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494 articles for “topical”
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Weighted Latent Dirichlet Allocation, an Optimized and Generalized Probabilistic Topic Model
Abstract: In this study, we have introduced a new distribution named as Mixture Weighted Dirichlet Distribution (MWDD) which acts as generalization to other distributions viz. Dirichlet Distribution, Length or Size-Biased Dirichlet, Area Biased and Volume Biased Dirichlet distributions. Aim of this research is to introduce and implement MWDD for Probabilistic Topic Modeling of Corpus of textual data as an optimized as well as generalized probabilistic topic model. Various statistical and structural …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 5, Issue 1, 2018 · pp. 18–31 Read article
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Formulation and Evaluation of a Natural Excipients-Based Diclofenac Sodium Topical Ointment
Abstract: The present study reports the formulation and evaluation of a diclofenac sodium topical ointment incorporating natural excipients to improve skin compatibility and formulation sustainability. Conventional topical non-steroidal anti-inflammatory drug (NSAID) formulations frequently rely on synthetic excipients that may cause dermal irritation and pose environmental concerns. To address these limitations, a 1% w/w diclofenac sodium ointment was developed using aloe vera gel, glycerin, xanthan gum, peppermint oil, vitamin E, and isopropyl …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 · pp. 14–26 Read article
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Polymeric Materials in Drug Delivery: Applications in Topical Formulations
Abstract: Polymeric materials play a crucial role in modern drug delivery systems, particularly in topical formulations. These materials enhance drug stability, control release rates, and improve bioavailability, making them essential components in pharmaceutical advancements. Polymers such as chitosan, hydrogels, and emulsifying agents are widely utilized in immediate-release topical formulations, where they contribute to improving therapeutic efficacy by ensuring uniform drug distribution, increased solubility, and enhanced skin penetration. The integration of polymer-based …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 34–41 Read article
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Formulation, Evaluation, and Stability Studies of a Topical Clotrimazole and Zinc Oxide Suspension with Enhanced Skin Protective Properties
Abstract: Background: Clotrimazole is a well-known antifungal agent frequently used in the treatment of various superficial fungal infections, while Zinc Oxide is a widely accepted skin protectant with soothing, astringent, and antimicrobial properties. Combining these agents in a topical suspension offers a dual therapeutic approach, enhancing both antifungal efficacy and skin protection. Objective: The objective of this study was to formulate, evaluate, and conduct stability studies on topical suspensions containing Clotrimazole …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 22–31 Read article
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Nanostructured Lipid Carriers as a Potential Topical Drug Delivery Approach
Abstract: Topical drug delivery is a remarkable approach to treat skin diseases and to avoid pain and low patient compliance in cases where a systemic delivery is required. However, the stratum corneum, which is the outermost skin layer, strongly protects the body from the entrance of substances, especially those hydrophilic in nature. For topical application of drugs generally application on skin is one of method of administration. But problem observed that …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 1, 2025 · pp. 40–49 Read article
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Role of Alkalinized Topical Heparin and Lignocaine Preparation in Burn Wound
Abstract: Burns can severely damage a patient's physical and mental health. We should consider pain, hospital stays, lost workdays, and financial strain while handling these patients. Burn patients need rapid specialist care to reduce morbidity and death. Heparin is anti-inflammatory, allergic, histaminic, serotonin-blocking, and proteolytic enzyme-blocking. Topical forms have been used to prevent burn extension, limit skin tissue loss, promote quicker healing with fewer contractures, relieve pain, reduce tissue oedema and …
Published in Trends in Drug Delivery · Vol. 10, Issue 2, 2023 · pp. 16–19 Read article
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Review On: Liquid Crystal Cream for Topical Drug Delivery
Abstract: A Liquid crystal creams represent a novel approach in skincare formulations, leveraging the unique properties of liquid crystal technology to improve skin hydration and barrier function. An overview of current developments in liquid crystal cream formulations is given in this article, with an emphasis on the benefits they offer for skincare and their composition and structure. Liquid crystal creams mimic the lipid bilayers of the skin, offering enhanced compatibility and …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 1–8 Read article
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Phytopharmacognostical Study and Development & Assessment of Topical Herbal Ointment from Leaves of Calotropis gigantea
Abstract: Joint pain is a common problem that affects people all over the world and calls for efficient treatment solutions. The present study investigated the creation of a topical formulation for the treatment of joint pain that uses an extract from the leaves of Calotropis gigantea. C. gigantea is sometimes referred to as huge milk weed and aak leaves. It is a member of the Apocynaceae family. This versatile plant has …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 114–120 Read article
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Formulation and Evaluation of Topical Antiacne Gel from Coriander and Garlic Extract
Abstract: Objective: To develop and evaluate a topical anti-acne gel formulated using aqueous extracts of coriander (Coriandrum sativum) and garlic (Allium sativum). The study aims to assess the antibacterial efficacy of the gel against acne-causing bacteria, specifically Propionibacterium acnes. Methods: 1.Extraction: Coriander Extract: Aqueous extraction was performed by soaking coriander seeds in distilled water, followed by filtration. Garlic Extract: Non-chemical extraction involved mixing crushed garlic with honey in a 1:1 ratio …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 3, 2024 · pp. 10–15 Read article
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Cosmetic Topical Formulations: Design Strategies, Skin Interaction Mechanisms, Clinical–Cosmetic Applications, and Emerging Trends
Abstract: Cosmetic topical products are central to modern skin care, as they deliver active ingredients directly to the skin surface and upper layers to improve appearance, texture, and function. By acting locally on the epidermis and adnexal structures, these preparations help manage dryness, photoaging, pigmentation, acne, and sensitive-skin conditions while minimizing systemic exposure. A wide range of dosage forms—creams, lotions, gels, ointments, serums, sprays, and transdermal-inspired cosmetic patches—are engineered to modulate …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 1, 2026 · pp. 39–47 Read article
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Topical Application of Acetone Solution of Cucurbitacin-A at 48 Hours After the Fourth Moult on the Parameters of Cocoon Spinned by Mature fifth instar larvae of Silkworm, Bombyx mori (L) [Race: Double Hybrid - (CSR6 x CSR26) x CSR2 x CSR27)].
Abstract: The topical application of acetone solution of Cucurbitacin-A at 48 hours after the fourth moult to the fifth instared larvae of silkworm, Bombyx mori (L) [Race: Double Hybrid - (CSR6 x CSR26) x CSR2 x CSR27)] was found significant influence on the parameteres of the silk cocoon and silk fibre. The weight of whole cocoon (deflossed), silk shell weight, weight of pupa and silk shell percentage or ratio in the …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 11, Issue 1, 2020 · pp. 16–25 Read article
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Assessing the Impact of Topical Steroids on Tinea Infections: An Epidemiological Investigation
Abstract: This retrospective epidemiological study investigates the prevalence and characteristics of modified tinea infections resulting from the use of topical steroids. Analyzing patient records from October 2022 at ‘District General Hospital, Amravati, the study reveals a significant association between topical steroid use and altered clinical features in 89% of cases. Factors such as steroid potency, duration of use, and specific tinea subtypes affected contribute to understanding the epidemiology of modified tinea …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 10–18 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Impact of Topical Pure Honey Application on Radiation-induced Oral Mucositis in Patients Receiving Radiation Therapy
Abstract: This quasi-experimental study assessed the effects of pure honey on radiation-induced oral mucositis in patients with head and neck cancer undergoing radiation therapy in Kottayam. The primary objectives were to evaluate the severity of oral mucositis in both experimental and control groups, determine the effectiveness of honey in alleviating symptoms, and examine the relationship between mucositis severity and selected demographic variables. Utilizing Bertalanffy’s General System Model as a conceptual framework, …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 14–18 Read article
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Development and Characterization of Bifonazole Nitrate Nanosuspension Loaded Topical Gel
Abstract: Objective: The goal of the present study was to formulate and evaluate nanosuspension-based topical delivery system of bifonazole nitrate (BN) or increased saturation solubility and controlled drug release. Methods: BN nanosuspension was prepared by pearl milling technique using zirconium oxide beads as a milling media, poloxamer 407 as a stabilizer and glycerol as wetting agent. Effect of various process parameters such as, stirring time and poloxamer concentration were optimized. The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 2, 2018 · pp. 36–48 Read article
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Design, Formulation, and Evaluation of Topical Meloxicam Emulgel
Abstract: AbstractThe study has the objective to formulate and evaluate meloxicam (MLX)-loaded nanoemulgel for topical drug delivery. Nanoemulsion is prepared by spontaneous emulsification technique. Nanoemulgel is prepared by adding nanoemulsion into the gel matrix. The characterization of meloxicam loaded nanoemulgel was performed. The formulations werecharacterized/evaluated for homogenicity, clarity, viscosity, pH, and drug release. In the present investigation, topical gel of MLX was formulated using pectin, polyethylene glycol (PEG), propylene glycol (PPG), …
Published in Trends in Drug Delivery · Vol. 9, Issue 3, 2022 · pp. 30–41 Read article
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Topical Luliconazole for the Management of Fungal Infections: A Review
Abstract: Luliconazole, an antifungal agent of the imidazole class, possesses a distinctive structure where the imidazole component is fused with the ketene dithioacetate configuration. It exists in its R-enantiomer form, which exhibits greater antifungal efficacy compared to lanoconazole, a compound comprising a racemic blend. Strong action is shown by luliconazole against filamentous fungi, such as dermatophytes. The pharmacokinetic characteristics of dermatophytes, such as Trichophyton rubrum and Microsporum gypseum, help explain why …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 1–6 Read article
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Polymer Chemistry in Sustained-Release Herbal Composites: Designing a Stable Euphorbia tithymaloides Topical System with Phospholipid and Polymer Matrices
Abstract: Polymer chemistry enables the stabilization and sustained release of herbal actives, critical for topical therapeutic applications. This study explores a novel process for preparing a stable, sustained-release topical composition of Euphorbia tithymaloides, leveraging polymer-based systems. Ethanolic extract (50 mg) of the plant, rich in unstable sugar moieties (e.g., D-ribose) and sterols (e.g., stigmasterol), is encapsulated within a phospholipid matrix of phosphatidylcholine (50–100 mg) and cholesterol (50–100 mg). This lipid-polymer complex, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 165–171 Read article
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Topic Detection in Tweets using Hashtags
Abstract: Data clustering is a common technique used for topic detection and identification in text. In this paper we propose tokenizing of hashtags as an effective and efficient way of generating bags of words for tweets (text messages on Twitter). The document- term matrix generated using these terms is smaller and more relevant compared to the full text tokenization. Tweets from the 2018 Oscars event tagged with #oscars hashtag were collected …
Published in Recent Trends in Programming languages · Vol. 5, Issue 2, 2018 · pp. 6–14 Read article
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Development and characterization of Emulgel a Novel formulation for topical drug delivery of Ofloxacin
Abstract: The aim of this work is to develop best Emulgel formulation carrying Antifungal agent Ofloxacin Emulgel has been emerged as a promising drug delivery system. Formulation of Ofloxacin Emulgel was done by using Carbopol 934 as a gelling agent, liquid paraffin as hydrophobic phase, Tween-80 and span-80 as emulsifiers and surfactant. Ofloxacin has been used in pharmaceutical formulation since it has antimicrobial activity. It acts by inhibiting bacterial DNA gyrase …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 2, 2019 · pp. 19–23 Read article