All articles
363 articles
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Protective Effects Of Curcumin Against Osteoporosis And Its Molecular Mechanism
Abstract: One of the most prevalent metabolic disorders is osteoporosis (OP), which primarily affects postmenopausal women and the elderly. It is often associated with gradual loss of bone density, ongoing destruction of bone microstructure, and increased risk of osteoporosis. Pharmacotherapy is the primary approach for treating and preventing osteoporosis. However, persistent medication therapy invariably results in drug responses and particular adverse effects. Therefore, scientists continue to search for new monomeric compounds …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 16–23 Read article
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Navigating the Horizon: Current Trends in Elevating Quality Assurance in Clinical Research
Abstract: The landscape of clinical research quality management has evolved significantly in recent years, driven by stringent regulatory frameworks and globalization of trials. This evolution underscores the importance of integrating quality into all aspects of the clinical trial process from design to postresearch activities. Concepts such as Good Clinical Practice (GCP) and Quality by Design (QbD) are central to ensuring the reliability and accuracy of trial data while safeguarding patient safety …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 1–8 Read article
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Substance Misuse Fallout: Investigating the Multifaceted Consequences Experienced by Individuals in the Realm of Drug Abuse
Abstract: The drug industry is a complex field that involves legal medicines and illegal substances. It affects many aspects of society, including health, the economy, crime, and how people interact. This industry includes both medicines prescribed by doctors and drugs that are not allowed, each with its own effects. Lately, drug abuse has become a big problem, affecting people of all ages. Using drugs, whether legal or not, can harm health …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 45–52 Read article
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In Silico Assessment of Demethoxycurcumin: Molecular Docking and Computational Insights into its various therapeutic Potential
Abstract: Natural compounds are increasingly explored for their therapeutic potential in medical research. Here, we focused on demethoxycurcumin (DMC), a polyphenolic bioactive compound extracted from Curcuma longa, commonly found in turmeric. DMC, with a chemical formula of C20H18O5 and a molecular weight of 340 g/mol, possesses two aromatic ring systems, each featuring a β-diketone moiety connected by a seven-carbon chain. This unique structure allows DMC to engage in tautomerism, which is …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 9–15 Read article
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Fast Dissolving Oral Thin Films: A Review
Abstract: Fast-dissolving oral thin films (FDOFs) represent a significant advancement in drug delivery technology, offering advantages over traditional solid dosage forms, especially for patients with swallowing difficulties. FDOFs dissolve rapidly in the mouth, releasing the active ingredient without the need for water or chewing. They have picked up ubiquity due to their comfort, taste veiling capabilities, and progressed persistent compliance. Ideal drugs for FDOFs should possess characteristics such as solubility, stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 24–31 Read article
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Revolutionizing Gastro-retentive Drug Delivery: Exploring Innovative Formulation Strategies and Mechanisms in Floating in Situ Gel Raft Forming System
Abstract: An in-depth exploration of the transformative shift underway in gastro-retentive drug delivery, spotlighting the utilization of Floating Drug Delivery Systems (FDDS) and specifically honing in on the innovative formulation strategies and mechanisms inherent in Floating In Situ Gel Raft Forming Systems. FDDS present a promising avenue for revolutionizing drug delivery efficacy by capitalizing on buoyancy to float atop the gastric fluid surface, thereby extending gastric residence time and improving drug …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 9–21 Read article
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Advancements in Method Development and Validation for Levocetirizine: A Comprehensive Review
Abstract: This review article delves into the intricate realm of concurrent estimation of multiple compounds, with a specific emphasis on Levocetirizine and its related substances. It looks into how to improve analytical process specificity by using reverse phase high-performance liquid chromatography (RP-HPLC) in conjunction with UV detection. The study meticulously explores the intricacies of method development and validation, offering invaluable insights into the realms of precision and accuracy within pharmaceutical analysis. …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 15–27 Read article
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Formulation and Analyzation of Murraya Koenigii Herbal Antimicrobial Cream
Abstract: A person's skin is a crucial indicator of their overall health. Everyone experiences skin issues from time to time in their lives. Wrinkles, acne, pimples, dark spots, hypersensitivity, and atopic dermatitis are some of the ways they might manifest. The aim of this project was to formulate the herbal cream for the purpose of the moisturising, cooling, cure inflammation, itching, skin eruptions, persistent boils, wound healing, antimicrobial, and treatment of …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 8–14 Read article
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Formulation and Evaluation of Aqueous Azadirachta indica Phytosome
Abstract: A phytosome is a complex created through the union of a natural compound, typically a plant extract, with a phospholipid. Phospholipids play a crucial role in cell membranes, possessing a structure comprising a hydrophilic (water-attracting) head and hydrophobic (water-repelling) tails. This distinctive structure enables phospholipids to construct lipid bilayers, fundamental elements of cell membranes. Phytosome increases the bioavailability, and absorption of active chemical constituents in the extract with the help …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 1, 2024 · pp. 17–30 Read article
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Evaluation Of Anti Obesity Activity Of Citrus Sinensis & Citrus Limon By High Fat Diet Induced Model Using Danio Rerio
Abstract: Obesity, defined by the World Health Organization (WHO) as an abnormal or excessive fat accumulation that may impair health, is becoming one of the greatest challenges to global health in this millennium, with more than 300 million men and nearly 450 million women obese globally in 2018. Obesity turns into serious problem globally. Zebrafish model can be used extensively for drug screening due to its low maintenance cost, comparatively short …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 24–31 Read article
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Antioxidant activity of Passiflora foetida leaf extracts and silver nanoparticles in diabetic induced rats
Abstract: The anti-oxidant system present in our body prevents against the free radicals. Anti-oxidants were glutathione peroxidise,serum catalase,vitamin E, ascorbic acid and superoxide. In our study the plant extract of Passiflora foetidae were used to estimate the antioxidant levels in diet-induced diabetic rats. The mean of glutathione peroxide of normal rats was 92.98±1.65. "The mean of diet-induced diabetic rats was 152.50 ± 1.92*. Diabetic rats treated with sitagliptin and vildagliptin had …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 10–16 Read article
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Data Integrity Best Practices in Pharmaceutical Quality Assurance: A Thorough Review
Abstract: Data integrity stands as a linchpin in the reliability and trustworthiness of systems involved in handling, analyzing, and retrieving information, safeguarding the accuracy and consistency of data from inception to disposal. This paper delves into the multifaceted realm of data integrity, encompassing its definition, pivotal importance, regulatory underpinnings, core principles, and practical implementation strategies. A comprehensive exploration of regulatory guidelines, including ICH Q7, EU Annexure 11, and FDA regulations, underscores …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 22–30 Read article
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Revamping of Pharmaceutical Manufacturing Processes
Abstract: The pharmaceutical sector is entering a new era marked by technological advancements and an emphasis on sustainability and efficiency. A commitment to compliance can help boost consumer confidence and regulatory approval. This abstract explores the multifaceted approach to revamping pharmaceutical manufacturing processes, encompassing technological integration, regulatory compliance, and sustainability initiatives. Technological advancements, including automation, data analytics, and artificial intelligence, are playing a pivotal role in streamlining manufacturing operations. These innovations …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 38–44 Read article
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Comprehensive Overview of Analytical Chemistry: Principles, Techniques, and Method Validation
Abstract: Analytical chemistry constitutes a vital discipline within the realm of scientific inquiry, facilitating the identification and measurement of components present in diverse substances and mixtures. This paper delineates the principles, methodologies, and applications of analytical chemistry, focusing on spectroscopy and chromatography techniques. Spectroscopy, including UV-Visible spectroscopy, elucidates molecular properties by analysing the absorption of electromagnetic radiation, while chromatography enables the separation of compound mixtures based on differential affinities to stationary …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 14–21 Read article
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A Comprehensive Review On Panic Disorders
Abstract: Panic disorder is a prevalent mental health condition characterized by sudden, recurring episodes of intense fear accompanied by physical symptoms. It is twice as likely to affect women and may have a genetic predisposition. This disorder stems from an exaggerated response of the body's survival mechanisms and hormones, impacting manifestations like agoraphobia. Additionally, it is associated with significant psychiatric comorbidity and impaired functioning in various roles. Recent research has delved …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 53–59 Read article
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Effects of Gypsophila on Airway Inflammation in Guinea pig model of ovalbumin‐induced Asthma
Abstract: To look at how Gypsophlia (GSP) affects airway inflammation in a model of ovalbumin-induced asthma in guinea pigs (OVA).Methods: Using a random number table, sixty healthy female guinea pigs were split into six groups, each consisting of ten rats: the normal control, OVA, and GSP (0.45, 0.9, 1.8, and 3.6 g/kg). The ovalbumin and lipopolysaccharide sensitization approach was used to create the OVA guinea pig model. The GSP groups received …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 17–23 Read article
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A Review on Evolution of Medicine After and During Corona
Abstract: As of the beginning of 2023, 6.7 million people had perished from COVID-19, according to the World Health Organization. However, there have also been some positive developments, such as the notable decline in influenza-related deaths in the first year of the pandemic as a result of masking and social isolation, as well as the quick adoption of vaccines utilizing cutting-edge technologies like mRNA vaccines, which hold out great promise for …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 1–9 Read article
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Harmonization For Medical Device Regulation In Asia: A Vital Need
Abstract: The Medical Device area is one of the most perplexing and testing business portions of the medical services industry with a close joint effort between science and design. Notwithstanding the way that Asia has 60% of the world populace giving enormous market potential, Asian medical care consumption comprises just 15% of the worldwide medical services consumption. The sped-up maturing populace and expanding pervasiveness of ongoing infection are the key drivers …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 31–37 Read article
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A Review On Wonder Plant Aloe Vera
Abstract: For millennia, people have utilized and appreciated the health, aesthetic, therapeutic, and skin- care benefits of aloe vera plants. Aloe is a plant that grows in dry regions of Africa, Asia, Europe, and America. It has approximately 300 species. Aloe barbadensis miller is the botanical name of aloe vera. It is a perennial, xerophytic, succulent, shrubby or arborescent plant with pea-green hue that is a member of the Asphodelaceae (Liliaceae) …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 1, 2024 · pp. 1–9 Read article
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The Study On Sphaeranthus Indicus
Abstract: The increasing usage of plant-based medications is mostly due to their lower costs, greater efficacy, and little or nonexistent adverse effects as compared to contemporary medications. To support the claims made about medicinal plants in traditional medicine systems, a great deal of research is being done on them. The Asteraceae family includes the aromatic herb Sphaeranthus indicus. It thrives as a weed in paddy fields and is found throughout India's …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 1, 2024 · pp. 37–43 Read article