
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Advanced Controlled Drug Delivery Systems
Abstract: Polymer-gel forms have gained popularity in medicine as means of medication delivery over the skin. This is so since they enable medications pass the skin more readily. These products allow medicine to be administered without surgery and provide continuous active ingredient supply. They are excellent for long-term therapy for managing conditions that keep resurfacing. From tiny synthetic ones to huge biological ones, polymer gels can store a wide spectrum of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 271–284 Read article
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Review on Unveiling the Shadow of Hyperpigmentation
Abstract: Natural products offer promising solutions for treating skin pigmentation disorders due to their non-toxic properties and effective mechanisms of action. Studies highlight their safety and efficacy through methods such as cytotoxicity tests, tyrosinase activity assays, and melanogenesis inhibition evaluations. Advanced delivery systems like liposomes and nanoparticles further enhance their performance by improving solubility and skin penetration. Skin pigmentation disorders, influenced by factors such as UV radiation, hormonal changes, and inflammation, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 59–66 Read article
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Ovarian Cancer: Understanding Risk Factors, Diagnosis, and Advances in Treatment
Abstract: Ovarian cancer is a leading cause of cancer-related mortality among women worldwide, often diagnosed at advanced stages due to its subtle early symptoms. Ovarian cancer develops due to a combination of factors, including genetics, environmental influences, and hormonal changes. This article explores the pathophysiology of ovarian cancer, highlighting the genetic mutations, such as BRCA1 and BRCA2, that contribute to its development. It also discusses current diagnostic methods, including imaging techniques …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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Pregnancy-Induced Post-Natal Back Pain
Abstract: Pregnancy-induced post-natal back pain (PNBP) is a common condition that affects many women following childbirth, significantly impacting their quality of life and physical functioning. The physiological and anatomical changes during pregnancy, such as weight gain, altered posture, and hormonal changes, contribute to the onset of back pain. As the body prepares for delivery, the pelvis and spine undergo structural shifts that can strain the muscles and ligaments supporting the lower …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 25–31 Read article