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550 articles for “HIV-1 Integrase” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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A Molecular Docking Study: Targetting HIV-1 Integrase Protein Against Selected Phytocompounds from Calophyllum Lanigerum
Abstract: Objectives: The most common form of HIV that causes AIDS is HIV-1. The World Health Organization has estimated roughly 75 million plus HIV-1 infections till date and roughly 40 million deaths (as of 2021). Thus, this study was done to identify natural compounds from Calophyllum lanigerum, a medicinal plant largely endemic to South-East Asia, to inhibit the spread of this disease. It did so by using molecular docking methods, Lipinski …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 43–55 Read article
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Impact of HIV on Global Health: A Comprehensive Review of Epidemiology and Interventions
Abstract: H.I.V remains a significant health issue of great concern to the world and with great impact to the individuals and communities on a global scale. This is a comprehensive literature review on the epidemiology of HIV, including both the world prevalence of HIV and the regional variations, especially in sub-Saharan Africa. It discusses the most important modes of transmission including sexual, blood, and vertical transmission and investigates the effectiveness of …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 39–45 Read article
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The Effects of HIV/AIDS Worldwide
Abstract: The Human Immunodeficiency Virus (HIV), which targets immune system conductors (CD4 cells), has infected millions throughout the world. HIV lowers the body's defences by infecting certain bodily fluids (blood, sperm, vaginal fluids, and breast milk) through unprotected sex, contaminated needles, or mother-to-child transmission. Early flu-like symptoms may go unrecognised, but if not treated, HIV advances to AIDS, which is characterised by severe immune system impairment. However, advances in antiretroviral therapy …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 26–31 Read article
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Millets as a Sustainable Crop for Nutritional Security: Addressing Malnutrition Challenges
Abstract: Millets are cereal crops belonging to the Poaceae family, which is the scientific name for the grass family. They are classified into two main groups: major millets which include Sorghum, Pearl, Finger millet, and minor millets, such as Little, Foxtail, Proso, Barnyard, and Kodo millet. India is the chief producer of millets, with an annual production of more than 17 million tonnes. This accounts for 80% of Asia’s millet production …
Published in International Journal of Nutritions · Vol. 2, Issue 1, 2025 · pp. 33–46 Read article
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Effect of Energy, Lysine and Energy/Lysine Ratio on Growth Performance Nutrient Digestibility and Serum Profile of Growing Locally Adapted Turkey
Abstract: This study investigated the effects of different levels of energy, lysine and energy/lysine ratios on growth performance, nutrient digestibility, and serum biochemical indices of locally adapted turkeys. The experiment lasted for 28 days. A total of one hundred and forty-four, 4-weeks old locally adapted turkey poults were completely randomized to six dietary treatments in a 2×3 factorial arrangement, replicated twice at 12 poults per replicate. Six diets were formulated. Diets …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 01–08 Read article
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Effect of Energy/Protein Ratio and Strain on Performance, Nutrient Digestibility and Serum Biochemical Indices of Exotic and Locally Adapted Turkey
Abstract: This study investigated the response of locally adapted and exotic turkeys raised under the same environmental conditions to diets with varying energy/protein ratio. One hundred and fourty-four (144) four-week old poults of each strain of turkey were randomly selected and assigned to six different diets in a 2 x 2 x 3 factorial arrangement. Each treatment diet were replicated twice with twelve (12) birds per replicate. Diets formulated with 28 …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 37–45 Read article
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Advances In HIV Research: Epidemiology, Pathogenesis, And Emerging Therapeutic Strategies
Abstract: Human Immunodeficiency Virus (HIV) remains a critical global health concern, infecting millions of individuals each year. The introduction of antiretroviral therapy (ART) has markedly improved disease outcomes by suppressing viral replication, restoring immune function, and extending patient longevity. Despite these advances, the complete eradication of HIV is hindered by the persistence of viral reservoirs, the emergence of drug-resistant strains, and disparities in healthcare accessibility. This review summarizes key developments in …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 1–5 Read article
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Decompensated Liver Failure and Acute Renal Failure in a Patient with Chronic HBV,HCV, and HIV Infections
Abstract: This case study focuses on a 30-year-old male patient suffering from decompensated liver failure and acute renal failure, complicated by chronic hepatitis B (HBV), hepatitis C (HCV), and HIV/AIDS. Presenting with severe abdominal pain, nausea, and general weakness, the patient had a history of alcohol and intravenous drug use, leading to chronic liver disease and acute renal failure. Despite aggressive interventions, including intravenous antibiotics and fluid therapy, his condition worsened …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 17–23 Read article
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Drug Repurposing of Anticancer Agents JP-8g and REDX05358 Against the Target Protein Plectin 1a in Epidemolysis Bullosa Simplex with Muscular Dystrophy (EBS-MD)
Abstract: Epidermolysis Bullosa Simplex with Muscle Dystrophy is a genetic disease affecting the skin and muscles which can be seen at birth or start at adulthood due to the mutation in the protein Plectin 1a (PLEC gene) causing skin blisters and muscle weakness. This protein is seen in sarcolemma, Z disks in skeletal muscles, hemidesmosomes in skin and cardiac muscles giving stability to cytoskeleton, playing a crucial role in neuromuscular transmission …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 22–34 Read article
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Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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Clinical Profile of Dengue Patients who had a Prior Infection with the Covid 19 Virus in a Tertiary Care Centre
Abstract: This cross-sectional analytical study conducted in a tertiary care center aims to investigate the clinical profile of Dengue virus-infected patients with a prior history of COVID-19 within the last three years. Dengue, a prevalent tropical disease, ranges from mild fever to severe conditions like hemorrhagic fever and shock syndrome. The study utilizes the World Health Organization's 2009 classification for Dengue and delineates the febrile, critical, and recovery phases of infection. …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 34–38 Read article
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Examining the Impact of a Nurse Navigator Program on Anxiety, Psychological Well-being, and Quality of Life in Breast Cancer Patients at a Tertiary Care Hospital in Haryana: A Randomized Controlled Trial
Abstract: Background of study: Breast cancer stands as the leading cancer type affecting women and remains a significant contributor to female mortality. It is a complex ailment influenced by multiple factors. Globally, in 2020, approximately 2.3 million women received diagnoses of breast cancer, resulting in 685,000 fatalities. This condition can profoundly impact various aspects of a person's existence, encompassing physical, psychological, emotional, social, and familial spheres. A notable observation is the …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 31–39 Read article
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A Study to Assess Effectiveness of Nurse Led Intervention on Knowledge and Attitude Towards Organ Donation Among B.Sc. Nursing 1st Year Students of College of Nursing, PGIMS, Rohtak
Abstract: Introduction: Life begins at birth and ends with death. In between, a person goes through various stages, each accompanied by different health challenges. Body donation is a noble act, and Shankaracharya strongly advocated the concept of organ donation, viewing the body as a means to help others. He believed that death is not the end, but rather a new beginning. Aim: To assess knowledge and attitude towards organ donation among …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 10–40 Read article
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Design and Simulation of Low Power Allow Area High Speed Carry Save Adder using CMOS 16 nm Technology.
Abstract: In this article, we propose a novel 1-bit hybrid full adder circuit that is implemented using eighteen transistors. Simulations are done using the Mentor Graphics Tool 16nm technologies. The performances are evaluated based on their speed, average power consumption, and power-delay product. The essential components of arithmetic units including compressors, comparators, parity checkers, etc. are full adders. Thus, raising the performance of the entire adder will raise the system's performance. …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 1, Issue 2, 2023 · pp. 17–28 Read article
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Design and Implementation of Low Power and Area Efficient Sub Threshold Level Shifter Using 16 nm CMOS Technology
Abstract: An efficient method of modifying subthreshold voltages is proposed here. As an alternative to static power dissipation, the suggested design allows for charging of internal nodes through VDDH. The force of the pull-down mechanism may be increased by connecting a second auxiliary circuit. The transition energy for input frequencies between 1 and 5 MHz is 84 fJ, the propagation delay is 46 ns, the dynamic power dissipation is 0.3 mW, …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 1, Issue 1, 2023 · pp. 16–24 Read article
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Experimental Investigation of Aerodynamic Characteristics of Dimpled 3D Aircraft Wing
Abstract: There is a strong demand for innovative designs, optimization of the aircraft components for their parts with respect to design, etc. One such innovation is by introduction of dimples in the wing of the aircraft. To study the effect of geometry modification of the wing, the present work compares the aerodynamic efficiency, ratio of lift to drag coefficients, along with different aerodynamic characteristics of an Inward and outward circular dimpled …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 1, Issue 1, 2023 · pp. 11–22 Read article
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IoT-based Smart EV Level 1 Charger: A Review
Abstract: This study presents the design and development of an IoT-based smart Level 1 charger for electric vehicles. The proposed system provides an intelligent and automated charging solution that optimizes the charging process, monitors the electricity consumption, and ensures the safety of the environment and the users. The system consists of a charging station equipped with a Wi-Fi module, a microcontroller, an LCD display, and an Android mobile application for remote …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 1, Issue 1, 2023 · pp. 14–20 Read article
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Design and Implementation of Low Noise Power Low and High Speed Three Stage Comparator Using 16nm Technology
Abstract: To meet the demands of quicker operation and reduced noise levels, this study proposes a new CMOS Three-based comparator version. Efficiency may be significantly improved by comparing the suggested model to existing ones. This is so because the suggested comparator would improve the efficiency of the current amplifier design. The suggested model drives the input pairs of the regenerator and the amplified stage, making for a quicker comparator. The structure …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 1, Issue 2, 2023 · pp. 10–16 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Tamil Migration to Colonial Malay and Burma from 1880-1920: Analysing the Acculturation Process through the Lens of Fashion
Abstract: This paper seeks to understand the cultural repercussions of colonial labour migration, which emerged as one of the key characteristics of the 19th century as European nations set up colonies in parts of Africa, Latin America, and South and Southeast Asia. The ‘coolie’ market consisted of indentured labourers and slaves and allowed the colonial rulers to supplement labour in new colonies. As the labourers migrated to new lands, they carried …
Published in International Journal of Trends in Humanities · Vol. 1, Issue 2, 2024 · pp. 19–24 Read article