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178 articles for “structural integrity”
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Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Crystalline and Polymeric Interactions in Multi- layered Bulletproof Glass: A Study of Ballistic Resistance and Structural Integrity
Abstract: Bulletproof glass is engineered to withstand high-impact projectiles, offering a critical line of defense in various industries such as banking, military, and armored vehicles. This study explores the structural composition, energy absorption mechanisms, and performance characteristics of bulletproof glass when exposed to ballistic threats. The glass consists of layered constructions, often involving polycarbonate and adhesive interfaces such as polyvinyl butyral, which enhance its energy absorption and resistance to projectiles. The …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 2, 2024 · pp. 10–17 Read article
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Optimization and Structural Integrity of Truck Chassis Using Finite Element Analysis
Abstract: The chassis of a truck is a crucial component, and it acts as a framework for the body and other components of the truck. It must also be strong enough to withstand pressures like shock, twisting, vibration, and more. When building a chassis, having enough bending stiffness for better handling characteristics is just as important as strength. Deflection, maximum stress, and maximum equilateral stress are crucial design factors for the …
Published in International Journal of Advanced Control and System Engineering · Vol. 3, Issue 1, 2025 · pp. 31–37 Read article
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STRUCTURAL–EPIGENOMIC ATLAS: CNV/SV- DRIVEN PROGNOSTIC REFINEMENT ACROSS CANCERS
Abstract: Structural genomic alterations, including copy number variations (CNVs) and structural variants (SVs), play a central role in cancer initiation and progression. These alterations extend beyond gene dosage effects and interact dynamically with epigenomic mechanisms such as DNA methylation, histone modifications, and three-dimensional chromatin organization. Recent pan-cancer studies have demonstrated that CNV burden and SV signatures reflect key oncogenic processes including chromothripsis, homologous recombination deficiency, enhancer hijacking, and extrachromosomal DNA (ecDNA) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
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Role of Fatigue and Creep in Structural Damage: A Comprehensive Review
Abstract: Fatigue and creep are two critical degradation mechanisms that significantly influence the structural integrity and longevity of engineering materials. These phenomena arise due to different loading and environmental conditions but often coexist in various industrial applications, leading to severe material degradation over time. Fatigue primarily results from cyclic loading, where repeated stress variations induce microstructural damage and crack initiation, ultimately causing catastrophic failure. Conversely, creep occurs under sustained stress at …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 1, 2025 · pp. 22–26 Read article
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Investigations of Mechanical Testing and its Effects on Lithium Ion Battery and Battery Pack for Electric Vehicle Application
Abstract: This research delves into the comprehensive study of mechanical testing methodologies and their consequential impact on the structural integrity, safety, and performance of Lithium-Ion batteries (Li-ion) and battery packs designed for electric vehicle (EV) applications. The investigation aims to enhance the understanding of mechanical stressors' influence on the reliability and safety of energy storage systems crucial for the sustainable advancement of electric mobility. The paper opens with mechanical testing protocols …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 2, 2024 · pp. 35–49 Read article
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Prediction of Depth-Induced Stress Distribution and Maintenance Cost Implications for Submerged Structural Components
Abstract: This study investigates the influence of water depth on stress distribution and structural integrity of submerged mechanical components . Structural models fabricated from mild steel, stainless steel, carbon steel, and copper alloy were examined under hydrostatic loading corresponding to water depths between 30 cm and 150 cm. Results indicate that normal and shear stresses increased proportionally with depth due to intensified hydrostatic pressure. Mild steel exhibited the highest stress concentrations, …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 2, 2025 · pp. 29–35 Read article
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Revolutionizing Form and Function: Exploring 4D Printing as a Novel Manufacturing Approach for Complex Generative Structures and Customized Formworks
Abstract: This research delves into the transformative potential of 4D printing manufacturing technology, focusing on its innovative application in fabricating intricate generative and computational structures for adaptable formwork in both individualized and mass-customized scenarios. Spanning the interdisciplinary realms of digital design, digital fabrication, and material science, the study comprehensively explores the integration of these diverse fields. Utilizing generative algorithms and parametric design tools, the research employs simulations to realize complex patterns …
Published in International Journal of Manufacturing and Production Engineering · Vol. 1, Issue 2, 2023 · pp. 41–50 Read article
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Crack Propagation Analysis in Metallic Alloys: A Comparative Study of Traditional and Advanced Materials
Abstract: A vital component of materials science and engineering, crack propagation analysis is essential to determining the structural integrity and dependability of materials. Designing safe and long-lasting structures for a variety of sectors required an understanding of how cracks begin, spread, and interact with a material's microstructure. To guarantee the performance, safety, and dependability of materials in a variety of applications, crack propagation analysis is essential. It offers insightful information about …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 1, Issue 1, 2023 · pp. 33–41 Read article
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Fracture Mechanics-based Assessment of Welded Joints in Structural Steel Components
Abstract: In many engineering applications, connection by welding are essential to the structural integrity of steel components. However, because of the intricate interplay between material qualities, welding techniques, and structural stress conditions, evaluating the dependability and safety of these welded connections continues to be a difficult challenge. A systematic framework that evaluates the behavior of cracks and faults in welded joints is provided by fracture mechanics, which also offers insights into …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 1, Issue 2, 2023 · pp. 16–22 Read article
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Evaluation of Critical MMAW Welding Defects Using Computer Simulation in Industrial Manufacturing Systems
Abstract: Manufacturing is one of the key sectors of any countries GDP and welding is one of the prime manufacturing processes of the manufacturing sector. Welding has several notable advantages over mechanical joining techniques, including higher structural integrity, design flexibility, and cost and weight lowers. Welded products/structures are subjected to serious issues of residual stresses and distortions. The performance and sturdiness of the welded structures are severely impacted by weld remaining …
Published in International Journal of Industrial and Product Design Engineering · Vol. 3, Issue 2, 2025 · pp. 18–26 Read article
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Design and Development of Pipe Bending Machine
Abstract: The design and development of a pipe bending machine are crucial for various industrial applications, including the construction, automotive, and manufacturing sectors. Bending is a fundamental metalworking process that involves deforming pipes, tubes, square hollows, and rods without compromising their structural integrity. This study focuses on designing a cost-effective and efficient pipe bending machine that can accommodate different pipe sizes and materials. The key design considerations include selecting an appropriate …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 1, 2025 · pp. 22–30 Read article
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Quantifying Damage Evolution in Fiber-reinforced Composites Using Fracture Mechanics
Abstract: By evaluating the evolution of damage, such as cracks or delamination, within the material over time or under various loading situations, damage evolution in fiber-reinforced composites can be characterized using fracture mechanics. Fracture mechanics offers a framework for understanding and projecting the behavior of materials that already have damage or flaws. Since they have a high strength-to-weight ratio and unique mechanical qualities, fiber-reinforced composites are essential in many branches of …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 1, Issue 1, 2023 · pp. 26–32 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Design and Optimization of Radial Turbines for Waste Heat Recovery Applications
Abstract: Waste heat recovery (WHR) offers a compelling way to improve sustainability and energy efficiency in several different industrial sectors. In waste heat recovery (WHR) systems, radial turbines are essential because they capture waste heat and transform it into useful mechanical or electrical energy. A thorough summary of the design and optimization concepts guiding radial turbines for WHR applications is given in this review article. After outlining the basic concepts of …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 1, Issue 2, 2023 · pp. 52–58 Read article
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Optimal Design of Solar Roof Top Photovoltaic Plant Under Various Operating Conditions
Abstract: As conventional energy sources are quickly exhausted, the need to switch to sustainable alternatives has never been more urgent. The transition from conventional energy resources to renewable sources, particularly solar energy, has emerged as a pivotal step towards sustainable development This paper explores the advantages of solar power plants, with a focus on rooftop solar installations. Installing solar panels on a roof is revolutionizing the industry. The design phase of …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 1, Issue 1, 2023 · pp. 35–45 Read article
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Innovative Approaches in Bioinspired and Biomimetic Membrane Technologies: Bridging Nature and Engineering
Abstract: Bioinspired and biomimetic membranes represent a ground breaking advancement in membrane technology, offering innovative solutions to critical global challenges in water purification, chemical separation, and energy conversion. These membranes leverage the exceptional transport properties of biological systems, particularly through the incorporation of aquaporin proteins, which facilitate rapid and selective water transport. This review synthesises recent developments in aquaporin-based membranes, highlighting their remarkable efficiency in desalination processes, where they serve as …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 53–60 Read article
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Development of Automobile Scaled Model from CAD (Blender) Using FDM 3D Printing
Abstract: Additive manufacturing (AM), also known as 3D printing, has emerged as a disruptive technology with the potential to transform automotive manufacturing. This paper reviews the applications of AM across the automotive product development lifecycle. The paper examines case studies demonstrating the use of AM for developing computer-aided design (CAD) models from concept sketches. Overall, AM brings several benefits such as design flexibility, faster time-to-market, and distributed production. However, there are …
Published in International Journal of Advanced Control and System Engineering · Vol. 2, Issue 2, 2024 · pp. 1–9 Read article
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Deep Learning Applications in Bone Fracture Detection for Improved Radiographic Diagnostics
Abstract: Bone fracture detection is a critical aspect of medical diagnostics, traditionally relying on manual interpretation of radiographic images by experienced radiologists. This discipline has undergone a revolution with the introduction of machine learning (ML), which can improve accuracy, shorten diagnosis times, and lessen human error. This study investigates the use of different machine learning methods to enhance and automate the identification of bone fractures in radiography pictures. We utilized a …
Published in International Journal of Optical Innovations & Research · Vol. 2, Issue 2, 2024 · pp. 17–22 Read article
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Performance and Structural Analysis of Different Lithium-Ion Battery Chemistries for Electric Vehicle Applications
Abstract: Lithium-ion batteries (LIBs) stand at the forefront of electric vehicle (EV) technology and have become a driving force behind the development of advanced energy storage systems. In this study, performance and structural analysis of different lithium-ion battery (LIB) chemistries—namely Lithium Nickel Manganese Cobalt Oxide (NMC), Lithium Iron Phosphate (LFP), Lithium Cobalt Oxide (LCO) and Lithium Nickel Cobalt Aluminum Oxide (NCA)—is presented. The study explores important performance parameters like energy density, …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 3, Issue 2, 2025 · pp. 13–31 Read article